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Acute Myeloid Leukemia Arising from Previous Myelodysplastic/Myeloproliferative Neoplasm

MedGen UID:
1760542
•Concept ID:
C5419465
•
Neoplastic Process

Definition

An acute myeloid leukemia developing in patients with a prior history of myelodysplastic/myeloproliferative neoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute Myeloid Leukemia Arising from Previous Myelodysplastic/Myeloproliferative Neoplasm

Recent clinical studies

Etiology

Alisertib plus induction chemotherapy in previously untreated patients with high-risk, acute myeloid leukaemia: a single-arm, phase 2 trial.
Brunner AM, Blonquist TM, DeAngelo DJ, McMasters M, Fell G, Hermance NM, Winer ES, Lindsley RC, Hobbs GS, Amrein PC, Hock HR, Steensma DP, Garcia JS, Luskin MR, Stone RM, Ballen KK, Rosenblatt J, Avigan D, Nahas MR, Mendez LM, McAfee SL, Moran JA, Bergeron M, Foster J, Bertoli C, Manning AL, McGregor KL, Fishman KM, Kuo FC, Baltay MT, Macrae M, Burke M, Behnan T, Wey MC, Som TT, Ramos AY, Rae J, Lombardi Story J, Nelson N, Logan E, Connolly C, Neuberg DS, Chen YB, Graubert TA, Fathi AT
Lancet Haematol 2020 Feb;7(2):e122-e133. Epub 2019 Dec 11 doi: 10.1016/S2352-3026(19)30203-0. PMID: 31837959Free PMC Article
Secondary acute myeloid leukemia - a single center experience.
Szotkowski T, Rohon P, Zapletalova L, Sicova K, Hubacek J, Indrak K
Neoplasma 2010;57(2):170-8. doi: 10.4149/neo_2010_02_170. PMID: 20099982

Diagnosis

Bone marrow morphological features and therapy in patients with Philadelphia-negative neoplasms.
Pich A, Beggiato E, Godio L, Riera L, Francia di Celle P, Lanzarone G, Benevolo G
Expert Rev Hematol 2021 Sep;14(9):841-850. Epub 2021 Aug 20 doi: 10.1080/17474086.2021.1967138. PMID: 34384330
Secondary acute myeloid leukemia - a single center experience.
Szotkowski T, Rohon P, Zapletalova L, Sicova K, Hubacek J, Indrak K
Neoplasma 2010;57(2):170-8. doi: 10.4149/neo_2010_02_170. PMID: 20099982
Chronic myelomonocytic leukemia evolving from preexisting myelodysplasia shares many features with de novo disease.
Wang SA, Galili N, Cerny J, Sechman E, Chen SS, Loew J, Liu Q, Fadare O, Hasserjian R, Jones D, Qawi H, Woda B, Raza A
Am J Clin Pathol 2006 Nov;126(5):789-97. doi: 10.1309/FU04-P779-U310-R3EE. PMID: 17050076

Therapy

Alisertib plus induction chemotherapy in previously untreated patients with high-risk, acute myeloid leukaemia: a single-arm, phase 2 trial.
Brunner AM, Blonquist TM, DeAngelo DJ, McMasters M, Fell G, Hermance NM, Winer ES, Lindsley RC, Hobbs GS, Amrein PC, Hock HR, Steensma DP, Garcia JS, Luskin MR, Stone RM, Ballen KK, Rosenblatt J, Avigan D, Nahas MR, Mendez LM, McAfee SL, Moran JA, Bergeron M, Foster J, Bertoli C, Manning AL, McGregor KL, Fishman KM, Kuo FC, Baltay MT, Macrae M, Burke M, Behnan T, Wey MC, Som TT, Ramos AY, Rae J, Lombardi Story J, Nelson N, Logan E, Connolly C, Neuberg DS, Chen YB, Graubert TA, Fathi AT
Lancet Haematol 2020 Feb;7(2):e122-e133. Epub 2019 Dec 11 doi: 10.1016/S2352-3026(19)30203-0. PMID: 31837959Free PMC Article
Secondary acute myeloid leukemia - a single center experience.
Szotkowski T, Rohon P, Zapletalova L, Sicova K, Hubacek J, Indrak K
Neoplasma 2010;57(2):170-8. doi: 10.4149/neo_2010_02_170. PMID: 20099982

Prognosis

Alisertib plus induction chemotherapy in previously untreated patients with high-risk, acute myeloid leukaemia: a single-arm, phase 2 trial.
Brunner AM, Blonquist TM, DeAngelo DJ, McMasters M, Fell G, Hermance NM, Winer ES, Lindsley RC, Hobbs GS, Amrein PC, Hock HR, Steensma DP, Garcia JS, Luskin MR, Stone RM, Ballen KK, Rosenblatt J, Avigan D, Nahas MR, Mendez LM, McAfee SL, Moran JA, Bergeron M, Foster J, Bertoli C, Manning AL, McGregor KL, Fishman KM, Kuo FC, Baltay MT, Macrae M, Burke M, Behnan T, Wey MC, Som TT, Ramos AY, Rae J, Lombardi Story J, Nelson N, Logan E, Connolly C, Neuberg DS, Chen YB, Graubert TA, Fathi AT
Lancet Haematol 2020 Feb;7(2):e122-e133. Epub 2019 Dec 11 doi: 10.1016/S2352-3026(19)30203-0. PMID: 31837959Free PMC Article
Secondary acute myeloid leukemia - a single center experience.
Szotkowski T, Rohon P, Zapletalova L, Sicova K, Hubacek J, Indrak K
Neoplasma 2010;57(2):170-8. doi: 10.4149/neo_2010_02_170. PMID: 20099982

Clinical prediction guides

Alisertib plus induction chemotherapy in previously untreated patients with high-risk, acute myeloid leukaemia: a single-arm, phase 2 trial.
Brunner AM, Blonquist TM, DeAngelo DJ, McMasters M, Fell G, Hermance NM, Winer ES, Lindsley RC, Hobbs GS, Amrein PC, Hock HR, Steensma DP, Garcia JS, Luskin MR, Stone RM, Ballen KK, Rosenblatt J, Avigan D, Nahas MR, Mendez LM, McAfee SL, Moran JA, Bergeron M, Foster J, Bertoli C, Manning AL, McGregor KL, Fishman KM, Kuo FC, Baltay MT, Macrae M, Burke M, Behnan T, Wey MC, Som TT, Ramos AY, Rae J, Lombardi Story J, Nelson N, Logan E, Connolly C, Neuberg DS, Chen YB, Graubert TA, Fathi AT
Lancet Haematol 2020 Feb;7(2):e122-e133. Epub 2019 Dec 11 doi: 10.1016/S2352-3026(19)30203-0. PMID: 31837959Free PMC Article

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