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Glomerular capillary wall duplication with cellular interposition

MedGen UID:
1783221
•Concept ID:
C5539516
•
Anatomical Abnormality
HPO: HP:0033323

Definition

Double contouring of the original glomerular basement membrane (GBM)/additional layer(s) of overlying basement membrane matrix with interposed migrated cells (mesangial, endothelial, monocytes) between the layers of original GBM and de novo GBM. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlomerular capillary wall duplication with cellular interposition

Recent clinical studies

Diagnosis

Patient with diffuse mesangial and endocapillary proliferative glomerulonephritis with hypocomplementemia and elevated anti-streptolysin O treated with prednisolone, angiotensin-converting enzyme inhibitor, and angiotensin II receptor antagonist.
Ito S, Kuriyama H, Iino N, Iguchi S, Shimada H, Ueno M, Narita I, Nakano M, Nishi S, Karasawa R, Gejyo F
Clin Exp Nephrol 2003 Dec;7(4):290-5. doi: 10.1007/s10157-003-0244-0. PMID: 14712359

Therapy

Patient with diffuse mesangial and endocapillary proliferative glomerulonephritis with hypocomplementemia and elevated anti-streptolysin O treated with prednisolone, angiotensin-converting enzyme inhibitor, and angiotensin II receptor antagonist.
Ito S, Kuriyama H, Iino N, Iguchi S, Shimada H, Ueno M, Narita I, Nakano M, Nishi S, Karasawa R, Gejyo F
Clin Exp Nephrol 2003 Dec;7(4):290-5. doi: 10.1007/s10157-003-0244-0. PMID: 14712359

Clinical prediction guides

Patient with diffuse mesangial and endocapillary proliferative glomerulonephritis with hypocomplementemia and elevated anti-streptolysin O treated with prednisolone, angiotensin-converting enzyme inhibitor, and angiotensin II receptor antagonist.
Ito S, Kuriyama H, Iino N, Iguchi S, Shimada H, Ueno M, Narita I, Nakano M, Nishi S, Karasawa R, Gejyo F
Clin Exp Nephrol 2003 Dec;7(4):290-5. doi: 10.1007/s10157-003-0244-0. PMID: 14712359

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