U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal astrocyte morphology

MedGen UID:
867605
•Concept ID:
C4021991
•
Finding
Synonym: Abnormality of the astrocytes
 
HPO: HP:0100707

Definition

An abnormality of astrocytes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal astrocyte morphology

Professional guidelines

PubMed

APOE genotype dependent molecular abnormalities in the cerebrovasculature of Alzheimer's disease and age-matched non-demented brains.
Ojo JO, Reed JM, Crynen G, Vallabhaneni P, Evans J, Shackleton B, Eisenbaum M, Ringland C, Edsell A, Mullan M, Crawford F, Bachmeier C
Mol Brain 2021 Jul 8;14(1):110. doi: 10.1186/s13041-021-00803-9. PMID: 34238312Free PMC Article
Mesencephalic astrocyte-derived neurotrophic factor: A treatment option for parkinson's disease.
Yang C, Gao Y
Front Biosci (Landmark Ed) 2020 Jun 1;25(9):1718-1731. doi: 10.2741/4874. PMID: 32472754
Fragile X-associated tremor/ataxia syndrome: clinical features, genetics, and testing guidelines.
Berry-Kravis E, Abrams L, Coffey SM, Hall DA, Greco C, Gane LW, Grigsby J, Bourgeois JA, Finucane B, Jacquemont S, Brunberg JA, Zhang L, Lin J, Tassone F, Hagerman PJ, Hagerman RJ, Leehey MA
Mov Disord 2007 Oct 31;22(14):2018-30, quiz 2140. doi: 10.1002/mds.21493. PMID: 17618523

Recent clinical studies

Etiology

Glial cells in schizophrenia: a unified hypothesis.
Dietz AG, Goldman SA, Nedergaard M
Lancet Psychiatry 2020 Mar;7(3):272-281. Epub 2019 Nov 6 doi: 10.1016/S2215-0366(19)30302-5. PMID: 31704113Free PMC Article
Cellular and regional vulnerability in frontotemporal tauopathies.
Forrest SL, Kril JJ, Halliday GM
Acta Neuropathol 2019 Nov;138(5):705-727. Epub 2019 Jun 15 doi: 10.1007/s00401-019-02035-7. PMID: 31203391
Evidence for brain glucose dysregulation in Alzheimer's disease.
An Y, Varma VR, Varma S, Casanova R, Dammer E, Pletnikova O, Chia CW, Egan JM, Ferrucci L, Troncoso J, Levey AI, Lah J, Seyfried NT, Legido-Quigley C, O'Brien R, Thambisetty M
Alzheimers Dement 2018 Mar;14(3):318-329. Epub 2017 Oct 19 doi: 10.1016/j.jalz.2017.09.011. PMID: 29055815Free PMC Article
The neuropathology of chronic traumatic encephalopathy.
McKee AC, Stein TD, Kiernan PT, Alvarez VE
Brain Pathol 2015 May;25(3):350-64. doi: 10.1111/bpa.12248. PMID: 25904048Free PMC Article
Gene therapy for leukodystrophies.
Biffi A, Aubourg P, Cartier N
Hum Mol Genet 2011 Apr 15;20(R1):R42-53. Epub 2011 Mar 31 doi: 10.1093/hmg/ddr142. PMID: 21459776

Diagnosis

The genomic landscape across 474 surgically accessible epileptogenic human brain lesions.
López-Rivera JA, Leu C, Macnee M, Khoury J, Hoffmann L, Coras R, Kobow K, Bhattarai N, Pérez-Palma E, Hamer H, Brandner S, Rössler K, Bien CG, Kalbhenn T, Pieper T, Hartlieb T, Butler E, Genovese G, Becker K, Altmüller J, Niestroj LM, Ferguson L, Busch RM, Nürnberg P, Najm I, Blümcke I, Lal D
Brain 2023 Apr 19;146(4):1342-1356. doi: 10.1093/brain/awac376. PMID: 36226386Free PMC Article
Congenital Opticmeningoceles.
Cruz AAV, Akaishi PMS, Bernardini F, Chahud F
Ophthalmic Plast Reconstr Surg 2021 May-Jun 01;37(3):e109-e111. doi: 10.1097/IOP.0000000000001864. PMID: 33229952
Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Review of the Literature.
Shan F, Long Y, Qiu W
Front Immunol 2018;9:2802. Epub 2018 Dec 5 doi: 10.3389/fimmu.2018.02802. PMID: 30568655Free PMC Article
The neuropathology of chronic traumatic encephalopathy.
Mckee AC, Abdolmohammadi B, Stein TD
Handb Clin Neurol 2018;158:297-307. doi: 10.1016/B978-0-444-63954-7.00028-8. PMID: 30482357
The neuropathology of chronic traumatic encephalopathy.
McKee AC, Stein TD, Kiernan PT, Alvarez VE
Brain Pathol 2015 May;25(3):350-64. doi: 10.1111/bpa.12248. PMID: 25904048Free PMC Article

Therapy

The Functional Roles of Curcumin on Astrocytes in Neurodegenerative Diseases.
Mohammadi A, Hosseinzadeh Colagar A, Khorshidian A, Amini SM
Neuroimmunomodulation 2022;29(1):4-14. Epub 2021 Sep 8 doi: 10.1159/000517901. PMID: 34496365
Microglia in depression: current perspectives.
Jia X, Gao Z, Hu H
Sci China Life Sci 2021 Jun;64(6):911-925. Epub 2020 Oct 14 doi: 10.1007/s11427-020-1815-6. PMID: 33068286
GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease.
Jo S, Yarishkin O, Hwang YJ, Chun YE, Park M, Woo DH, Bae JY, Kim T, Lee J, Chun H, Park HJ, Lee DY, Hong J, Kim HY, Oh SJ, Park SJ, Lee H, Yoon BE, Kim Y, Jeong Y, Shim I, Bae YC, Cho J, Kowall NW, Ryu H, Hwang E, Kim D, Lee CJ
Nat Med 2014 Aug;20(8):886-96. Epub 2014 Jun 29 doi: 10.1038/nm.3639. PMID: 24973918Free PMC Article
Molecular dissection of reactive astrogliosis and glial scar formation.
Sofroniew MV
Trends Neurosci 2009 Dec;32(12):638-47. Epub 2009 Sep 24 doi: 10.1016/j.tins.2009.08.002. PMID: 19782411Free PMC Article
Hepatic encephalopathy.
Córdoba J, Mínguez B
Semin Liver Dis 2008 Feb;28(1):70-80. doi: 10.1055/s-2008-1040322. PMID: 18293278

Prognosis

Microglia-Mediated Neurovascular Unit Dysfunction in Alzheimer's Disease.
Huang W, Xia Q, Zheng F, Zhao X, Ge F, Xiao J, Liu Z, Shen Y, Ye K, Wang D, Li Y
J Alzheimers Dis 2023;94(s1):S335-S354. doi: 10.3233/JAD-221064. PMID: 36683511Free PMC Article
The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson's disease.
de Rus Jacquet A, Tancredi JL, Lemire AL, DeSantis MC, Li WP, O'Shea EK
Elife 2021 Sep 30;10 doi: 10.7554/eLife.73062. PMID: 34590578Free PMC Article
Possible inflammatory mechanisms and predictors of Parkinson's disease patients with fatigue (Brief Review).
Wang H, Liu Y, Zhao J, Guo X, Hu M, Chen Y
Clin Neurol Neurosurg 2021 Sep;208:106844. Epub 2021 Aug 4 doi: 10.1016/j.clineuro.2021.106844. PMID: 34388595
Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Review of the Literature.
Shan F, Long Y, Qiu W
Front Immunol 2018;9:2802. Epub 2018 Dec 5 doi: 10.3389/fimmu.2018.02802. PMID: 30568655Free PMC Article
Glioblastoma: pathology, molecular mechanisms and markers.
Aldape K, Zadeh G, Mansouri S, Reifenberger G, von Deimling A
Acta Neuropathol 2015 Jun;129(6):829-48. Epub 2015 May 6 doi: 10.1007/s00401-015-1432-1. PMID: 25943888

Clinical prediction guides

The genomic landscape across 474 surgically accessible epileptogenic human brain lesions.
López-Rivera JA, Leu C, Macnee M, Khoury J, Hoffmann L, Coras R, Kobow K, Bhattarai N, Pérez-Palma E, Hamer H, Brandner S, Rössler K, Bien CG, Kalbhenn T, Pieper T, Hartlieb T, Butler E, Genovese G, Becker K, Altmüller J, Niestroj LM, Ferguson L, Busch RM, Nürnberg P, Najm I, Blümcke I, Lal D
Brain 2023 Apr 19;146(4):1342-1356. doi: 10.1093/brain/awac376. PMID: 36226386Free PMC Article
Motor neuron pathology in CANVAS due to RFC1 expansions.
Huin V, Coarelli G, Guemy C, Boluda S, Debs R, Mochel F, Stojkovic T, Grabli D, Maisonobe T, Gaymard B, Lenglet T, Tard C, Davion JB, Sablonnière B, Monin ML, Ewenczyk C, Viala K, Charles P, Le Ber I, Reilly MM, Houlden H, Cortese A, Seilhean D, Brice A, Durr A
Brain 2022 Jun 30;145(6):2121-2132. doi: 10.1093/brain/awab449. PMID: 34927205
Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Review of the Literature.
Shan F, Long Y, Qiu W
Front Immunol 2018;9:2802. Epub 2018 Dec 5 doi: 10.3389/fimmu.2018.02802. PMID: 30568655Free PMC Article
Glioblastoma: pathology, molecular mechanisms and markers.
Aldape K, Zadeh G, Mansouri S, Reifenberger G, von Deimling A
Acta Neuropathol 2015 Jun;129(6):829-48. Epub 2015 May 6 doi: 10.1007/s00401-015-1432-1. PMID: 25943888
GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease.
Jo S, Yarishkin O, Hwang YJ, Chun YE, Park M, Woo DH, Bae JY, Kim T, Lee J, Chun H, Park HJ, Lee DY, Hong J, Kim HY, Oh SJ, Park SJ, Lee H, Yoon BE, Kim Y, Jeong Y, Shim I, Bae YC, Cho J, Kowall NW, Ryu H, Hwang E, Kim D, Lee CJ
Nat Med 2014 Aug;20(8):886-96. Epub 2014 Jun 29 doi: 10.1038/nm.3639. PMID: 24973918Free PMC Article

Recent systematic reviews

Glial Markers of Suicidal Behavior in the Human Brain-A Systematic Review of Postmortem Studies.
Yamamoto M, Sakai M, Yu Z, Nakanishi M, Yoshii H
Int J Mol Sci 2024 May 25;25(11) doi: 10.3390/ijms25115750. PMID: 38891940Free PMC Article
Clinical and neuroimaging phenotypes of autoimmune glial fibrillary acidic protein astrocytopathy: A systematic review and meta-analysis.
Hagbohm C, Ouellette R, Flanagan EP, Jonsson DI, Piehl F, Banwell B, Wickström R, Iacobaeus E, Granberg T, Ineichen BV
Eur J Neurol 2024 Jul;31(7):e16284. Epub 2024 Mar 20 doi: 10.1111/ene.16284. PMID: 38506182Free PMC Article
The role of radiotherapy in the management of patients with diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline.
Ryken TC, Parney I, Buatti J, Kalkanis SN, Olson JJ
J Neurooncol 2015 Dec;125(3):551-83. Epub 2015 Nov 3 doi: 10.1007/s11060-015-1948-1. PMID: 26530266
Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations.
Gouw AA, Seewann A, van der Flier WM, Barkhof F, Rozemuller AM, Scheltens P, Geurts JJ
J Neurol Neurosurg Psychiatry 2011 Feb;82(2):126-35. Epub 2010 Oct 9 doi: 10.1136/jnnp.2009.204685. PMID: 20935330
High incidence of progressive postnatal cerebellar enlargement in Costello syndrome: brain overgrowth associated with HRAS mutations as the likely cause of structural brain and spinal cord abnormalities.
Gripp KW, Hopkins E, Doyle D, Dobyns WB
Am J Med Genet A 2010 May;152A(5):1161-8. doi: 10.1002/ajmg.a.33391. PMID: 20425820Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...