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Abnormal amygdala morphology

MedGen UID:
1779036
•Concept ID:
C5539752
•
Anatomical Abnormality
Synonym: Abnormal morphology of the amygdala
 
HPO: HP:0033668

Definition

A structural anomaly of the amygdala. [from HPO]

Professional guidelines

PubMed

Glutamate-Mediated Excitotoxicity in the Pathogenesis and Treatment of Neurodevelopmental and Adult Mental Disorders.
Nicosia N, Giovenzana M, Misztak P, Mingardi J, Musazzi L
Int J Mol Sci 2024 Jun 13;25(12) doi: 10.3390/ijms25126521. PMID: 38928227Free PMC Article
Spine synapse remodeling in the pathophysiology and treatment of depression.
Duman CH, Duman RS
Neurosci Lett 2015 Aug 5;601:20-9. Epub 2015 Jan 9 doi: 10.1016/j.neulet.2015.01.022. PMID: 25582786Free PMC Article
HMPAO SPECT brain imaging in treatment-resistant depression.
Hornig M, Mozley PD, Amsterdam JD
Prog Neuropsychopharmacol Biol Psychiatry 1997 Oct;21(7):1097-114. doi: 10.1016/s0278-5846(97)00100-0. PMID: 9421825

Recent clinical studies

Etiology

Stress-Induced Metabolic Disorder in Peripheral CD4(+) T Cells Leads to Anxiety-like Behavior.
Fan KQ, Li YY, Wang HL, Mao XT, Guo JX, Wang F, Huang LJ, Li YN, Ma XY, Gao ZJ, Chen W, Qian DD, Xue WJ, Cao Q, Zhang L, Shen L, Zhang L, Tong C, Zhong JY, Lu W, Lu L, Ren KM, Zhong G, Wang Y, Tang M, Feng XH, Chai RJ, Jin J
Cell 2019 Oct 31;179(4):864-879.e19. doi: 10.1016/j.cell.2019.10.001. PMID: 31675497
Anatomical Abnormalities in Autism?
Haar S, Berman S, Behrmann M, Dinstein I
Cereb Cortex 2016 Apr;26(4):1440-52. Epub 2014 Oct 14 doi: 10.1093/cercor/bhu242. PMID: 25316335
Brain alterations in paedophilia: a critical review.
Mohnke S, Müller S, Amelung T, Krüger TH, Ponseti J, Schiffer B, Walter M, Beier KM, Walter H
Prog Neurobiol 2014 Nov;122:1-23. Epub 2014 Aug 10 doi: 10.1016/j.pneurobio.2014.07.005. PMID: 25116710
The neurobiology of psychopathy: a neurodevelopmental perspective.
Gao Y, Glenn AL, Schug RA, Yang Y, Raine A
Can J Psychiatry 2009 Dec;54(12):813-23. doi: 10.1177/070674370905401204. PMID: 20047720
Structural brain abnormalities in psychopaths-a review.
Weber S, Habel U, Amunts K, Schneider F
Behav Sci Law 2008;26(1):7-28. doi: 10.1002/bsl.802. PMID: 18327824

Diagnosis

The Role of the Thalamus in Post-Traumatic Stress Disorder.
Yoshii T
Int J Mol Sci 2021 Feb 9;22(4) doi: 10.3390/ijms22041730. PMID: 33572198Free PMC Article
PTSD-related neuroimaging abnormalities in brain function, structure, and biochemistry.
Harnett NG, Goodman AM, Knight DC
Exp Neurol 2020 Aug;330:113331. Epub 2020 Apr 25 doi: 10.1016/j.expneurol.2020.113331. PMID: 32343956
Aging and Alzheimer's disease pathology.
Sengoku R
Neuropathology 2020 Feb;40(1):22-29. Epub 2019 Dec 21 doi: 10.1111/neup.12626. PMID: 31863504
Autism spectrum disorder: neuropathology and animal models.
Varghese M, Keshav N, Jacot-Descombes S, Warda T, Wicinski B, Dickstein DL, Harony-Nicolas H, De Rubeis S, Drapeau E, Buxbaum JD, Hof PR
Acta Neuropathol 2017 Oct;134(4):537-566. Epub 2017 Jun 5 doi: 10.1007/s00401-017-1736-4. PMID: 28584888Free PMC Article
Reward and aversion in a heterogeneous midbrain dopamine system.
Lammel S, Lim BK, Malenka RC
Neuropharmacology 2014 Jan;76 Pt B(0 0):351-9. Epub 2013 Apr 8 doi: 10.1016/j.neuropharm.2013.03.019. PMID: 23578393Free PMC Article

Therapy

Endocrine Factors in Key Structural and Intracellular Changes in Depression.
Gold PW
Trends Endocrinol Metab 2021 Apr;32(4):212-223. Epub 2021 Feb 20 doi: 10.1016/j.tem.2021.01.003. PMID: 33622587
The Role of the Thalamus in Post-Traumatic Stress Disorder.
Yoshii T
Int J Mol Sci 2021 Feb 9;22(4) doi: 10.3390/ijms22041730. PMID: 33572198Free PMC Article
Symptomatic neurocutaneous melanosis: mild clinical onset in a teenager.
Vanood A, Lee YA, Leleszi E, Krishnan A
BMJ Case Rep 2020 Nov 30;13(11) doi: 10.1136/bcr-2020-235772. PMID: 33257354Free PMC Article
Exercise effects on depression: Possible neural mechanisms.
Gujral S, Aizenstein H, Reynolds CF 3rd, Butters MA, Erickson KI
Gen Hosp Psychiatry 2017 Nov;49:2-10. doi: 10.1016/j.genhosppsych.2017.04.012. PMID: 29122145Free PMC Article
Affect recognition deficits in schizophrenia: neural substrates and psychopharmacological implications.
Pinkham AE, Gur RE, Gur RC
Expert Rev Neurother 2007 Jul;7(7):807-16. doi: 10.1586/14737175.7.7.807. PMID: 17610388

Prognosis

Symptomatic neurocutaneous melanosis: mild clinical onset in a teenager.
Vanood A, Lee YA, Leleszi E, Krishnan A
BMJ Case Rep 2020 Nov 30;13(11) doi: 10.1136/bcr-2020-235772. PMID: 33257354Free PMC Article
PTSD-related neuroimaging abnormalities in brain function, structure, and biochemistry.
Harnett NG, Goodman AM, Knight DC
Exp Neurol 2020 Aug;330:113331. Epub 2020 Apr 25 doi: 10.1016/j.expneurol.2020.113331. PMID: 32343956
Aging and Alzheimer's disease pathology.
Sengoku R
Neuropathology 2020 Feb;40(1):22-29. Epub 2019 Dec 21 doi: 10.1111/neup.12626. PMID: 31863504
Brain-heart interaction in perseverative cognition.
Ottaviani C
Psychophysiology 2018 Jul;55(7):e13082. Epub 2018 Apr 1 doi: 10.1111/psyp.13082. PMID: 29607505
Hippocampal sclerosis--origins and imaging.
Malmgren K, Thom M
Epilepsia 2012 Sep;53 Suppl 4:19-33. doi: 10.1111/j.1528-1167.2012.03610.x. PMID: 22946718

Clinical prediction guides

PTSD-related neuroimaging abnormalities in brain function, structure, and biochemistry.
Harnett NG, Goodman AM, Knight DC
Exp Neurol 2020 Aug;330:113331. Epub 2020 Apr 25 doi: 10.1016/j.expneurol.2020.113331. PMID: 32343956
Aging and Alzheimer's disease pathology.
Sengoku R
Neuropathology 2020 Feb;40(1):22-29. Epub 2019 Dec 21 doi: 10.1111/neup.12626. PMID: 31863504
Exercise effects on depression: Possible neural mechanisms.
Gujral S, Aizenstein H, Reynolds CF 3rd, Butters MA, Erickson KI
Gen Hosp Psychiatry 2017 Nov;49:2-10. doi: 10.1016/j.genhosppsych.2017.04.012. PMID: 29122145Free PMC Article
Reward and aversion in a heterogeneous midbrain dopamine system.
Lammel S, Lim BK, Malenka RC
Neuropharmacology 2014 Jan;76 Pt B(0 0):351-9. Epub 2013 Apr 8 doi: 10.1016/j.neuropharm.2013.03.019. PMID: 23578393Free PMC Article
Neuroimaging in bipolar disorder.
Strakowski SM, DelBello MP, Adler C, Cecil DM, Sax KW
Bipolar Disord 2000 Sep;2(3 Pt 1):148-64. doi: 10.1034/j.1399-5618.2000.020302.x. PMID: 11256682

Recent systematic reviews

Perineuronal net density in schizophrenia: A systematic review of postmortem brain studies.
Lisboa JRF, Costa O, Pakes GH, Colodete DAE, Gomes FV
Schizophr Res 2024 Sep;271:100-109. Epub 2024 Jul 16 doi: 10.1016/j.schres.2024.07.023. PMID: 39018984
Does pediatric post-traumatic stress disorder alter the brain? Systematic review and meta-analysis of structural and functional magnetic resonance imaging studies.
Milani AC, Hoffmann EV, Fossaluza V, Jackowski AP, Mello MF
Psychiatry Clin Neurosci 2017 Mar;71(3):154-169. Epub 2017 Jan 6 doi: 10.1111/pcn.12473. PMID: 27778421
A Systematic Review and Meta-analysis of Neuroimaging in Oppositional Defiant Disorder (ODD) and Conduct Disorder (CD) Taking Attention-Deficit Hyperactivity Disorder (ADHD) Into Account.
Noordermeer SD, Luman M, Oosterlaan J
Neuropsychol Rev 2016 Mar;26(1):44-72. Epub 2016 Feb 5 doi: 10.1007/s11065-015-9315-8. PMID: 26846227Free PMC Article
Biomarkers and staging of bipolar disorder: a systematic review.
Roda Â, Chendo I, Kunz M
Trends Psychiatry Psychother 2015 Jan-Mar;37(1):3-11. Epub 2014 Dec 9 doi: 10.1590/2237-6089-2014-0002. PMID: 25860561
Can pharmacological and psychological treatment change brain structure and function in PTSD? A systematic review.
Thomaes K, Dorrepaal E, Draijer N, Jansma EP, Veltman DJ, van Balkom AJ
J Psychiatr Res 2014 Mar;50:1-15. Epub 2013 Nov 12 doi: 10.1016/j.jpsychires.2013.11.002. PMID: 24321592

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