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Refractory Renal Pelvis Urothelial Carcinoma

MedGen UID:
1778784
•Concept ID:
C5447548
•
Neoplastic Process

Definition

Renal pelvis urothelial carcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Renal Pelvis Urothelial Carcinoma

Recent clinical studies

Etiology

Salvage topical therapy for upper tract urothelial carcinoma.
Balasubramanian A, Metcalfe MJ, Wagenheim G, Xiao L, Papadopoulos J, Navai N, Davis JW, Karam JA, Kamat AM, Wood CG, Dinney CP, Matin SF
World J Urol 2018 Dec;36(12):2027-2034. Epub 2018 May 26 doi: 10.1007/s00345-018-2349-9. PMID: 29804202Free PMC Article
Open surgical partial nephrectomy for upper tract urothelial carcinoma.
Macari D, Faerber GJ, Hafez KS, Hollenbeck BK, Montie JE, Wood DP, Wolf JS Jr
Int J Urol 2014 Apr;21(4):409-12. Epub 2013 Oct 17 doi: 10.1111/iju.12301. PMID: 24134309
Oral 5-aminolevulinic acid in simultaneous photodynamic diagnosis of upper and lower urinary tract transitional cell carcinoma - a prospective audit.
Ahmad S, Aboumarzouk O, Somani B, Nabi G, Kata SG
BJU Int 2012 Dec;110(11 Pt B):E596-600. Epub 2012 Jul 3 doi: 10.1111/j.1464-410X.2012.11326.x. PMID: 22758907
Laparoendoscopic single-site radical cystectomy and pelvic lymph node dissection: initial experience and 2-year follow-up.
Kaouk JH, Goel RK, White MA, White WM, Autorino R, Haber GP, Campbell SC
Urology 2010 Oct;76(4):857-61. Epub 2010 Jun 19 doi: 10.1016/j.urology.2010.04.024. PMID: 20646750

Diagnosis

Open surgical partial nephrectomy for upper tract urothelial carcinoma.
Macari D, Faerber GJ, Hafez KS, Hollenbeck BK, Montie JE, Wood DP, Wolf JS Jr
Int J Urol 2014 Apr;21(4):409-12. Epub 2013 Oct 17 doi: 10.1111/iju.12301. PMID: 24134309
Oral 5-aminolevulinic acid in simultaneous photodynamic diagnosis of upper and lower urinary tract transitional cell carcinoma - a prospective audit.
Ahmad S, Aboumarzouk O, Somani B, Nabi G, Kata SG
BJU Int 2012 Dec;110(11 Pt B):E596-600. Epub 2012 Jul 3 doi: 10.1111/j.1464-410X.2012.11326.x. PMID: 22758907

Therapy

Complete Pathologic Response With Pembrolizumab and Enfortumab Vedotin in Urothelial Carcinoma of the Upper Urinary Tract.
Chan KH, Shu T, Al Shaarani M, Cen P
J Investig Med High Impact Case Rep 2024 Jan-Dec;12:23247096241257333. doi: 10.1177/23247096241257333. PMID: 38804541Free PMC Article
Salvage topical therapy for upper tract urothelial carcinoma.
Balasubramanian A, Metcalfe MJ, Wagenheim G, Xiao L, Papadopoulos J, Navai N, Davis JW, Karam JA, Kamat AM, Wood CG, Dinney CP, Matin SF
World J Urol 2018 Dec;36(12):2027-2034. Epub 2018 May 26 doi: 10.1007/s00345-018-2349-9. PMID: 29804202Free PMC Article
Open surgical partial nephrectomy for upper tract urothelial carcinoma.
Macari D, Faerber GJ, Hafez KS, Hollenbeck BK, Montie JE, Wood DP, Wolf JS Jr
Int J Urol 2014 Apr;21(4):409-12. Epub 2013 Oct 17 doi: 10.1111/iju.12301. PMID: 24134309
Oral 5-aminolevulinic acid in simultaneous photodynamic diagnosis of upper and lower urinary tract transitional cell carcinoma - a prospective audit.
Ahmad S, Aboumarzouk O, Somani B, Nabi G, Kata SG
BJU Int 2012 Dec;110(11 Pt B):E596-600. Epub 2012 Jul 3 doi: 10.1111/j.1464-410X.2012.11326.x. PMID: 22758907
Phase I trial of paclitaxel and gemcitabine administered every two weeks in patients with refractory solid tumors.
Rothenberg ML, Sharma A, Weiss GR, Villalona-Calero MA, Eckardt JR, Aylesworth C, Kraynak MA, Rinaldi DA, Rodriguez GI, Burris HA 3rd, Eckhardt SG, Stephens CD, Forral K, Nicol SJ, Von Hoff DD
Ann Oncol 1998 Jul;9(7):733-8. doi: 10.1023/a:1008286908930. PMID: 9739439

Prognosis

Next-Generation Sequencing and In Silico Analysis Facilitate Prolonged Response to Pazopanib in a Patient With Metastatic Urothelial Carcinoma of the Renal Pelvis.
Hahn AW, Giri S, Patel D, Sluder H, Vanderwalde A, Martin MG
J Natl Compr Canc Netw 2015 Oct;13(10):1181-5. doi: 10.6004/jnccn.2015.0147. PMID: 26483058
Open surgical partial nephrectomy for upper tract urothelial carcinoma.
Macari D, Faerber GJ, Hafez KS, Hollenbeck BK, Montie JE, Wood DP, Wolf JS Jr
Int J Urol 2014 Apr;21(4):409-12. Epub 2013 Oct 17 doi: 10.1111/iju.12301. PMID: 24134309
Laparoendoscopic single-site radical cystectomy and pelvic lymph node dissection: initial experience and 2-year follow-up.
Kaouk JH, Goel RK, White MA, White WM, Autorino R, Haber GP, Campbell SC
Urology 2010 Oct;76(4):857-61. Epub 2010 Jun 19 doi: 10.1016/j.urology.2010.04.024. PMID: 20646750

Clinical prediction guides

Next-Generation Sequencing and In Silico Analysis Facilitate Prolonged Response to Pazopanib in a Patient With Metastatic Urothelial Carcinoma of the Renal Pelvis.
Hahn AW, Giri S, Patel D, Sluder H, Vanderwalde A, Martin MG
J Natl Compr Canc Netw 2015 Oct;13(10):1181-5. doi: 10.6004/jnccn.2015.0147. PMID: 26483058
Phase I trial of paclitaxel and gemcitabine administered every two weeks in patients with refractory solid tumors.
Rothenberg ML, Sharma A, Weiss GR, Villalona-Calero MA, Eckardt JR, Aylesworth C, Kraynak MA, Rinaldi DA, Rodriguez GI, Burris HA 3rd, Eckhardt SG, Stephens CD, Forral K, Nicol SJ, Von Hoff DD
Ann Oncol 1998 Jul;9(7):733-8. doi: 10.1023/a:1008286908930. PMID: 9739439

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