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Bladder Flat Urothelial Carcinoma

MedGen UID:
1781277
•Concept ID:
C5447837
•
Neoplastic Process
Synonym: Bladder Sessile Urothelial Carcinoma

Definition

An in situ or invasive urothelial carcinoma that arises from the bladder wall and does not grow toward the hollow part of the bladder. [from NCI]

Professional guidelines

PubMed

The Genitourinary Pathology Society Update on Classification and Grading of Flat and Papillary Urothelial Neoplasia With New Reporting Recommendations and Approach to Lesions With Mixed and Early Patterns of Neoplasia.
Amin MB, Comperat E, Epstein JI, True LD, Hansel D, Paner GP, Al-Ahmadie H, Baydar D, Bivalacqua T, Brimo F, Cheng L, Cheville J, Dalbagni G, Falzarano S, Gordetsky J, Guo CC, Gupta S, Hes O, Iyer G, Kaushal S, Kunju L, Magi-Galluzzi C, Matoso A, Netto G, Osunkoya AO, Pan CC, Pivovarcikova K, Raspollini MR, Reis H, Rosenberg J, Roupret M, Shah RB, Shariat S, Trpkov K, Weyerer V, Zhou M, McKenney J, Reuter VE
Adv Anat Pathol 2021 Jul 1;28(4):179-195. doi: 10.1097/PAP.0000000000000308. PMID: 34128483
Role of Narrow Band Imaging in Management of Urothelial Carcinoma.
Altobelli E, Zlatev DV, Liao JC
Curr Urol Rep 2015 Aug;16(8):58. doi: 10.1007/s11934-015-0527-5. PMID: 26093973
Diagnosis and treatment of bladder cancer.
Sharma S, Ksheersagar P, Sharma P
Am Fam Physician 2009 Oct 1;80(7):717-23. PMID: 19817342

Recent clinical studies

Etiology

Precursors of urinary bladder cancer: molecular alterations and biomarkers.
Taylor AS, Acosta AM, Al-Ahmadie HA, Mehra R
Hum Pathol 2023 Mar;133:5-21. Epub 2022 Jun 15 doi: 10.1016/j.humpath.2022.06.006. PMID: 35716731
Precursor lesions of the urinary bladder.
McKenney JK
Histopathology 2019 Jan;74(1):68-76. doi: 10.1111/his.13762. PMID: 30565304
Iatrogenic pathology of the urinary bladder.
Lopez-Beltran A, Montironi R, Raspollini MR, Cheng L, Netto GJ
Semin Diagn Pathol 2018 Jul;35(4):218-227. Epub 2018 Mar 14 doi: 10.1053/j.semdp.2018.03.001. PMID: 29576423
Iatrogenic changes in the urinary tract.
Lopez-Beltran A, Paner GP, Montironi R, Raspollini MR, Cheng L
Histopathology 2017 Jan;70(1):10-25. doi: 10.1111/his.13090. PMID: 27960233
Pathology of upper tract urothelial carcinoma with emphasis on staging.
Mazzucchelli R, Scarpelli M, Galosi AB, Di Primio R, Lopez-Beltran A, Cheng L, Montironi R
Int J Immunopathol Pharmacol 2014 Oct-Dec;27(4):509-16. doi: 10.1177/039463201402700406. PMID: 25572730

Diagnosis

The Genitourinary Pathology Society Update on Classification and Grading of Flat and Papillary Urothelial Neoplasia With New Reporting Recommendations and Approach to Lesions With Mixed and Early Patterns of Neoplasia.
Amin MB, Comperat E, Epstein JI, True LD, Hansel D, Paner GP, Al-Ahmadie H, Baydar D, Bivalacqua T, Brimo F, Cheng L, Cheville J, Dalbagni G, Falzarano S, Gordetsky J, Guo CC, Gupta S, Hes O, Iyer G, Kaushal S, Kunju L, Magi-Galluzzi C, Matoso A, Netto G, Osunkoya AO, Pan CC, Pivovarcikova K, Raspollini MR, Reis H, Rosenberg J, Roupret M, Shah RB, Shariat S, Trpkov K, Weyerer V, Zhou M, McKenney J, Reuter VE
Adv Anat Pathol 2021 Jul 1;28(4):179-195. doi: 10.1097/PAP.0000000000000308. PMID: 34128483
Urothelial carcinoma in situ: diagnostic update.
McKenney JK
Pathology 2021 Jan;53(1):86-95. Epub 2020 Nov 21 doi: 10.1016/j.pathol.2020.10.001. PMID: 33234229
Photodynamic diagnosis and therapy for urothelial carcinoma and prostate cancer: new imaging technology and therapy.
Fukuhara H, Yamamoto S, Karashima T, Inoue K
Int J Clin Oncol 2021 Jan;26(1):18-25. Epub 2020 May 26 doi: 10.1007/s10147-020-01704-y. PMID: 32451769
Targets for Therapy of Bladder Cancer.
Seidl C
Semin Nucl Med 2020 Mar;50(2):162-170. Epub 2020 Feb 29 doi: 10.1053/j.semnuclmed.2020.02.006. PMID: 32172801
Dysplasia and carcinoma in situ of the urinary bladder.
Lopez-Beltran A, Marques RC, Montironi R, Reymundo C, Fonseca J, Cheng L
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):29-38. PMID: 26072632

Therapy

Anti-CSF-1R emactuzumab in combination with anti-PD-L1 atezolizumab in advanced solid tumor patients naïve or experienced for immune checkpoint blockade.
Gomez-Roca C, Cassier P, Zamarin D, Machiels JP, Perez Gracia JL, Stephen Hodi F, Taus A, Martinez Garcia M, Boni V, Eder JP, Hafez N, Sullivan R, Mcdermott D, Champiat S, Aspeslagh S, Terret C, Jegg AM, Jacob W, Cannarile MA, Ries C, Korski K, Michielin F, Christen R, Babitzki G, Watson C, Meneses-Lorente G, Weisser M, Rüttinger D, Delord JP, Marabelle A
J Immunother Cancer 2022 May;10(5) doi: 10.1136/jitc-2021-004076. PMID: 35577503Free PMC Article
Photodynamic diagnosis and therapy for urothelial carcinoma and prostate cancer: new imaging technology and therapy.
Fukuhara H, Yamamoto S, Karashima T, Inoue K
Int J Clin Oncol 2021 Jan;26(1):18-25. Epub 2020 May 26 doi: 10.1007/s10147-020-01704-y. PMID: 32451769
Targets for Therapy of Bladder Cancer.
Seidl C
Semin Nucl Med 2020 Mar;50(2):162-170. Epub 2020 Feb 29 doi: 10.1053/j.semnuclmed.2020.02.006. PMID: 32172801
Iatrogenic pathology of the urinary bladder.
Lopez-Beltran A, Montironi R, Raspollini MR, Cheng L, Netto GJ
Semin Diagn Pathol 2018 Jul;35(4):218-227. Epub 2018 Mar 14 doi: 10.1053/j.semdp.2018.03.001. PMID: 29576423
Iatrogenic changes in the urinary tract.
Lopez-Beltran A, Paner GP, Montironi R, Raspollini MR, Cheng L
Histopathology 2017 Jan;70(1):10-25. doi: 10.1111/his.13090. PMID: 27960233

Prognosis

Precursors of urinary bladder cancer: molecular alterations and biomarkers.
Taylor AS, Acosta AM, Al-Ahmadie HA, Mehra R
Hum Pathol 2023 Mar;133:5-21. Epub 2022 Jun 15 doi: 10.1016/j.humpath.2022.06.006. PMID: 35716731
The Genitourinary Pathology Society Update on Classification and Grading of Flat and Papillary Urothelial Neoplasia With New Reporting Recommendations and Approach to Lesions With Mixed and Early Patterns of Neoplasia.
Amin MB, Comperat E, Epstein JI, True LD, Hansel D, Paner GP, Al-Ahmadie H, Baydar D, Bivalacqua T, Brimo F, Cheng L, Cheville J, Dalbagni G, Falzarano S, Gordetsky J, Guo CC, Gupta S, Hes O, Iyer G, Kaushal S, Kunju L, Magi-Galluzzi C, Matoso A, Netto G, Osunkoya AO, Pan CC, Pivovarcikova K, Raspollini MR, Reis H, Rosenberg J, Roupret M, Shah RB, Shariat S, Trpkov K, Weyerer V, Zhou M, McKenney J, Reuter VE
Adv Anat Pathol 2021 Jul 1;28(4):179-195. doi: 10.1097/PAP.0000000000000308. PMID: 34128483
Urinary Bladder Pathology: World Health Organization Classification and American Joint Committee on Cancer Staging Update.
Wang G, McKenney JK
Arch Pathol Lab Med 2019 May;143(5):571-577. Epub 2018 Jul 25 doi: 10.5858/arpa.2017-0539-RA. PMID: 30044124
Pathology of upper tract urothelial carcinoma with emphasis on staging.
Mazzucchelli R, Scarpelli M, Galosi AB, Di Primio R, Lopez-Beltran A, Cheng L, Montironi R
Int J Immunopathol Pharmacol 2014 Oct-Dec;27(4):509-16. doi: 10.1177/039463201402700406. PMID: 25572730
Utility of diagnostic and prognostic markers in urothelial carcinoma of the bladder.
Coleman JF, Hansel DE
Adv Anat Pathol 2009 Mar;16(2):67-78. doi: 10.1097/PAP.0b013e318199f89e. PMID: 19550368

Clinical prediction guides

Precursors of urinary bladder cancer: molecular alterations and biomarkers.
Taylor AS, Acosta AM, Al-Ahmadie HA, Mehra R
Hum Pathol 2023 Mar;133:5-21. Epub 2022 Jun 15 doi: 10.1016/j.humpath.2022.06.006. PMID: 35716731
Flat Urothelial Lesions With Atypia: Interobserver Concordance and Added Value of Immunohistochemical Profiling.
Lawless ME, Tretiakova MS, True LD, Vakar-Lopez F
Appl Immunohistochem Mol Morphol 2018 Mar;26(3):180-185. doi: 10.1097/PAI.0000000000000401. PMID: 27299187
Nephrogenic adenoma of the urinary tract: A 6-year single center experience.
Turcan D, Acikalin MF, Yilmaz E, Canaz F, Arik D
Pathol Res Pract 2017 Jul;213(7):831-835. Epub 2017 Mar 25 doi: 10.1016/j.prp.2017.03.001. PMID: 28554748
Novel endoscopic diagnosis for bladder cancer.
Lerner SP, Goh A
Cancer 2015 Jan 15;121(2):169-78. Epub 2014 Aug 5 doi: 10.1002/cncr.28905. PMID: 25132313
Bladder carcinoma in situ in 2003: state of the art.
Witjes JA
Eur Urol 2004 Feb;45(2):142-6. doi: 10.1016/j.eururo.2003.09.013. PMID: 14733997

Recent systematic reviews

Diagnostic and prognostic roles of CK20 in the pathology of urothelial lesions. A systematic review.
Sanguedolce F, Russo D, Calò B, Cindolo L, Carrieri G, Cormio L
Pathol Res Pract 2019 Jun;215(6):152413. Epub 2019 Apr 6 doi: 10.1016/j.prp.2019.04.005. PMID: 30987832
Hexyl aminolevulinate-guided fluorescence cystoscopy in the diagnosis and follow-up of patients with non-muscle-invasive bladder cancer: a critical review of the current literature.
Rink M, Babjuk M, Catto JW, Jichlinski P, Shariat SF, Stenzl A, Stepp H, Zaak D, Witjes JA
Eur Urol 2013 Oct;64(4):624-38. Epub 2013 Jul 19 doi: 10.1016/j.eururo.2013.07.007. PMID: 23906669

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