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Enlarged amygdala

MedGen UID:
1786163
•Concept ID:
C5539753
•
Anatomical Abnormality
Synonym: Amygdalar enlargement
 
HPO: HP:0033669

Definition

A increase in the volume (size) of the amygdyla. [from HPO]

Professional guidelines

PubMed

Diagnosis and surgical treatment of non-lesional temporal lobe epilepsy with unilateral amygdala enlargement.
Fan Z, Sun B, Lang LQ, Hu J, Hameed NUF, Wei ZX, Zhuang QY, Cai JJ, Liu FT, Mao YT, Feng R, Pan L
Neurol Sci 2021 Jun;42(6):2353-2361. Epub 2020 Oct 12 doi: 10.1007/s10072-020-04794-8. PMID: 33044668

Recent clinical studies

Etiology

Alterations of amygdala volume and functional connectivity in migraine patients comorbid with and without depression.
Chen X, Gui W, Li HL, Deng ZR, Wang Y
Brain Behav 2024 Feb;14(2):e3427. doi: 10.1002/brb3.3427. PMID: 38361322Free PMC Article
Prenatal stress: Effects on fetal and child brain development.
Lautarescu A, Craig MC, Glover V
Int Rev Neurobiol 2020;150:17-40. Epub 2019 Dec 14 doi: 10.1016/bs.irn.2019.11.002. PMID: 32204831
Sex Differences in Trauma-Related Psychopathology: a Critical Review of Neuroimaging Literature (2014-2017).
Helpman L, Zhu X, Suarez-Jimenez B, Lazarov A, Monk C, Neria Y
Curr Psychiatry Rep 2017 Nov 8;19(12):104. doi: 10.1007/s11920-017-0854-y. PMID: 29116470Free PMC Article
Reduced anterior insula, enlarged amygdala in alcoholism and associated depleted von Economo neurons.
Senatorov VV, Damadzic R, Mann CL, Schwandt ML, George DT, Hommer DW, Heilig M, Momenan R
Brain 2015 Jan;138(Pt 1):69-79. Epub 2014 Nov 2 doi: 10.1093/brain/awu305. PMID: 25367022Free PMC Article
Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis.
Arnone D, Cavanagh J, Gerber D, Lawrie SM, Ebmeier KP, McIntosh AM
Br J Psychiatry 2009 Sep;195(3):194-201. doi: 10.1192/bjp.bp.108.059717. PMID: 19721106

Diagnosis

Diagnosis and surgical treatment of non-lesional temporal lobe epilepsy with unilateral amygdala enlargement.
Fan Z, Sun B, Lang LQ, Hu J, Hameed NUF, Wei ZX, Zhuang QY, Cai JJ, Liu FT, Mao YT, Feng R, Pan L
Neurol Sci 2021 Jun;42(6):2353-2361. Epub 2020 Oct 12 doi: 10.1007/s10072-020-04794-8. PMID: 33044668
Temporal lobe epilepsy with amygdala enlargement: a morphologic and functional study.
Takaya S, Ikeda A, Mitsueda-Ono T, Matsumoto R, Inouchi M, Namiki C, Oishi N, Mikuni N, Ishizu K, Takahashi R, Fukuyama H
J Neuroimaging 2014 Jan-Feb;24(1):54-62. Epub 2012 Feb 3 doi: 10.1111/j.1552-6569.2011.00694.x. PMID: 22304227
Amygdala volume in combat-exposed veterans with and without posttraumatic stress disorder: a cross-sectional study.
Kuo JR, Kaloupek DG, Woodward SH
Arch Gen Psychiatry 2012 Oct;69(10):1080-6. doi: 10.1001/archgenpsychiatry.2012.73. PMID: 23026958
Larger amygdala but no change in hippocampal volume in 10-year-old children exposed to maternal depressive symptomatology since birth.
Lupien SJ, Parent S, Evans AC, Tremblay RE, Zelazo PD, Corbo V, Pruessner JC, Séguin JR
Proc Natl Acad Sci U S A 2011 Aug 23;108(34):14324-9. Epub 2011 Aug 15 doi: 10.1073/pnas.1105371108. PMID: 21844357Free PMC Article
Abnormal size of the amygdala predicts impaired emotional memory in major depressive disorder.
Weniger G, Lange C, Irle E
J Affect Disord 2006 Aug;94(1-3):219-29. Epub 2006 Jun 5 doi: 10.1016/j.jad.2006.04.017. PMID: 16740316

Therapy

Volume change in amygdala enlargement as a prognostic factor in patients with temporal lobe epilepsy: A longitudinal study.
Na HK, Lee HJ, Hong SJ, Lee DH, Kim KM, Lee HW, Heo K, Cho KH
Epilepsia 2020 Jan;61(1):70-80. Epub 2019 Dec 11 doi: 10.1111/epi.16400. PMID: 31828789
Evaluation of amygdala pathology using (11)C-methionine positron emission tomography/computed tomography in patients with temporal lobe epilepsy and amygdala enlargement.
Sone D, Ito K, Taniguchi G, Murata Y, Nakata Y, Watanabe Y, Okazaki M, Sato N, Matsuda H, Watanabe M
Epilepsy Res 2015 May;112:114-21. Epub 2015 Mar 10 doi: 10.1016/j.eplepsyres.2015.02.018. PMID: 25847346
Cortical brain morphology in young, estrogen-naive, and adolescent, estrogen-treated girls with Turner syndrome.
Lepage JF, Mazaika PK, Hong DS, Raman M, Reiss AL
Cereb Cortex 2013 Sep;23(9):2159-68. Epub 2012 Jul 17 doi: 10.1093/cercor/bhs195. PMID: 22806268Free PMC Article
Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis.
Arnone D, Cavanagh J, Gerber D, Lawrie SM, Ebmeier KP, McIntosh AM
Br J Psychiatry 2009 Sep;195(3):194-201. doi: 10.1192/bjp.bp.108.059717. PMID: 19721106
Larger amygdala volumes in first depressive episode as compared to recurrent major depression and healthy control subjects.
Frodl T, Meisenzahl EM, Zetzsche T, Born C, Jäger M, Groll C, Bottlender R, Leinsinger G, Möller HJ
Biol Psychiatry 2003 Feb 15;53(4):338-44. doi: 10.1016/s0006-3223(02)01474-9. PMID: 12586453

Prognosis

Diagnosis and surgical treatment of non-lesional temporal lobe epilepsy with unilateral amygdala enlargement.
Fan Z, Sun B, Lang LQ, Hu J, Hameed NUF, Wei ZX, Zhuang QY, Cai JJ, Liu FT, Mao YT, Feng R, Pan L
Neurol Sci 2021 Jun;42(6):2353-2361. Epub 2020 Oct 12 doi: 10.1007/s10072-020-04794-8. PMID: 33044668
Evaluation of amygdala pathology using (11)C-methionine positron emission tomography/computed tomography in patients with temporal lobe epilepsy and amygdala enlargement.
Sone D, Ito K, Taniguchi G, Murata Y, Nakata Y, Watanabe Y, Okazaki M, Sato N, Matsuda H, Watanabe M
Epilepsy Res 2015 May;112:114-21. Epub 2015 Mar 10 doi: 10.1016/j.eplepsyres.2015.02.018. PMID: 25847346
Amygdala subregional structure and intrinsic functional connectivity predicts individual differences in anxiety during early childhood.
Qin S, Young CB, Duan X, Chen T, Supekar K, Menon V
Biol Psychiatry 2014 Jun 1;75(11):892-900. Epub 2013 Oct 11 doi: 10.1016/j.biopsych.2013.10.006. PMID: 24268662Free PMC Article
Abnormal size of the amygdala predicts impaired emotional memory in major depressive disorder.
Weniger G, Lange C, Irle E
J Affect Disord 2006 Aug;94(1-3):219-29. Epub 2006 Jun 5 doi: 10.1016/j.jad.2006.04.017. PMID: 16740316
Larger amygdala volumes in first depressive episode as compared to recurrent major depression and healthy control subjects.
Frodl T, Meisenzahl EM, Zetzsche T, Born C, Jäger M, Groll C, Bottlender R, Leinsinger G, Möller HJ
Biol Psychiatry 2003 Feb 15;53(4):338-44. doi: 10.1016/s0006-3223(02)01474-9. PMID: 12586453

Clinical prediction guides

Prenatal stress: Effects on fetal and child brain development.
Lautarescu A, Craig MC, Glover V
Int Rev Neurobiol 2020;150:17-40. Epub 2019 Dec 14 doi: 10.1016/bs.irn.2019.11.002. PMID: 32204831
The epileptogenic zone in pharmaco-resistant temporal lobe epilepsy with amygdala enlargement.
Suzuki H, Sugano H, Nakajima M, Higo T, Iimura Y, Mitsuhashi T, Fusegi K, Kakita A, Otsubo H, Arai H
Epileptic Disord 2019 Jun 1;21(3):252-264. doi: 10.1684/epd.2019.1075. PMID: 31225808
Reduced anterior insula, enlarged amygdala in alcoholism and associated depleted von Economo neurons.
Senatorov VV, Damadzic R, Mann CL, Schwandt ML, George DT, Hommer DW, Heilig M, Momenan R
Brain 2015 Jan;138(Pt 1):69-79. Epub 2014 Nov 2 doi: 10.1093/brain/awu305. PMID: 25367022Free PMC Article
Temporal lobe epilepsy with amygdala enlargement: a morphologic and functional study.
Takaya S, Ikeda A, Mitsueda-Ono T, Matsumoto R, Inouchi M, Namiki C, Oishi N, Mikuni N, Ishizu K, Takahashi R, Fukuyama H
J Neuroimaging 2014 Jan-Feb;24(1):54-62. Epub 2012 Feb 3 doi: 10.1111/j.1552-6569.2011.00694.x. PMID: 22304227
Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis.
Arnone D, Cavanagh J, Gerber D, Lawrie SM, Ebmeier KP, McIntosh AM
Br J Psychiatry 2009 Sep;195(3):194-201. doi: 10.1192/bjp.bp.108.059717. PMID: 19721106

Recent systematic reviews

Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis.
Arnone D, Cavanagh J, Gerber D, Lawrie SM, Ebmeier KP, McIntosh AM
Br J Psychiatry 2009 Sep;195(3):194-201. doi: 10.1192/bjp.bp.108.059717. PMID: 19721106

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