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Non-Muscle Invasive Bladder Urothelial Carcinoma

MedGen UID:
1773170
•Concept ID:
C5418781
•
Neoplastic Process
Synonyms: Non-Muscle Invasive Bladder Transitional Cell Carcinoma; Superficial Bladder Transitional Cell Carcinoma; Superficial Bladder Urothelial Carcinoma

Definition

An infiltrating urothelial carcinoma of the bladder that has not invaded into the bladder muscularis propria. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Muscle Invasive Bladder Urothelial Carcinoma

Professional guidelines

PubMed

A model of thermotherapy treatment for bladder cancer.
Sadee C, Kashdan E
Math Biosci Eng 2016 Dec 1;13(6):1169-1183. doi: 10.3934/mbe.2016037. PMID: 27775374
New insights in intravesical treatment for intermediate- and high-risk non-muscle-invasive urothelial bladder carcinoma.
Babjuk M
Eur Urol 2010 May;57(5):774-6; author reply 776-7. Epub 2010 Jan 14 doi: 10.1016/j.eururo.2010.01.004. PMID: 20080332

Recent clinical studies

Etiology

Impact of sex on outcomes after surgery for non-muscle-invasive and muscle-invasive bladder urothelial carcinoma: a systematic review and meta-analysis.
Mori K, Yanagisawa T, Katayama S, Laukhtina E, Pradere B, Mostafaei H, Quhal F, Rajwa P, Moschini M, Soria F, D'andrea D, Abufaraj M, Albisinni S, Krajewski W, Fukuokaya W, Miki J, Kimura T, Egawa S, Teoh JY, Shariat SF; European Association of Urology–Young Academic Urologists Urothelial Carcinoma Working Group (EAU-YAU)
World J Urol 2023 Apr;41(4):909-919. Epub 2022 Aug 13 doi: 10.1007/s00345-022-04116-x. PMID: 35963957Free PMC Article
A Nomogram Model to Predict Recurrence of Non-Muscle Invasive Bladder Urothelial Carcinoma After Resection Based on Clinical Parameters and Immunohistochemical Markers.
Pi J, Xiong Y, Liu C, Liao J, Liu J, Li C, Fu W, Zhao T
J Invest Surg 2022 May;35(5):1186-1194. Epub 2021 Dec 16 doi: 10.1080/08941939.2021.2017080. PMID: 34913802
Overexpression of Eg5 predicts unfavorable prognosis in non-muscle invasive bladder urothelial carcinoma.
Ding S, Xing N, Lu J, Zhang H, Nishizawa K, Liu S, Yuan X, Qin Y, Liu Y, Ogawa O, Nishiyama H
Int J Urol 2011 Jun;18(6):432-8. Epub 2011 Mar 30 doi: 10.1111/j.1442-2042.2011.02751.x. PMID: 21449971
Characteristics of female non-muscle-invasive bladder cancer in Taiwan: association with upper tract urothelial carcinoma and end-stage renal disease.
Chen CH, Shun CT, Huang KH, Huang CY, Yu HJ, Pu YS
Urology 2008 Jun;71(6):1155-60. Epub 2008 Apr 18 doi: 10.1016/j.urology.2007.11.140. PMID: 18372011

Diagnosis

Differential expression of WNT5A long and short isoforms in non-muscle-invasive bladder urothelial carcinoma.
Strope AM, Phillips C, Khadgi S, Jenkinson SA, Coschigano KT, Malgor R
Histol Histopathol 2024 Jun;39(6):715-727. Epub 2024 Feb 23 doi: 10.14670/HH-18-723. PMID: 38445662
Paraneoplastic autoimmune autonomic ganglionopathy as the first symptom of bladder cancer: a case report and review of literature.
de Rojas Leal C, Lage-Sánchez JM, Pinel-Ríos J, León Plaza O, Hamad-Cueto O, Dawid de Vera MT, Dawid-Milner MS
Neurol Sci 2022 Aug;43(8):4841-4845. Epub 2022 Apr 28 doi: 10.1007/s10072-022-06075-y. PMID: 35482157
A Nomogram Model to Predict Recurrence of Non-Muscle Invasive Bladder Urothelial Carcinoma After Resection Based on Clinical Parameters and Immunohistochemical Markers.
Pi J, Xiong Y, Liu C, Liao J, Liu J, Li C, Fu W, Zhao T
J Invest Surg 2022 May;35(5):1186-1194. Epub 2021 Dec 16 doi: 10.1080/08941939.2021.2017080. PMID: 34913802
Overexpression of Eg5 predicts unfavorable prognosis in non-muscle invasive bladder urothelial carcinoma.
Ding S, Xing N, Lu J, Zhang H, Nishizawa K, Liu S, Yuan X, Qin Y, Liu Y, Ogawa O, Nishiyama H
Int J Urol 2011 Jun;18(6):432-8. Epub 2011 Mar 30 doi: 10.1111/j.1442-2042.2011.02751.x. PMID: 21449971
Characteristics of female non-muscle-invasive bladder cancer in Taiwan: association with upper tract urothelial carcinoma and end-stage renal disease.
Chen CH, Shun CT, Huang KH, Huang CY, Yu HJ, Pu YS
Urology 2008 Jun;71(6):1155-60. Epub 2008 Apr 18 doi: 10.1016/j.urology.2007.11.140. PMID: 18372011

Therapy

HER2/neu expression status of post BCG recurrent non-muscle-invasive bladder urothelial carcinomas in relation to their primary ones.
Ali MY, Aboelsaad AY, Abdel Gawad AM, Abouelgreed TA, El Gammal AA, Ghoneimy OM, El-Dydamony EM, Alrefaey AA, Mohamed E, Azzam S, Abdulmohaymen A, Mohammed Y, Abdelwahed MS, Elsayed AFA, Fathi BA, Abd Alrahim NM, Farag AS, Mahmoud AR, Mohamed HI, Horsu S, Hasan A
Arch Ital Urol Androl 2023 May 30;95(2):11313. doi: 10.4081/aiua.2023.11313. PMID: 37254927
Prognostic value of T1 substaging on oncological outcomes in patients with non-muscle-invasive bladder urothelial carcinoma: a systematic literature review and meta-analysis.
Kardoust Parizi M, Enikeev D, Glybochko PV, Seebacher V, Janisch F, Fajkovic H, Chłosta PL, Shariat SF
World J Urol 2020 Jun;38(6):1437-1449. Epub 2019 Sep 6 doi: 10.1007/s00345-019-02936-y. PMID: 31493109Free PMC Article
Efficacy of instillations with chemotherapy or immunotherapy following endoscopic resection for upper tract urothelial carcinoma.
Bachir BG, Kassouf W
Expert Rev Anticancer Ther 2012 Jan;12(1):63-75. doi: 10.1586/era.11.193. PMID: 22149433

Prognosis

HER2/neu expression status of post BCG recurrent non-muscle-invasive bladder urothelial carcinomas in relation to their primary ones.
Ali MY, Aboelsaad AY, Abdel Gawad AM, Abouelgreed TA, El Gammal AA, Ghoneimy OM, El-Dydamony EM, Alrefaey AA, Mohamed E, Azzam S, Abdulmohaymen A, Mohammed Y, Abdelwahed MS, Elsayed AFA, Fathi BA, Abd Alrahim NM, Farag AS, Mahmoud AR, Mohamed HI, Horsu S, Hasan A
Arch Ital Urol Androl 2023 May 30;95(2):11313. doi: 10.4081/aiua.2023.11313. PMID: 37254927
Impact of sex on outcomes after surgery for non-muscle-invasive and muscle-invasive bladder urothelial carcinoma: a systematic review and meta-analysis.
Mori K, Yanagisawa T, Katayama S, Laukhtina E, Pradere B, Mostafaei H, Quhal F, Rajwa P, Moschini M, Soria F, D'andrea D, Abufaraj M, Albisinni S, Krajewski W, Fukuokaya W, Miki J, Kimura T, Egawa S, Teoh JY, Shariat SF; European Association of Urology–Young Academic Urologists Urothelial Carcinoma Working Group (EAU-YAU)
World J Urol 2023 Apr;41(4):909-919. Epub 2022 Aug 13 doi: 10.1007/s00345-022-04116-x. PMID: 35963957Free PMC Article
A Nomogram Model to Predict Recurrence of Non-Muscle Invasive Bladder Urothelial Carcinoma After Resection Based on Clinical Parameters and Immunohistochemical Markers.
Pi J, Xiong Y, Liu C, Liao J, Liu J, Li C, Fu W, Zhao T
J Invest Surg 2022 May;35(5):1186-1194. Epub 2021 Dec 16 doi: 10.1080/08941939.2021.2017080. PMID: 34913802
Prognostic value of T1 substaging on oncological outcomes in patients with non-muscle-invasive bladder urothelial carcinoma: a systematic literature review and meta-analysis.
Kardoust Parizi M, Enikeev D, Glybochko PV, Seebacher V, Janisch F, Fajkovic H, Chłosta PL, Shariat SF
World J Urol 2020 Jun;38(6):1437-1449. Epub 2019 Sep 6 doi: 10.1007/s00345-019-02936-y. PMID: 31493109Free PMC Article
Overexpression of Eg5 predicts unfavorable prognosis in non-muscle invasive bladder urothelial carcinoma.
Ding S, Xing N, Lu J, Zhang H, Nishizawa K, Liu S, Yuan X, Qin Y, Liu Y, Ogawa O, Nishiyama H
Int J Urol 2011 Jun;18(6):432-8. Epub 2011 Mar 30 doi: 10.1111/j.1442-2042.2011.02751.x. PMID: 21449971

Clinical prediction guides

Paraneoplastic autoimmune autonomic ganglionopathy as the first symptom of bladder cancer: a case report and review of literature.
de Rojas Leal C, Lage-Sánchez JM, Pinel-Ríos J, León Plaza O, Hamad-Cueto O, Dawid de Vera MT, Dawid-Milner MS
Neurol Sci 2022 Aug;43(8):4841-4845. Epub 2022 Apr 28 doi: 10.1007/s10072-022-06075-y. PMID: 35482157
A Nomogram Model to Predict Recurrence of Non-Muscle Invasive Bladder Urothelial Carcinoma After Resection Based on Clinical Parameters and Immunohistochemical Markers.
Pi J, Xiong Y, Liu C, Liao J, Liu J, Li C, Fu W, Zhao T
J Invest Surg 2022 May;35(5):1186-1194. Epub 2021 Dec 16 doi: 10.1080/08941939.2021.2017080. PMID: 34913802
Overexpression of Eg5 predicts unfavorable prognosis in non-muscle invasive bladder urothelial carcinoma.
Ding S, Xing N, Lu J, Zhang H, Nishizawa K, Liu S, Yuan X, Qin Y, Liu Y, Ogawa O, Nishiyama H
Int J Urol 2011 Jun;18(6):432-8. Epub 2011 Mar 30 doi: 10.1111/j.1442-2042.2011.02751.x. PMID: 21449971
Characteristics of female non-muscle-invasive bladder cancer in Taiwan: association with upper tract urothelial carcinoma and end-stage renal disease.
Chen CH, Shun CT, Huang KH, Huang CY, Yu HJ, Pu YS
Urology 2008 Jun;71(6):1155-60. Epub 2008 Apr 18 doi: 10.1016/j.urology.2007.11.140. PMID: 18372011

Recent systematic reviews

Impact of sex on outcomes after surgery for non-muscle-invasive and muscle-invasive bladder urothelial carcinoma: a systematic review and meta-analysis.
Mori K, Yanagisawa T, Katayama S, Laukhtina E, Pradere B, Mostafaei H, Quhal F, Rajwa P, Moschini M, Soria F, D'andrea D, Abufaraj M, Albisinni S, Krajewski W, Fukuokaya W, Miki J, Kimura T, Egawa S, Teoh JY, Shariat SF; European Association of Urology–Young Academic Urologists Urothelial Carcinoma Working Group (EAU-YAU)
World J Urol 2023 Apr;41(4):909-919. Epub 2022 Aug 13 doi: 10.1007/s00345-022-04116-x. PMID: 35963957Free PMC Article
Prognostic value of T1 substaging on oncological outcomes in patients with non-muscle-invasive bladder urothelial carcinoma: a systematic literature review and meta-analysis.
Kardoust Parizi M, Enikeev D, Glybochko PV, Seebacher V, Janisch F, Fajkovic H, Chłosta PL, Shariat SF
World J Urol 2020 Jun;38(6):1437-1449. Epub 2019 Sep 6 doi: 10.1007/s00345-019-02936-y. PMID: 31493109Free PMC Article

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