U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Benign Lacrimal System Neoplasm

MedGen UID:
1781905
•Concept ID:
C5446422
•
Neoplastic Process
Synonyms: Benign Lacrimal Apparatus Neoplasm; Benign neoplasm of lacrimal apparatus
SNOMED CT: Benign neoplasm of lacrimal apparatus (1196815001)

Definition

A neoplasm that arises from the lacrimal gland or lacrimal drainage system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

The forgotten lacrimal gland and lacrimal drainage apparatus: pictorial review of CT and MRI findings and differential diagnosis.
Nair JR, Syed R, Chan IYM, Gorelik N, Chankowsky J, Del Carpio-O'Donovan R
Br J Radiol 2022 Jul 1;95(1135):20211333. Epub 2022 May 19 doi: 10.1259/bjr.20211333. PMID: 35522773
Comparison of Clinical Features and Treatment Outcome in Benign and Malignant Lacrimal Sac Tumors.
Kuo CY, Tsai CC, Kao SC, Hsu WM, Jui-Ling Liu C
Biomed Res Int 2020;2020:3545839. Epub 2020 Jan 31 doi: 10.1155/2020/3545839. PMID: 32090081Free PMC Article
Clinical presentation and management of lacrimal gland tumours.
Wright JE, Stewart WB, Krohel GB
Br J Ophthalmol 1979 Sep;63(9):600-6. doi: 10.1136/bjo.63.9.600. PMID: 486378Free PMC Article

Recent clinical studies

Etiology

Blood-stained tears-a red flag for malignancy?
Kaushik M, Juniat V, Ezra DG, Verity DH, Uddin J, Timlin H
Eye (Lond) 2023 Jun;37(8):1711-1716. Epub 2022 Sep 10 doi: 10.1038/s41433-022-02224-x. PMID: 36088421Free PMC Article
Carcinomas of the lacrimal drainage system.
Ramberg I, Toft PB, Heegaard S
Surv Ophthalmol 2020 Nov-Dec;65(6):691-707. Epub 2020 Apr 15 doi: 10.1016/j.survophthal.2020.04.001. PMID: 32304675
More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003
Lacrimal gland pleomorphic adenoma and malignant epithelial tumours: clinical and imaging differences.
Young SM, Kim YD, Shin HJ, Imagawa Y, Lang SS, Woo KI
Br J Ophthalmol 2019 Feb;103(2):264-268. Epub 2018 Apr 21 doi: 10.1136/bjophthalmol-2017-311538. PMID: 29680804
Overview of benign and malignant lacrimal gland tumors.
Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745

Diagnosis

Carcinomas of the lacrimal drainage system.
Ramberg I, Toft PB, Heegaard S
Surv Ophthalmol 2020 Nov-Dec;65(6):691-707. Epub 2020 Apr 15 doi: 10.1016/j.survophthal.2020.04.001. PMID: 32304675
Dacryops - A review.
Tanaboonyawat S, Idowu OO, Copperman TS, Vagefi MR, Kersten RC
Orbit 2020 Apr;39(2):128-134. Epub 2019 Sep 12 doi: 10.1080/01676830.2019.1608564. PMID: 31512543
More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003
Overview of benign and malignant lacrimal gland tumors.
Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745
An Update on Tumors of the Lacrimal Gland.
Andreasen S, Esmaeli B, Holstein SL, Mikkelsen LH, Rasmussen PK, Heegaard S
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):159-172. doi: 10.22608/APO.201707. PMID: 28399336

Therapy

Outcomes of lacrimal punctal tumors treated with a superpulse CO(2) laser.
Chen C, Lee YK, Lai CC
Lasers Med Sci 2022 Jun;37(4):2287-2291. Epub 2022 Jan 6 doi: 10.1007/s10103-021-03500-0. PMID: 34993707
Angioleiomyoma of the nasolacrimal duct: case report and literature review.
Azhdam AM, Wang Y, Douglas RS, Chang EE, Wu AW
Orbit 2022 Dec;41(6):783-785. Epub 2021 May 30 doi: 10.1080/01676830.2021.1933080. PMID: 34057005
Case Series of Laser Therapy of Eyelid Peripunctal Benign Tumor.
Song N, Tong H, Ma J, Zhang J
Photobiomodul Photomed Laser Surg 2021 Oct;39(10):661-664. Epub 2021 Oct 1 doi: 10.1089/photob.2021.0007. PMID: 34597195
Incidence of neoplasia in patients with unilateral epiphora.
Bewes T, Sacks R, Sacks PL, Chin D, Mrad N, Wilcsek G, Tumuluri K, Harvey R
J Laryngol Otol 2015 Jul;129 Suppl 3:S53-7. doi: 10.1017/S0022215115001504. PMID: 26173845
CORE needle biopsy of orbital tumors.
Yarovoy AA, Bulgakova ES, Shatskikh AV, Uzunyan DG, Kleyankina SS, Golubeva OV
Graefes Arch Clin Exp Ophthalmol 2013 Aug;251(8):2057-61. Epub 2013 Mar 21 doi: 10.1007/s00417-013-2315-6. PMID: 23515750

Prognosis

More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003
Overview of benign and malignant lacrimal gland tumors.
Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745
An Update on Tumors of the Lacrimal Gland.
Andreasen S, Esmaeli B, Holstein SL, Mikkelsen LH, Rasmussen PK, Heegaard S
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):159-172. doi: 10.22608/APO.201707. PMID: 28399336
Schneiderian papillomas and carcinomas: a review.
Batsakis JG, Suarez P
Adv Anat Pathol 2001 Mar;8(2):53-64. doi: 10.1097/00125480-200103000-00001. PMID: 11236954
Epithelial tumors of the lacrimal gland: clinico-pathologic correlation and management.
Riedel KG, Markl A, Hasenfratz G, Kampik A, Stefani FH, Lund OE
Neurosurg Rev 1990;13(4):289-98. doi: 10.1007/BF00346367. PMID: 2177857

Clinical prediction guides

Risk and Lag-time for Development of Lacrimal Gland Carcinoma Expleomorphic Adenoma: Observations and Conjectural Study.
Rose GE, Vahdani K, Lewis J, Rose AM
Ophthalmic Plast Reconstr Surg 2022 Nov-Dec 01;38(6):563-566. Epub 2022 May 13 doi: 10.1097/IOP.0000000000002203. PMID: 35550483
Clinicopathological and immunohistochemical behavior of ductal carcinoma of the salivary and lacrimal gland in a Mexican Mestizo population.
Luna-Ortiz K, Dominguez-Malagon H, Corredor-Alonso GE, Reynoso-Noveron N, Herrera-Ponzanelli C, Luna-Peteuil Z, Zacarias-Ramon LC
Eur Arch Otorhinolaryngol 2022 Jan;279(1):327-333. Epub 2021 Mar 24 doi: 10.1007/s00405-021-06757-x. PMID: 33763743
Dacryops - A review.
Tanaboonyawat S, Idowu OO, Copperman TS, Vagefi MR, Kersten RC
Orbit 2020 Apr;39(2):128-134. Epub 2019 Sep 12 doi: 10.1080/01676830.2019.1608564. PMID: 31512543
More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003
Schneiderian papillomas and carcinomas: a review.
Batsakis JG, Suarez P
Adv Anat Pathol 2001 Mar;8(2):53-64. doi: 10.1097/00125480-200103000-00001. PMID: 11236954

Recent systematic reviews

Nasolacrimal duct tumours in the era of endoscopic dacryocystorhinostomy: literature review.
Tanweer F, Mahkamova K, Harkness P
J Laryngol Otol 2013 Jul;127(7):670-5. Epub 2013 Jun 12 doi: 10.1017/S0022215113001163. PMID: 23756574

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...