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Macrotrabecular Massive Hepatocellular Carcinoma

MedGen UID:
1768325
•Concept ID:
C5417719
•
Neoplastic Process

Definition

Hepatocellular carcinoma characterized by more than 50% growth of macrotrabecular pattern (equal to or more than 6 to 10 cells thick). It presents with higher grade and stage compared to conventional hepatocellular carcinoma. It has poor prognosis with early recurrence and poor overall survival. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMacrotrabecular Massive Hepatocellular Carcinoma

Recent clinical studies

Etiology

Dual-Energy CT Deep Learning Radiomics to Predict Macrotrabecular-Massive Hepatocellular Carcinoma.
Li M, Fan Y, You H, Li C, Luo M, Zhou J, Li A, Zhang L, Yu X, Deng W, Zhou J, Zhang D, Zhang Z, Chen H, Xiao Y, Huang B, Wang J
Radiology 2023 Aug;308(2):e230255. doi: 10.1148/radiol.230255. PMID: 37606573
Preoperative prediction of macrotrabecular-massive hepatocellular carcinoma through dynamic contrast-enhanced magnetic resonance imaging-based radiomics.
Zhang Y, He D, Liu J, Wei YG, Shi LL
World J Gastroenterol 2023 Apr 7;29(13):2001-2014. doi: 10.3748/wjg.v29.i13.2001. PMID: 37155523Free PMC Article
Preoperative prediction of macrotrabecular-massive hepatocellular carcinoma based on B-Mode US and CEUS.
Luo M, Liu X, Yong J, Ou B, Xu X, Zhao X, Liang M, Zhao Z, Ruan J, Luo B
Eur Radiol 2023 Jun;33(6):4024-4033. Epub 2022 Dec 9 doi: 10.1007/s00330-022-09322-0. PMID: 36484835
Macrotrabecular-massive hepatocellular carcinoma: imaging identification and prediction based on gadoxetic acid-enhanced magnetic resonance imaging.
Chen J, Xia C, Duan T, Cao L, Jiang H, Liu X, Zhang Z, Ye Z, Wu Z, Gao R, Shi Y, Song B
Eur Radiol 2021 Oct;31(10):7696-7704. Epub 2021 Apr 15 doi: 10.1007/s00330-021-07898-7. PMID: 33856520
Macrotrabecular-massive hepatocellular carcinoma: A distinctive histological subtype with clinical relevance.
Ziol M, Poté N, Amaddeo G, Laurent A, Nault JC, Oberti F, Costentin C, Michalak S, Bouattour M, Francoz C, Pageaux GP, Ramos J, Decaens T, Luciani A, Guiu B, Vilgrain V, Aubé C, Derman J, Charpy C, Zucman-Rossi J, Barget N, Seror O, Ganne-Carrié N, Paradis V, Calderaro J
Hepatology 2018 Jul;68(1):103-112. Epub 2018 May 9 doi: 10.1002/hep.29762. PMID: 29281854

Diagnosis

Dual-Energy CT Deep Learning Radiomics to Predict Macrotrabecular-Massive Hepatocellular Carcinoma.
Li M, Fan Y, You H, Li C, Luo M, Zhou J, Li A, Zhang L, Yu X, Deng W, Zhou J, Zhang D, Zhang Z, Chen H, Xiao Y, Huang B, Wang J
Radiology 2023 Aug;308(2):e230255. doi: 10.1148/radiol.230255. PMID: 37606573
Preoperative prediction of macrotrabecular-massive hepatocellular carcinoma based on B-Mode US and CEUS.
Luo M, Liu X, Yong J, Ou B, Xu X, Zhao X, Liang M, Zhao Z, Ruan J, Luo B
Eur Radiol 2023 Jun;33(6):4024-4033. Epub 2022 Dec 9 doi: 10.1007/s00330-022-09322-0. PMID: 36484835
Gadoxetic acid-enhanced MRI of macrotrabecular-massive hepatocellular carcinoma and its prognostic implications.
Rhee H, Cho ES, Nahm JH, Jang M, Chung YE, Baek SE, Lee S, Kim MJ, Park MS, Han DH, Choi JY, Park YN
J Hepatol 2021 Jan;74(1):109-121. Epub 2020 Aug 18 doi: 10.1016/j.jhep.2020.08.013. PMID: 32818570
ESM1 as a Marker of Macrotrabecular-Massive Hepatocellular Carcinoma.
Calderaro J, Meunier L, Nguyen CT, Boubaya M, Caruso S, Luciani A, Amaddeo G, Regnault H, Nault JC, Cohen J, Oberti F, Michalak S, Bouattour M, Vilgrain V, Pageaux GP, Ramos J, Barget N, Guiu B, Paradis V, Aubé C, Laurent A, Pawlotsky JM, Ganne-Carrié N, Zucman-Rossi J, Seror O, Ziol M
Clin Cancer Res 2019 Oct 1;25(19):5859-5865. Epub 2019 Jul 29 doi: 10.1158/1078-0432.CCR-19-0859. PMID: 31358545
Macrotrabecular-massive hepatocellular carcinoma: A distinctive histological subtype with clinical relevance.
Ziol M, Poté N, Amaddeo G, Laurent A, Nault JC, Oberti F, Costentin C, Michalak S, Bouattour M, Francoz C, Pageaux GP, Ramos J, Decaens T, Luciani A, Guiu B, Vilgrain V, Aubé C, Derman J, Charpy C, Zucman-Rossi J, Barget N, Seror O, Ganne-Carrié N, Paradis V, Calderaro J
Hepatology 2018 Jul;68(1):103-112. Epub 2018 May 9 doi: 10.1002/hep.29762. PMID: 29281854

Therapy

MRI imaging features for predicting macrotrabecular-massive subtype hepatocellular carcinoma: a systematic review and meta-analysis.
Kim TH, Woo S, Lee DH, Do RK, Chernyak V
Eur Radiol 2024 Oct;34(10):6896-6907. Epub 2024 Mar 20 doi: 10.1007/s00330-024-10671-1. PMID: 38507054
Prediction of macrotrabecular-massive hepatocellular carcinoma by using MR-based models and their prognostic implications.
Chai F, Ma Y, Feng C, Jia X, Cui J, Cheng J, Hong N, Wang Y
Abdom Radiol (NY) 2024 Feb;49(2):447-457. Epub 2023 Dec 2 doi: 10.1007/s00261-023-04121-7. PMID: 38042762
Synthetic MR image generation of macrotrabecular-massive hepatocellular carcinoma using generative adversarial networks.
Couteaux V, Zhang C, Mulé S, Milot L, Valette PJ, Raynaud C, Vlachomitrou AS, Ciofolo-Veit C, Lawrance L, Belkouchi Y, Vilgrain V, Lewin M, Trillaud H, Hoeffel C, Laurent V, Ammari S, Morand E, Faucoz O, Tenenhaus A, Talbot H, Luciani A, Lassau N, Lazarus C
Diagn Interv Imaging 2023 May;104(5):243-247. Epub 2023 Jan 20 doi: 10.1016/j.diii.2023.01.003. PMID: 36681532

Prognosis

Dual-Energy CT Deep Learning Radiomics to Predict Macrotrabecular-Massive Hepatocellular Carcinoma.
Li M, Fan Y, You H, Li C, Luo M, Zhou J, Li A, Zhang L, Yu X, Deng W, Zhou J, Zhang D, Zhang Z, Chen H, Xiao Y, Huang B, Wang J
Radiology 2023 Aug;308(2):e230255. doi: 10.1148/radiol.230255. PMID: 37606573
Preoperative prediction of macrotrabecular-massive hepatocellular carcinoma through dynamic contrast-enhanced magnetic resonance imaging-based radiomics.
Zhang Y, He D, Liu J, Wei YG, Shi LL
World J Gastroenterol 2023 Apr 7;29(13):2001-2014. doi: 10.3748/wjg.v29.i13.2001. PMID: 37155523Free PMC Article
Preoperative prediction of macrotrabecular-massive hepatocellular carcinoma based on B-Mode US and CEUS.
Luo M, Liu X, Yong J, Ou B, Xu X, Zhao X, Liang M, Zhao Z, Ruan J, Luo B
Eur Radiol 2023 Jun;33(6):4024-4033. Epub 2022 Dec 9 doi: 10.1007/s00330-022-09322-0. PMID: 36484835
Gadoxetic acid-enhanced MRI of macrotrabecular-massive hepatocellular carcinoma and its prognostic implications.
Rhee H, Cho ES, Nahm JH, Jang M, Chung YE, Baek SE, Lee S, Kim MJ, Park MS, Han DH, Choi JY, Park YN
J Hepatol 2021 Jan;74(1):109-121. Epub 2020 Aug 18 doi: 10.1016/j.jhep.2020.08.013. PMID: 32818570
Macrotrabecular-massive hepatocellular carcinoma: A distinctive histological subtype with clinical relevance.
Ziol M, Poté N, Amaddeo G, Laurent A, Nault JC, Oberti F, Costentin C, Michalak S, Bouattour M, Francoz C, Pageaux GP, Ramos J, Decaens T, Luciani A, Guiu B, Vilgrain V, Aubé C, Derman J, Charpy C, Zucman-Rossi J, Barget N, Seror O, Ganne-Carrié N, Paradis V, Calderaro J
Hepatology 2018 Jul;68(1):103-112. Epub 2018 May 9 doi: 10.1002/hep.29762. PMID: 29281854

Clinical prediction guides

MRI imaging features for predicting macrotrabecular-massive subtype hepatocellular carcinoma: a systematic review and meta-analysis.
Kim TH, Woo S, Lee DH, Do RK, Chernyak V
Eur Radiol 2024 Oct;34(10):6896-6907. Epub 2024 Mar 20 doi: 10.1007/s00330-024-10671-1. PMID: 38507054
Dual-Energy CT Deep Learning Radiomics to Predict Macrotrabecular-Massive Hepatocellular Carcinoma.
Li M, Fan Y, You H, Li C, Luo M, Zhou J, Li A, Zhang L, Yu X, Deng W, Zhou J, Zhang D, Zhang Z, Chen H, Xiao Y, Huang B, Wang J
Radiology 2023 Aug;308(2):e230255. doi: 10.1148/radiol.230255. PMID: 37606573
Preoperative prediction of macrotrabecular-massive hepatocellular carcinoma based on B-Mode US and CEUS.
Luo M, Liu X, Yong J, Ou B, Xu X, Zhao X, Liang M, Zhao Z, Ruan J, Luo B
Eur Radiol 2023 Jun;33(6):4024-4033. Epub 2022 Dec 9 doi: 10.1007/s00330-022-09322-0. PMID: 36484835
Gadoxetic acid-enhanced MRI of macrotrabecular-massive hepatocellular carcinoma and its prognostic implications.
Rhee H, Cho ES, Nahm JH, Jang M, Chung YE, Baek SE, Lee S, Kim MJ, Park MS, Han DH, Choi JY, Park YN
J Hepatol 2021 Jan;74(1):109-121. Epub 2020 Aug 18 doi: 10.1016/j.jhep.2020.08.013. PMID: 32818570
Macrotrabecular-massive hepatocellular carcinoma: A distinctive histological subtype with clinical relevance.
Ziol M, Poté N, Amaddeo G, Laurent A, Nault JC, Oberti F, Costentin C, Michalak S, Bouattour M, Francoz C, Pageaux GP, Ramos J, Decaens T, Luciani A, Guiu B, Vilgrain V, Aubé C, Derman J, Charpy C, Zucman-Rossi J, Barget N, Seror O, Ganne-Carrié N, Paradis V, Calderaro J
Hepatology 2018 Jul;68(1):103-112. Epub 2018 May 9 doi: 10.1002/hep.29762. PMID: 29281854

Recent systematic reviews

MRI imaging features for predicting macrotrabecular-massive subtype hepatocellular carcinoma: a systematic review and meta-analysis.
Kim TH, Woo S, Lee DH, Do RK, Chernyak V
Eur Radiol 2024 Oct;34(10):6896-6907. Epub 2024 Mar 20 doi: 10.1007/s00330-024-10671-1. PMID: 38507054

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