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Macrotrabecular Massive Hepatocellular Carcinoma

MedGen UID:
1768325
Concept ID:
C5417719
Neoplastic Process

Definition

Hepatocellular carcinoma characterized by more than 50% growth of macrotrabecular pattern (equal to or more than 6 to 10 cells thick). It presents with higher grade and stage compared to conventional hepatocellular carcinoma. It has poor prognosis with early recurrence and poor overall survival. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMacrotrabecular Massive Hepatocellular Carcinoma

Recent clinical studies

Etiology

Cheng J, Li X, Wang L, Chen F, Li Y, Zuo G, Pei M, Zhang H, Yu L, Liu C, Wang J, Han Q, Cai P, Li X
J Magn Reson Imaging 2024 Jun;59(6):2071-2081. Epub 2023 Oct 15 doi: 10.1002/jmri.29052. PMID: 37840197
Li M, Fan Y, You H, Li C, Luo M, Zhou J, Li A, Zhang L, Yu X, Deng W, Zhou J, Zhang D, Zhang Z, Chen H, Xiao Y, Huang B, Wang J
Radiology 2023 Aug;308(2):e230255. doi: 10.1148/radiol.230255. PMID: 37606573
Zhang Y, He D, Liu J, Wei YG, Shi LL
World J Gastroenterol 2023 Apr 7;29(13):2001-2014. doi: 10.3748/wjg.v29.i13.2001. PMID: 37155523Free PMC Article
Luo M, Liu X, Yong J, Ou B, Xu X, Zhao X, Liang M, Zhao Z, Ruan J, Luo B
Eur Radiol 2023 Jun;33(6):4024-4033. Epub 2022 Dec 9 doi: 10.1007/s00330-022-09322-0. PMID: 36484835
Chen J, Xia C, Duan T, Cao L, Jiang H, Liu X, Zhang Z, Ye Z, Wu Z, Gao R, Shi Y, Song B
Eur Radiol 2021 Oct;31(10):7696-7704. Epub 2021 Apr 15 doi: 10.1007/s00330-021-07898-7. PMID: 33856520

Diagnosis

Cheng J, Li X, Wang L, Chen F, Li Y, Zuo G, Pei M, Zhang H, Yu L, Liu C, Wang J, Han Q, Cai P, Li X
J Magn Reson Imaging 2024 Jun;59(6):2071-2081. Epub 2023 Oct 15 doi: 10.1002/jmri.29052. PMID: 37840197
Li M, Fan Y, You H, Li C, Luo M, Zhou J, Li A, Zhang L, Yu X, Deng W, Zhou J, Zhang D, Zhang Z, Chen H, Xiao Y, Huang B, Wang J
Radiology 2023 Aug;308(2):e230255. doi: 10.1148/radiol.230255. PMID: 37606573
Luo M, Liu X, Yong J, Ou B, Xu X, Zhao X, Liang M, Zhao Z, Ruan J, Luo B
Eur Radiol 2023 Jun;33(6):4024-4033. Epub 2022 Dec 9 doi: 10.1007/s00330-022-09322-0. PMID: 36484835
Chen J, Xia C, Duan T, Cao L, Jiang H, Liu X, Zhang Z, Ye Z, Wu Z, Gao R, Shi Y, Song B
Eur Radiol 2021 Oct;31(10):7696-7704. Epub 2021 Apr 15 doi: 10.1007/s00330-021-07898-7. PMID: 33856520
Rhee H, Cho ES, Nahm JH, Jang M, Chung YE, Baek SE, Lee S, Kim MJ, Park MS, Han DH, Choi JY, Park YN
J Hepatol 2021 Jan;74(1):109-121. Epub 2020 Aug 18 doi: 10.1016/j.jhep.2020.08.013. PMID: 32818570

Therapy

Chai F, Ma Y, Feng C, Jia X, Cui J, Cheng J, Hong N, Wang Y
Abdom Radiol (NY) 2024 Feb;49(2):447-457. Epub 2023 Dec 2 doi: 10.1007/s00261-023-04121-7. PMID: 38042762
Couteaux V, Zhang C, Mulé S, Milot L, Valette PJ, Raynaud C, Vlachomitrou AS, Ciofolo-Veit C, Lawrance L, Belkouchi Y, Vilgrain V, Lewin M, Trillaud H, Hoeffel C, Laurent V, Ammari S, Morand E, Faucoz O, Tenenhaus A, Talbot H, Luciani A, Lassau N, Lazarus C
Diagn Interv Imaging 2023 May;104(5):243-247. Epub 2023 Jan 20 doi: 10.1016/j.diii.2023.01.003. PMID: 36681532

Prognosis

Li M, Fan Y, You H, Li C, Luo M, Zhou J, Li A, Zhang L, Yu X, Deng W, Zhou J, Zhang D, Zhang Z, Chen H, Xiao Y, Huang B, Wang J
Radiology 2023 Aug;308(2):e230255. doi: 10.1148/radiol.230255. PMID: 37606573
Zhang Y, He D, Liu J, Wei YG, Shi LL
World J Gastroenterol 2023 Apr 7;29(13):2001-2014. doi: 10.3748/wjg.v29.i13.2001. PMID: 37155523Free PMC Article
Luo M, Liu X, Yong J, Ou B, Xu X, Zhao X, Liang M, Zhao Z, Ruan J, Luo B
Eur Radiol 2023 Jun;33(6):4024-4033. Epub 2022 Dec 9 doi: 10.1007/s00330-022-09322-0. PMID: 36484835
Chen J, Xia C, Duan T, Cao L, Jiang H, Liu X, Zhang Z, Ye Z, Wu Z, Gao R, Shi Y, Song B
Eur Radiol 2021 Oct;31(10):7696-7704. Epub 2021 Apr 15 doi: 10.1007/s00330-021-07898-7. PMID: 33856520
Rhee H, Cho ES, Nahm JH, Jang M, Chung YE, Baek SE, Lee S, Kim MJ, Park MS, Han DH, Choi JY, Park YN
J Hepatol 2021 Jan;74(1):109-121. Epub 2020 Aug 18 doi: 10.1016/j.jhep.2020.08.013. PMID: 32818570

Clinical prediction guides

Li M, Fan Y, You H, Li C, Luo M, Zhou J, Li A, Zhang L, Yu X, Deng W, Zhou J, Zhang D, Zhang Z, Chen H, Xiao Y, Huang B, Wang J
Radiology 2023 Aug;308(2):e230255. doi: 10.1148/radiol.230255. PMID: 37606573
Zhang Y, He D, Liu J, Wei YG, Shi LL
World J Gastroenterol 2023 Apr 7;29(13):2001-2014. doi: 10.3748/wjg.v29.i13.2001. PMID: 37155523Free PMC Article
Luo M, Liu X, Yong J, Ou B, Xu X, Zhao X, Liang M, Zhao Z, Ruan J, Luo B
Eur Radiol 2023 Jun;33(6):4024-4033. Epub 2022 Dec 9 doi: 10.1007/s00330-022-09322-0. PMID: 36484835
Chen J, Xia C, Duan T, Cao L, Jiang H, Liu X, Zhang Z, Ye Z, Wu Z, Gao R, Shi Y, Song B
Eur Radiol 2021 Oct;31(10):7696-7704. Epub 2021 Apr 15 doi: 10.1007/s00330-021-07898-7. PMID: 33856520
Rhee H, Cho ES, Nahm JH, Jang M, Chung YE, Baek SE, Lee S, Kim MJ, Park MS, Han DH, Choi JY, Park YN
J Hepatol 2021 Jan;74(1):109-121. Epub 2020 Aug 18 doi: 10.1016/j.jhep.2020.08.013. PMID: 32818570

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