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Metastatic Medulloblastoma

MedGen UID:
1783727
•Concept ID:
C5447976
•
Neoplastic Process

Definition

Medulloblastoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Medulloblastoma

Professional guidelines

PubMed

Intrathecal delivery of nanoparticle PARP inhibitor to the cerebrospinal fluid for the treatment of metastatic medulloblastoma.
Khang M, Lee JH, Lee T, Suh HW, Lee S, Cavaliere A, Rushing A, Geraldo LH, Belitzky E, Rossano S, de Feyter HM, Shin K, Huttner A, Roussel MF, Thomas JL, Carson RE, Marquez-Nostra B, Bindra RS, Saltzman WM
Sci Transl Med 2023 Nov;15(720):eadi1617. Epub 2023 Nov 1 doi: 10.1126/scitranslmed.adi1617. PMID: 37910601Free PMC Article
Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma-an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial.
Dietzsch S, Braesigk A, Seidel C, Remmele J, Kitzing R, Schlender T, Mynarek M, Geismar D, Jablonska K, Schwarz R, Pazos M, Weber DC, Frick S, Gurtner K, Matuschek C, Harrabi SB, Glück A, Lewitzki V, Dieckmann K, Benesch M, Gerber NU, Obrecht D, Rutkowski S, Timmermann B, Kortmann RD
Strahlenther Onkol 2022 Mar;198(3):282-290. Epub 2021 Aug 5 doi: 10.1007/s00066-021-01822-0. PMID: 34351451Free PMC Article
Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma.
Donovan LK, Delaidelli A, Joseph SK, Bielamowicz K, Fousek K, Holgado BL, Manno A, Srikanthan D, Gad AZ, Van Ommeren R, Przelicki D, Richman C, Ramaswamy V, Daniels C, Pallota JG, Douglas T, Joynt ACM, Haapasalo J, Nor C, Vladoiu MC, Kuzan-Fischer CM, Garzia L, Mack SC, Varadharajan S, Baker ML, Hendrikse L, Ly M, Kharas K, Balin P, Wu X, Qin L, Huang N, Stucklin AG, Morrissy AS, Cavalli FMG, Luu B, Suarez R, De Antonellis P, Michealraj A, Rastan A, Hegde M, Komosa M, Sirbu O, Kumar SA, Abdullaev Z, Faria CC, Yip S, Hukin J, Tabori U, Hawkins C, Aldape K, Daugaard M, Maris JM, Sorensen PH, Ahmed N, Taylor MD
Nat Med 2020 May;26(5):720-731. Epub 2020 Apr 27 doi: 10.1038/s41591-020-0827-2. PMID: 32341580Free PMC Article

Recent clinical studies

Etiology

Prolonged response to vismodegib in a patient with systemic medulloblastoma metastases.
Climans SA, Macdonald DR, Sutherland DE, Mason WP
BMJ Case Rep 2020 Oct 29;13(10) doi: 10.1136/bcr-2020-236406. PMID: 33122230Free PMC Article
Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma.
Donovan LK, Delaidelli A, Joseph SK, Bielamowicz K, Fousek K, Holgado BL, Manno A, Srikanthan D, Gad AZ, Van Ommeren R, Przelicki D, Richman C, Ramaswamy V, Daniels C, Pallota JG, Douglas T, Joynt ACM, Haapasalo J, Nor C, Vladoiu MC, Kuzan-Fischer CM, Garzia L, Mack SC, Varadharajan S, Baker ML, Hendrikse L, Ly M, Kharas K, Balin P, Wu X, Qin L, Huang N, Stucklin AG, Morrissy AS, Cavalli FMG, Luu B, Suarez R, De Antonellis P, Michealraj A, Rastan A, Hegde M, Komosa M, Sirbu O, Kumar SA, Abdullaev Z, Faria CC, Yip S, Hukin J, Tabori U, Hawkins C, Aldape K, Daugaard M, Maris JM, Sorensen PH, Ahmed N, Taylor MD
Nat Med 2020 May;26(5):720-731. Epub 2020 Apr 27 doi: 10.1038/s41591-020-0827-2. PMID: 32341580Free PMC Article
Quality of life in long-term survivors treated for metastatic medulloblastoma with a hyperfractionated accelerated radiotherapy (HART) strategy.
Veneroni L, Boschetti L, Barretta F, Clerici CA, Simonetti F, Schiavello E, Biassoni V, Spreafico F, Gandola L, Pecori E, Diletto B, Poggi G, Gariboldi F, Sensi R, Massimino M
Childs Nerv Syst 2017 Nov;33(11):1969-1976. Epub 2017 Aug 2 doi: 10.1007/s00381-017-3548-1. PMID: 28770391
A Proteogenomic Approach to Understanding MYC Function in Metastatic Medulloblastoma Tumors.
Staal JA, Pei Y, Rood BR
Int J Mol Sci 2016 Oct 19;17(10) doi: 10.3390/ijms17101744. PMID: 27775567Free PMC Article
Chronic residual lesions in metastatic medulloblastoma patients.
Fried I, Huang A, Bartels U, Tabori U, Laperriere N, Dirks P, Bouffet E
J Pediatr Hematol Oncol 2014 Jan;36(1):71-5. doi: 10.1097/MPH.0b013e3182843b40. PMID: 23528902

Diagnosis

Prolonged response to vismodegib in a patient with systemic medulloblastoma metastases.
Climans SA, Macdonald DR, Sutherland DE, Mason WP
BMJ Case Rep 2020 Oct 29;13(10) doi: 10.1136/bcr-2020-236406. PMID: 33122230Free PMC Article
Induction of medulloblastoma cell apoptosis by sulforaphane, a dietary anticarcinogen from Brassica vegetables.
Gingras D, Gendron M, Boivin D, Moghrabi A, Théorêt Y, Béliveau R
Cancer Lett 2004 Jan 8;203(1):35-43. doi: 10.1016/j.canlet.2003.08.025. PMID: 14670615
Cicatricial fibromatosis mimics metastatic medulloblastoma.
Okamoto K, Ito J, Sakai K
AJNR Am J Neuroradiol 1999 Mar;20(3):472-3. PMID: 10219414Free PMC Article
Metastatic medulloblastoma simulating acute leukemia.
Chu JY
J Pediatr 1979 Jun;94(6):921-3. doi: 10.1016/s0022-3476(79)80216-4. PMID: 448535
Metastatic medulloblastoma.
Parkinson D, Ross RT, Shields CB
Can J Neurol Sci 1974 Nov;1(4):253-4. doi: 10.1017/s0317167100019867. PMID: 4441991

Therapy

Intrathecal delivery of nanoparticle PARP inhibitor to the cerebrospinal fluid for the treatment of metastatic medulloblastoma.
Khang M, Lee JH, Lee T, Suh HW, Lee S, Cavaliere A, Rushing A, Geraldo LH, Belitzky E, Rossano S, de Feyter HM, Shin K, Huttner A, Roussel MF, Thomas JL, Carson RE, Marquez-Nostra B, Bindra RS, Saltzman WM
Sci Transl Med 2023 Nov;15(720):eadi1617. Epub 2023 Nov 1 doi: 10.1126/scitranslmed.adi1617. PMID: 37910601Free PMC Article
Prolonged response to vismodegib in a patient with systemic medulloblastoma metastases.
Climans SA, Macdonald DR, Sutherland DE, Mason WP
BMJ Case Rep 2020 Oct 29;13(10) doi: 10.1136/bcr-2020-236406. PMID: 33122230Free PMC Article
Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma.
Donovan LK, Delaidelli A, Joseph SK, Bielamowicz K, Fousek K, Holgado BL, Manno A, Srikanthan D, Gad AZ, Van Ommeren R, Przelicki D, Richman C, Ramaswamy V, Daniels C, Pallota JG, Douglas T, Joynt ACM, Haapasalo J, Nor C, Vladoiu MC, Kuzan-Fischer CM, Garzia L, Mack SC, Varadharajan S, Baker ML, Hendrikse L, Ly M, Kharas K, Balin P, Wu X, Qin L, Huang N, Stucklin AG, Morrissy AS, Cavalli FMG, Luu B, Suarez R, De Antonellis P, Michealraj A, Rastan A, Hegde M, Komosa M, Sirbu O, Kumar SA, Abdullaev Z, Faria CC, Yip S, Hukin J, Tabori U, Hawkins C, Aldape K, Daugaard M, Maris JM, Sorensen PH, Ahmed N, Taylor MD
Nat Med 2020 May;26(5):720-731. Epub 2020 Apr 27 doi: 10.1038/s41591-020-0827-2. PMID: 32341580Free PMC Article
Quality of life in long-term survivors treated for metastatic medulloblastoma with a hyperfractionated accelerated radiotherapy (HART) strategy.
Veneroni L, Boschetti L, Barretta F, Clerici CA, Simonetti F, Schiavello E, Biassoni V, Spreafico F, Gandola L, Pecori E, Diletto B, Poggi G, Gariboldi F, Sensi R, Massimino M
Childs Nerv Syst 2017 Nov;33(11):1969-1976. Epub 2017 Aug 2 doi: 10.1007/s00381-017-3548-1. PMID: 28770391
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449.
Rudin CM, Hann CL, Laterra J, Yauch RL, Callahan CA, Fu L, Holcomb T, Stinson J, Gould SE, Coleman B, LoRusso PM, Von Hoff DD, de Sauvage FJ, Low JA
N Engl J Med 2009 Sep 17;361(12):1173-8. Epub 2009 Sep 2 doi: 10.1056/NEJMoa0902903. PMID: 19726761Free PMC Article

Prognosis

Case of Adult Metastatic Medulloblastoma Demonstrated on 18F-DOPA PET/CT.
Marafi F, Sadeq A, Esmail A, Usmani S
Clin Nucl Med 2022 Mar 1;47(3):e318-e320. doi: 10.1097/RLU.0000000000004037. PMID: 35025808
Prolonged response to vismodegib in a patient with systemic medulloblastoma metastases.
Climans SA, Macdonald DR, Sutherland DE, Mason WP
BMJ Case Rep 2020 Oct 29;13(10) doi: 10.1136/bcr-2020-236406. PMID: 33122230Free PMC Article
Graft versus tumor effect in the brain of a child with recurrent metastatic medulloblastoma.
Abdel-Azim H, Kapoor N, Mahadeo KM, Finlay JL
Pediatr Blood Cancer 2015 Sep;62(9):1667-9. Epub 2015 Apr 20 doi: 10.1002/pbc.25525. PMID: 25894457
Chronic residual lesions in metastatic medulloblastoma patients.
Fried I, Huang A, Bartels U, Tabori U, Laperriere N, Dirks P, Bouffet E
J Pediatr Hematol Oncol 2014 Jan;36(1):71-5. doi: 10.1097/MPH.0b013e3182843b40. PMID: 23528902
Sonographic appearance of a metastasis to the breast from a cerebellar medulloblastoma.
Ternier F, Hadjaj D, Jacquemier J
J Clin Ultrasound 2010 Jul;38(6):335-7. doi: 10.1002/jcu.20698. PMID: 20544872

Clinical prediction guides

Cerebrospinal fluid cytokines in metastatic group 3 and 4 medulloblastoma.
Low SYY, Bte Syed Sulaiman N, Tan EEK, Ng LP, Kuick CH, Chang KTE, Tang PH, Wong RX, Looi WS, Low DCY, Seow WT
BMC Cancer 2020 Jun 15;20(1):554. doi: 10.1186/s12885-020-07048-0. PMID: 32539808Free PMC Article
Quality of life in long-term survivors treated for metastatic medulloblastoma with a hyperfractionated accelerated radiotherapy (HART) strategy.
Veneroni L, Boschetti L, Barretta F, Clerici CA, Simonetti F, Schiavello E, Biassoni V, Spreafico F, Gandola L, Pecori E, Diletto B, Poggi G, Gariboldi F, Sensi R, Massimino M
Childs Nerv Syst 2017 Nov;33(11):1969-1976. Epub 2017 Aug 2 doi: 10.1007/s00381-017-3548-1. PMID: 28770391
Hand1 overexpression inhibits medulloblastoma metastasis.
Asuthkar S, Guda MR, Martin SE, Antony R, Fernandez K, Lin J, Tsung AJ, Velpula KK
Biochem Biophys Res Commun 2016 Aug 19;477(2):215-21. Epub 2016 Jun 11 doi: 10.1016/j.bbrc.2016.06.045. PMID: 27297109
Medulloblastoma subgroups remain stable across primary and metastatic compartments.
Wang X, Dubuc AM, Ramaswamy V, Mack S, Gendoo DM, Remke M, Wu X, Garzia L, Luu B, Cavalli F, Peacock J, López B, Skowron P, Zagzag D, Lyden D, Hoffman C, Cho YJ, Eberhart C, MacDonald T, Li XN, Van Meter T, Northcott PA, Haibe-Kains B, Hawkins C, Rutka JT, Bouffet E, Pfister SM, Korshunov A, Taylor MD
Acta Neuropathol 2015 Mar;129(3):449-57. Epub 2015 Jan 21 doi: 10.1007/s00401-015-1389-0. PMID: 25689980Free PMC Article
Tumor cell phagocytosis. Its occurrence in a patient with medulloblastoma.
Youness E, Barlogie B, Ahearn M, Trujillo JM
Arch Pathol Lab Med 1980 Dec;104(12):651-3. PMID: 6893661

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