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Abnormal alveolar type II pneumocyte morphology

MedGen UID:
1779549
•Concept ID:
C5539454
•
Finding
Synonyms: Abnormal alveolar epithelial type II cell morphology; Abnormal pulmonary type II cell morphology; Abnormal type II pneumocyte morphology
 
HPO: HP:0033245

Definition

Any structural abnormality of alveolar type 2 (ATII) cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal alveolar type II pneumocyte morphology

Professional guidelines

PubMed

NOX enzymes: potential target for the treatment of acute lung injury.
Carnesecchi S, Pache JC, Barazzone-Argiroffo C
Cell Mol Life Sci 2012 Jul;69(14):2373-85. Epub 2012 May 13 doi: 10.1007/s00018-012-1013-6. PMID: 22581364Free PMC Article
Recent advances in molecular targets and treatment of idiopathic pulmonary fibrosis: focus on TGFbeta signaling and the myofibroblast.
Gharaee-Kermani M, Hu B, Phan SH, Gyetko MR
Curr Med Chem 2009;16(11):1400-17. doi: 10.2174/092986709787846497. PMID: 19355895

Recent clinical studies

Etiology

ILC2 influence the differentiation of alveolar type II epithelial cells in bronchopulmonary dysplasia mice.
Lu HY, Wang MY, Zhu SX, Ju HM, Xu SQ, Qiao Y, Wei SJ, Su ZL
J Leukoc Biol 2023 Nov 24;114(6):604-614. doi: 10.1093/jleuko/qiad092. PMID: 37647586
Cellular and Molecular Mechanisms in Idiopathic Pulmonary Fibrosis.
Zhang Y, Wang J
Adv Respir Med 2023 Jan 31;91(1):26-48. doi: 10.3390/arm91010005. PMID: 36825939Free PMC Article
The leading role of epithelial cells in the pathogenesis of idiopathic pulmonary fibrosis.
Selman M, Pardo A
Cell Signal 2020 Feb;66:109482. Epub 2019 Nov 21 doi: 10.1016/j.cellsig.2019.109482. PMID: 31760172
Nrf2 antioxidant pathway suppresses Numb-mediated epithelial-mesenchymal transition during pulmonary fibrosis.
Zhang Z, Qu J, Zheng C, Zhang P, Zhou W, Cui W, Mo X, Li L, Xu L, Gao J
Cell Death Dis 2018 Jan 23;9(2):83. doi: 10.1038/s41419-017-0198-x. PMID: 29362432Free PMC Article
PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis.
Bueno M, Lai YC, Romero Y, Brands J, St Croix CM, Kamga C, Corey C, Herazo-Maya JD, Sembrat J, Lee JS, Duncan SR, Rojas M, Shiva S, Chu CT, Mora AL
J Clin Invest 2015 Feb;125(2):521-38. Epub 2014 Dec 22 doi: 10.1172/JCI74942. PMID: 25562319Free PMC Article

Diagnosis

Toll-like receptors in the pathogenesis of pulmonary fibrosis.
Karampitsakos T, Woolard T, Bouros D, Tzouvelekis A
Eur J Pharmacol 2017 Aug 5;808:35-43. Epub 2016 Jun 27 doi: 10.1016/j.ejphar.2016.06.045. PMID: 27364757
Circulating tumor cells in sarcomas: a brief review.
Chang L, Asatrian G, Dry SM, James AW
Med Oncol 2015 Jan;32(1):430. Epub 2014 Dec 10 doi: 10.1007/s12032-014-0430-9. PMID: 25491143
Idiopathic pulmonary fibrosis.
King TE Jr, Pardo A, Selman M
Lancet 2011 Dec 3;378(9807):1949-61. Epub 2011 Jun 28 doi: 10.1016/S0140-6736(11)60052-4. PMID: 21719092
Alveolar surfactant homeostasis and the pathogenesis of pulmonary disease.
Whitsett JA, Wert SE, Weaver TE
Annu Rev Med 2010;61:105-19. doi: 10.1146/annurev.med.60.041807.123500. PMID: 19824815Free PMC Article
Type I pleuropulmonary blastoma: pathology and biology study of 51 cases from the international pleuropulmonary blastoma registry.
Hill DA, Jarzembowski JA, Priest JR, Williams G, Schoettler P, Dehner LP
Am J Surg Pathol 2008 Feb;32(2):282-95. doi: 10.1097/PAS.0b013e3181484165. PMID: 18223332

Therapy

Targeting Histone Deacetylases in Idiopathic Pulmonary Fibrosis: A Future Therapeutic Option.
Korfei M, Mahavadi P, Guenther A
Cells 2022 May 12;11(10) doi: 10.3390/cells11101626. PMID: 35626663Free PMC Article
Chronic E-Cigarette Exposure Alters Human Alveolar Macrophage Morphology and Gene Expression.
Davis ES, Ghosh A, Coakley RD, Wrennall JA, Lubamba BA, Rowell TR, Dang H, Pawlak EA, Li Q, Alexis NE, Ribeiro CMP, Tarran R
Nicotine Tob Res 2022 Feb 14;24(3):395-399. doi: 10.1093/ntr/ntab186. PMID: 34519792Free PMC Article
Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis.
Cheng H, Feng D, Li X, Gao L, Tang S, Liu W, Wu X, Yue S, Li C, Luo Z
Biochim Biophys Acta Mol Basis Dis 2021 Dec 1;1867(12):166204. Epub 2021 Jun 24 doi: 10.1016/j.bbadis.2021.166204. PMID: 34175430
Mitochondrial dysfunction in human primary alveolar type II cells in emphysema.
Kosmider B, Lin CR, Karim L, Tomar D, Vlasenko L, Marchetti N, Bolla S, Madesh M, Criner GJ, Bahmed K
EBioMedicine 2019 Aug;46:305-316. Epub 2019 Aug 2 doi: 10.1016/j.ebiom.2019.07.063. PMID: 31383554Free PMC Article
NOX enzymes: potential target for the treatment of acute lung injury.
Carnesecchi S, Pache JC, Barazzone-Argiroffo C
Cell Mol Life Sci 2012 Jul;69(14):2373-85. Epub 2012 May 13 doi: 10.1007/s00018-012-1013-6. PMID: 22581364Free PMC Article

Prognosis

Monocytes and macrophages: emerging mechanisms and novel therapeutic targets in pulmonary fibrosis.
Perrot CY, Karampitsakos T, Herazo-Maya JD
Am J Physiol Cell Physiol 2023 Oct 1;325(4):C1046-C1057. Epub 2023 Sep 11 doi: 10.1152/ajpcell.00302.2023. PMID: 37694283Free PMC Article
Cellular and Molecular Control of Lipid Metabolism in Idiopathic Pulmonary Fibrosis: Clinical Application of the Lysophosphatidic Acid Pathway.
Nakamura Y, Shimizu Y
Cells 2023 Feb 8;12(4) doi: 10.3390/cells12040548. PMID: 36831215Free PMC Article
The Epithelial-Immune Crosstalk in Pulmonary Fibrosis.
Planté-Bordeneuve T, Pilette C, Froidure A
Front Immunol 2021;12:631235. Epub 2021 May 19 doi: 10.3389/fimmu.2021.631235. PMID: 34093523Free PMC Article
What We Know About the Pathogenesis of Idiopathic Pulmonary Fibrosis.
Puglisi S, Torrisi SE, Giuliano R, Vindigni V, Vancheri C
Semin Respir Crit Care Med 2016 Jun;37(3):358-67. Epub 2016 May 27 doi: 10.1055/s-0036-1580693. PMID: 27231860
Idiopathic pulmonary fibrosis.
King TE Jr, Pardo A, Selman M
Lancet 2011 Dec 3;378(9807):1949-61. Epub 2011 Jun 28 doi: 10.1016/S0140-6736(11)60052-4. PMID: 21719092

Clinical prediction guides

Targeting Histone Deacetylases in Idiopathic Pulmonary Fibrosis: A Future Therapeutic Option.
Korfei M, Mahavadi P, Guenther A
Cells 2022 May 12;11(10) doi: 10.3390/cells11101626. PMID: 35626663Free PMC Article
Disease modeling of pulmonary fibrosis using human pluripotent stem cell-derived alveolar organoids.
Suezawa T, Kanagaki S, Moriguchi K, Masui A, Nakao K, Toyomoto M, Tamai K, Mikawa R, Hirai T, Murakami K, Hagiwara M, Gotoh S
Stem Cell Reports 2021 Dec 14;16(12):2973-2987. Epub 2021 Nov 18 doi: 10.1016/j.stemcr.2021.10.015. PMID: 34798066Free PMC Article
Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis.
Cheng H, Feng D, Li X, Gao L, Tang S, Liu W, Wu X, Yue S, Li C, Luo Z
Biochim Biophys Acta Mol Basis Dis 2021 Dec 1;1867(12):166204. Epub 2021 Jun 24 doi: 10.1016/j.bbadis.2021.166204. PMID: 34175430
Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis.
Kobayashi Y, Tata A, Konkimalla A, Katsura H, Lee RF, Ou J, Banovich NE, Kropski JA, Tata PR
Nat Cell Biol 2020 Aug;22(8):934-946. Epub 2020 Jul 13 doi: 10.1038/s41556-020-0542-8. PMID: 32661339Free PMC Article
Nrf2 antioxidant pathway suppresses Numb-mediated epithelial-mesenchymal transition during pulmonary fibrosis.
Zhang Z, Qu J, Zheng C, Zhang P, Zhou W, Cui W, Mo X, Li L, Xu L, Gao J
Cell Death Dis 2018 Jan 23;9(2):83. doi: 10.1038/s41419-017-0198-x. PMID: 29362432Free PMC Article

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