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Increased circulating lipoprotein lipase concentration

MedGen UID:
1778380
•Concept ID:
C5539628
•
Finding
Synonym: Elevated lipoprotein lipase level
 
HPO: HP:0033478

Definition

Increased concentration of lipoprotein lipase in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating lipoprotein lipase concentration

Recent clinical studies

Etiology

Inverse association between apolipoprotein C-II and cardiovascular mortality: role of lipoprotein lipase activity modulation.
Silbernagel G, Chen YQ, Rief M, Kleber ME, Hoffmann MM, Stojakovic T, Stang A, Sarzynski MA, Bouchard C, März W, Qian YW, Scharnagl H, Konrad RJ
Eur Heart J 2023 Jul 1;44(25):2335-2345. doi: 10.1093/eurheartj/ehad261. PMID: 37155355
Konjac Glucomannan Attenuated Triglyceride Metabolism during Rice Gruel Tolerance Test.
Nagasawa T, Kimura T, Yoshida A, Tsunekawa K, Araki O, Ushiki K, Ishigaki H, Shoho Y, Suda I, Hiramoto S, Murakami M
Nutrients 2021 Jun 25;13(7) doi: 10.3390/nu13072191. PMID: 34202167Free PMC Article
Moderate alcohol consumption and triglyceridemia.
Kovář J, Zemánková K
Physiol Res 2015;64(Suppl 3):S371-5. doi: 10.33549/physiolres.933178. PMID: 26680670
Pitavastatin - pharmacological profile from early phase studies.
Catapano AL
Atheroscler Suppl 2010 Dec;11(3):3-7. doi: 10.1016/S1567-5688(10)71063-1. PMID: 21193152
Hyperglycemia, lipoprotein glycation, and vascular disease.
Veiraiah A
Angiology 2005 Jul-Aug;56(4):431-8. doi: 10.1177/000331970505600411. PMID: 16079928

Diagnosis

Circulating FGF21 in humans is potently induced by short term overfeeding of carbohydrates.
Lundsgaard AM, Fritzen AM, Sjøberg KA, Myrmel LS, Madsen L, Wojtaszewski JFP, Richter EA, Kiens B
Mol Metab 2017 Jan;6(1):22-29. Epub 2016 Nov 16 doi: 10.1016/j.molmet.2016.11.001. PMID: 28123934Free PMC Article
Endothelial lipase is increased in vivo by inflammation in humans.
Badellino KO, Wolfe ML, Reilly MP, Rader DJ
Circulation 2008 Feb 5;117(5):678-85. Epub 2008 Jan 22 doi: 10.1161/CIRCULATIONAHA.107.707349. PMID: 18212282
Contribution of triglyceride-rich lipoproteins to plasma free fatty acids.
Miles JM, Nelson RH
Horm Metab Res 2007 Oct;39(10):726-9. doi: 10.1055/s-2007-990273. PMID: 17952834
Adiponectin and the metabolic syndrome: mechanisms mediating risk for metabolic and cardiovascular disease.
Lara-Castro C, Fu Y, Chung BH, Garvey WT
Curr Opin Lipidol 2007 Jun;18(3):263-70. doi: 10.1097/MOL.0b013e32814a645f. PMID: 17495599
Pro-inflammatory cytokines and adipose tissue.
Coppack SW
Proc Nutr Soc 2001 Aug;60(3):349-56. doi: 10.1079/pns2001110. PMID: 11681809

Therapy

Konjac Glucomannan Attenuated Triglyceride Metabolism during Rice Gruel Tolerance Test.
Nagasawa T, Kimura T, Yoshida A, Tsunekawa K, Araki O, Ushiki K, Ishigaki H, Shoho Y, Suda I, Hiramoto S, Murakami M
Nutrients 2021 Jun 25;13(7) doi: 10.3390/nu13072191. PMID: 34202167Free PMC Article
Postprandial remnant lipoproteins as targets for the prevention of atherosclerosis.
Nakajima K, Tanaka A
Curr Opin Endocrinol Diabetes Obes 2018 Apr;25(2):108-117. doi: 10.1097/MED.0000000000000393. PMID: 29493553
Chronic dexamethasone exposure markedly decreased the hepatic triglyceride accumulation in growing goats.
Chen Q, Niu L, Hua C, Geng Y, Cai L, Tao S, Ni Y, Zhao R
Gen Comp Endocrinol 2018 Apr 1;259:115-121. Epub 2017 Nov 16 doi: 10.1016/j.ygcen.2017.11.011. PMID: 29155266
Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and their mechanisms of action on apolipoprotein B-containing lipoproteins in humans: a review.
Oscarsson J, Hurt-Camejo E
Lipids Health Dis 2017 Aug 10;16(1):149. doi: 10.1186/s12944-017-0541-3. PMID: 28797250Free PMC Article
Circulating FGF21 in humans is potently induced by short term overfeeding of carbohydrates.
Lundsgaard AM, Fritzen AM, Sjøberg KA, Myrmel LS, Madsen L, Wojtaszewski JFP, Richter EA, Kiens B
Mol Metab 2017 Jan;6(1):22-29. Epub 2016 Nov 16 doi: 10.1016/j.molmet.2016.11.001. PMID: 28123934Free PMC Article

Prognosis

Elevated circulating levels of lipoprotein-associated phospholipase A2 in obese children.
Sakka S, Siahanidou T, Voyatzis C, Pervanidou P, Kaminioti C, Lazopoulou N, Kanaka-Gantenbein C, Chrousos GP, Papassotiriou I
Clin Chem Lab Med 2015 Jun;53(7):1119-25. doi: 10.1515/cclm-2014-1081. PMID: 25581763
Prolactin and insulin ultradian secretion and adipose tissue lipoprotein lipase expression in severely obese women after bariatric surgery.
Mingrone G, Manco M, Iaconelli A, Gniuli D, Bracaglia R, Leccesi L, Calvani M, Nolfe G, Basu S, Berria R
Obesity (Silver Spring) 2008 Aug;16(8):1831-7. Epub 2008 Jun 5 doi: 10.1038/oby.2008.297. PMID: 18535540
Lipids and lipoprotein subfractions in women with PCOS: relationship to metabolic and endocrine parameters.
Pirwany IR, Fleming R, Greer IA, Packard CJ, Sattar N
Clin Endocrinol (Oxf) 2001 Apr;54(4):447-53. doi: 10.1046/j.1365-2265.2001.01228.x. PMID: 11318779
Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?
Yudkin JS, Kumari M, Humphries SE, Mohamed-Ali V
Atherosclerosis 2000 Feb;148(2):209-14. doi: 10.1016/s0021-9150(99)00463-3. PMID: 10657556
Acute dyslipoproteinemia induced by interleukin-2: lecithin:cholesteryl acyltransferase, lipoprotein lipase, and hepatic lipase deficiencies.
Kwong LK, Ridinger DN, Bandhauer M, Ward JH, Samlowski WE, Iverius PH, Pritchard H, Wilson DE
J Clin Endocrinol Metab 1997 May;82(5):1572-81. doi: 10.1210/jcem.82.5.3937. PMID: 9141552

Clinical prediction guides

Inverse association between apolipoprotein C-II and cardiovascular mortality: role of lipoprotein lipase activity modulation.
Silbernagel G, Chen YQ, Rief M, Kleber ME, Hoffmann MM, Stojakovic T, Stang A, Sarzynski MA, Bouchard C, März W, Qian YW, Scharnagl H, Konrad RJ
Eur Heart J 2023 Jul 1;44(25):2335-2345. doi: 10.1093/eurheartj/ehad261. PMID: 37155355
Konjac Glucomannan Attenuated Triglyceride Metabolism during Rice Gruel Tolerance Test.
Nagasawa T, Kimura T, Yoshida A, Tsunekawa K, Araki O, Ushiki K, Ishigaki H, Shoho Y, Suda I, Hiramoto S, Murakami M
Nutrients 2021 Jun 25;13(7) doi: 10.3390/nu13072191. PMID: 34202167Free PMC Article
Chronic dexamethasone exposure markedly decreased the hepatic triglyceride accumulation in growing goats.
Chen Q, Niu L, Hua C, Geng Y, Cai L, Tao S, Ni Y, Zhao R
Gen Comp Endocrinol 2018 Apr 1;259:115-121. Epub 2017 Nov 16 doi: 10.1016/j.ygcen.2017.11.011. PMID: 29155266
Genetic Determinants of Circulating Lipoproteins in Nonalcoholic Fatty Liver Disease.
Jiang ZG, Tapper EB, Kim M, Connelly MA, Krawczyk SA, Yee EU, Herman MA, Mukamal KJ, Lai M
J Clin Gastroenterol 2018 May/Jun;52(5):444-451. doi: 10.1097/MCG.0000000000000816. PMID: 28362682Free PMC Article
Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and their mechanisms of action on apolipoprotein B-containing lipoproteins in humans: a review.
Oscarsson J, Hurt-Camejo E
Lipids Health Dis 2017 Aug 10;16(1):149. doi: 10.1186/s12944-017-0541-3. PMID: 28797250Free PMC Article

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