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Glomerular endothelial tubuloreticular inclusion

MedGen UID:
1778753
•Concept ID:
C5539474
•
Finding
HPO: HP:0033275

Definition

Inter-anastomosing tubular structures located within cisternae of endoplasmic reticulum, most often within endothelial cells and associated with exposure to interferon. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlomerular endothelial tubuloreticular inclusion

Recent clinical studies

Etiology

Tubuloreticular Inclusions in Renal Allografts Associate with Viral Infections and Donor-Specific Antibodies.
Willicombe M, Moss J, Moran L, Brookes P, Santos-Nunez E, McLean AG, Cairns T, Taube D, Cook TH, Roufosse C
J Am Soc Nephrol 2016 Jul;27(7):2188-95. Epub 2015 Nov 27 doi: 10.1681/ASN.2015050478. PMID: 26614383Free PMC Article
The clinicopathologic significance of endothelial tubuloreticular inclusions in glomerular diseases.
Lee CJ, Suh KS, Kim KH, Chang YK, Na KR, Lee KW
Ultrastruct Pathol 2013 Dec;37(6):386-94. Epub 2013 Aug 19 doi: 10.3109/01913123.2013.814738. PMID: 23957425
The clinicopathological implications of endothelial tubuloreticular inclusions found in glomeruli having histopathology of idiopathic membranous nephropathy.
Yang AH, Lin BS, Kuo KL, Chang CC, Ng YY, Yang WC
Nephrol Dial Transplant 2009 Nov;24(11):3419-25. Epub 2009 Jun 17 doi: 10.1093/ndt/gfp288. PMID: 19535433
Pauci-immune and immune glomerular lesions in kidney transplants for systemic lupus erythematosus.
Meehan SM, Chang A, Khurana A, Baliga R, Kadambi PV, Javaid B
Clin J Am Soc Nephrol 2008 Sep;3(5):1469-78. Epub 2008 Jun 18 doi: 10.2215/CJN.00790208. PMID: 18562595Free PMC Article
The effect of cyclosporine on the progression of human immunodeficiency virus type 1 infection transmitted by transplantation--data on four cases and review of the literature.
Schwarz A, Offermann G, Keller F, Bennhold I, L'age-Stehr J, Krause PH, Mihatsch MJ
Transplantation 1993 Jan;55(1):95-103. doi: 10.1097/00007890-199301000-00019. PMID: 8420072

Diagnosis

Kidney transplant dysfunction in a patient with COVID - 19 infection: role of concurrent Sars-Cov 2 nephropathy, chronic rejection and vitamin C-mediated hyperoxalosis: case report.
Anandh U, Gowrishankar S, Sharma A, Salama A, Dasgupta I
BMC Nephrol 2021 Mar 15;22(1):91. doi: 10.1186/s12882-021-02298-x. PMID: 33722190Free PMC Article
Tubuloreticular inclusions in peritubular capillaries of renal allografts.
Lee JY, Song SH, Kim YS, Lim BJ, Kim SI, Kim MS, Jeong HJ
Pathol Res Pract 2017 Sep;213(9):1185-1190. Epub 2017 Jun 6 doi: 10.1016/j.prp.2017.06.009. PMID: 28647211
The clinicopathologic significance of endothelial tubuloreticular inclusions in glomerular diseases.
Lee CJ, Suh KS, Kim KH, Chang YK, Na KR, Lee KW
Ultrastruct Pathol 2013 Dec;37(6):386-94. Epub 2013 Aug 19 doi: 10.3109/01913123.2013.814738. PMID: 23957425
Hypocomplementemic urticarial vasculitis or systemic lupus erythematosus?
Trendelenburg M, Courvoisier S, Späth PJ, Moll S, Mihatsch M, Itin P, Schifferli JA
Am J Kidney Dis 1999 Oct;34(4):745-51. doi: 10.1016/S0272-6386(99)70402-6. PMID: 10516358
Tubuloreticular inclusions in systemic lupus pneumonitis. Report of a case and review of the literature.
Lyon MG, Bewtra C, Kenik JG, Hurley JA
Arch Pathol Lab Med 1984 Jul;108(7):599-600. PMID: 6329130

Therapy

Kidney transplant dysfunction in a patient with COVID - 19 infection: role of concurrent Sars-Cov 2 nephropathy, chronic rejection and vitamin C-mediated hyperoxalosis: case report.
Anandh U, Gowrishankar S, Sharma A, Salama A, Dasgupta I
BMC Nephrol 2021 Mar 15;22(1):91. doi: 10.1186/s12882-021-02298-x. PMID: 33722190Free PMC Article
Pauci-immune and immune glomerular lesions in kidney transplants for systemic lupus erythematosus.
Meehan SM, Chang A, Khurana A, Baliga R, Kadambi PV, Javaid B
Clin J Am Soc Nephrol 2008 Sep;3(5):1469-78. Epub 2008 Jun 18 doi: 10.2215/CJN.00790208. PMID: 18562595Free PMC Article
Idiopathic collapsing glomerulopathy in children.
Singh HK, Baldree LA, McKenney DW, Hogan SL, Jennette JC
Pediatr Nephrol 2000 Feb;14(2):132-7. doi: 10.1007/s004670050028. PMID: 10684363
Human immunodeficiency virus nephropathy.
Strauss J, Zilleruelo G, Abitbol C, Montane B, Pardo V
Pediatr Nephrol 1993 Apr;7(2):220-5. doi: 10.1007/BF00864411. PMID: 8476724
The effect of cyclosporine on the progression of human immunodeficiency virus type 1 infection transmitted by transplantation--data on four cases and review of the literature.
Schwarz A, Offermann G, Keller F, Bennhold I, L'age-Stehr J, Krause PH, Mihatsch MJ
Transplantation 1993 Jan;55(1):95-103. doi: 10.1097/00007890-199301000-00019. PMID: 8420072

Prognosis

Kidney transplant dysfunction in a patient with COVID - 19 infection: role of concurrent Sars-Cov 2 nephropathy, chronic rejection and vitamin C-mediated hyperoxalosis: case report.
Anandh U, Gowrishankar S, Sharma A, Salama A, Dasgupta I
BMC Nephrol 2021 Mar 15;22(1):91. doi: 10.1186/s12882-021-02298-x. PMID: 33722190Free PMC Article
The clinicopathologic significance of endothelial tubuloreticular inclusions in glomerular diseases.
Lee CJ, Suh KS, Kim KH, Chang YK, Na KR, Lee KW
Ultrastruct Pathol 2013 Dec;37(6):386-94. Epub 2013 Aug 19 doi: 10.3109/01913123.2013.814738. PMID: 23957425
Collapsing glomerulopathy--a new pattern of renal injury.
Laurinavicius A, Rennke HG
Semin Diagn Pathol 2002 Aug;19(3):106-15. PMID: 12180632
Human immunodeficiency virus nephropathy.
Strauss J, Zilleruelo G, Abitbol C, Montane B, Pardo V
Pediatr Nephrol 1993 Apr;7(2):220-5. doi: 10.1007/BF00864411. PMID: 8476724
Pathologic differentiation between lupus and nonlupus membranous glomerulopathy.
Jennette JC, Iskandar SS, Dalldorf FG
Kidney Int 1983 Sep;24(3):377-85. doi: 10.1038/ki.1983.170. PMID: 6358633

Clinical prediction guides

Pauci-immune and immune glomerular lesions in kidney transplants for systemic lupus erythematosus.
Meehan SM, Chang A, Khurana A, Baliga R, Kadambi PV, Javaid B
Clin J Am Soc Nephrol 2008 Sep;3(5):1469-78. Epub 2008 Jun 18 doi: 10.2215/CJN.00790208. PMID: 18562595Free PMC Article
Collapsing glomerulopathy--a new pattern of renal injury.
Laurinavicius A, Rennke HG
Semin Diagn Pathol 2002 Aug;19(3):106-15. PMID: 12180632
Glomerular lesions in HIV-infected patients: a Yale University Department of Medicine Residency Peer-Teaching Conference.
Wrone EM, Carey H, Reilly RF
Yale J Biol Med 1997 Mar-Apr;70(2):161-73. PMID: 9493848Free PMC Article
Renal ultrastructural markers in AIDS-associated nephropathy.
Chander P, Soni A, Suri A, Bhagwat R, Yoo J, Treser G
Am J Pathol 1987 Mar;126(3):513-26. PMID: 3548410Free PMC Article
Pathologic differentiation between lupus and nonlupus membranous glomerulopathy.
Jennette JC, Iskandar SS, Dalldorf FG
Kidney Int 1983 Sep;24(3):377-85. doi: 10.1038/ki.1983.170. PMID: 6358633

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