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Hippocampal sclerosis

MedGen UID:
1778719
Concept ID:
C1504404
Disease or Syndrome
Synonyms: Ammon Horn Scleroses; Ammon Horn Sclerosis; Hippocampal Scleroses; Hippocampal Sclerosis; Horn Sclerosis, Ammon; Sclerosis, Ammon Horn; Sclerosis, Hippocampal
 
HPO: HP:0033715

Definition

Hippocampal sclerosis is a neuropathologic finding characterized by neuronal loss and gliosis in the CA-1 and subiculum of the hippocampus. [from HPO]

Conditions with this feature

Epilepsy, familial adult myoclonic, 5
MedGen UID:
815704
Concept ID:
C3809374
Disease or Syndrome
Familial adult myoclonic epilepsy-5 is an autosomal recessive neurologic disorder characterized by onset of seizures in adolescence, followed by the development of cortical myoclonic tremor later in life. Some patients may also have neuropsychiatric abnormalities (summary by Stogmann et al., 2013).

Professional guidelines

PubMed

Riney K, Bogacz A, Somerville E, Hirsch E, Nabbout R, Scheffer IE, Zuberi SM, Alsaadi T, Jain S, French J, Specchio N, Trinka E, Wiebe S, Auvin S, Cabral-Lim L, Naidoo A, Perucca E, Moshé SL, Wirrell EC, Tinuper P
Epilepsia 2022 Jun;63(6):1443-1474. Epub 2022 May 3 doi: 10.1111/epi.17240. PMID: 35503725
Asadi-Pooya AA, Bartolini L
Int J Neurosci 2020 Nov;130(11):1151-1155. Epub 2020 Feb 27 doi: 10.1080/00207454.2020.1730370. PMID: 32053411
Montine TJ, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, Nelson PT, Schneider JA, Thal DR, Trojanowski JQ, Vinters HV, Hyman BT; National Institute on Aging; Alzheimer’s Association
Acta Neuropathol 2012 Jan;123(1):1-11. Epub 2011 Nov 20 doi: 10.1007/s00401-011-0910-3. PMID: 22101365Free PMC Article

Recent clinical studies

Etiology

Kim D, Lee J, Moon J, Moon T
Epilepsia Open 2022 Dec;7(4):747-757. Epub 2022 Oct 5 doi: 10.1002/epi4.12655. PMID: 36177546Free PMC Article
Kilpattu Ramaniharan A, Zhang MW, Selladurai G, Martin R, Ver Hoef L
Epilepsia 2022 May;63(5):1104-1114. Epub 2022 Mar 20 doi: 10.1111/epi.17211. PMID: 35243619
Duque KR, Burneo JG
Epilepsy Behav 2017 Nov;76:151-157. Epub 2017 Sep 5 doi: 10.1016/j.yebeh.2017.08.008. PMID: 28882721
Dutra JR, Cortés EP, Vonsattel JP
Curr Neurol Neurosci Rep 2015 Oct;15(10):67. doi: 10.1007/s11910-015-0592-7. PMID: 26299276
Thom M
Neuropathol Appl Neurobiol 2014 Aug;40(5):520-43. doi: 10.1111/nan.12150. PMID: 24762203Free PMC Article

Diagnosis

Henning O, Heuser K, Larsen VS, Kyte EB, Kostov H, Marthinsen PB, Egge A, Alfstad KÅ, Nakken KO
Tidsskr Nor Laegeforen 2023 Jan 31;143(2) Epub 2023 Jan 30 doi: 10.4045/tidsskr.22.0369. PMID: 36718887
López-Rivera JA, Leu C, Macnee M, Khoury J, Hoffmann L, Coras R, Kobow K, Bhattarai N, Pérez-Palma E, Hamer H, Brandner S, Rössler K, Bien CG, Kalbhenn T, Pieper T, Hartlieb T, Butler E, Genovese G, Becker K, Altmüller J, Niestroj LM, Ferguson L, Busch RM, Nürnberg P, Najm I, Blümcke I, Lal D
Brain 2023 Apr 19;146(4):1342-1356. doi: 10.1093/brain/awac376. PMID: 36226386Free PMC Article
Bien CG
Handb Clin Neurol 2022;187:467-487. doi: 10.1016/B978-0-12-823493-8.00024-9. PMID: 35964988
Thom M
Neuropathol Appl Neurobiol 2014 Aug;40(5):520-43. doi: 10.1111/nan.12150. PMID: 24762203Free PMC Article
Guerrini R
Lancet 2006 Feb 11;367(9509):499-524. doi: 10.1016/S0140-6736(06)68182-8. PMID: 16473127

Therapy

Fang Y, Si X, Wang J, Wang Z, Chen Y, Liu Y, Yan Y, Tian J, Zhang B, Pu J
Neurology 2023 Jul 25;101(4):e399-e409. Epub 2023 May 24 doi: 10.1212/WNL.0000000000207423. PMID: 37225432Free PMC Article
Riney K, Bogacz A, Somerville E, Hirsch E, Nabbout R, Scheffer IE, Zuberi SM, Alsaadi T, Jain S, French J, Specchio N, Trinka E, Wiebe S, Auvin S, Cabral-Lim L, Naidoo A, Perucca E, Moshé SL, Wirrell EC, Tinuper P
Epilepsia 2022 Jun;63(6):1443-1474. Epub 2022 May 3 doi: 10.1111/epi.17240. PMID: 35503725
Steinhoff BJ, Staack AM
Epilepsy Behav 2019 Feb;91:4-8. Epub 2018 Jun 28 doi: 10.1016/j.yebeh.2018.05.025. PMID: 29960857
Steve TA, Jirsch JD, Gross DW
Epilepsy Res 2014 Oct;108(8):1279-85. Epub 2014 Jul 23 doi: 10.1016/j.eplepsyres.2014.07.003. PMID: 25107686
Guerrini R
Lancet 2006 Feb 11;367(9509):499-524. doi: 10.1016/S0140-6736(06)68182-8. PMID: 16473127

Prognosis

Bien CG
Handb Clin Neurol 2022;187:467-487. doi: 10.1016/B978-0-12-823493-8.00024-9. PMID: 35964988
Hoffmann L, Blümcke I
Curr Opin Neurol 2022 Apr 1;35(2):202-207. doi: 10.1097/WCO.0000000000001030. PMID: 35067500
Sidhu MK, Duncan JS, Sander JW
Curr Opin Neurol 2018 Aug;31(4):371-378. doi: 10.1097/WCO.0000000000000568. PMID: 29782369
Kobow K, Blümcke I
Neurosci Lett 2018 Feb 22;667:40-46. Epub 2017 Jan 19 doi: 10.1016/j.neulet.2017.01.012. PMID: 28111355
Guerrini R
Lancet 2006 Feb 11;367(9509):499-524. doi: 10.1016/S0140-6736(06)68182-8. PMID: 16473127

Clinical prediction guides

Fang Y, Si X, Wang J, Wang Z, Chen Y, Liu Y, Yan Y, Tian J, Zhang B, Pu J
Neurology 2023 Jul 25;101(4):e399-e409. Epub 2023 May 24 doi: 10.1212/WNL.0000000000207423. PMID: 37225432Free PMC Article
Sidhu MK, Duncan JS, Sander JW
Curr Opin Neurol 2018 Aug;31(4):371-378. doi: 10.1097/WCO.0000000000000568. PMID: 29782369
Chatzikonstantinou A
Front Neurol Neurosci 2014;34:121-42. Epub 2014 Apr 16 doi: 10.1159/000356435. PMID: 24777136
Kovac S, Walker MC
J Neurol 2014 Apr;261(4):837-41. Epub 2014 Mar 4 doi: 10.1007/s00415-014-7294-y. PMID: 24590406
Malmgren K, Thom M
Epilepsia 2012 Sep;53 Suppl 4:19-33. doi: 10.1111/j.1528-1167.2012.03610.x. PMID: 22946718

Recent systematic reviews

Li Y, Liu P, Lin Q, Zhou D, An D
Epilepsia 2023 Nov;64(11):2845-2860. Epub 2023 Sep 30 doi: 10.1111/epi.17757. PMID: 37611927
Mariajoseph FP, Sagar P, Muthusamy S, Amukotuwa S, Seneviratne U
Seizure 2021 Nov;92:166-173. Epub 2021 Sep 7 doi: 10.1016/j.seizure.2021.09.002. PMID: 34525432
Fernández-Vega N, Ramos-Rodriguez JR, Alfaro F, Barbancho MÁ, García-Casares N
Neuroradiology 2021 Sep;63(9):1395-1405. Epub 2021 Apr 13 doi: 10.1007/s00234-021-02704-z. PMID: 33851253
Dallaire-Théroux C, Callahan BL, Potvin O, Saikali S, Duchesne S
J Alzheimers Dis 2017;57(2):575-601. doi: 10.3233/JAD-161028. PMID: 28282807
Steve TA, Jirsch JD, Gross DW
Epilepsy Res 2014 Oct;108(8):1279-85. Epub 2014 Jul 23 doi: 10.1016/j.eplepsyres.2014.07.003. PMID: 25107686

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