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Glomerular capillary wall duplication without cellular interposition

MedGen UID:
1781847
•Concept ID:
C5539515
•
Anatomical Abnormality
HPO: HP:0033322

Definition

Double contouring of the original glomerular basement membrane (GBM)/additional layer(s) of overlying basement membrane matrix, with or without endocapillary hypercellularity and no evidence of interposed migrated cells (mesangial, endothelial, monocytes) between the layers of original GBM and de novo GBM. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlomerular capillary wall duplication without cellular interposition

Recent clinical studies

Diagnosis

Patient with diffuse mesangial and endocapillary proliferative glomerulonephritis with hypocomplementemia and elevated anti-streptolysin O treated with prednisolone, angiotensin-converting enzyme inhibitor, and angiotensin II receptor antagonist.
Ito S, Kuriyama H, Iino N, Iguchi S, Shimada H, Ueno M, Narita I, Nakano M, Nishi S, Karasawa R, Gejyo F
Clin Exp Nephrol 2003 Dec;7(4):290-5. doi: 10.1007/s10157-003-0244-0. PMID: 14712359

Therapy

Patient with diffuse mesangial and endocapillary proliferative glomerulonephritis with hypocomplementemia and elevated anti-streptolysin O treated with prednisolone, angiotensin-converting enzyme inhibitor, and angiotensin II receptor antagonist.
Ito S, Kuriyama H, Iino N, Iguchi S, Shimada H, Ueno M, Narita I, Nakano M, Nishi S, Karasawa R, Gejyo F
Clin Exp Nephrol 2003 Dec;7(4):290-5. doi: 10.1007/s10157-003-0244-0. PMID: 14712359

Clinical prediction guides

Patient with diffuse mesangial and endocapillary proliferative glomerulonephritis with hypocomplementemia and elevated anti-streptolysin O treated with prednisolone, angiotensin-converting enzyme inhibitor, and angiotensin II receptor antagonist.
Ito S, Kuriyama H, Iino N, Iguchi S, Shimada H, Ueno M, Narita I, Nakano M, Nishi S, Karasawa R, Gejyo F
Clin Exp Nephrol 2003 Dec;7(4):290-5. doi: 10.1007/s10157-003-0244-0. PMID: 14712359

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