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Benign Lacrimal System Neoplasm

MedGen UID:: 1781905
•Concept ID:: C5446422
•: Neoplastic Process

Synonyms:	Benign Lacrimal Apparatus Neoplasm; Benign neoplasm of lacrimal apparatus
SNOMED CT:	Benign neoplasm of lacrimal apparatus (1196815001)

Definition

A neoplasm that arises from the lacrimal gland or lacrimal drainage system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBenign Lacrimal System Neoplasm

Pathological process
- Disease
  - Neoplasm
    - Neoplasm by Special Category
      - Benign neoplasm
        Benign Eye Neoplasm
        Benign Lacrimal System Neoplasm
        Benign Lacrimal Drainage System Neoplasm
        Benign Nasolacrimal Duct Neoplasm
        Lacrimal Drainage System Exophytic Papilloma
        Lacrimal Drainage System Inverted Papilloma
        Benign neoplasm of lacrimal gland
        Lacrimal Gland Myoepithelioma
        Lacrimal Gland Oncocytoma
        Lacrimal Gland Pleomorphic Adenoma
        Lacrimal Gland Warthin Tumor

Professional guidelines

PubMed

The forgotten lacrimal gland and lacrimal drainage apparatus: pictorial review of CT and MRI findings and differential diagnosis.

Nair JR, Syed R, Chan IYM, Gorelik N, Chankowsky J, Del Carpio-O'Donovan R
Br J Radiol 2022 Jul 1;95(1135):20211333. Epub 2022 May 19 doi: 10.1259/bjr.20211333. PMID: 35522773 Free PMC Article

Comparison of Clinical Features and Treatment Outcome in Benign and Malignant Lacrimal Sac Tumors.

Kuo CY, Tsai CC, Kao SC, Hsu WM, Jui-Ling Liu C
Biomed Res Int 2020;2020:3545839. Epub 2020 Jan 31 doi: 10.1155/2020/3545839. PMID: 32090081 Free PMC Article

Epithelial tumors of the lacrimal gland: clinico-pathologic correlation and management.

Riedel KG, Markl A, Hasenfratz G, Kampik A, Stefani FH, Lund OE
Neurosurg Rev 1990;13(4):289-98. doi: 10.1007/BF00346367. PMID: 2177857

See all (6)

Recent clinical studies

Etiology

More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.

Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003

Nasolacrimal duct tumours in the era of endoscopic dacryocystorhinostomy: literature review.

Tanweer F, Mahkamova K, Harkness P
J Laryngol Otol 2013 Jul;127(7):670-5. Epub 2013 Jun 12 doi: 10.1017/S0022215113001163. PMID: 23756574

Ethmoid sinus osteoma presenting as epiphora and orbital cellulitis: case report and literature review.

Mansour AM, Salti H, Uwaydat S, Dakroub R, Bashshour Z
Surv Ophthalmol 1999 Mar-Apr;43(5):413-26. doi: 10.1016/s0039-6257(99)00004-1. PMID: 10340560

Ostensible oncocytoma of accessory lacrimal glands.

Pecorella I, Garner A
Histopathology 1997 Mar;30(3):264-70. doi: 10.1046/j.1365-2559.1997.d01-601.x. PMID: 9088957

A 20-year series of orbital exenteration.

Levin PS, Dutton JJ
Am J Ophthalmol 1991 Nov 15;112(5):496-501. doi: 10.1016/s0002-9394(14)76848-5. PMID: 1951584

See all (78)

Diagnosis

Mucoepidermoid Carcinoma Ex Pleomorphic Adenoma of Lacrimal Gland: Case Report and Review of Literature.

Khademi B, Zia Z, Kohandel-Shirazi M
Ophthalmic Plast Reconstr Surg 2023 Jan-Feb 01;39(1):e22-e25. Epub 2022 Aug 8 doi: 10.1097/IOP.0000000000002258. PMID: 35943428

Congenital dacryocystocele diagnosed by antenatal ultrasonography with spontaneous resolution.

Cruciat G, Florian A, Cotutiu P, Nemeti G, Nicoara S
Arq Bras Oftalmol 2020 Aug;83(4):332-334. Epub 2020 Jul 29 doi: 10.5935/0004-2749.20200055. PMID: 32756791

Nasolacrimal duct tumours in the era of endoscopic dacryocystorhinostomy: literature review.

Tanweer F, Mahkamova K, Harkness P
J Laryngol Otol 2013 Jul;127(7):670-5. Epub 2013 Jun 12 doi: 10.1017/S0022215113001163. PMID: 23756574

Pleomorphic adenoma originates from inferior nasal turbinate causing epiphora.

Erol B, Selçuk ÖT, Gürses C, Osma Ü, Köroğlu M, Süren D
Clin Imaging 2013 Jul-Aug;37(4):747-9. Epub 2013 Jan 26 doi: 10.1016/j.clinimag.2012.12.010. PMID: 23357689

Epidermoid cyst masquerading as dacryocystocele: case report and review.

Lelli GJ, Levy RL
Orbit 2011 Mar;30(2):114-5. doi: 10.3109/01676830.2010.551799. PMID: 21438735

See all (155)

Therapy

Accumulation of 131Iodine in the nasolacrimal sac/duct after radioiodine therapy for papillary thyroid cancer.

Usmani S, Jain A, Al-Riyami K, Abubakar S
J Pak Med Assoc 2023 Mar;73(3):713-714. doi: 10.47391/JPMA.23-22. PMID: 36932793

Angioleiomyoma of the nasolacrimal duct: case report and literature review.

Azhdam AM, Wang Y, Douglas RS, Chang EE, Wu AW
Orbit 2022 Dec;41(6):783-785. Epub 2021 May 30 doi: 10.1080/01676830.2021.1933080. PMID: 34057005

Mitomycin C in the treatment of a Schneiderian (inverted) papilloma of the lacrimal sac.

Woodcock M, Mollan SP, Harrison D, Taylor D, Lecuona K
Int Ophthalmol 2010 Jun;30(3):303-5. Epub 2009 Jul 23 doi: 10.1007/s10792-009-9314-y. PMID: 19629401

Complications of mitomycin C therapy in 100 eyes with ocular surface neoplasia.

Khong JJ, Muecke J
Br J Ophthalmol 2006 Jul;90(7):819-22. Epub 2006 May 3 doi: 10.1136/bjo.2005.086850. PMID: 16672325 Free PMC Article

Aberrant lacrimal gland and pleomorphic adenoma within the muscle cone.

Mueller EC, Borit A
Ann Ophthalmol 1979 Apr;11(4):661-3. PMID: 453762

See all (14)

Prognosis

More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.

Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003

The nasolabial cyst: a nonodontogenic oral cyst related to nasolacrimal duct epithelium.

Toribio Y, Roehrl MH
Arch Pathol Lab Med 2011 Nov;135(11):1499-503. doi: 10.5858/arpa.2010-0338-RS. PMID: 22032581

Schneiderian papillomas and carcinomas: a review.

Batsakis JG, Suarez P
Adv Anat Pathol 2001 Mar;8(2):53-64. doi: 10.1097/00125480-200103000-00001. PMID: 11236954

Ethmoid sinus osteoma presenting as epiphora and orbital cellulitis: case report and literature review.

Mansour AM, Salti H, Uwaydat S, Dakroub R, Bashshour Z
Surv Ophthalmol 1999 Mar-Apr;43(5):413-26. doi: 10.1016/s0039-6257(99)00004-1. PMID: 10340560

Lacrimal gland and fossa lesions: role of computed tomography.

Mafee MF, Haik BG
Radiol Clin North Am 1987 Jul;25(4):767-79. PMID: 3299475

See all (56)

Clinical prediction guides

Dacryops - A review.

Tanaboonyawat S, Idowu OO, Copperman TS, Vagefi MR, Kersten RC
Orbit 2020 Apr;39(2):128-134. Epub 2019 Sep 12 doi: 10.1080/01676830.2019.1608564. PMID: 31512543

More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.

Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003

Oncocytoma of the lacrimal gland: a case report.

Fenelon EM, Balby IT, Neves NTD, Figueiredo F, Duarte ECB, Tzelikis PF
Arq Bras Oftalmol 2017 Mar-Apr;80(2):128-130. doi: 10.5935/0004-2749.20170031. PMID: 28591289

Schneiderian papillomas and carcinomas: a review.

Batsakis JG, Suarez P
Adv Anat Pathol 2001 Mar;8(2):53-64. doi: 10.1097/00125480-200103000-00001. PMID: 11236954

Ectopic lacrimal gland of the orbit.

Sakurai H, Mitsuhashi N, Hayakawa K, Nozaki M, Kurosaki H, Kishi S, Joshita T, Niibe H
J Nucl Med 1997 Sep;38(9):1498-500. PMID: 9293818

See all (35)