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Metastatic Fallopian Tube High Grade Serous Adenocarcinoma

MedGen UID:
1744905
•Concept ID:
C5418954
•
Neoplastic Process
Synonyms: Metastatic Fallopian Tube High-Grade Serous Adenocarcinoma; Metastatic High Grade Fallopian Tube Serous Adenocarcinoma; Metastatic High-Grade Fallopian Tube Serous Adenocarcinoma

Definition

Fallopian tube high-grade serous adenocarcinoma that has spread from its original site of growth to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Fallopian Tube High Grade Serous Adenocarcinoma

Professional guidelines

PubMed

Uptake of testing for germline BRCA mutations in patients with non-mucinous epithelial ovarian cancers in Western Australia: a comparison of different genetic counseling methods.
Stearnes G, Nichols CB, Schofield L, O'Sullivan S, Pachter N, Cohen PA
Int J Gynecol Cancer 2019 Jul;29(6):1038-1042. Epub 2019 May 17 doi: 10.1136/ijgc-2019-000389. PMID: 31101686
Disease Distribution in Low-stage Tubo-ovarian High-grade Serous Carcinoma (HGSC): Implications for Assigning Primary Site and FIGO Stage.
Singh N, Benson JL, Gan C, Anglesio M, Arora R, Faruqi AZ, Hirschowitz L, Kommoss F, Scott K, Trevisan G, Leen SLS, Wilkinson N, Gilks CB, McCluggage WG
Int J Gynecol Pathol 2018 Jul;37(4):324-330. doi: 10.1097/PGP.0000000000000429. PMID: 28787323

Recent clinical studies

Etiology

Evolutionary states and trajectories characterized by distinct pathways stratify patients with ovarian high grade serous carcinoma.
Lahtinen A, Lavikka K, Virtanen A, Li Y, Jamalzadeh S, Skorda A, Lauridsen AR, Zhang K, Marchi G, Isoviita VM, Ariotta V, Lehtonen O, Muranen TA, Huhtinen K, Carpén O, Hietanen S, Senkowski W, Kallunki T, Häkkinen A, Hynninen J, Oikkonen J, Hautaniemi S
Cancer Cell 2023 Jun 12;41(6):1103-1117.e12. Epub 2023 May 18 doi: 10.1016/j.ccell.2023.04.017. PMID: 37207655
Genomic catastrophe, the peritoneal cavity and ovarian cancer prevention.
Yoon JY, Chapel DB, Goebel E, Qian X, Mito JK, Horowitz NS, Miron A, Soong TR, Xian W, Crum CP
J Pathol 2022 Jul;257(3):255-261. Epub 2022 Apr 18 doi: 10.1002/path.5891. PMID: 35238033
Fibronectin and Periostin as Prognostic Markers in Ovarian Cancer.
Kujawa KA, Zembala-Nożyńska E, Cortez AJ, Kujawa T, Kupryjańczyk J, Lisowska KM
Cells 2020 Jan 8;9(1) doi: 10.3390/cells9010149. PMID: 31936272Free PMC Article
Serous tubal intraepithelial neoplasia: the concept and its application.
Meserve EEK, Brouwer J, Crum CP
Mod Pathol 2017 May;30(5):710-721. Epub 2017 Jan 20 doi: 10.1038/modpathol.2016.238. PMID: 28106106
Low-Stage High-Grade Serous Ovarian Carcinomas: Support for an Extraovarian Origin.
Morency E, Leitao MM Jr, Soslow RA
Int J Gynecol Pathol 2016 May;35(3):222-9. doi: 10.1097/PGP.0000000000000256. PMID: 26630225Free PMC Article

Diagnosis

Evolutionary states and trajectories characterized by distinct pathways stratify patients with ovarian high grade serous carcinoma.
Lahtinen A, Lavikka K, Virtanen A, Li Y, Jamalzadeh S, Skorda A, Lauridsen AR, Zhang K, Marchi G, Isoviita VM, Ariotta V, Lehtonen O, Muranen TA, Huhtinen K, Carpén O, Hietanen S, Senkowski W, Kallunki T, Häkkinen A, Hynninen J, Oikkonen J, Hautaniemi S
Cancer Cell 2023 Jun 12;41(6):1103-1117.e12. Epub 2023 May 18 doi: 10.1016/j.ccell.2023.04.017. PMID: 37207655
Extracellular matrix in high-grade serous ovarian cancer: Advances in understanding of carcinogenesis and cancer biology.
Brown Y, Hua S, Tanwar PS
Matrix Biol 2023 Apr;118:16-46. Epub 2023 Feb 11 doi: 10.1016/j.matbio.2023.02.004. PMID: 36781087
Fallopian tube initiation of high grade serous ovarian cancer and ovarian metastasis: Mechanisms and therapeutic implications.
Bergsten TM, Burdette JE, Dean M
Cancer Lett 2020 Apr 28;476:152-160. Epub 2020 Feb 15 doi: 10.1016/j.canlet.2020.02.017. PMID: 32067992Free PMC Article
Fallopian Tube Neoplasia and Mimics.
Kolin DL, Nucci MR
Surg Pathol Clin 2019 Jun;12(2):457-479. doi: 10.1016/j.path.2019.01.006. PMID: 31097111
Serous Tubal Intraepithelial Carcinoma or Not? Metastases to Fallopian Tube Mucosa Can Masquerade as In Situ Lesions.
Singh R, Cho KR
Arch Pathol Lab Med 2017 Oct;141(10):1313-1315. doi: 10.5858/arpa.2017-0231-RA. PMID: 28968160

Therapy

In vivo modeling of metastatic human high-grade serous ovarian cancer in mice.
Kim O, Park EY, Klinkebiel DL, Pack SD, Shin YH, Abdullaev Z, Emerson RE, Coffey DM, Kwon SY, Creighton CJ, Kwon S, Chang EC, Chiang T, Yatsenko AN, Chien J, Cheon DJ, Yang-Hartwich Y, Nakshatri H, Nephew KP, Behringer RR, Fernández FM, Cho CH, Vanderhyden B, Drapkin R, Bast RC Jr, Miller KD, Karpf AR, Kim J
PLoS Genet 2020 Jun;16(6):e1008808. Epub 2020 Jun 4 doi: 10.1371/journal.pgen.1008808. PMID: 32497036Free PMC Article
Fibronectin and Periostin as Prognostic Markers in Ovarian Cancer.
Kujawa KA, Zembala-Nożyńska E, Cortez AJ, Kujawa T, Kupryjańczyk J, Lisowska KM
Cells 2020 Jan 8;9(1) doi: 10.3390/cells9010149. PMID: 31936272Free PMC Article
PAX2 function, regulation and targeting in fallopian tube-derived high-grade serous ovarian cancer.
Modi DA, Tagare RD, Karthikeyan S, Russo A, Dean M, Davis DA, Lantvit DD, Burdette JE
Oncogene 2017 May 25;36(21):3015-3024. Epub 2016 Dec 19 doi: 10.1038/onc.2016.455. PMID: 27991925Free PMC Article
Discrete molecular classes of ovarian cancer suggestive of unique mechanisms of transformation and metastases.
Gardi NL, Deshpande TU, Kamble SC, Budhe SR, Bapat SA
Clin Cancer Res 2014 Jan 1;20(1):87-99. Epub 2013 Oct 16 doi: 10.1158/1078-0432.CCR-13-2063. PMID: 24132919
An orthotopic model of platinum-sensitive high grade serous fallopian tube carcinoma.
Khabele D, Fadare O, Liu AY, Wilson AJ, Wass E, Osteen K, Crispens MA
Int J Clin Exp Pathol 2012;5(1):37-45. Epub 2011 Jan 1 PMID: 22295145Free PMC Article

Prognosis

Fallopian tube initiation of high grade serous ovarian cancer and ovarian metastasis: Mechanisms and therapeutic implications.
Bergsten TM, Burdette JE, Dean M
Cancer Lett 2020 Apr 28;476:152-160. Epub 2020 Feb 15 doi: 10.1016/j.canlet.2020.02.017. PMID: 32067992Free PMC Article
Fibronectin and Periostin as Prognostic Markers in Ovarian Cancer.
Kujawa KA, Zembala-Nożyńska E, Cortez AJ, Kujawa T, Kupryjańczyk J, Lisowska KM
Cells 2020 Jan 8;9(1) doi: 10.3390/cells9010149. PMID: 31936272Free PMC Article
Invasion patterns of metastatic high-grade serous carcinoma of ovary or fallopian tube associated with BRCA deficiency.
Reyes MC, Arnold AG, Kauff ND, Levine DA, Soslow RA
Mod Pathol 2014 Oct;27(10):1405-11. Epub 2014 Feb 28 doi: 10.1038/modpathol.2013.237. PMID: 24577588
The molecular fingerprint of high grade serous ovarian cancer reflects its fallopian tube origin.
Kessler M, Fotopoulou C, Meyer T
Int J Mol Sci 2013 Mar 25;14(4):6571-96. doi: 10.3390/ijms14046571. PMID: 23528888Free PMC Article
Morphological subtypes of ovarian carcinoma: a review with emphasis on new developments and pathogenesis.
McCluggage WG
Pathology 2011 Aug;43(5):420-32. doi: 10.1097/PAT.0b013e328348a6e7. PMID: 21716157

Clinical prediction guides

The genomic trajectory of ovarian high-grade serous carcinoma can be observed in STIC lesions.
Cheng Z, Ennis DP, Lu B, Mirza HB, Sokota C, Kaur B, Singh N, Le Saux O, Russo G, Giannone G, Tookman LA, Krell J, Barnes C, McDermott J, McNeish IA
J Pathol 2024 Sep;264(1):42-54. Epub 2024 Jul 2 doi: 10.1002/path.6322. PMID: 38956451
Genomic catastrophe, the peritoneal cavity and ovarian cancer prevention.
Yoon JY, Chapel DB, Goebel E, Qian X, Mito JK, Horowitz NS, Miron A, Soong TR, Xian W, Crum CP
J Pathol 2022 Jul;257(3):255-261. Epub 2022 Apr 18 doi: 10.1002/path.5891. PMID: 35238033
Fibronectin and Periostin as Prognostic Markers in Ovarian Cancer.
Kujawa KA, Zembala-Nożyńska E, Cortez AJ, Kujawa T, Kupryjańczyk J, Lisowska KM
Cells 2020 Jan 8;9(1) doi: 10.3390/cells9010149. PMID: 31936272Free PMC Article
Invasion patterns of metastatic high-grade serous carcinoma of ovary or fallopian tube associated with BRCA deficiency.
Reyes MC, Arnold AG, Kauff ND, Levine DA, Soslow RA
Mod Pathol 2014 Oct;27(10):1405-11. Epub 2014 Feb 28 doi: 10.1038/modpathol.2013.237. PMID: 24577588
Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling.
Bashashati A, Ha G, Tone A, Ding J, Prentice LM, Roth A, Rosner J, Shumansky K, Kalloger S, Senz J, Yang W, McConechy M, Melnyk N, Anglesio M, Luk MT, Tse K, Zeng T, Moore R, Zhao Y, Marra MA, Gilks B, Yip S, Huntsman DG, McAlpine JN, Shah SP
J Pathol 2013 Sep;231(1):21-34. doi: 10.1002/path.4230. PMID: 23780408Free PMC Article

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