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Cutaneous Acute Graft versus Host Disease

MedGen UID:
1756560
•Concept ID:
C5419484
•
Disease or Syndrome
Synonyms: Acute Cutaneous Graft versus Host Disease; Acute Cutaneous GvHD; Cutaneous Acute GvHD

Definition

Skin manifestations of acute graft versus host disease, which typically presents as an erythematous maculopapular rash involving the face, ears, palms, and soles that may spread to the trunk and evolve to erythroderma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCutaneous Acute Graft versus Host Disease

Professional guidelines

PubMed

Understanding and treatment of cutaneous graft-versus-host-disease.
Hong J, Fraebel J, Yang Y, Tkacyk E, Kitko C, Kim TK
Bone Marrow Transplant 2023 Dec;58(12):1298-1313. Epub 2023 Sep 20 doi: 10.1038/s41409-023-02109-x. PMID: 37730800
Cutaneous Graft-Versus-Host Disease: Diagnosis and Treatment.
Strong Rodrigues K, Oliveira-Ribeiro C, de Abreu Fiuza Gomes S, Knobler R
Am J Clin Dermatol 2018 Feb;19(1):33-50. doi: 10.1007/s40257-017-0306-9. PMID: 28656563Free PMC Article
Phototherapy for the treatment of cutaneous graft versus host disease.
Garbutcheon-Singh KB, Fernández-Peñas P
Australas J Dermatol 2015 May;56(2):93-9. Epub 2014 Oct 10 doi: 10.1111/ajd.12191. PMID: 25302552

Recent clinical studies

Etiology

Photochemotherapy and Graft-versus-Leukemia Reaction in Acute Leukemia: Tumor Immunity and Survival Are Dependent on Timing of Photochemotherapy of the Skin.
Feldreich N, Ringden O, Emtestam L
Dermatology 2017;233(4):303-313. Epub 2017 Dec 13 doi: 10.1159/000484138. PMID: 29232687
Increased plasmacytoid dendritic cells and RORγt-expressing immune effectors in cutaneous acute graft-versus-host disease.
Malard F, Bossard C, Brissot E, Chevallier P, Guillaume T, Delaunay J, Mosnier JF, Moreau P, Grégoire M, Gaugler B, Mohty M
J Leukoc Biol 2013 Dec;94(6):1337-43. Epub 2013 Aug 29 doi: 10.1189/jlb.0513295. PMID: 23990625
Stage IV cutaneous acute graft-versus-host disease. Clinical and histological study of 15 cases.
Goiriz R, Peñas P, Pérez-Gala S, Delgado-Jiménez Y, Aragüés M, García-Diez A, Fraga J, Figuera A, Fernández-Herrera J
J Eur Acad Dermatol Venereol 2009 Dec;23(12):1398-404. Epub 2009 Jun 8 doi: 10.1111/j.1468-3083.2009.03326.x. PMID: 19522707
Psoralen and ultraviolet A irradiation (PUVA) as therapy for steroid-resistant cutaneous acute graft-versus-host disease.
Furlong T, Leisenring W, Storb R, Anasetti C, Appelbaum FR, Carpenter PA, Deeg HJ, Doney K, Kiem HP, Nash RA, Sanders JE, Witherspoon R, Thompson D, Martin PJ
Biol Blood Marrow Transplant 2002;8(4):206-12. doi: 10.1053/bbmt.2002.v8.pm12014809. PMID: 12014809
Umbilical cord and placental blood transplantation: analysis of the clinical results.
Wagner JE Jr
J Hematother 1993 Summer;2(2):265-8. doi: 10.1089/scd.1.1993.2.265. PMID: 7921988

Diagnosis

Delayed presentation of toxic epidermal necrolysis-like cutaneous acute graft-versus-host disease in the setting of recent immunosuppressant discontinuation.
Goyal PKK, Xu S, Choi J
Dermatol Online J 2017 Oct 15;23(10) PMID: 29469783
Histopathologic Features of Cutaneous Acute Graft-Versus-Host Disease in T-Cell-Depleted Peripheral Blood Stem Cell Transplant Recipients.
Fischer A, Jakubowski AA, Lacouture ME, Hollmann TJ, Drucker AM, Maloy M, Prockop S, Querfeld C, Busam KJ, Pulitzer MP
Am J Dermatopathol 2015 Jul;37(7):523-9. doi: 10.1097/DAD.0000000000000357. PMID: 26091510Free PMC Article
Increased plasmacytoid dendritic cells and RORγt-expressing immune effectors in cutaneous acute graft-versus-host disease.
Malard F, Bossard C, Brissot E, Chevallier P, Guillaume T, Delaunay J, Mosnier JF, Moreau P, Grégoire M, Gaugler B, Mohty M
J Leukoc Biol 2013 Dec;94(6):1337-43. Epub 2013 Aug 29 doi: 10.1189/jlb.0513295. PMID: 23990625
Increased interleukin 10, tumor necrosis factor alpha, and interleukin 6 levels in blister fluid of toxic epidermal necrolysis.
Correia O, Delgado L, Barbosa IL, Campilho F, Fleming-Torrinha J
J Am Acad Dermatol 2002 Jul;47(1):58-62. doi: 10.1067/mjd.2002.120473. PMID: 12077582
Umbilical cord and placental blood transplantation: analysis of the clinical results.
Wagner JE Jr
J Hematother 1993 Summer;2(2):265-8. doi: 10.1089/scd.1.1993.2.265. PMID: 7921988

Therapy

Photochemotherapy and Graft-versus-Leukemia Reaction in Acute Leukemia: Tumor Immunity and Survival Are Dependent on Timing of Photochemotherapy of the Skin.
Feldreich N, Ringden O, Emtestam L
Dermatology 2017;233(4):303-313. Epub 2017 Dec 13 doi: 10.1159/000484138. PMID: 29232687
Histopathologic Features of Cutaneous Acute Graft-Versus-Host Disease in T-Cell-Depleted Peripheral Blood Stem Cell Transplant Recipients.
Fischer A, Jakubowski AA, Lacouture ME, Hollmann TJ, Drucker AM, Maloy M, Prockop S, Querfeld C, Busam KJ, Pulitzer MP
Am J Dermatopathol 2015 Jul;37(7):523-9. doi: 10.1097/DAD.0000000000000357. PMID: 26091510Free PMC Article
Acute cutaneous graft-versus-host disease resembling type II (atypical adult) pityriasis rubra pilaris.
Surjana D, Robertson I, Kennedy G, James D, Weedon D
Australas J Dermatol 2015 Feb;56(1):e21-3. Epub 2013 Oct 8 doi: 10.1111/ajd.12108. PMID: 25688705
Increased plasmacytoid dendritic cells and RORγt-expressing immune effectors in cutaneous acute graft-versus-host disease.
Malard F, Bossard C, Brissot E, Chevallier P, Guillaume T, Delaunay J, Mosnier JF, Moreau P, Grégoire M, Gaugler B, Mohty M
J Leukoc Biol 2013 Dec;94(6):1337-43. Epub 2013 Aug 29 doi: 10.1189/jlb.0513295. PMID: 23990625
Psoralen and ultraviolet A irradiation (PUVA) as therapy for steroid-resistant cutaneous acute graft-versus-host disease.
Furlong T, Leisenring W, Storb R, Anasetti C, Appelbaum FR, Carpenter PA, Deeg HJ, Doney K, Kiem HP, Nash RA, Sanders JE, Witherspoon R, Thompson D, Martin PJ
Biol Blood Marrow Transplant 2002;8(4):206-12. doi: 10.1053/bbmt.2002.v8.pm12014809. PMID: 12014809

Prognosis

Delayed presentation of toxic epidermal necrolysis-like cutaneous acute graft-versus-host disease in the setting of recent immunosuppressant discontinuation.
Goyal PKK, Xu S, Choi J
Dermatol Online J 2017 Oct 15;23(10) PMID: 29469783
Photochemotherapy and Graft-versus-Leukemia Reaction in Acute Leukemia: Tumor Immunity and Survival Are Dependent on Timing of Photochemotherapy of the Skin.
Feldreich N, Ringden O, Emtestam L
Dermatology 2017;233(4):303-313. Epub 2017 Dec 13 doi: 10.1159/000484138. PMID: 29232687
Stage IV cutaneous acute graft-versus-host disease. Clinical and histological study of 15 cases.
Goiriz R, Peñas P, Pérez-Gala S, Delgado-Jiménez Y, Aragüés M, García-Diez A, Fraga J, Figuera A, Fernández-Herrera J
J Eur Acad Dermatol Venereol 2009 Dec;23(12):1398-404. Epub 2009 Jun 8 doi: 10.1111/j.1468-3083.2009.03326.x. PMID: 19522707
Pneumatosis intestinalis in children after allogeneic bone marrow transplantation.
Yeager AM, Kanof ME, Kramer SS, Jones B, Saral R, Lake AM, Santos GW
Pediatr Radiol 1987;17(1):18-22. doi: 10.1007/BF02386589. PMID: 3547276

Clinical prediction guides

In Vivo reflectance confocal microscopy of cutaneous acute graft-versus-host disease: concordance with histopathology and interobserver reproducibility of a glossary with representative images.
Saknite I, Gill M, Alessi-Fox C, Zwerner JP, Lehman JS, Shinohara MM, Novoa RA, Chen H, Byrne M, Gonzalez S, Ardigo M, Tkaczyk ER
J Eur Acad Dermatol Venereol 2022 Jul;36(7):1034-1044. Epub 2022 Mar 22 doi: 10.1111/jdv.18004. PMID: 35175678Free PMC Article
Photochemotherapy and Graft-versus-Leukemia Reaction in Acute Leukemia: Tumor Immunity and Survival Are Dependent on Timing of Photochemotherapy of the Skin.
Feldreich N, Ringden O, Emtestam L
Dermatology 2017;233(4):303-313. Epub 2017 Dec 13 doi: 10.1159/000484138. PMID: 29232687
Increased plasmacytoid dendritic cells and RORγt-expressing immune effectors in cutaneous acute graft-versus-host disease.
Malard F, Bossard C, Brissot E, Chevallier P, Guillaume T, Delaunay J, Mosnier JF, Moreau P, Grégoire M, Gaugler B, Mohty M
J Leukoc Biol 2013 Dec;94(6):1337-43. Epub 2013 Aug 29 doi: 10.1189/jlb.0513295. PMID: 23990625
Stage IV cutaneous acute graft-versus-host disease. Clinical and histological study of 15 cases.
Goiriz R, Peñas P, Pérez-Gala S, Delgado-Jiménez Y, Aragüés M, García-Diez A, Fraga J, Figuera A, Fernández-Herrera J
J Eur Acad Dermatol Venereol 2009 Dec;23(12):1398-404. Epub 2009 Jun 8 doi: 10.1111/j.1468-3083.2009.03326.x. PMID: 19522707

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