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Abnormal circulating keto acid concentration

MedGen UID:
1778408
•Concept ID:
C5539588
•
Finding
HPO: HP:0033435

Definition

A deviation from the normal concentration of a keto acid in the blood circulation. Keto acids or ketoacids are organic compounds that contain a carboxylic acid group and a ketone group. [from HPO]

Professional guidelines

PubMed

Twenty-four hour hormonal and metabolic profiles in uraemic patients before and during treatment with continuous ambulatory peritoneal dialysis.
Heaton A, Johnston DG, Haigh JW, Ward MK, Alberti KG, Kerr DN
Clin Sci (Lond) 1985 Oct;69(4):449-57. doi: 10.1042/cs0690449. PMID: 4042546

Recent clinical studies

Etiology

Renal tubular dysfunction in patients with cystic disease of the kidneys.
Pabico RC, McKenna BA, Freeman RB
Urology 1998 May;51(5A Suppl):156-60. doi: 10.1016/s0090-4295(98)00081-8. PMID: 9610573
Estrogens do not affect whole-body protein metabolism in the prepubertal female.
Mauras N
J Clin Endocrinol Metab 1995 Oct;80(10):2842-5. doi: 10.1210/jcem.80.10.7559861. PMID: 7559861
Abnormal regulation of carbohydrate metabolism in motor neurone disease.
Krentz AJ, Williams AC, Nattrass M
Diabetes Res 1991 Feb;16(2):93-9. PMID: 1817811
Inhibitory effect of acetylsalicylic acid on platelet function in patients with completed stroke or reversible ischemic neurologic deficit.
Lee TK, Chen YC, Lien IN, Liu MC, Huang ZS
Stroke 1988 May;19(5):566-70. doi: 10.1161/01.str.19.5.566. PMID: 3363589
Plasma immunoreactive somatostatin is elevated in diabetic ketoacidosis and correlates with plasma non-esterified fatty acid concentration.
Binimelis J, Webb SM, Serrano J, Codina M, Corcoy R, Perez A, Peinado MA, Puig M, de la Torre W, Serrat J
Diabet Med 1987 May-Jun;4(3):221-4. doi: 10.1111/j.1464-5491.1987.tb00866.x. PMID: 2886248

Diagnosis

Copeptin, a surrogate marker of vasopressin, is associated with disease severity in autosomal dominant polycystic kidney disease.
Meijer E, Bakker SJ, van der Jagt EJ, Navis G, de Jong PE, Struck J, Gansevoort RT
Clin J Am Soc Nephrol 2011 Feb;6(2):361-8. Epub 2010 Oct 7 doi: 10.2215/CJN.04560510. PMID: 20930090Free PMC Article
Abnormal regulation of carbohydrate metabolism in motor neurone disease.
Krentz AJ, Williams AC, Nattrass M
Diabetes Res 1991 Feb;16(2):93-9. PMID: 1817811
Inhibitory effect of acetylsalicylic acid on platelet function in patients with completed stroke or reversible ischemic neurologic deficit.
Lee TK, Chen YC, Lien IN, Liu MC, Huang ZS
Stroke 1988 May;19(5):566-70. doi: 10.1161/01.str.19.5.566. PMID: 3363589
Plasma biguanide levels are correlated with metabolic effects in diabetic patients.
Marchetti P, Benzi L, Cecchetti P, Giannarelli R, Boni C, Ciociaro D, Ciccarone AM, Di Cianni G, Zappella A, Navalesi R
Clin Pharmacol Ther 1987 Apr;41(4):450-4. doi: 10.1038/clpt.1987.55. PMID: 3829580
Comparison of the effect of acetylsalicylic acid on platelet function in male and female patients with ischemic stroke.
Lee TK, Chen YC, Kuo TL
Thromb Res 1987 Aug 1;47(3):295-304. doi: 10.1016/0049-3848(87)90143-5. PMID: 3629557

Therapy

Abnormal response of urinary eicosanoid system to norepinephrine infusion in patients with essential hypertension.
Uehara Y, Ishimitsu T, Kawabata Y, Matsuoka H, Ishii M, Sugimoto T
Prostaglandins Leukot Essent Fatty Acids 1992 Jun;46(2):99-104. doi: 10.1016/0952-3278(92)90215-5. PMID: 1502257
Plasma biguanide levels are correlated with metabolic effects in diabetic patients.
Marchetti P, Benzi L, Cecchetti P, Giannarelli R, Boni C, Ciociaro D, Ciccarone AM, Di Cianni G, Zappella A, Navalesi R
Clin Pharmacol Ther 1987 Apr;41(4):450-4. doi: 10.1038/clpt.1987.55. PMID: 3829580
Comparison of the effect of acetylsalicylic acid on platelet function in male and female patients with ischemic stroke.
Lee TK, Chen YC, Kuo TL
Thromb Res 1987 Aug 1;47(3):295-304. doi: 10.1016/0049-3848(87)90143-5. PMID: 3629557
Renal hemodynamics and water excretion in Addison's disease.
Quintanilla AP, Delgado-Butron C, Zeballos J
Metabolism 1976 Apr;25(4):419-25. doi: 10.1016/0026-0495(76)90074-3. PMID: 1263836
Alterations in renal cortical blood flow in infants and children with urinary tract infections.
Calcagno PL, D'Albora JB, Tina LU, Papadopoulou ZL, Deasy PF, Hollerman CE
Pediatr Res 1968 Sep;2(5):332-51. doi: 10.1203/00006450-196809000-00002. PMID: 5672694

Prognosis

Copeptin, a surrogate marker of vasopressin, is associated with disease severity in autosomal dominant polycystic kidney disease.
Meijer E, Bakker SJ, van der Jagt EJ, Navis G, de Jong PE, Struck J, Gansevoort RT
Clin J Am Soc Nephrol 2011 Feb;6(2):361-8. Epub 2010 Oct 7 doi: 10.2215/CJN.04560510. PMID: 20930090Free PMC Article

Clinical prediction guides

Copeptin, a surrogate marker of vasopressin, is associated with disease severity in autosomal dominant polycystic kidney disease.
Meijer E, Bakker SJ, van der Jagt EJ, Navis G, de Jong PE, Struck J, Gansevoort RT
Clin J Am Soc Nephrol 2011 Feb;6(2):361-8. Epub 2010 Oct 7 doi: 10.2215/CJN.04560510. PMID: 20930090Free PMC Article
Estrogens do not affect whole-body protein metabolism in the prepubertal female.
Mauras N
J Clin Endocrinol Metab 1995 Oct;80(10):2842-5. doi: 10.1210/jcem.80.10.7559861. PMID: 7559861
Impaired glucose tolerance is characterized by multiple abnormalities in the regulation of intermediary metabolism.
Krentz AJ, Singh BM, Nattrass M
Diabet Med 1991 Nov;8(9):848-54. doi: 10.1111/j.1464-5491.1991.tb02123.x. PMID: 1837511
Comparison of the effect of acetylsalicylic acid on platelet function in male and female patients with ischemic stroke.
Lee TK, Chen YC, Kuo TL
Thromb Res 1987 Aug 1;47(3):295-304. doi: 10.1016/0049-3848(87)90143-5. PMID: 3629557
Twenty-four hour hormonal and metabolic profiles in uraemic patients before and during treatment with continuous ambulatory peritoneal dialysis.
Heaton A, Johnston DG, Haigh JW, Ward MK, Alberti KG, Kerr DN
Clin Sci (Lond) 1985 Oct;69(4):449-57. doi: 10.1042/cs0690449. PMID: 4042546

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