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Metastatic Ovarian Endometrioid Adenocarcinoma

MedGen UID:
1759420
•Concept ID:
C5418890
•
Neoplastic Process

Definition

Ovarian endometrioid adenocarcinoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Ovarian Endometrioid Adenocarcinoma

Professional guidelines

PubMed

Past, Present, and Future of Serum Tumor Markers in Management of Ovarian Cancer: A Guide for the Radiologist.
Rao S, Smith DA, Guler E, Kikano EG, Rajdev MA, Yoest JM, Ramaiya NH, Tirumani SH
Radiographics 2021 Oct;41(6):1839-1856. doi: 10.1148/rg.2021210005. PMID: 34597221
Risk-stratifying clinicopathologic criteria for ovarian preservation in premenopausal women with early stage low-risk endometrial cancer.
Khadraoui W, Tierney C, Chung S, Mutlu L, Lu L, Azodi M, Ratner E, Menderes G
Int J Gynaecol Obstet 2020 Sep;150(3):385-391. Epub 2020 Jun 26 doi: 10.1002/ijgo.13254. PMID: 32506422
CT and MR imaging of ovarian tumors with emphasis on differential diagnosis.
Jung SE, Lee JM, Rha SE, Byun JY, Jung JI, Hahn ST
Radiographics 2002 Nov-Dec;22(6):1305-25. doi: 10.1148/rg.226025033. PMID: 12432104

Recent clinical studies

Etiology

Overview of Tumor Heterogeneity in High-Grade Serous Ovarian Cancers.
Azzalini E, Stanta G, Canzonieri V, Bonin S
Int J Mol Sci 2023 Oct 11;24(20) doi: 10.3390/ijms242015077. PMID: 37894756Free PMC Article
Synchronous endometrial and ovarian cancer and its recurrent risk factors: Case series.
Hoorshad N, Nassiri S, Najibi S, Feizabad E, Zamani N
Cancer Treat Res Commun 2023;36:100731. Epub 2023 Jun 25 doi: 10.1016/j.ctarc.2023.100731. PMID: 37429245
The relation between endometrioma and ovarian cancer.
Sorbi F, Capezzuoli T, Saso S, Fambrini M, Corda M, Fantappiè G, Petraglia F
Minerva Obstet Gynecol 2021 Jun;73(3):347-353. doi: 10.23736/S2724-606X.21.04757-2. PMID: 34008389
Mucinous Ovarian Tumors.
Mills AM, Shanes ED
Surg Pathol Clin 2019 Jun;12(2):565-585. doi: 10.1016/j.path.2019.01.008. PMID: 31097115
Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723

Diagnosis

DNA Methylation Signature of Synchronous Endometrioid Endometrial and Ovarian Carcinomas.
Hsu Lin L, Allison DHR, Turashvili G, Vasudevaraja V, Tran I, Serrano J, Weigelt B, Ladanyi M, Abu-Rustum NR, Snuderl M, Chiang S
Mod Pathol 2023 Nov;36(11):100321. Epub 2023 Aug 29 doi: 10.1016/j.modpat.2023.100321. PMID: 37652400
The diverse morphology and immunophenotype of ovarian endometrioid carcinomas.
Talia KL, McCluggage WG
Pathology 2023 Apr;55(3):269-286. Epub 2023 Jan 21 doi: 10.1016/j.pathol.2023.01.003. PMID: 36759286
Mucinous Ovarian Tumors.
Mills AM, Shanes ED
Surg Pathol Clin 2019 Jun;12(2):565-585. doi: 10.1016/j.path.2019.01.008. PMID: 31097115
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723

Therapy

Relacorilant + Nab-Paclitaxel in Patients With Recurrent, Platinum-Resistant Ovarian Cancer: A Three-Arm, Randomized, Controlled, Open-Label Phase II Study.
Colombo N, Van Gorp T, Matulonis UA, Oaknin A, Grisham RN, Fleming GF, Olawaiye AB, Nguyen DD, Greenstein AE, Custodio JM, Pashova HI, Tudor IC, Lorusso D
J Clin Oncol 2023 Oct 20;41(30):4779-4789. Epub 2023 Jun 26 doi: 10.1200/JCO.22.02624. PMID: 37364223Free PMC Article
Clinical implications of neoadjuvant chemotherapy in advanced endometrial cancer: a multi-center retrospective cohort study.
Lim H, Bang SH, Kim Y, Cho SH, Shin W, Kim SI, Kim TH, Suh DH, Lim MC, Kim JW
BMC Cancer 2022 Jun 27;22(1):703. doi: 10.1186/s12885-022-09746-3. PMID: 35761211Free PMC Article
Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications.
Kurman RJ, Shih IeM
Int J Gynecol Pathol 2008 Apr;27(2):151-60. doi: 10.1097/PGP.0b013e318161e4f5. PMID: 18317228Free PMC Article
Endometriosis-associated ovarian cancer: a clinicopathologic review.
Steed H, Chapman W, Laframboise S
J Obstet Gynaecol Can 2004 Aug;26(8):709-15. doi: 10.1016/s1701-2163(16)30642-9. PMID: 15307975
Evidence that endometriosis behaves in a malignant manner.
Thomas EJ, Campbell IG
Gynecol Obstet Invest 2000;50 Suppl 1:2-10. doi: 10.1159/000052872. PMID: 11093055

Prognosis

Overview of Tumor Heterogeneity in High-Grade Serous Ovarian Cancers.
Azzalini E, Stanta G, Canzonieri V, Bonin S
Int J Mol Sci 2023 Oct 11;24(20) doi: 10.3390/ijms242015077. PMID: 37894756Free PMC Article
Single-Cell RNA-Sequencing Atlas Reveals the Tumor Microenvironment of Metastatic High-Grade Serous Ovarian Carcinoma.
Deng Y, Tan Y, Zhou D, Bai Y, Cao T, Zhong C, Huang W, Ou Y, Guo L, Liu Q, Yin D, Chen L, Luo X, Sun D, Sheng X
Front Immunol 2022;13:923194. Epub 2022 Jul 22 doi: 10.3389/fimmu.2022.923194. PMID: 35935940Free PMC Article
The relation between endometrioma and ovarian cancer.
Sorbi F, Capezzuoli T, Saso S, Fambrini M, Corda M, Fantappiè G, Petraglia F
Minerva Obstet Gynecol 2021 Jun;73(3):347-353. doi: 10.23736/S2724-606X.21.04757-2. PMID: 34008389
p53 immunohistochemistry is an accurate surrogate for TP53 mutational analysis in endometrial carcinoma biopsies.
Singh N, Piskorz AM, Bosse T, Jimenez-Linan M, Rous B, Brenton JD, Gilks CB, Köbel M
J Pathol 2020 Mar;250(3):336-345. Epub 2020 Jan 29 doi: 10.1002/path.5375. PMID: 31829441
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974

Clinical prediction guides

Lymph node staging in grade 1-2 endometrioid ovarian carcinoma apparently confined to the ovary: Is it worth?
Bizzarri N, Imterat M, Fruscio R, Giannarelli D, Perrone AM, Mancari R, Traut A, Rosati A, du Bois A, Ferrari D, De Iaco P, Ergasti R, Ataseven B, Bianchi T, Di Stanislao M, Perri MT, Heitz F, Concin N, Fanfani F, Vizza E, Scambia G, Harter P, Fagotti A
Eur J Cancer 2023 Dec;195:113398. Epub 2023 Oct 20 doi: 10.1016/j.ejca.2023.113398. PMID: 37890354
Synchronous endometrial and ovarian cancer and its recurrent risk factors: Case series.
Hoorshad N, Nassiri S, Najibi S, Feizabad E, Zamani N
Cancer Treat Res Commun 2023;36:100731. Epub 2023 Jun 25 doi: 10.1016/j.ctarc.2023.100731. PMID: 37429245
p53 immunohistochemistry is an accurate surrogate for TP53 mutational analysis in endometrial carcinoma biopsies.
Singh N, Piskorz AM, Bosse T, Jimenez-Linan M, Rous B, Brenton JD, Gilks CB, Köbel M
J Pathol 2020 Mar;250(3):336-345. Epub 2020 Jan 29 doi: 10.1002/path.5375. PMID: 31829441
Prognostic factors of synchronous endometrial and ovarian endometrioid carcinoma.
Yoneoka Y, Yoshida H, Ishikawa M, Shimizu H, Uehara T, Murakami T, Kato T
J Gynecol Oncol 2019 Jan;30(1):e7. Epub 2018 Sep 17 doi: 10.3802/jgo.2019.30.e7. PMID: 30479091Free PMC Article
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974

Recent systematic reviews

Histologic Subtypes in Endometriosis-Associated Ovarian Cancer and Ovarian Cancer Arising in Endometriosis: A Systematic Review and Meta-Analysis.
Chiaffarino F, Cipriani S, Ricci E, Esposito G, Parazzini F, Vercellini P
Reprod Sci 2024 Jun;31(6):1642-1650. Epub 2024 Mar 4 doi: 10.1007/s43032-024-01489-9. PMID: 38438776Free PMC Article
Mismatch-repair deficiency, microsatellite instability, and lynch syndrome in ovarian cancer: A systematic review and meta-analysis.
Mitric C, Salman L, Abrahamyan L, Kim SR, Pechlivanoglou P, Chan KKW, Gien LT, Ferguson SE
Gynecol Oncol 2023 Mar;170:133-142. Epub 2023 Jan 20 doi: 10.1016/j.ygyno.2022.12.008. PMID: 36682091

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