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Alveolar septal thickening

MedGen UID:
1779532
•Concept ID:
C5539545
•
Finding
HPO: HP:0033376

Definition

Increased width of the alveolar septum, which is the structure that separates neighboring alveoli. This finding can be appreciated on histology. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAlveolar septal thickening

Professional guidelines

PubMed

Lung inflammation in hyperoxia can be prevented by antichemokine treatment in newborn rats.
Deng H, Mason SN, Auten RL Jr
Am J Respir Crit Care Med 2000 Dec;162(6):2316-23. doi: 10.1164/ajrccm.162.6.9911020. PMID: 11112157

Recent clinical studies

Etiology

Pulmonary lesions induced by SARS-CoV-2 infection in domestic cats.
Patania OM, Chiba S, Halfmann PJ, Hatta M, Maemura T, Bernard KA, Kawaoka Y, Crawford LK
Vet Pathol 2022 Jul;59(4):696-706. Epub 2021 Dec 29 doi: 10.1177/03009858211066840. PMID: 34963403Free PMC Article
Clinical, radiological and pathological features of idiopathic and secondary interstitial pneumonia with pleuroparenchymal fibroelastosis in patients undergoing lung transplantation.
Ikegami N, Nakajima N, Yoshizawa A, Handa T, Chen-Yoshikawa T, Kubo T, Tanizawa K, Ohsumi A, Yamada Y, Hamaji M, Nakajima D, Yutaka Y, Tanaka S, Watanabe K, Nakatsuka Y, Murase Y, Nakanishi T, Niwamoto T, Chin K, Date H, Hirai T
Histopathology 2022 Mar;80(4):665-676. Epub 2022 Jan 5 doi: 10.1111/his.14595. PMID: 34747513
Oxidative stress following acute kidney injury causes disruption of lung cell cilia and their release into the bronchoaveolar lavage fluid and lung injury, which are exacerbated by Idh2 deletion.
Han YK, Kim JS, Lee GB, Lim JH, Park KM
Redox Biol 2021 Oct;46:102077. Epub 2021 Jul 21 doi: 10.1016/j.redox.2021.102077. PMID: 34315110Free PMC Article
Human umbilical cord mesenchymal stem cell-derived extracellular vesicles ameliorate airway inflammation in a rat model of chronic obstructive pulmonary disease (COPD).
Ridzuan N, Zakaria N, Widera D, Sheard J, Morimoto M, Kiyokawa H, Mohd Isa SA, Chatar Singh GK, Then KY, Ooi GC, Yahaya BH
Stem Cell Res Ther 2021 Jan 12;12(1):54. doi: 10.1186/s13287-020-02088-6. PMID: 33436065Free PMC Article
Intratracheal budesonide/surfactant attenuates hyperoxia-induced lung injury in preterm rabbits.
Gie AG, Regin Y, Salaets T, Casiraghi C, Salomone F, Deprest J, Vanoirbeek J, Toelen J
Am J Physiol Lung Cell Mol Physiol 2020 Dec 1;319(6):L949-L956. Epub 2020 Sep 9 doi: 10.1152/ajplung.00162.2020. PMID: 32903026

Diagnosis

Lung Findings in a Patient with a History of Nicotine Vaping and Cannabis Smoking.
McCormick W, Baykara Y, Siddique A, Van Truong L, Corbett M, Hacking SM
R I Med J (2013) 2022 Jun 1;105(5):36-40. PMID: 35617040
Clinical, radiological and pathological features of idiopathic and secondary interstitial pneumonia with pleuroparenchymal fibroelastosis in patients undergoing lung transplantation.
Ikegami N, Nakajima N, Yoshizawa A, Handa T, Chen-Yoshikawa T, Kubo T, Tanizawa K, Ohsumi A, Yamada Y, Hamaji M, Nakajima D, Yutaka Y, Tanaka S, Watanabe K, Nakatsuka Y, Murase Y, Nakanishi T, Niwamoto T, Chin K, Date H, Hirai T
Histopathology 2022 Mar;80(4):665-676. Epub 2022 Jan 5 doi: 10.1111/his.14595. PMID: 34747513
The role of extracellular vesicles in traumatic brain injury-induced acute lung injury.
Zhang CN, Li FJ, Zhao ZL, Zhang JN
Am J Physiol Lung Cell Mol Physiol 2021 Nov 1;321(5):L885-L891. Epub 2021 Sep 22 doi: 10.1152/ajplung.00023.2021. PMID: 34549593
Aripiprazole-induced hypersensitivity pneumonitis.
Gunasekaran K, Murthi S, Jennings J, Lone N
BMJ Case Rep 2017 May 9;2017 doi: 10.1136/bcr-2017-219929. PMID: 28487307Free PMC Article
Pulmonary adenocarcinoma mutation profile in smokers with smoking-related interstitial fibrosis.
Primiani A, Dias-Santagata D, Iafrate AJ, Kradin RL
Int J Chron Obstruct Pulmon Dis 2014;9:525-31. Epub 2014 May 24 doi: 10.2147/COPD.S61932. PMID: 24920890Free PMC Article

Therapy

Lung Findings in a Patient with a History of Nicotine Vaping and Cannabis Smoking.
McCormick W, Baykara Y, Siddique A, Van Truong L, Corbett M, Hacking SM
R I Med J (2013) 2022 Jun 1;105(5):36-40. PMID: 35617040
Aripiprazole-induced hypersensitivity pneumonitis.
Gunasekaran K, Murthi S, Jennings J, Lone N
BMJ Case Rep 2017 May 9;2017 doi: 10.1136/bcr-2017-219929. PMID: 28487307Free PMC Article
Inhibition and role of let-7d in idiopathic pulmonary fibrosis.
Pandit KV, Corcoran D, Yousef H, Yarlagadda M, Tzouvelekis A, Gibson KF, Konishi K, Yousem SA, Singh M, Handley D, Richards T, Selman M, Watkins SC, Pardo A, Ben-Yehudah A, Bouros D, Eickelberg O, Ray P, Benos PV, Kaminski N
Am J Respir Crit Care Med 2010 Jul 15;182(2):220-9. Epub 2010 Apr 15 doi: 10.1164/rccm.200911-1698OC. PMID: 20395557Free PMC Article
Lung inflammation in hyperoxia can be prevented by antichemokine treatment in newborn rats.
Deng H, Mason SN, Auten RL Jr
Am J Respir Crit Care Med 2000 Dec;162(6):2316-23. doi: 10.1164/ajrccm.162.6.9911020. PMID: 11112157
1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced pulmonary fibrosis.
Selker RG, Jacobs SA, Moore PB, Wald M, Fisher ER, Cohen M, Bellot P
Neurosurgery 1980 Dec;7(6):560-5. doi: 10.1227/00006123-198012000-00003. PMID: 7207751

Prognosis

Clinical, radiological and pathological features of idiopathic and secondary interstitial pneumonia with pleuroparenchymal fibroelastosis in patients undergoing lung transplantation.
Ikegami N, Nakajima N, Yoshizawa A, Handa T, Chen-Yoshikawa T, Kubo T, Tanizawa K, Ohsumi A, Yamada Y, Hamaji M, Nakajima D, Yutaka Y, Tanaka S, Watanabe K, Nakatsuka Y, Murase Y, Nakanishi T, Niwamoto T, Chin K, Date H, Hirai T
Histopathology 2022 Mar;80(4):665-676. Epub 2022 Jan 5 doi: 10.1111/his.14595. PMID: 34747513
Is it possible to detect ulcerative colitis-related respiratory syndrome early?
Karadag F, Ozhan MH, Akçiçek E, Günel O, Alper H, Veral A
Respirology 2001 Dec;6(4):341-6. doi: 10.1046/j.1440-1843.2001.00347.x. PMID: 11844126
Diagnostic imaging of idiopathic adult respiratory distress syndrome (ARDS)/diffuse alveolar damage (DAD) histopathological correlation with radiological imaging.
Kobayashi H, Itoh T, Sasaki Y, Konishi J
Clin Imaging 1996 Jan-Mar;20(1):1-7. doi: 10.1016/0899-7071(94)00057-3. PMID: 8846301

Clinical prediction guides

Clinical, radiological and pathological features of idiopathic and secondary interstitial pneumonia with pleuroparenchymal fibroelastosis in patients undergoing lung transplantation.
Ikegami N, Nakajima N, Yoshizawa A, Handa T, Chen-Yoshikawa T, Kubo T, Tanizawa K, Ohsumi A, Yamada Y, Hamaji M, Nakajima D, Yutaka Y, Tanaka S, Watanabe K, Nakatsuka Y, Murase Y, Nakanishi T, Niwamoto T, Chin K, Date H, Hirai T
Histopathology 2022 Mar;80(4):665-676. Epub 2022 Jan 5 doi: 10.1111/his.14595. PMID: 34747513
Evaluation of K18-hACE2 Mice as a Model of SARS-CoV-2 Infection.
Moreau GB, Burgess SL, Sturek JM, Donlan AN, Petri WA, Mann BJ
Am J Trop Med Hyg 2020 Sep;103(3):1215-1219. doi: 10.4269/ajtmh.20-0762. PMID: 32723427Free PMC Article
Pulmonary adenocarcinoma mutation profile in smokers with smoking-related interstitial fibrosis.
Primiani A, Dias-Santagata D, Iafrate AJ, Kradin RL
Int J Chron Obstruct Pulmon Dis 2014;9:525-31. Epub 2014 May 24 doi: 10.2147/COPD.S61932. PMID: 24920890Free PMC Article
Surface and transmission ultrastructural characteristics of desquamative interstitial pneumonitis.
Tubbs RR, Benjamin SP, Osborne DG, Barenberg S
Hum Pathol 1978 Nov;9(6):693-703. doi: 10.1016/s0046-8177(78)80052-5. PMID: 730151

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