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Glomerular endotheliosis

MedGen UID:
1780514
•Concept ID:
C5539473
•
Pathologic Function
HPO: HP:0033274

Definition

Enlargement of glomerular endothelial cells by cytoplasmic swelling with resulting partial or complete occlusion of the lumen. [from HPO]

Professional guidelines

PubMed

Molecular and vascular targets in the pathogenesis and management of the hypertension associated with preeclampsia.
Reslan OM, Khalil RA
Cardiovasc Hematol Agents Med Chem 2010 Oct 1;8(4):204-26. doi: 10.2174/187152510792481234. PMID: 20923405Free PMC Article

Recent clinical studies

Etiology

Smooth Muscle Mineralocorticoid Receptor Promotes Hypertension After Preeclampsia.
Biwer LA, Lu Q, Ibarrola J, Stepanian A, Man JJ, Carvajal BV, Camarda ND, Zsengeller Z, Skurnik G, Seely EW, Karumanchi SA, Jaffe IZ
Circ Res 2023 Mar 17;132(6):674-689. Epub 2023 Feb 23 doi: 10.1161/CIRCRESAHA.122.321228. PMID: 36815487Free PMC Article
Perfluorooctane sulfonate exposure induces preeclampsia-like syndromes by damaging trophoblast mitochondria in pregnant mice.
Zhao Y, Zhao H, Xu H, An P, Ma B, Lu H, Zhou Q, Li X, Xiong Y
Ecotoxicol Environ Saf 2022 Dec 1;247:114256. Epub 2022 Oct 31 doi: 10.1016/j.ecoenv.2022.114256. PMID: 36327784
The pathology of eclampsia: An autopsy series.
Hecht JL, Ordi J, Carrilho C, Ismail MR, Zsengeller ZK, Karumanchi SA, Rosen S
Hypertens Pregnancy 2017 Aug;36(3):259-268. Epub 2017 Jul 5 doi: 10.1080/10641955.2017.1329430. PMID: 28678644
Pre-eclampsia: clinical manifestations and molecular mechanisms.
Baumwell S, Karumanchi SA
Nephron Clin Pract 2007;106(2):c72-81. Epub 2007 Jun 6 doi: 10.1159/000101801. PMID: 17570933
Serum cystatin C reflects glomerular endotheliosis in normal, hypertensive and pre-eclamptic pregnancies.
Strevens H, Wide-Swensson D, Grubb A, Hansen A, Horn T, Ingemarsson I, Larsen S, Nyengaard JR, Torffvit O, Willner J, Olsen S
BJOG 2003 Sep;110(9):825-30. PMID: 14511964

Diagnosis

Smooth Muscle Mineralocorticoid Receptor Promotes Hypertension After Preeclampsia.
Biwer LA, Lu Q, Ibarrola J, Stepanian A, Man JJ, Carvajal BV, Camarda ND, Zsengeller Z, Skurnik G, Seely EW, Karumanchi SA, Jaffe IZ
Circ Res 2023 Mar 17;132(6):674-689. Epub 2023 Feb 23 doi: 10.1161/CIRCRESAHA.122.321228. PMID: 36815487Free PMC Article
Glomerular Endothelial Cell-Derived miR-200c Impairs Glomerular Homeostasis by Targeting Podocyte VEGF-A.
Ursu R, Sopel N, Ohs A, Tati R, Buvall L, Nyström J, Schiffer M, Müller-Deile J
Int J Mol Sci 2022 Dec 1;23(23) doi: 10.3390/ijms232315070. PMID: 36499397Free PMC Article
Imbalances in circulating angiogenic factors in the pathophysiology of preeclampsia and related disorders.
Rana S, Burke SD, Karumanchi SA
Am J Obstet Gynecol 2022 Feb;226(2S):S1019-S1034. Epub 2020 Oct 20 doi: 10.1016/j.ajog.2020.10.022. PMID: 33096092Free PMC Article
Pathogenesis of preeclampsia.
Young BC, Levine RJ, Karumanchi SA
Annu Rev Pathol 2010;5:173-92. doi: 10.1146/annurev-pathol-121808-102149. PMID: 20078220
Urinary N-acetyl-beta-glucosaminidase in the prediction of preeclampsia.
Pérez-Blanco FJ, Sanabria MC, Huertas JM, Cantero J, Rodríguez-Cuartero A
Clin Nephrol 1998 Sep;50(3):169-71. PMID: 9776420

Therapy

Identifying mitigating strategies for endothelial cell dysfunction and hypertension in response to VEGF receptor inhibitors.
Camarda ND, Lu Q, Meola DM, Man JJ, Song Z, Travers RJ, Lopez KE, Powers SN, Papanastasiou M, DeRuff KC, Mullahoo J, Egri SB, Davison D, Sebastiani P, Eblen ST, Buchsbaum R, Huggins GS, London CA, Jaffe JD, Upshaw JN, Yang VK, Jaffe IZ
Clin Sci (Lond) 2024 Sep 18;138(18):1131-1150. doi: 10.1042/CS20240537. PMID: 39282930
Nephrotic syndrome due to preeclampsia before 20 weeks of gestation: a case report.
Suzuki T, Ichikawa D, Nakata M, Watanabe S, Han W, Kohatsu K, Shirai S, Imai N, Koike J, Shibagaki Y
BMC Nephrol 2020 Jun 29;21(1):240. doi: 10.1186/s12882-020-01876-9. PMID: 32600286Free PMC Article
Effect of recombinant placental growth factor 2 on hypertension induced by full-length mouse soluble fms-like tyrosine kinase 1 adenoviral vector in pregnant mice.
Suzuki H, Ohkuchi A, Matsubara S, Takei Y, Murakami M, Shibuya M, Suzuki M, Sato Y
Hypertension 2009 Nov;54(5):1129-35. Epub 2009 Sep 28 doi: 10.1161/HYPERTENSIONAHA.109.134668. PMID: 19786649
Antepartum percutaneous renal biopsy.
Wide-Swensson D, Strevens H, Willner J
Int J Gynaecol Obstet 2007 Aug;98(2):88-92. Epub 2007 Jun 25 doi: 10.1016/j.ijgo.2007.03.049. PMID: 17586507
Glomerular endotheliosis in normal pregnancy and pre-eclampsia.
Strevens H, Wide-Swensson D, Hansen A, Horn T, Ingemarsson I, Larsen S, Willner J, Olsen S
BJOG 2003 Sep;110(9):831-6. PMID: 14511965

Prognosis

Imbalances in circulating angiogenic factors in the pathophysiology of preeclampsia and related disorders.
Rana S, Burke SD, Karumanchi SA
Am J Obstet Gynecol 2022 Feb;226(2S):S1019-S1034. Epub 2020 Oct 20 doi: 10.1016/j.ajog.2020.10.022. PMID: 33096092Free PMC Article
Pathogenesis of preeclampsia.
Young BC, Levine RJ, Karumanchi SA
Annu Rev Pathol 2010;5:173-92. doi: 10.1146/annurev-pathol-121808-102149. PMID: 20078220
Pre-eclampsia: clinical manifestations and molecular mechanisms.
Baumwell S, Karumanchi SA
Nephron Clin Pract 2007;106(2):c72-81. Epub 2007 Jun 6 doi: 10.1159/000101801. PMID: 17570933
Urinary N-acetyl-beta-glucosaminidase in the prediction of preeclampsia.
Pérez-Blanco FJ, Sanabria MC, Huertas JM, Cantero J, Rodríguez-Cuartero A
Clin Nephrol 1998 Sep;50(3):169-71. PMID: 9776420
Preeclampsia: an endothelial cell disorder.
Roberts JM, Taylor RN, Musci TJ, Rodgers GM, Hubel CA, McLaughlin MK
Am J Obstet Gynecol 1989 Nov;161(5):1200-4. doi: 10.1016/0002-9378(89)90665-0. PMID: 2589440

Clinical prediction guides

Imbalances in circulating angiogenic factors in the pathophysiology of preeclampsia and related disorders.
Rana S, Burke SD, Karumanchi SA
Am J Obstet Gynecol 2022 Feb;226(2S):S1019-S1034. Epub 2020 Oct 20 doi: 10.1016/j.ajog.2020.10.022. PMID: 33096092Free PMC Article
Pathogenesis of preeclampsia.
Young BC, Levine RJ, Karumanchi SA
Annu Rev Pathol 2010;5:173-92. doi: 10.1146/annurev-pathol-121808-102149. PMID: 20078220
Glomerular endothelial cell differentiation.
Ballermann BJ
Kidney Int 2005 May;67(5):1668-71. doi: 10.1111/j.1523-1755.2005.00260.x. PMID: 15840009
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia.
Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, Libermann TA, Morgan JP, Sellke FW, Stillman IE, Epstein FH, Sukhatme VP, Karumanchi SA
J Clin Invest 2003 Mar;111(5):649-58. doi: 10.1172/JCI17189. PMID: 12618519Free PMC Article
Preeclampsia: the endothelium, circulating factor(s) and vascular endothelial growth factor.
Hayman R, Brockelsby J, Kenny L, Baker P
J Soc Gynecol Investig 1999 Jan-Feb;6(1):3-10. PMID: 10065419

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