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Recurrent Low Grade Astrocytoma

MedGen UID:
1781955
•Concept ID:
C5447259
•
Neoplastic Process
Synonym: Recurrent Low Grade Astrocytic Tumor

Definition

The reemergence of a low grade astrocytoma after a period of remission. [from NCI]

Professional guidelines

PubMed

Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting.
Rautajoki KJ, Jaatinen S, Hartewig A, Tiihonen AM, Annala M, Salonen I, Valkonen M, Simola V, Vuorinen EM, Kivinen A, Rauhala MJ, Nurminen R, Maass KK, Lahtela SL, Jukkola A, Yli-Harja O, Helén P, Pajtler KW, Ruusuvuori P, Haapasalo J, Zhang W, Haapasalo H, Nykter M
Acta Neuropathol Commun 2023 Nov 6;11(1):176. doi: 10.1186/s40478-023-01669-9. PMID: 37932833Free PMC Article
Treatment options for progression or recurrence of glioblastoma: a network meta-analysis.
McBain C, Lawrie TA, Rogozińska E, Kernohan A, Robinson T, Jefferies S
Cochrane Database Syst Rev 2021 May 4;5(1):CD013579. doi: 10.1002/14651858.CD013579.pub2. PMID: 34559423Free PMC Article
Is chemotherapy alone an option as initial treatment for low-grade oligodendrogliomas?
Rudà R, Touat M, Soffietti R
Curr Opin Neurol 2020 Dec;33(6):707-715. doi: 10.1097/WCO.0000000000000866. PMID: 33027142

Recent clinical studies

Etiology

First-line temozolomide chemotherapy in progressive low-grade astrocytomas after radiotherapy: molecular characteristics in relation to response.
Taal W, Dubbink HJ, Zonnenberg CB, Zonnenberg BA, Postma TJ, Gijtenbeek JM, Boogerd W, Groenendijk FH, Kros JM, Kouwenhoven MC, van Marion R, van Heuvel I, van der Holt B, Bromberg JE, Sillevis Smitt PA, Dinjens WN, van den Bent MJ; Dutch Society for Neuro-Oncology
Neuro Oncol 2011 Feb;13(2):235-41. Epub 2010 Dec 21 doi: 10.1093/neuonc/noq177. PMID: 21177338Free PMC Article
Conformal proton radiation therapy for pediatric low-grade astrocytomas.
Hug EB, Muenter MW, Archambeau JO, DeVries A, Liwnicz B, Loredo LN, Grove RI, Slater JD
Strahlenther Onkol 2002 Jan;178(1):10-7. doi: 10.1007/s00066-002-0874-2. PMID: 11977386

Diagnosis

First-line temozolomide chemotherapy in progressive low-grade astrocytomas after radiotherapy: molecular characteristics in relation to response.
Taal W, Dubbink HJ, Zonnenberg CB, Zonnenberg BA, Postma TJ, Gijtenbeek JM, Boogerd W, Groenendijk FH, Kros JM, Kouwenhoven MC, van Marion R, van Heuvel I, van der Holt B, Bromberg JE, Sillevis Smitt PA, Dinjens WN, van den Bent MJ; Dutch Society for Neuro-Oncology
Neuro Oncol 2011 Feb;13(2):235-41. Epub 2010 Dec 21 doi: 10.1093/neuonc/noq177. PMID: 21177338Free PMC Article
Vincristine and carboplatin chemotherapy for unresectable and/or recurrent low-grade astrocytoma of the brainstem.
Ronghe M, Hargrave D, Bartels U, Tabori U, Vaidya S, Chandler C, Kulkarni A, Bouffet E
Pediatr Blood Cancer 2010 Sep;55(3):471-7. doi: 10.1002/pbc.22557. PMID: 20535831
Development and rapid growth of a desmoid tumor in the surgical corridor after suboccipital craniotomy for recurrent low-grade astrocytoma.
McCall T, Rao G, Jensen R
J Neurooncol 2006 Nov;80(2):167-70. Epub 2006 Apr 28 doi: 10.1007/s11060-006-9166-5. PMID: 16645711
Conformal proton radiation therapy for pediatric low-grade astrocytomas.
Hug EB, Muenter MW, Archambeau JO, DeVries A, Liwnicz B, Loredo LN, Grove RI, Slater JD
Strahlenther Onkol 2002 Jan;178(1):10-7. doi: 10.1007/s00066-002-0874-2. PMID: 11977386
Chemotherapy for spinal cord astrocytoma: can natural history be modified?
Lowis SP, Pizer BL, Coakham H, Nelson RJ, Bouffet E
Childs Nerv Syst 1998 Jul;14(7):317-21. doi: 10.1007/s003810050233. PMID: 9726582

Therapy

First-line temozolomide chemotherapy in progressive low-grade astrocytomas after radiotherapy: molecular characteristics in relation to response.
Taal W, Dubbink HJ, Zonnenberg CB, Zonnenberg BA, Postma TJ, Gijtenbeek JM, Boogerd W, Groenendijk FH, Kros JM, Kouwenhoven MC, van Marion R, van Heuvel I, van der Holt B, Bromberg JE, Sillevis Smitt PA, Dinjens WN, van den Bent MJ; Dutch Society for Neuro-Oncology
Neuro Oncol 2011 Feb;13(2):235-41. Epub 2010 Dec 21 doi: 10.1093/neuonc/noq177. PMID: 21177338Free PMC Article
Vincristine and carboplatin chemotherapy for unresectable and/or recurrent low-grade astrocytoma of the brainstem.
Ronghe M, Hargrave D, Bartels U, Tabori U, Vaidya S, Chandler C, Kulkarni A, Bouffet E
Pediatr Blood Cancer 2010 Sep;55(3):471-7. doi: 10.1002/pbc.22557. PMID: 20535831
Conformal proton radiation therapy for pediatric low-grade astrocytomas.
Hug EB, Muenter MW, Archambeau JO, DeVries A, Liwnicz B, Loredo LN, Grove RI, Slater JD
Strahlenther Onkol 2002 Jan;178(1):10-7. doi: 10.1007/s00066-002-0874-2. PMID: 11977386
Chemotherapy for spinal cord astrocytoma: can natural history be modified?
Lowis SP, Pizer BL, Coakham H, Nelson RJ, Bouffet E
Childs Nerv Syst 1998 Jul;14(7):317-21. doi: 10.1007/s003810050233. PMID: 9726582

Prognosis

First-line temozolomide chemotherapy in progressive low-grade astrocytomas after radiotherapy: molecular characteristics in relation to response.
Taal W, Dubbink HJ, Zonnenberg CB, Zonnenberg BA, Postma TJ, Gijtenbeek JM, Boogerd W, Groenendijk FH, Kros JM, Kouwenhoven MC, van Marion R, van Heuvel I, van der Holt B, Bromberg JE, Sillevis Smitt PA, Dinjens WN, van den Bent MJ; Dutch Society for Neuro-Oncology
Neuro Oncol 2011 Feb;13(2):235-41. Epub 2010 Dec 21 doi: 10.1093/neuonc/noq177. PMID: 21177338Free PMC Article
Vincristine and carboplatin chemotherapy for unresectable and/or recurrent low-grade astrocytoma of the brainstem.
Ronghe M, Hargrave D, Bartels U, Tabori U, Vaidya S, Chandler C, Kulkarni A, Bouffet E
Pediatr Blood Cancer 2010 Sep;55(3):471-7. doi: 10.1002/pbc.22557. PMID: 20535831
Conformal proton radiation therapy for pediatric low-grade astrocytomas.
Hug EB, Muenter MW, Archambeau JO, DeVries A, Liwnicz B, Loredo LN, Grove RI, Slater JD
Strahlenther Onkol 2002 Jan;178(1):10-7. doi: 10.1007/s00066-002-0874-2. PMID: 11977386
Molecular analysis of CDKN2 (p16) in gliomas associated with clinical data.
De Souza Nascimento P, Maciel CM, Kawamura MT, Oliveira JA, Teixeira A, Carvalho Mda G, Alves G
Oncol Rep 2001 Sep-Oct;8(5):1039-43. doi: 10.3892/or.8.5.1039. PMID: 11496313

Clinical prediction guides

Intra-individual comparison of ¹⁸F-FET and ¹⁸F-DOPA in PET imaging of recurrent brain tumors.
Kratochwil C, Combs SE, Leotta K, Afshar-Oromieh A, Rieken S, Debus J, Haberkorn U, Giesel FL
Neuro Oncol 2014 Mar;16(3):434-40. Epub 2013 Dec 4 doi: 10.1093/neuonc/not199. PMID: 24305717Free PMC Article
First-line temozolomide chemotherapy in progressive low-grade astrocytomas after radiotherapy: molecular characteristics in relation to response.
Taal W, Dubbink HJ, Zonnenberg CB, Zonnenberg BA, Postma TJ, Gijtenbeek JM, Boogerd W, Groenendijk FH, Kros JM, Kouwenhoven MC, van Marion R, van Heuvel I, van der Holt B, Bromberg JE, Sillevis Smitt PA, Dinjens WN, van den Bent MJ; Dutch Society for Neuro-Oncology
Neuro Oncol 2011 Feb;13(2):235-41. Epub 2010 Dec 21 doi: 10.1093/neuonc/noq177. PMID: 21177338Free PMC Article

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