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Salivary Gland Large Cell Neuroendocrine Carcinoma

MedGen UID:
1731460
•Concept ID:
C2111748
•
Neoplastic Process

Definition

A large cell carcinoma that arises from the salivary glands and exhibits neuroendocrine differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSalivary Gland Large Cell Neuroendocrine Carcinoma

Recent clinical studies

Etiology

The histological spectrum and immunoprofile of head and neck NUT carcinoma: A multicentre series of 30 cases.
Viswanathan K, Hahn E, Dogan S, Weinreb I, Dickson BC, MacMillan C, Katabi N, Magliocca K, Ghossein R, Xu B
Histopathology 2024 Aug;85(2):317-326. Epub 2024 May 6 doi: 10.1111/his.15204. PMID: 38708903Free PMC Article
Large cell neuroendocrine carcinoma on the floor of the mouth: a rare entity in an unusual location.
Agea Martínez M, Navarro Cuéllar I, Sada Urmeneta A, Alijo Serrano F, Navarro Cuéllar C
Int J Oral Maxillofac Surg 2022 Jun;51(6):742-745. Epub 2021 Sep 2 doi: 10.1016/j.ijom.2021.08.021. PMID: 34481737
Large cell neuroendocrine carcinoma of the submandibular gland: a case report and literature review.
Mascitti M, Luconi E, Togni L, Rubini C
Pathologica 2019 Jun;111(2):70-75. doi: 10.32074/1591-951X-13-19. PMID: 31388199
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
Neuroectodermal neoplasms of the head and neck with emphasis on neuroendocrine carcinomas.
Mills SE
Mod Pathol 2002 Mar;15(3):264-78. doi: 10.1038/modpathol.3880522. PMID: 11904342

Diagnosis

Adamantinoma-like Ewing Sarcoma (ALES) May Harbor FUS Rearrangements : A Potential Diagnostic Pitfall.
Palsgrove DN, Foss RD, Yu W, Garcia J, Rooper LM, Rekhtman N, Antonescu C, Gagan J, Agaimy A, Bishop JA
Am J Surg Pathol 2023 Nov 1;47(11):1243-1251. Epub 2023 Jul 27 doi: 10.1097/PAS.0000000000002100. PMID: 37494548
Metastatic Neuroendocrine Tumors to Parotid Gland: Where Do They Come From?
Braun A, Cheng L, Reddy S, Gattuso P, Yan L
Int J Surg Pathol 2023 Apr;31(2):167-174. Epub 2022 Apr 24 doi: 10.1177/10668969221095267. PMID: 35466730
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Overview of the 2022 WHO Classification of Head and Neck Neuroendocrine Neoplasms.
Mete O, Wenig BM
Head Neck Pathol 2022 Mar;16(1):123-142. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01435-8. PMID: 35312985Free PMC Article
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
Large cell neuroendocrine carcinoma of the head and neck.
Kusafuka K, Ferlito A, Lewis JS Jr, Woolgar JA, Rinaldo A, Slootweg PJ, Gnepp DR, Devaney KO, Travis WD, Barnes L
Oral Oncol 2012 Mar;48(3):211-5. Epub 2011 Oct 22 doi: 10.1016/j.oraloncology.2011.09.016. PMID: 22024350

Prognosis

Large cell neuroendocrine carcinoma of the submandibular gland: a case report and literature review.
Mascitti M, Luconi E, Togni L, Rubini C
Pathologica 2019 Jun;111(2):70-75. doi: 10.32074/1591-951X-13-19. PMID: 31388199
Genomic profiling of a combined large cell neuroendocrine carcinoma of the submandibular gland.
Andreasen S, Persson M, Kiss K, Homøe P, Heegaard S, Stenman G
Oncol Rep 2016 Apr;35(4):2177-82. Epub 2016 Feb 12 doi: 10.3892/or.2016.4621. PMID: 26883388
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
Large cell neuroendocrine carcinoma of the submandibular gland: case report and literature review.
Yamamoto N, Minami S, Kidoguchi M, Shindo A, Tokumaru Y, Fujii M
Auris Nasus Larynx 2014 Feb;41(1):105-8. Epub 2013 Aug 13 doi: 10.1016/j.anl.2013.07.010. PMID: 23953500
Large cell neuroendocrine carcinoma of the head and neck.
Kusafuka K, Ferlito A, Lewis JS Jr, Woolgar JA, Rinaldo A, Slootweg PJ, Gnepp DR, Devaney KO, Travis WD, Barnes L
Oral Oncol 2012 Mar;48(3):211-5. Epub 2011 Oct 22 doi: 10.1016/j.oraloncology.2011.09.016. PMID: 22024350

Clinical prediction guides

The histological spectrum and immunoprofile of head and neck NUT carcinoma: A multicentre series of 30 cases.
Viswanathan K, Hahn E, Dogan S, Weinreb I, Dickson BC, MacMillan C, Katabi N, Magliocca K, Ghossein R, Xu B
Histopathology 2024 Aug;85(2):317-326. Epub 2024 May 6 doi: 10.1111/his.15204. PMID: 38708903Free PMC Article
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
Next-generation sequencing of salivary high-grade neuroendocrine carcinomas identifies alterations in RB1 and the mTOR pathway.
Goyal B, Duncavage EJ, Martinez D, Lewis JS Jr, Chernock RD
Exp Mol Pathol 2014 Dec;97(3):572-8. Epub 2014 Oct 29 doi: 10.1016/j.yexmp.2014.10.011. PMID: 25446844
ΔNp63 (p40) distribution inside lung cancer: a driver biomarker approach to tumor characterization.
Pelosi G, Rossi G, Cavazza A, Righi L, Maisonneuve P, Barbareschi M, Graziano P, Pastorino U, Garassino M, de Braud F, Papotti M
Int J Surg Pathol 2013 Jun;21(3):229-39. Epub 2013 Mar 12 doi: 10.1177/1066896913476750. PMID: 23486764
Merkel cell carcinoma and multiple primary cancers.
Howard RA, Dores GM, Curtis RE, Anderson WF, Travis LB
Cancer Epidemiol Biomarkers Prev 2006 Aug;15(8):1545-9. doi: 10.1158/1055-9965.EPI-05-0895. PMID: 16896047

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