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Disorder of salivary gland

MedGen UID:
48537
•Concept ID:
C0036093
•
Disease or Syndrome
Synonyms: Disease, Salivary Gland; Diseases, Salivary Gland; Gland Disease, Salivary; Gland Diseases, Salivary; Salivary Gland Disease; Salivary Gland Diseases
SNOMED CT: Disorder of salivary gland (10890000); Salivary gland disease (10890000)

Definition

A non-neoplastic or neoplastic (benign or malignant) disorder involving a salivary gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDisorder of salivary gland

Professional guidelines

PubMed

Salivary gland stones: diagnosis and treatment.
Bull PD
Hosp Med 2001 Jul;62(7):396-9. doi: 10.12968/hosp.2001.62.7.1607. PMID: 11480125

Recent clinical studies

Etiology

Adenoid Cystic Carcinoma from the salivary and lacrimal glands and the breast: Different clinical outcomes to the same tumor.
Emerick C, Mariano FV, Vargas PA, Nör JE, Squarize CH, Castilho RM
Crit Rev Oncol Hematol 2022 Nov;179:103792. Epub 2022 Aug 13 doi: 10.1016/j.critrevonc.2022.103792. PMID: 35973662
Salivary Gland Hypofunction and/or Xerostomia Induced by Nonsurgical Cancer Therapies: ISOO/MASCC/ASCO Guideline.
Mercadante V, Jensen SB, Smith DK, Bohlke K, Bauman J, Brennan MT, Coppes RP, Jessen N, Malhotra NK, Murphy B, Rosenthal DI, Vissink A, Wu J, Saunders DP, Peterson DE
J Clin Oncol 2021 Sep 1;39(25):2825-2843. Epub 2021 Jul 20 doi: 10.1200/JCO.21.01208. PMID: 34283635
Identification of predictive variables for the recurrence of oral mucocele.
Choi YJ, Byun JS, Choi JK, Jung JK
Med Oral Patol Oral Cir Bucal 2019 Mar 1;24(2):e231-e235. doi: 10.4317/medoral.22690. PMID: 30818316Free PMC Article
Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy.
Riley P, Glenny AM, Hua F, Worthington HV
Cochrane Database Syst Rev 2017 Jul 31;7(7):CD012744. doi: 10.1002/14651858.CD012744. PMID: 28759701Free PMC Article
Xerostomia: diagnosis and management.
Greenspan D
Oncology (Williston Park) 1996 Mar;10(3 Suppl):7-11. PMID: 8723427

Diagnosis

Salivary Gland Hypofunction and Xerostomia in Head and Neck Radiation Patients.
Jensen SB, Vissink A, Limesand KH, Reyland ME
J Natl Cancer Inst Monogr 2019 Aug 1;2019(53) doi: 10.1093/jncimonographs/lgz016. PMID: 31425600
Identification of predictive variables for the recurrence of oral mucocele.
Choi YJ, Byun JS, Choi JK, Jung JK
Med Oral Patol Oral Cir Bucal 2019 Mar 1;24(2):e231-e235. doi: 10.4317/medoral.22690. PMID: 30818316Free PMC Article
Salivary gland disorders.
Wilson KF, Meier JD, Ward PD
Am Fam Physician 2014 Jun 1;89(11):882-8. PMID: 25077394
Salivary gland diseases: infections, sialolithiasis and mucoceles.
Delli K, Spijkervet FK, Vissink A
Monogr Oral Sci 2014;24:135-48. Epub 2014 May 23 doi: 10.1159/000358794. PMID: 24862601
Salivary glands.
Silvers AR, Som PM
Radiol Clin North Am 1998 Sep;36(5):941-66, vi. doi: 10.1016/s0033-8389(05)70070-1. PMID: 9747195

Therapy

Treatment for sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis.
James E, Ellis C, Brassington R, Sathasivam S, Young CA
Cochrane Database Syst Rev 2022 May 20;5(5):CD006981. doi: 10.1002/14651858.CD006981.pub3. PMID: 35593746Free PMC Article
Efficacy and safety of topical and systemic medications: a systematic literature review informing the EULAR recommendations for the management of Sjögren's syndrome.
Brito-Zerón P, Retamozo S, Kostov B, Baldini C, Bootsma H, De Vita S, Dörner T, Gottenberg JE, Kruize AA, Mandl T, Ng WF, Seror R, Tzioufas AG, Vitali C, Bowman S, Mariette X, Ramos-Casals M
RMD Open 2019;5(2):e001064. Epub 2019 Oct 28 doi: 10.1136/rmdopen-2019-001064. PMID: 31749986Free PMC Article
Salivary Gland Hypofunction and Xerostomia in Head and Neck Radiation Patients.
Jensen SB, Vissink A, Limesand KH, Reyland ME
J Natl Cancer Inst Monogr 2019 Aug 1;2019(53) doi: 10.1093/jncimonographs/lgz016. PMID: 31425600
Interventions for the management of radiotherapy-induced xerostomia and hyposalivation: A systematic review and meta-analysis.
Mercadante V, Al Hamad A, Lodi G, Porter S, Fedele S
Oral Oncol 2017 Mar;66:64-74. Epub 2017 Jan 19 doi: 10.1016/j.oraloncology.2016.12.031. PMID: 28249650
Xerostomia: diagnosis and management.
Greenspan D
Oncology (Williston Park) 1996 Mar;10(3 Suppl):7-11. PMID: 8723427

Prognosis

Sjögren's syndrome: one year in review 2022.
Manfrè V, Chatzis LG, Cafaro G, Fonzetti S, Calvacchi S, Fulvio G, Navarro Garcia IC, La Rocca G, Ferro F, Perricone C, Bartoloni E, Baldini C
Clin Exp Rheumatol 2022 Dec;40(12):2211-2224. Epub 2022 Dec 20 doi: 10.55563/clinexprheumatol/43z8gu. PMID: 36541236
Adenoid Cystic Carcinoma from the salivary and lacrimal glands and the breast: Different clinical outcomes to the same tumor.
Emerick C, Mariano FV, Vargas PA, Nör JE, Squarize CH, Castilho RM
Crit Rev Oncol Hematol 2022 Nov;179:103792. Epub 2022 Aug 13 doi: 10.1016/j.critrevonc.2022.103792. PMID: 35973662
Salivary Gland Hypofunction and/or Xerostomia Induced by Nonsurgical Cancer Therapies: ISOO/MASCC/ASCO Guideline.
Mercadante V, Jensen SB, Smith DK, Bohlke K, Bauman J, Brennan MT, Coppes RP, Jessen N, Malhotra NK, Murphy B, Rosenthal DI, Vissink A, Wu J, Saunders DP, Peterson DE
J Clin Oncol 2021 Sep 1;39(25):2825-2843. Epub 2021 Jul 20 doi: 10.1200/JCO.21.01208. PMID: 34283635
Minor salivary gland tumors of the head and neck-Memorial Sloan Kettering experience: Incidence and outcomes by site and histological type.
Hay AJ, Migliacci J, Karassawa Zanoni D, McGill M, Patel S, Ganly I
Cancer 2019 Oct 1;125(19):3354-3366. Epub 2019 Jun 7 doi: 10.1002/cncr.32208. PMID: 31174233Free PMC Article
Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy.
Riley P, Glenny AM, Hua F, Worthington HV
Cochrane Database Syst Rev 2017 Jul 31;7(7):CD012744. doi: 10.1002/14651858.CD012744. PMID: 28759701Free PMC Article

Clinical prediction guides

Sjögren's syndrome: one year in review 2022.
Manfrè V, Chatzis LG, Cafaro G, Fonzetti S, Calvacchi S, Fulvio G, Navarro Garcia IC, La Rocca G, Ferro F, Perricone C, Bartoloni E, Baldini C
Clin Exp Rheumatol 2022 Dec;40(12):2211-2224. Epub 2022 Dec 20 doi: 10.55563/clinexprheumatol/43z8gu. PMID: 36541236
Adenoid Cystic Carcinoma from the salivary and lacrimal glands and the breast: Different clinical outcomes to the same tumor.
Emerick C, Mariano FV, Vargas PA, Nör JE, Squarize CH, Castilho RM
Crit Rev Oncol Hematol 2022 Nov;179:103792. Epub 2022 Aug 13 doi: 10.1016/j.critrevonc.2022.103792. PMID: 35973662
Sjögren's syndrome: a systemic autoimmune disease.
Negrini S, Emmi G, Greco M, Borro M, Sardanelli F, Murdaca G, Indiveri F, Puppo F
Clin Exp Med 2022 Feb;22(1):9-25. Epub 2021 Jun 7 doi: 10.1007/s10238-021-00728-6. PMID: 34100160Free PMC Article
Xerostomia of Various Etiologies: A Review of the Literature.
Tanasiewicz M, Hildebrandt T, Obersztyn I
Adv Clin Exp Med 2016 Jan-Feb;25(1):199-206. doi: 10.17219/acem/29375. PMID: 26935515
Salivary gland diseases: infections, sialolithiasis and mucoceles.
Delli K, Spijkervet FK, Vissink A
Monogr Oral Sci 2014;24:135-48. Epub 2014 May 23 doi: 10.1159/000358794. PMID: 24862601

Recent systematic reviews

Advances in Pathogenesis of Sjögren's Syndrome.
Tian Y, Yang H, Liu N, Li Y, Chen J
J Immunol Res 2021;2021:5928232. Epub 2021 Oct 7 doi: 10.1155/2021/5928232. PMID: 34660815Free PMC Article
Triple vs Dual Inhaler Therapy and Asthma Outcomes in Moderate to Severe Asthma: A Systematic Review and Meta-analysis.
Kim LHY, Saleh C, Whalen-Browne A, O'Byrne PM, Chu DK
JAMA 2021 Jun 22;325(24):2466-2479. doi: 10.1001/jama.2021.7872. PMID: 34009257Free PMC Article
Effect of advanced age and/or systemic medical conditions on dental implant survival: A systematic review and meta-analysis.
Schimmel M, Srinivasan M, McKenna G, Müller F
Clin Oral Implants Res 2018 Oct;29 Suppl 16:311-330. doi: 10.1111/clr.13288. PMID: 30328186
Treatment of xerostomia and hyposalivation in the elderly: A systematic review.
Gil-Montoya JA, Silvestre FJ, Barrios R, Silvestre-Rangil J
Med Oral Patol Oral Cir Bucal 2016 May 1;21(3):e355-66. doi: 10.4317/medoral.20969. PMID: 27031061Free PMC Article
Epidemiology of primary Sjögren's syndrome: a systematic review and meta-analysis.
Qin B, Wang J, Yang Z, Yang M, Ma N, Huang F, Zhong R
Ann Rheum Dis 2015 Nov;74(11):1983-9. Epub 2014 Jun 17 doi: 10.1136/annrheumdis-2014-205375. PMID: 24938285

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