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Elevated circulating hydroxybutyric acid concentration

MedGen UID:
1781896
•Concept ID:
C5539577
•
Finding
HPO: HP:0033417

Definition

An increased concentration in the blood circulation of a hydroxybutyric acid, that is, of a compound comprising a butyric acid core carrying at least one hydroxy substituent. [from HPO]

Recent clinical studies

Etiology

Oral ketone monoester supplementation does not accelerate recovery of muscle force or modulate circulating cytokine concentrations after muscle-damaging eccentric exercise in healthy males and females.
Jameson TSO, Islam H, Wall BT, Little JP, Stephens FB
Exp Physiol 2022 Nov;107(11):1339-1348. Epub 2022 Sep 26 doi: 10.1113/EP090546. PMID: 36114653Free PMC Article
Serum metabolomic signatures of gestational diabetes in South Asian and white European women.
Sikorski C, Azab S, de Souza RJ, Shanmuganathan M, Desai D, Teo K, Atkinson SA, Morrison K, Gupta M, Britz-McKibbin P, Anand SS
BMJ Open Diabetes Res Care 2022 Apr;10(2) doi: 10.1136/bmjdrc-2021-002733. PMID: 35450870Free PMC Article
Altered cholesterol homeostasis in critical illness-induced muscle weakness: effect of exogenous 3-hydroxybutyrate.
Goossens C, Weckx R, Derde S, Vander Perre S, Derese I, Van Veldhoven PP, Ghesquière B, Van den Berghe G, Langouche L
Crit Care 2021 Jul 17;25(1):252. doi: 10.1186/s13054-021-03688-1. PMID: 34274000Free PMC Article
A Pre-Workout Supplement of Ketone Salts, Caffeine, and Amino Acids Improves High-Intensity Exercise Performance in Keto-Naïve and Keto-Adapted Individuals.
Kackley ML, Short JA, Hyde PN, LaFountain RA, Buga A, Miller VJ, Dickerson RM, Sapper TN, Barnhart EC, Krishnan D, McElroy CA, Maresh CM, Kraemer WJ, Volek JS
J Am Coll Nutr 2020 May-Jun;39(4):290-300. Epub 2020 Apr 24 doi: 10.1080/07315724.2020.1752846. PMID: 32330107
Plasma immunoreactive somatostatin is elevated in diabetic ketoacidosis and correlates with plasma non-esterified fatty acid concentration.
Binimelis J, Webb SM, Serrano J, Codina M, Corcoy R, Perez A, Peinado MA, Puig M, de la Torre W, Serrat J
Diabet Med 1987 May-Jun;4(3):221-4. doi: 10.1111/j.1464-5491.1987.tb00866.x. PMID: 2886248

Therapy

Oral ketone monoester supplementation does not accelerate recovery of muscle force or modulate circulating cytokine concentrations after muscle-damaging eccentric exercise in healthy males and females.
Jameson TSO, Islam H, Wall BT, Little JP, Stephens FB
Exp Physiol 2022 Nov;107(11):1339-1348. Epub 2022 Sep 26 doi: 10.1113/EP090546. PMID: 36114653Free PMC Article
Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity.
Sharma R, Reinstadler B, Engelstad K, Skinner OS, Stackowitz E, Haller RG, Clish CB, Pierce K, Walker MA, Fryer R, Oglesbee D, Mao X, Shungu DC, Khatri A, Hirano M, De Vivo DC, Mootha VK
J Clin Invest 2021 Jan 19;131(2) doi: 10.1172/JCI136055. PMID: 33463549Free PMC Article
The Effect of Blood Ketone Concentration and Exercise Intensity on Exogenous Ketone Oxidation Rates in Athletes.
Dearlove DJ, Harrison OK, Hodson L, Jefferson A, Clarke K, Cox PJ
Med Sci Sports Exerc 2021 Mar 1;53(3):505-516. doi: 10.1249/MSS.0000000000002502. PMID: 32868580Free PMC Article
Circulating lipids in men with type 2 diabetes following 3 days on a carbohydrate-free diet versus 3 days of fasting.
Nuttall FQ, Almokayyad RM, Gannon MC
Physiol Rep 2020 Oct;8(19):e14569. doi: 10.14814/phy2.14569. PMID: 33030304Free PMC Article
A Pre-Workout Supplement of Ketone Salts, Caffeine, and Amino Acids Improves High-Intensity Exercise Performance in Keto-Naïve and Keto-Adapted Individuals.
Kackley ML, Short JA, Hyde PN, LaFountain RA, Buga A, Miller VJ, Dickerson RM, Sapper TN, Barnhart EC, Krishnan D, McElroy CA, Maresh CM, Kraemer WJ, Volek JS
J Am Coll Nutr 2020 May-Jun;39(4):290-300. Epub 2020 Apr 24 doi: 10.1080/07315724.2020.1752846. PMID: 32330107

Prognosis

Circulating lipids in men with type 2 diabetes following 3 days on a carbohydrate-free diet versus 3 days of fasting.
Nuttall FQ, Almokayyad RM, Gannon MC
Physiol Rep 2020 Oct;8(19):e14569. doi: 10.14814/phy2.14569. PMID: 33030304Free PMC Article
Total parenteral nutrition in infants. Blood levels of glucose, lactate, pyruvate, free fatty acids, glycerol, d-beta-hydroxybutyrate, triglycerides, free amino acids and insulin.
Lindblad BS, Settergren G, Feychting H, Persson B
Acta Paediatr Scand 1977 Jul;66(4):409-19. doi: 10.1111/j.1651-2227.1977.tb07920.x. PMID: 409094

Clinical prediction guides

Defining ketone supplementation: the evolving evidence for postexercise ketone supplementation to improve recovery and adaptation to exercise.
Robberechts R, Poffé C
Am J Physiol Cell Physiol 2024 Jan 1;326(1):C143-C160. Epub 2023 Nov 20 doi: 10.1152/ajpcell.00485.2023. PMID: 37982172
Gut and liver coordinated metabolic response following major torso injury.
Poggetti RS, Moore EE, Moore FA, Bensard DD, Parsons P, Anderson BO, Banerjee A
J Surg Res 1992 Jan;52(1):27-33. doi: 10.1016/0022-4804(92)90274-4. PMID: 1548864
Metabolic effects of adrenaline and noradrenaline in man: studies with somatostatin.
Pernet A, Walker M, Gill GV, Orskov H, Alberti KG, Johnston DG
Diabete Metab 1984 May;10(2):98-105. PMID: 6146542

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