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Medulloblastoma with Leptomeningeal Spread

MedGen UID:
277356
•Concept ID:
C1334685
•
Neoplastic Process

Definition

A medulloblastoma which has spread from its original site to the leptomeninges surrounding the brain and spinal cord. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMedulloblastoma with Leptomeningeal Spread

Professional guidelines

PubMed

Intrathecal delivery of nanoparticle PARP inhibitor to the cerebrospinal fluid for the treatment of metastatic medulloblastoma.
Khang M, Lee JH, Lee T, Suh HW, Lee S, Cavaliere A, Rushing A, Geraldo LH, Belitzky E, Rossano S, de Feyter HM, Shin K, Huttner A, Roussel MF, Thomas JL, Carson RE, Marquez-Nostra B, Bindra RS, Saltzman WM
Sci Transl Med 2023 Nov;15(720):eadi1617. Epub 2023 Nov 1 doi: 10.1126/scitranslmed.adi1617. PMID: 37910601Free PMC Article
Magnetic Resonance Imaging in the Contemporary Management of Medulloblastoma: Current and Emerging Applications.
Dasgupta A, Maitre M, Pungavkar S, Gupta T
Methods Mol Biol 2022;2423:187-214. doi: 10.1007/978-1-0716-1952-0_18. PMID: 34978700
Medulloblastoma in infants and children: computed tomographic follow-up after treatment.
Lee YY, Glass JP, van Eys J, Wallace S
Radiology 1985 Mar;154(3):677-82. doi: 10.1148/radiology.154.3.3969470. PMID: 3969470

Recent clinical studies

Etiology

5ALA in pediatric brain tumors is not routinely beneficial.
Roth J, Constantini S
Childs Nerv Syst 2017 May;33(5):787-792. Epub 2017 Mar 14 doi: 10.1007/s00381-017-3371-8. PMID: 28293736

Therapy

5ALA in pediatric brain tumors is not routinely beneficial.
Roth J, Constantini S
Childs Nerv Syst 2017 May;33(5):787-792. Epub 2017 Mar 14 doi: 10.1007/s00381-017-3371-8. PMID: 28293736

Prognosis

Cerebellar swelling after surgery for medulloblastoma with leptomeningeal dissemination in children. A case based-update.
Todeschi J, Stella I, Entz-Werle N, Coca HA, Joud A, Chastagner P, Proust F, Klein O
Neurochirurgie 2021 Apr;67(2):145-151. Epub 2020 Dec 16 doi: 10.1016/j.neuchi.2020.11.015. PMID: 33340509

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