U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Loss of glomerular endothelial cell fenestration

MedGen UID:
1780639
•Concept ID:
C5539472
•
Finding
HPO: HP:0033273

Definition

Loss of round to oval discontinuities normally present in the glomerular capillary endothelial cell cytoplasm. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoss of glomerular endothelial cell fenestration

Recent clinical studies

Etiology

White blood cell fractions correlate with lesions of diabetic kidney disease and predict loss of kidney function in Type 2 diabetes.
Wheelock KM, Saulnier PJ, Tanamas SK, Vijayakumar P, Weil EJ, Looker HC, Hanson RL, Lemley KV, Yee B, Knowler WC, Hadjadj S, Najafian B, Mauer M, Nelson RG
Nephrol Dial Transplant 2018 Jun 1;33(6):1001-1009. doi: 10.1093/ndt/gfx231. PMID: 28992267Free PMC Article
Structural Predictors of Loss of Renal Function in American Indians with Type 2 Diabetes.
Fufaa GD, Weil EJ, Lemley KV, Knowler WC, Brosius FC 3rd, Yee B, Mauer M, Nelson RG
Clin J Am Soc Nephrol 2016 Feb 5;11(2):254-61. Epub 2016 Jan 20 doi: 10.2215/CJN.05760515. PMID: 26792530Free PMC Article

Diagnosis

A case of proliferative glomerulonephritis with monoclonal IgG3κ deposits accompanied by glomerular capillary microaneurysms.
Mii A, Terasaki M, Kunugi S, Seki M, Kashiwagi T, Sakai Y, Shimizu A
CEN Case Rep 2022 Aug;11(3):333-338. Epub 2022 Jan 13 doi: 10.1007/s13730-021-00676-w. PMID: 35025059Free PMC Article
Structural Predictors of Loss of Renal Function in American Indians with Type 2 Diabetes.
Fufaa GD, Weil EJ, Lemley KV, Knowler WC, Brosius FC 3rd, Yee B, Mauer M, Nelson RG
Clin J Am Soc Nephrol 2016 Feb 5;11(2):254-61. Epub 2016 Jan 20 doi: 10.2215/CJN.05760515. PMID: 26792530Free PMC Article

Therapy

Nivolumab-associated glomerular endothelial injury in a patient with gastric cancer.
Shim J, Tochio A, Ueda N, Tsuji S, Koizumi M, Seta K, Yahata K
CEN Case Rep 2021 Nov;10(4):576-581. Epub 2021 May 25 doi: 10.1007/s13730-021-00610-0. PMID: 34033070Free PMC Article
Structural Predictors of Loss of Renal Function in American Indians with Type 2 Diabetes.
Fufaa GD, Weil EJ, Lemley KV, Knowler WC, Brosius FC 3rd, Yee B, Mauer M, Nelson RG
Clin J Am Soc Nephrol 2016 Feb 5;11(2):254-61. Epub 2016 Jan 20 doi: 10.2215/CJN.05760515. PMID: 26792530Free PMC Article
The role of vascular endothelial growth factor (VEGF) in renal pathophysiology.
Schrijvers BF, Flyvbjerg A, De Vriese AS
Kidney Int 2004 Jun;65(6):2003-17. doi: 10.1111/j.1523-1755.2004.00621.x. PMID: 15149314

Prognosis

White blood cell fractions correlate with lesions of diabetic kidney disease and predict loss of kidney function in Type 2 diabetes.
Wheelock KM, Saulnier PJ, Tanamas SK, Vijayakumar P, Weil EJ, Looker HC, Hanson RL, Lemley KV, Yee B, Knowler WC, Hadjadj S, Najafian B, Mauer M, Nelson RG
Nephrol Dial Transplant 2018 Jun 1;33(6):1001-1009. doi: 10.1093/ndt/gfx231. PMID: 28992267Free PMC Article
Structural Predictors of Loss of Renal Function in American Indians with Type 2 Diabetes.
Fufaa GD, Weil EJ, Lemley KV, Knowler WC, Brosius FC 3rd, Yee B, Mauer M, Nelson RG
Clin J Am Soc Nephrol 2016 Feb 5;11(2):254-61. Epub 2016 Jan 20 doi: 10.2215/CJN.05760515. PMID: 26792530Free PMC Article

Clinical prediction guides

Nivolumab-associated glomerular endothelial injury in a patient with gastric cancer.
Shim J, Tochio A, Ueda N, Tsuji S, Koizumi M, Seta K, Yahata K
CEN Case Rep 2021 Nov;10(4):576-581. Epub 2021 May 25 doi: 10.1007/s13730-021-00610-0. PMID: 34033070Free PMC Article
White blood cell fractions correlate with lesions of diabetic kidney disease and predict loss of kidney function in Type 2 diabetes.
Wheelock KM, Saulnier PJ, Tanamas SK, Vijayakumar P, Weil EJ, Looker HC, Hanson RL, Lemley KV, Yee B, Knowler WC, Hadjadj S, Najafian B, Mauer M, Nelson RG
Nephrol Dial Transplant 2018 Jun 1;33(6):1001-1009. doi: 10.1093/ndt/gfx231. PMID: 28992267Free PMC Article
Structural Predictors of Loss of Renal Function in American Indians with Type 2 Diabetes.
Fufaa GD, Weil EJ, Lemley KV, Knowler WC, Brosius FC 3rd, Yee B, Mauer M, Nelson RG
Clin J Am Soc Nephrol 2016 Feb 5;11(2):254-61. Epub 2016 Jan 20 doi: 10.2215/CJN.05760515. PMID: 26792530Free PMC Article
Glomerular endothelial cell injury and cross talk in diabetic kidney disease.
Fu J, Lee K, Chuang PY, Liu Z, He JC
Am J Physiol Renal Physiol 2015 Feb 15;308(4):F287-97. Epub 2014 Nov 19 doi: 10.1152/ajprenal.00533.2014. PMID: 25411387Free PMC Article
Glomerular endothelial cell differentiation.
Ballermann BJ
Kidney Int 2005 May;67(5):1668-71. doi: 10.1111/j.1523-1755.2005.00260.x. PMID: 15840009

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...