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Secondary Acute Myeloid Leukemia

MedGen UID:
76113
•Concept ID:
C0280449
•
Neoplastic Process
Synonyms: Secondary Acute Myeloblastic Leukemia; Secondary Acute Myelogenous Leukemia; Secondary AGL; Secondary AML

Definition

An acute myeloid leukemia arising from prior myelodysplastic syndrome, myeloproliferative neoplasm, or myelodysplastic/myeloproliferative neoplasm, or as a result of previous exposure to alkylating agents or topoisomerase II inhibitors. [from NCI]

Professional guidelines

PubMed

Management and Outcomes of Blast Transformed Chronic Myelomonocytic Leukemia.
Hammond D, Montalban-Bravo G
Curr Hematol Malig Rep 2021 Oct;16(5):405-417. Epub 2021 Sep 9 doi: 10.1007/s11899-021-00643-3. PMID: 34499330
Secondary Acute Myeloid Leukemia: A Primary Challenge of Diagnosis and Treatment.
Winer ES
Hematol Oncol Clin North Am 2020 Apr;34(2):449-463. Epub 2020 Jan 7 doi: 10.1016/j.hoc.2019.11.003. PMID: 32089222
Challenges in the diagnosis and treatment of secondary acute myeloid leukemia.
Ossenkoppele G, Montesinos P
Crit Rev Oncol Hematol 2019 Jun;138:6-13. Epub 2019 Mar 16 doi: 10.1016/j.critrevonc.2019.03.003. PMID: 31092386

Recent clinical studies

Etiology

Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution.
Rodriguez-Meira A, Norfo R, Wen S, Chédeville AL, Rahman H, O'Sullivan J, Wang G, Louka E, Kretzschmar WW, Paterson A, Brierley C, Martin JE, Demeule C, Bashton M, Sousos N, Moralli D, Subha Meem L, Carrelha J, Wu B, Hamblin A, Guermouche H, Pasquier F, Marzac C, Girodon F, Vainchenker W, Drummond M, Harrison C, Chapman JR, Plo I, Jacobsen SEW, Psaila B, Thongjuea S, Antony-Debré I, Mead AJ
Nat Genet 2023 Sep;55(9):1531-1541. Epub 2023 Sep 4 doi: 10.1038/s41588-023-01480-1. PMID: 37666991Free PMC Article
A randomized comparison of CPX-351 and FLAG-Ida in adverse karyotype AML and high-risk MDS: the UK NCRI AML19 trial.
Othman J, Wilhelm-Benartzi C, Dillon R, Knapper S, Freeman SD, Batten LM, Canham J, Hinson EL, Wych J, Betteridge S, Villiers W, Kleeman M, Gilkes A, Potter N, Overgaard UM, Mehta P, Kottaridis P, Cavenagh J, Hemmaway C, Arnold C, Dennis M, Russell NH
Blood Adv 2023 Aug 22;7(16):4539-4549. doi: 10.1182/bloodadvances.2023010276. PMID: 37171402Free PMC Article
CCRL2 affects the sensitivity of myelodysplastic syndrome and secondary acute myeloid leukemia cells to azacitidine.
Karantanos T, Teodorescu P, Arvanitis M, Perkins B, Jain T, DeZern AE, Dalton WB, Christodoulou I, Paun BC, Varadhan R, Esteb C, Rajkhowa T, Bonifant C, Gondek LP, Levis MJ, Yegnasubramanian S, Ghiaur G, Jones RJ
Haematologica 2023 Jul 1;108(7):1886-1899. doi: 10.3324/haematol.2022.281444. PMID: 36519323Free PMC Article
MDS overlap disorders and diagnostic boundaries.
Tanaka TN, Bejar R
Blood 2019 Mar 7;133(10):1086-1095. Epub 2019 Jan 22 doi: 10.1182/blood-2018-10-844670. PMID: 30670443
CPX-351 (cytarabine and daunorubicin) Liposome for Injection Versus Conventional Cytarabine Plus Daunorubicin in Older Patients With Newly Diagnosed Secondary Acute Myeloid Leukemia.
Lancet JE, Uy GL, Cortes JE, Newell LF, Lin TL, Ritchie EK, Stuart RK, Strickland SA, Hogge D, Solomon SR, Stone RM, Bixby DL, Kolitz JE, Schiller GJ, Wieduwilt MJ, Ryan DH, Hoering A, Banerjee K, Chiarella M, Louie AC, Medeiros BC
J Clin Oncol 2018 Sep 10;36(26):2684-2692. Epub 2018 Jul 19 doi: 10.1200/JCO.2017.77.6112. PMID: 30024784Free PMC Article

Diagnosis

Molecular patterns identify distinct subclasses of myeloid neoplasia.
Kewan T, Durmaz A, Bahaj W, Gurnari C, Terkawi L, Awada H, Ogbue OD, Ahmed R, Pagliuca S, Awada H, Kubota Y, Mori M, Ponvilawan B, Al-Share B, Patel BJ, Carraway HE, Scott J, Balasubramanian SK, Bat T, Madanat Y, Sekeres MA, Haferlach T, Visconte V, Maciejewski JP
Nat Commun 2023 May 30;14(1):3136. doi: 10.1038/s41467-023-38515-4. PMID: 37253784Free PMC Article
A randomized comparison of CPX-351 and FLAG-Ida in adverse karyotype AML and high-risk MDS: the UK NCRI AML19 trial.
Othman J, Wilhelm-Benartzi C, Dillon R, Knapper S, Freeman SD, Batten LM, Canham J, Hinson EL, Wych J, Betteridge S, Villiers W, Kleeman M, Gilkes A, Potter N, Overgaard UM, Mehta P, Kottaridis P, Cavenagh J, Hemmaway C, Arnold C, Dennis M, Russell NH
Blood Adv 2023 Aug 22;7(16):4539-4549. doi: 10.1182/bloodadvances.2023010276. PMID: 37171402Free PMC Article
Secondary Acute Myeloid Leukemia: A Primary Challenge of Diagnosis and Treatment.
Winer ES
Hematol Oncol Clin North Am 2020 Apr;34(2):449-463. Epub 2020 Jan 7 doi: 10.1016/j.hoc.2019.11.003. PMID: 32089222
MDS overlap disorders and diagnostic boundaries.
Tanaka TN, Bejar R
Blood 2019 Mar 7;133(10):1086-1095. Epub 2019 Jan 22 doi: 10.1182/blood-2018-10-844670. PMID: 30670443
CPX-351 (cytarabine and daunorubicin) Liposome for Injection Versus Conventional Cytarabine Plus Daunorubicin in Older Patients With Newly Diagnosed Secondary Acute Myeloid Leukemia.
Lancet JE, Uy GL, Cortes JE, Newell LF, Lin TL, Ritchie EK, Stuart RK, Strickland SA, Hogge D, Solomon SR, Stone RM, Bixby DL, Kolitz JE, Schiller GJ, Wieduwilt MJ, Ryan DH, Hoering A, Banerjee K, Chiarella M, Louie AC, Medeiros BC
J Clin Oncol 2018 Sep 10;36(26):2684-2692. Epub 2018 Jul 19 doi: 10.1200/JCO.2017.77.6112. PMID: 30024784Free PMC Article

Therapy

Sustained Survival Benefit in Recurrent Medulloblastoma by a Metronomic Antiangiogenic Regimen: A Nonrandomized Controlled Trial.
Peyrl A, Chocholous M, Sabel M, Lassaletta A, Sterba J, Leblond P, Nysom K, Torsvik I, Chi SN, Perwein T, Jones N, Holm S, Nyman P, Mörse H, Öberg A, Weiler-Wichtl L, Leiss U, Haberler C, Schmook MT, Mayr L, Dieckmann K, Kool M, Gojo J, Azizi AA, André N, Kieran M, Slavc I
JAMA Oncol 2023 Dec 1;9(12):1688-1695. doi: 10.1001/jamaoncol.2023.4437. PMID: 37883081Free PMC Article
A randomized comparison of CPX-351 and FLAG-Ida in adverse karyotype AML and high-risk MDS: the UK NCRI AML19 trial.
Othman J, Wilhelm-Benartzi C, Dillon R, Knapper S, Freeman SD, Batten LM, Canham J, Hinson EL, Wych J, Betteridge S, Villiers W, Kleeman M, Gilkes A, Potter N, Overgaard UM, Mehta P, Kottaridis P, Cavenagh J, Hemmaway C, Arnold C, Dennis M, Russell NH
Blood Adv 2023 Aug 22;7(16):4539-4549. doi: 10.1182/bloodadvances.2023010276. PMID: 37171402Free PMC Article
CCRL2 affects the sensitivity of myelodysplastic syndrome and secondary acute myeloid leukemia cells to azacitidine.
Karantanos T, Teodorescu P, Arvanitis M, Perkins B, Jain T, DeZern AE, Dalton WB, Christodoulou I, Paun BC, Varadhan R, Esteb C, Rajkhowa T, Bonifant C, Gondek LP, Levis MJ, Yegnasubramanian S, Ghiaur G, Jones RJ
Haematologica 2023 Jul 1;108(7):1886-1899. doi: 10.3324/haematol.2022.281444. PMID: 36519323Free PMC Article
MDS overlap disorders and diagnostic boundaries.
Tanaka TN, Bejar R
Blood 2019 Mar 7;133(10):1086-1095. Epub 2019 Jan 22 doi: 10.1182/blood-2018-10-844670. PMID: 30670443
CPX-351 (cytarabine and daunorubicin) Liposome for Injection Versus Conventional Cytarabine Plus Daunorubicin in Older Patients With Newly Diagnosed Secondary Acute Myeloid Leukemia.
Lancet JE, Uy GL, Cortes JE, Newell LF, Lin TL, Ritchie EK, Stuart RK, Strickland SA, Hogge D, Solomon SR, Stone RM, Bixby DL, Kolitz JE, Schiller GJ, Wieduwilt MJ, Ryan DH, Hoering A, Banerjee K, Chiarella M, Louie AC, Medeiros BC
J Clin Oncol 2018 Sep 10;36(26):2684-2692. Epub 2018 Jul 19 doi: 10.1200/JCO.2017.77.6112. PMID: 30024784Free PMC Article

Prognosis

Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution.
Rodriguez-Meira A, Norfo R, Wen S, Chédeville AL, Rahman H, O'Sullivan J, Wang G, Louka E, Kretzschmar WW, Paterson A, Brierley C, Martin JE, Demeule C, Bashton M, Sousos N, Moralli D, Subha Meem L, Carrelha J, Wu B, Hamblin A, Guermouche H, Pasquier F, Marzac C, Girodon F, Vainchenker W, Drummond M, Harrison C, Chapman JR, Plo I, Jacobsen SEW, Psaila B, Thongjuea S, Antony-Debré I, Mead AJ
Nat Genet 2023 Sep;55(9):1531-1541. Epub 2023 Sep 4 doi: 10.1038/s41588-023-01480-1. PMID: 37666991Free PMC Article
Molecular patterns identify distinct subclasses of myeloid neoplasia.
Kewan T, Durmaz A, Bahaj W, Gurnari C, Terkawi L, Awada H, Ogbue OD, Ahmed R, Pagliuca S, Awada H, Kubota Y, Mori M, Ponvilawan B, Al-Share B, Patel BJ, Carraway HE, Scott J, Balasubramanian SK, Bat T, Madanat Y, Sekeres MA, Haferlach T, Visconte V, Maciejewski JP
Nat Commun 2023 May 30;14(1):3136. doi: 10.1038/s41467-023-38515-4. PMID: 37253784Free PMC Article
A randomized comparison of CPX-351 and FLAG-Ida in adverse karyotype AML and high-risk MDS: the UK NCRI AML19 trial.
Othman J, Wilhelm-Benartzi C, Dillon R, Knapper S, Freeman SD, Batten LM, Canham J, Hinson EL, Wych J, Betteridge S, Villiers W, Kleeman M, Gilkes A, Potter N, Overgaard UM, Mehta P, Kottaridis P, Cavenagh J, Hemmaway C, Arnold C, Dennis M, Russell NH
Blood Adv 2023 Aug 22;7(16):4539-4549. doi: 10.1182/bloodadvances.2023010276. PMID: 37171402Free PMC Article
Secondary Acute Myeloid Leukemia: A Primary Challenge of Diagnosis and Treatment.
Winer ES
Hematol Oncol Clin North Am 2020 Apr;34(2):449-463. Epub 2020 Jan 7 doi: 10.1016/j.hoc.2019.11.003. PMID: 32089222
MDS overlap disorders and diagnostic boundaries.
Tanaka TN, Bejar R
Blood 2019 Mar 7;133(10):1086-1095. Epub 2019 Jan 22 doi: 10.1182/blood-2018-10-844670. PMID: 30670443

Clinical prediction guides

Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution.
Rodriguez-Meira A, Norfo R, Wen S, Chédeville AL, Rahman H, O'Sullivan J, Wang G, Louka E, Kretzschmar WW, Paterson A, Brierley C, Martin JE, Demeule C, Bashton M, Sousos N, Moralli D, Subha Meem L, Carrelha J, Wu B, Hamblin A, Guermouche H, Pasquier F, Marzac C, Girodon F, Vainchenker W, Drummond M, Harrison C, Chapman JR, Plo I, Jacobsen SEW, Psaila B, Thongjuea S, Antony-Debré I, Mead AJ
Nat Genet 2023 Sep;55(9):1531-1541. Epub 2023 Sep 4 doi: 10.1038/s41588-023-01480-1. PMID: 37666991Free PMC Article
Development of a scoring system for predicting primary resistance to venetoclax plus hypomethylating agents (HMAs) in acute myeloid leukemia patients.
Zong L, Yin M, Kong J, Zhang J, Song B, Zhu J, Xue S, Wu X, Wu D, Bao X, Qiu H
Mol Carcinog 2023 Oct;62(10):1572-1584. Epub 2023 Aug 9 doi: 10.1002/mc.23600. PMID: 37555764
What is relative survival and what is its role in haematology?
Pohar Perme M, de Wreede LC, Manevski D
Best Pract Res Clin Haematol 2023 Jun;36(2):101474. Epub 2023 May 8 doi: 10.1016/j.beha.2023.101474. PMID: 37353298
Molecular patterns identify distinct subclasses of myeloid neoplasia.
Kewan T, Durmaz A, Bahaj W, Gurnari C, Terkawi L, Awada H, Ogbue OD, Ahmed R, Pagliuca S, Awada H, Kubota Y, Mori M, Ponvilawan B, Al-Share B, Patel BJ, Carraway HE, Scott J, Balasubramanian SK, Bat T, Madanat Y, Sekeres MA, Haferlach T, Visconte V, Maciejewski JP
Nat Commun 2023 May 30;14(1):3136. doi: 10.1038/s41467-023-38515-4. PMID: 37253784Free PMC Article
CPX-351 (cytarabine and daunorubicin) Liposome for Injection Versus Conventional Cytarabine Plus Daunorubicin in Older Patients With Newly Diagnosed Secondary Acute Myeloid Leukemia.
Lancet JE, Uy GL, Cortes JE, Newell LF, Lin TL, Ritchie EK, Stuart RK, Strickland SA, Hogge D, Solomon SR, Stone RM, Bixby DL, Kolitz JE, Schiller GJ, Wieduwilt MJ, Ryan DH, Hoering A, Banerjee K, Chiarella M, Louie AC, Medeiros BC
J Clin Oncol 2018 Sep 10;36(26):2684-2692. Epub 2018 Jul 19 doi: 10.1200/JCO.2017.77.6112. PMID: 30024784Free PMC Article

Recent systematic reviews

Overall survival and risk of second malignancies with cancer chemotherapy and G-CSF support.
Lyman GH, Yau L, Nakov R, Krendyukov A
Ann Oncol 2018 Sep 1;29(9):1903-1910. doi: 10.1093/annonc/mdy311. PMID: 30099478

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