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Bladder flat intraepithelial lesion

MedGen UID:
231947
•Concept ID:
C1332559
•
Neoplastic Process
Synonyms: Bladder Flat Intraepithelial Lesion; bladder flat intraepithelial lesion; Bladder Urothelial Carcinoma In Situ; Flat Intraepithelial Lesion of the Bladder; flat intraepithelial lesion of the bladder; Flat Intraepithelial Lesion of the Urinary Bladder; flat intraepithelial lesion of the urinary bladder; Urinary Bladder Flat Intraepithelial Lesion; urinary bladder flat intraepithelial lesion
 
Monarch Initiative: MONDO:0006111

Definition

A flat urothelial lesion of variable thickness in the bladder, devoid of papillary structures containing cytologically malignant cells. (WHO 2016) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBladder flat intraepithelial lesion

Recent clinical studies

Etiology

Iatrogenic pathology of the urinary bladder.
Lopez-Beltran A, Montironi R, Raspollini MR, Cheng L, Netto GJ
Semin Diagn Pathol 2018 Jul;35(4):218-227. Epub 2018 Mar 14 doi: 10.1053/j.semdp.2018.03.001. PMID: 29576423
Iatrogenic changes in the urinary tract.
Lopez-Beltran A, Paner GP, Montironi R, Raspollini MR, Cheng L
Histopathology 2017 Jan;70(1):10-25. doi: 10.1111/his.13090. PMID: 27960233
Intraepithelial lesions of urinary bladder: morphologic considerations.
Murphy WM, Busch C, Algaba F
Scand J Urol Nephrol Suppl 2000;(205):67-81. PMID: 11144906
Flat intraepithelial lesions of the urinary bladder.
Cheng L, Cheville JC, Neumann RM, Bostwick DG
Cancer 2000 Feb 1;88(3):625-31. PMID: 10649257

Diagnosis

Iatrogenic changes in the urinary tract.
Lopez-Beltran A, Paner GP, Montironi R, Raspollini MR, Cheng L
Histopathology 2017 Jan;70(1):10-25. doi: 10.1111/his.13090. PMID: 27960233
Molecular and immunohistologic analyses cannot reliably solve diagnostic variation of flat intraepithelial lesions of the urinary bladder.
Murata S, Iseki M, Kinjo M, Matsuzaki O, Moriuchi A, Ohtani H, Sakurai T, Satake T, Tsuzuki T
Am J Clin Pathol 2010 Dec;134(6):862-72. doi: 10.1309/AJCPACNUDWEN9GN4. PMID: 21088148
Review. Non-papillary urothelial lesions of the urinary bladder: morphological classification and immunohistochemical markers.
Petraki CD, Sfikas CP
In Vivo 2008 Jul-Aug;22(4):493-501. PMID: 18712178
An approach to the diagnosis of flat intraepithelial lesions of the urinary bladder using the World Health Organization/ International Society of Urological Pathology consensus classification system.
Amin MB, McKenney JK
Adv Anat Pathol 2002 Jul;9(4):222-32. doi: 10.1097/00125480-200207000-00002. PMID: 12072813
Preneoplastic non-papillary lesions and conditions of the urinary bladder: an update based on the Ancona International Consultation.
Lopez-Beltran A, Cheng L, Andersson L, Brausi M, de Matteis A, Montironi R, Sesterhenn I, van det Kwast KT, Mazerolles C
Virchows Arch 2002 Jan;440(1):3-11. doi: 10.1007/s00428-001-0577-6. PMID: 11942574

Therapy

Iatrogenic pathology of the urinary bladder.
Lopez-Beltran A, Montironi R, Raspollini MR, Cheng L, Netto GJ
Semin Diagn Pathol 2018 Jul;35(4):218-227. Epub 2018 Mar 14 doi: 10.1053/j.semdp.2018.03.001. PMID: 29576423
Iatrogenic changes in the urinary tract.
Lopez-Beltran A, Paner GP, Montironi R, Raspollini MR, Cheng L
Histopathology 2017 Jan;70(1):10-25. doi: 10.1111/his.13090. PMID: 27960233

Prognosis

Precancerous lesions of the biliary tree.
Klöppel G, Adsay V, Konukiewitz B, Kleeff J, Schlitter AM, Esposito I
Best Pract Res Clin Gastroenterol 2013 Apr;27(2):285-97. doi: 10.1016/j.bpg.2013.04.002. PMID: 23809246
Review. Non-papillary urothelial lesions of the urinary bladder: morphological classification and immunohistochemical markers.
Petraki CD, Sfikas CP
In Vivo 2008 Jul-Aug;22(4):493-501. PMID: 18712178
Intraepithelial lesions of urinary bladder: morphologic considerations.
Murphy WM, Busch C, Algaba F
Scand J Urol Nephrol Suppl 2000;(205):67-81. PMID: 11144906
Flat intraepithelial lesions of the urinary bladder.
Cheng L, Cheville JC, Neumann RM, Bostwick DG
Cancer 2000 Feb 1;88(3):625-31. PMID: 10649257

Clinical prediction guides

Molecular and immunohistologic analyses cannot reliably solve diagnostic variation of flat intraepithelial lesions of the urinary bladder.
Murata S, Iseki M, Kinjo M, Matsuzaki O, Moriuchi A, Ohtani H, Sakurai T, Satake T, Tsuzuki T
Am J Clin Pathol 2010 Dec;134(6):862-72. doi: 10.1309/AJCPACNUDWEN9GN4. PMID: 21088148
Intraepithelial lesions of urinary bladder: morphologic considerations.
Murphy WM, Busch C, Algaba F
Scand J Urol Nephrol Suppl 2000;(205):67-81. PMID: 11144906

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