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Lymphoepithelial Sialadenitis

MedGen UID:
1775671
•Concept ID:
C5420328
•
Disease or Syndrome

Definition

A benign salivary gland lesion characterized by acinar atrophy, ductal hyperplasia, and epimyoepithelial islands in lymphoid stroma. (WHO 2017) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLymphoepithelial Sialadenitis

Professional guidelines

PubMed

Pathology and management of masses in the accessory parotid gland region: 24-year experience at a single institution.
Ma H, Jin S, Du Z, Wang L, Zhang Z, Wang Y
J Craniomaxillofac Surg 2018 Feb;46(2):183-189. Epub 2017 Nov 17 doi: 10.1016/j.jcms.2017.11.001. PMID: 29229364
Differential diagnosis of IgG4-related sialadenitis, primary Sjögren syndrome, and chronic obstructive submandibular sialadenitis.
Hong X, Li W, Xie XY, Zhang ZY, Chen Y, Gao Y, Peng X, Su JZ, Zhang YY, Wang Z, Cai ZG, Zhang L, Liu YY, He J, Ren LM, Li ZG, Yu GY
Br J Oral Maxillofac Surg 2017 Feb;55(2):179-184. Epub 2016 Nov 17 doi: 10.1016/j.bjoms.2016.10.021. PMID: 27866757
Diagnosis and management of lymphoepithelial lesion of the parotid gland.
Ma Q, Song H
Rheumatol Int 2011 Jul;31(7):959-62. Epub 2010 Nov 11 doi: 10.1007/s00296-010-1617-9. PMID: 21069527

Recent clinical studies

Etiology

Benign lesions of the mediastinum.
Gerber TS, Porubsky S
Histopathology 2024 Jan;84(1):183-195. Epub 2023 Nov 21 doi: 10.1111/his.15088. PMID: 37988262
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
Thymic hyperplasia with lymphoepithelial sialadenitis (LESA)-like features: a clinicopathologic and immunohistochemical study of 4 cases.
Weissferdt A, Moran CA
Am J Clin Pathol 2012 Dec;138(6):816-22. doi: 10.1309/AJCPM6W5MHZMUZRS. PMID: 23161715
Primary non-Hodgkin's lymphoma of the salivary gland: a spectrum of lymphoepithelial sialadenitis, low-grade B-cell lymphoma of mucosa-associated lymphoid tissue with transformation to high-grade lymphoma.
Agale SV, D'Costa GF, Hastak MS, Shedge RT
Indian J Pathol Microbiol 2010 Apr-Jun;53(2):364-7. doi: 10.4103/0377-4929.64351. PMID: 20551561
Lymphoid lesions of salivary glands: malignant and benign.
Ellis GL
Med Oral Patol Oral Cir Bucal 2007 Nov 1;12(7):E479-85. PMID: 17978770

Diagnosis

Benign lesions of the mediastinum.
Gerber TS, Porubsky S
Histopathology 2024 Jan;84(1):183-195. Epub 2023 Nov 21 doi: 10.1111/his.15088. PMID: 37988262
Lymphoepithelial sialadenitis of minor salivary glands no Sjögren Syndrome related.
Russo D, DI Stasio D, Montella M, Romano A, Fiorillo L, Laino L, Lucchese A
Minerva Dent Oral Sci 2021 Oct;70(5):229-231. Epub 2021 Jun 29 doi: 10.23736/S2724-6329.21.04524-1. PMID: 34182750
Myoepithelial sialadenitis with metachromatic matrix: A diagnostic pitfall. A case of salivary gland swelling in a paediatric patient evaluated by fine needle aspiration cytology.
Ronchi A, Montella M, Marra PM, Colella G, Franco R, Cozzolino I
Cytopathology 2021 Mar;32(2):257-260. Epub 2020 Oct 11 doi: 10.1111/cyt.12916. PMID: 32931074
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
Primary non-Hodgkin's lymphoma of the salivary gland: a spectrum of lymphoepithelial sialadenitis, low-grade B-cell lymphoma of mucosa-associated lymphoid tissue with transformation to high-grade lymphoma.
Agale SV, D'Costa GF, Hastak MS, Shedge RT
Indian J Pathol Microbiol 2010 Apr-Jun;53(2):364-7. doi: 10.4103/0377-4929.64351. PMID: 20551561

Therapy

Ultrasound-guided core needle biopsy compared with open biopsy: a new diagnostic approach to salivary gland enlargement in Sjögren's syndrome?
Zabotti A, Zandonella Callegher S, Lorenzon M, Pegolo E, Scott CA, Tel A, Giovannini I, Robiony M, Di Loreto C, Zuiani C, De Vita S
Rheumatology (Oxford) 2021 Mar 2;60(3):1282-1290. doi: 10.1093/rheumatology/keaa441. PMID: 32940706

Prognosis

Ultrasound-Guided Biopsy of Suspected Salivary Gland Lymphoma in Sjögren's Syndrome.
Baer AN, Grader-Beck T, Antiochos B, Birnbaum J, Fradin JM
Arthritis Care Res (Hoboken) 2021 Jun;73(6):849-855. doi: 10.1002/acr.24203. PMID: 32248649Free PMC Article
Intraparotid classical and nodular lymphocyte-predominant Hodgkin lymphoma: pattern analysis with emphasis on associated lymphadenoma-like proliferations.
Agaimy A, Wild V, Märkl B, Wachter DL, Hartmann A, Rosenwald A, Ihrler S
Am J Surg Pathol 2015 Sep;39(9):1206-12. doi: 10.1097/PAS.0000000000000440. PMID: 25929348
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
Thymic hyperplasia with lymphoepithelial sialadenitis (LESA)-like features: a clinicopathologic and immunohistochemical study of 4 cases.
Weissferdt A, Moran CA
Am J Clin Pathol 2012 Dec;138(6):816-22. doi: 10.1309/AJCPM6W5MHZMUZRS. PMID: 23161715
Lymphoid lesions of salivary glands: malignant and benign.
Ellis GL
Med Oral Patol Oral Cir Bucal 2007 Nov 1;12(7):E479-85. PMID: 17978770

Clinical prediction guides

Ultrasound-Guided Biopsy of Suspected Salivary Gland Lymphoma in Sjögren's Syndrome.
Baer AN, Grader-Beck T, Antiochos B, Birnbaum J, Fradin JM
Arthritis Care Res (Hoboken) 2021 Jun;73(6):849-855. doi: 10.1002/acr.24203. PMID: 32248649Free PMC Article
Intraparotid classical and nodular lymphocyte-predominant Hodgkin lymphoma: pattern analysis with emphasis on associated lymphadenoma-like proliferations.
Agaimy A, Wild V, Märkl B, Wachter DL, Hartmann A, Rosenwald A, Ihrler S
Am J Surg Pathol 2015 Sep;39(9):1206-12. doi: 10.1097/PAS.0000000000000440. PMID: 25929348
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
Cystic lymphoid hyperplasia of the parotid gland in HIV-positive and HIV-negative patients: quantitative immunopathology.
Kreisel FH, Frater JL, Hassan A, El-Mofty SK
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010 Apr;109(4):567-74. doi: 10.1016/j.tripleo.2009.12.008. PMID: 20303054
Chronic sclerosing sialadenitis (Küttner tumor) is an IgG4-associated disease.
Geyer JT, Ferry JA, Harris NL, Stone JH, Zukerberg LR, Lauwers GY, Pilch BZ, Deshpande V
Am J Surg Pathol 2010 Feb;34(2):202-10. doi: 10.1097/PAS.0b013e3181c811ad. PMID: 20061932

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