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Secondary Acute Myeloid Leukemia

MedGen UID:
76113
Concept ID:
C0280449
Neoplastic Process
Synonyms: Secondary Acute Myeloblastic Leukemia; Secondary Acute Myelogenous Leukemia; Secondary AGL; Secondary AML

Definition

An acute myeloid leukemia arising from prior myelodysplastic syndrome, myeloproliferative neoplasm, or myelodysplastic/myeloproliferative neoplasm, or as a result of previous exposure to alkylating agents or topoisomerase II inhibitors. [from NCI]

Professional guidelines

PubMed

Hammond D, Montalban-Bravo G
Curr Hematol Malig Rep 2021 Oct;16(5):405-417. Epub 2021 Sep 9 doi: 10.1007/s11899-021-00643-3. PMID: 34499330
Winer ES
Hematol Oncol Clin North Am 2020 Apr;34(2):449-463. Epub 2020 Jan 7 doi: 10.1016/j.hoc.2019.11.003. PMID: 32089222
Ossenkoppele G, Montesinos P
Crit Rev Oncol Hematol 2019 Jun;138:6-13. Epub 2019 Mar 16 doi: 10.1016/j.critrevonc.2019.03.003. PMID: 31092386

Recent clinical studies

Etiology

Notarantonio AB, Robin M, D'Aveni M
Blood Rev 2024 Sep;67:101223. Epub 2024 Jul 10 doi: 10.1016/j.blre.2024.101223. PMID: 39089962
Rodriguez-Sevilla JJ, Adema V, Garcia-Manero G, Colla S
Cell Rep Med 2023 Feb 21;4(2):100940. Epub 2023 Feb 13 doi: 10.1016/j.xcrm.2023.100940. PMID: 36787738Free PMC Article
Tanaka TN, Bejar R
Blood 2019 Mar 7;133(10):1086-1095. Epub 2019 Jan 22 doi: 10.1182/blood-2018-10-844670. PMID: 30670443
Bejar R
Best Pract Res Clin Haematol 2018 Dec;31(4):341-345. Epub 2018 Oct 23 doi: 10.1016/j.beha.2018.10.002. PMID: 30466744
Lancet JE, Uy GL, Cortes JE, Newell LF, Lin TL, Ritchie EK, Stuart RK, Strickland SA, Hogge D, Solomon SR, Stone RM, Bixby DL, Kolitz JE, Schiller GJ, Wieduwilt MJ, Ryan DH, Hoering A, Banerjee K, Chiarella M, Louie AC, Medeiros BC
J Clin Oncol 2018 Sep 10;36(26):2684-2692. Epub 2018 Jul 19 doi: 10.1200/JCO.2017.77.6112. PMID: 30024784Free PMC Article

Diagnosis

Notarantonio AB, Robin M, D'Aveni M
Blood Rev 2024 Sep;67:101223. Epub 2024 Jul 10 doi: 10.1016/j.blre.2024.101223. PMID: 39089962
Othman J, Wilhelm-Benartzi C, Dillon R, Knapper S, Freeman SD, Batten LM, Canham J, Hinson EL, Wych J, Betteridge S, Villiers W, Kleeman M, Gilkes A, Potter N, Overgaard UM, Mehta P, Kottaridis P, Cavenagh J, Hemmaway C, Arnold C, Dennis M, Russell NH
Blood Adv 2023 Aug 22;7(16):4539-4549. doi: 10.1182/bloodadvances.2023010276. PMID: 37171402Free PMC Article
Tanaka TN, Bejar R
Blood 2019 Mar 7;133(10):1086-1095. Epub 2019 Jan 22 doi: 10.1182/blood-2018-10-844670. PMID: 30670443
Bejar R
Best Pract Res Clin Haematol 2018 Dec;31(4):341-345. Epub 2018 Oct 23 doi: 10.1016/j.beha.2018.10.002. PMID: 30466744
Lancet JE, Uy GL, Cortes JE, Newell LF, Lin TL, Ritchie EK, Stuart RK, Strickland SA, Hogge D, Solomon SR, Stone RM, Bixby DL, Kolitz JE, Schiller GJ, Wieduwilt MJ, Ryan DH, Hoering A, Banerjee K, Chiarella M, Louie AC, Medeiros BC
J Clin Oncol 2018 Sep 10;36(26):2684-2692. Epub 2018 Jul 19 doi: 10.1200/JCO.2017.77.6112. PMID: 30024784Free PMC Article

Therapy

Notarantonio AB, Robin M, D'Aveni M
Blood Rev 2024 Sep;67:101223. Epub 2024 Jul 10 doi: 10.1016/j.blre.2024.101223. PMID: 39089962
Peyrl A, Chocholous M, Sabel M, Lassaletta A, Sterba J, Leblond P, Nysom K, Torsvik I, Chi SN, Perwein T, Jones N, Holm S, Nyman P, Mörse H, Öberg A, Weiler-Wichtl L, Leiss U, Haberler C, Schmook MT, Mayr L, Dieckmann K, Kool M, Gojo J, Azizi AA, André N, Kieran M, Slavc I
JAMA Oncol 2023 Dec 1;9(12):1688-1695. doi: 10.1001/jamaoncol.2023.4437. PMID: 37883081Free PMC Article
Heuser M, Smith BD, Fiedler W, Sekeres MA, Montesinos P, Leber B, Merchant A, Papayannidis C, Pérez-Simón JA, Hoang CJ, O'Brien T, Ma WW, Zeremski M, O'Connell A, Chan G, Cortes JE
Ann Hematol 2021 May;100(5):1181-1194. Epub 2021 Mar 19 doi: 10.1007/s00277-021-04465-4. PMID: 33740113Free PMC Article
Tanaka TN, Bejar R
Blood 2019 Mar 7;133(10):1086-1095. Epub 2019 Jan 22 doi: 10.1182/blood-2018-10-844670. PMID: 30670443
Lancet JE, Uy GL, Cortes JE, Newell LF, Lin TL, Ritchie EK, Stuart RK, Strickland SA, Hogge D, Solomon SR, Stone RM, Bixby DL, Kolitz JE, Schiller GJ, Wieduwilt MJ, Ryan DH, Hoering A, Banerjee K, Chiarella M, Louie AC, Medeiros BC
J Clin Oncol 2018 Sep 10;36(26):2684-2692. Epub 2018 Jul 19 doi: 10.1200/JCO.2017.77.6112. PMID: 30024784Free PMC Article

Prognosis

Notarantonio AB, Robin M, D'Aveni M
Blood Rev 2024 Sep;67:101223. Epub 2024 Jul 10 doi: 10.1016/j.blre.2024.101223. PMID: 39089962
Tanaka TN, Bejar R
Blood 2019 Mar 7;133(10):1086-1095. Epub 2019 Jan 22 doi: 10.1182/blood-2018-10-844670. PMID: 30670443
Bejar R
Best Pract Res Clin Haematol 2018 Dec;31(4):341-345. Epub 2018 Oct 23 doi: 10.1016/j.beha.2018.10.002. PMID: 30466744
Khan M, Siddiqi R, Gangat N
Leuk Res 2017 Dec;63:78-84. Epub 2017 Oct 27 doi: 10.1016/j.leukres.2017.10.009. PMID: 29121538
Gill H, Leung AY, Kwong YL
Int J Mol Sci 2016 Mar 24;17(4):440. doi: 10.3390/ijms17040440. PMID: 27023522Free PMC Article

Clinical prediction guides

Rodriguez-Meira A, Norfo R, Wen S, Chédeville AL, Rahman H, O'Sullivan J, Wang G, Louka E, Kretzschmar WW, Paterson A, Brierley C, Martin JE, Demeule C, Bashton M, Sousos N, Moralli D, Subha Meem L, Carrelha J, Wu B, Hamblin A, Guermouche H, Pasquier F, Marzac C, Girodon F, Vainchenker W, Drummond M, Harrison C, Chapman JR, Plo I, Jacobsen SEW, Psaila B, Thongjuea S, Antony-Debré I, Mead AJ
Nat Genet 2023 Sep;55(9):1531-1541. Epub 2023 Sep 4 doi: 10.1038/s41588-023-01480-1. PMID: 37666991Free PMC Article
Heuser M, Smith BD, Fiedler W, Sekeres MA, Montesinos P, Leber B, Merchant A, Papayannidis C, Pérez-Simón JA, Hoang CJ, O'Brien T, Ma WW, Zeremski M, O'Connell A, Chan G, Cortes JE
Ann Hematol 2021 May;100(5):1181-1194. Epub 2021 Mar 19 doi: 10.1007/s00277-021-04465-4. PMID: 33740113Free PMC Article
Bejar R
Best Pract Res Clin Haematol 2018 Dec;31(4):341-345. Epub 2018 Oct 23 doi: 10.1016/j.beha.2018.10.002. PMID: 30466744
Lancet JE, Uy GL, Cortes JE, Newell LF, Lin TL, Ritchie EK, Stuart RK, Strickland SA, Hogge D, Solomon SR, Stone RM, Bixby DL, Kolitz JE, Schiller GJ, Wieduwilt MJ, Ryan DH, Hoering A, Banerjee K, Chiarella M, Louie AC, Medeiros BC
J Clin Oncol 2018 Sep 10;36(26):2684-2692. Epub 2018 Jul 19 doi: 10.1200/JCO.2017.77.6112. PMID: 30024784Free PMC Article
Kollmannsberger C, Beyer J, Droz JP, Harstrick A, Hartmann JT, Biron P, Fléchon A, Schöffski P, Kuczyk M, Schmoll HJ, Kanz L, Bokemeyer C
J Clin Oncol 1998 Oct;16(10):3386-91. doi: 10.1200/JCO.1998.16.10.3386. PMID: 9779717

Recent systematic reviews

Lyman GH, Yau L, Nakov R, Krendyukov A
Ann Oncol 2018 Sep 1;29(9):1903-1910. doi: 10.1093/annonc/mdy311. PMID: 30099478

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