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Disorder of salivary gland

MedGen UID:
48537
•Concept ID:
C0036093
•
Disease or Syndrome
Synonyms: Disease, Salivary Gland; Diseases, Salivary Gland; Gland Disease, Salivary; Gland Diseases, Salivary; Salivary Gland Disease; Salivary Gland Diseases
SNOMED CT: Disorder of salivary gland (10890000); Salivary gland disease (10890000)

Definition

A non-neoplastic or neoplastic (benign or malignant) disorder involving a salivary gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDisorder of salivary gland

Professional guidelines

PubMed

Salivary gland stones: diagnosis and treatment.
Bull PD
Hosp Med 2001 Jul;62(7):396-9. doi: 10.12968/hosp.2001.62.7.1607. PMID: 11480125

Recent clinical studies

Therapy

Inhibition of JAK-STAT pathway corrects salivary gland inflammation and interferon driven immune activation in Sjögren's disease.
Gupta S, Yamada E, Nakamura H, Perez P, Pranzatelli TJ, Dominick K, Jang SI, Abed M, Martin D, Burbelo P, Zheng C, French B, Alevizos I, Khavandgar Z, Beach M, Pelayo E, Walitt B, Hasni S, Kaplan MJ, Tandon M, Magone MT, Kleiner DE, Chiorini JA, Baer A, Warner BM
Ann Rheum Dis 2024 Jul 15;83(8):1034-1047. doi: 10.1136/ard-2023-224842. PMID: 38527764Free PMC Article
Drooling and Aspiration of Saliva.
Hughes A, Lambert EM
Otolaryngol Clin North Am 2022 Dec;55(6):1181-1194. doi: 10.1016/j.otc.2022.07.007. PMID: 36371134
Treatment for sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis.
James E, Ellis C, Brassington R, Sathasivam S, Young CA
Cochrane Database Syst Rev 2022 May 20;5(5):CD006981. doi: 10.1002/14651858.CD006981.pub3. PMID: 35593746Free PMC Article
Efficacy and safety of topical and systemic medications: a systematic literature review informing the EULAR recommendations for the management of Sjögren's syndrome.
Brito-Zerón P, Retamozo S, Kostov B, Baldini C, Bootsma H, De Vita S, Dörner T, Gottenberg JE, Kruize AA, Mandl T, Ng WF, Seror R, Tzioufas AG, Vitali C, Bowman S, Mariette X, Ramos-Casals M
RMD Open 2019;5(2):e001064. Epub 2019 Oct 28 doi: 10.1136/rmdopen-2019-001064. PMID: 31749986Free PMC Article
Salivary gland swellings.
Mehanna H, McQueen A, Robinson M, Paleri V
Clin Otolaryngol 2013 Feb;38(1):58-65. doi: 10.1111/coa.12056. PMID: 23418969

Prognosis

Salivary gland cancer: ESMO-European Reference Network on Rare Adult Solid Cancers (EURACAN) Clinical Practice Guideline for diagnosis, treatment and follow-up.
van Herpen C, Vander Poorten V, Skalova A, Terhaard C, Maroldi R, van Engen A, Baujat B, Locati LD, Jensen AD, Smeele L, Hardillo J, Martineau VC, Trama A, Kinloch E, Even C, Machiels JP; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
ESMO Open 2022 Dec;7(6):100602. Epub 2022 Nov 2 doi: 10.1016/j.esmoop.2022.100602. PMID: 36567082Free PMC Article
Utility of Ultrasonography for Diagnosis of Salivary Gland Sialolithiasis: A Meta-Analysis.
Kim DH, Kang JM, Kim SW, Kim SH, Jung JH, Hwang SH
Laryngoscope 2022 Sep;132(9):1785-1791. Epub 2022 Jan 19 doi: 10.1002/lary.30020. PMID: 35043982
Salivary duct carcinoma.
D'heygere E, Meulemans J, Vander Poorten V
Curr Opin Otolaryngol Head Neck Surg 2018 Apr;26(2):142-151. doi: 10.1097/MOO.0000000000000436. PMID: 29373327
Multidisciplinary Management of Salivary Gland Cancers.
Mifsud MJ, Burton JN, Trotti AM, Padhya TA
Cancer Control 2016 Jul;23(3):242-8. doi: 10.1177/107327481602300307. PMID: 27556664
HIV-related oral disease.
Greenspan D, Greenspan JS
Lancet 1996 Sep 14;348(9029):729-33. doi: 10.1016/S0140-6736(96)02308-2. PMID: 8806295

Clinical prediction guides

Inhibition of JAK-STAT pathway corrects salivary gland inflammation and interferon driven immune activation in Sjögren's disease.
Gupta S, Yamada E, Nakamura H, Perez P, Pranzatelli TJ, Dominick K, Jang SI, Abed M, Martin D, Burbelo P, Zheng C, French B, Alevizos I, Khavandgar Z, Beach M, Pelayo E, Walitt B, Hasni S, Kaplan MJ, Tandon M, Magone MT, Kleiner DE, Chiorini JA, Baer A, Warner BM
Ann Rheum Dis 2024 Jul 15;83(8):1034-1047. doi: 10.1136/ard-2023-224842. PMID: 38527764Free PMC Article
Utility of Ultrasonography for Diagnosis of Salivary Gland Sialolithiasis: A Meta-Analysis.
Kim DH, Kang JM, Kim SW, Kim SH, Jung JH, Hwang SH
Laryngoscope 2022 Sep;132(9):1785-1791. Epub 2022 Jan 19 doi: 10.1002/lary.30020. PMID: 35043982
Sjögren's syndrome: a systemic autoimmune disease.
Negrini S, Emmi G, Greco M, Borro M, Sardanelli F, Murdaca G, Indiveri F, Puppo F
Clin Exp Med 2022 Feb;22(1):9-25. Epub 2021 Jun 7 doi: 10.1007/s10238-021-00728-6. PMID: 34100160Free PMC Article
Xerostomia of Various Etiologies: A Review of the Literature.
Tanasiewicz M, Hildebrandt T, Obersztyn I
Adv Clin Exp Med 2016 Jan-Feb;25(1):199-206. doi: 10.17219/acem/29375. PMID: 26935515
EULAR Sjogren's syndrome disease activity index: development of a consensus systemic disease activity index for primary Sjogren's syndrome.
Seror R, Ravaud P, Bowman SJ, Baron G, Tzioufas A, Theander E, Gottenberg JE, Bootsma H, Mariette X, Vitali C; EULAR Sjögren's Task Force
Ann Rheum Dis 2010 Jun;69(6):1103-9. Epub 2009 Jun 28 doi: 10.1136/ard.2009.110619. PMID: 19561361Free PMC Article

Recent systematic reviews

Primary Sjögren syndrome-related peripheral neuropathy: A systematic review and meta-analysis.
Liampas A, Parperis K, Erotocritou MF, Nteveros A, Papadopoulou M, Moschovos C, Akil M, Coaccioli S, Hadjigeorgiou GM, Hadjivassiliou M, Zis P
Eur J Neurol 2023 Jan;30(1):255-265. Epub 2022 Sep 23 doi: 10.1111/ene.15555. PMID: 36086910Free PMC Article
Oral Manifestations of Systemic Lupus Erythematosus: A Systematic Review.
García-Ríos P, Pecci-Lloret MP, Oñate-Sánchez RE
Int J Environ Res Public Health 2022 Sep 21;19(19) doi: 10.3390/ijerph191911910. PMID: 36231212Free PMC Article
Advances in Pathogenesis of Sjögren's Syndrome.
Tian Y, Yang H, Liu N, Li Y, Chen J
J Immunol Res 2021;2021:5928232. Epub 2021 Oct 7 doi: 10.1155/2021/5928232. PMID: 34660815Free PMC Article
American Cancer Society Head and Neck Cancer Survivorship Care Guideline.
Cohen EE, LaMonte SJ, Erb NL, Beckman KL, Sadeghi N, Hutcheson KA, Stubblefield MD, Abbott DM, Fisher PS, Stein KD, Lyman GH, Pratt-Chapman ML
CA Cancer J Clin 2016 May;66(3):203-39. Epub 2016 Mar 22 doi: 10.3322/caac.21343. PMID: 27002678
Epidemiology of primary Sjögren's syndrome: a systematic review and meta-analysis.
Qin B, Wang J, Yang Z, Yang M, Ma N, Huang F, Zhong R
Ann Rheum Dis 2015 Nov;74(11):1983-9. Epub 2014 Jun 17 doi: 10.1136/annrheumdis-2014-205375. PMID: 24938285

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