U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Medulloblastoma with Leptomeningeal Spread

MedGen UID:
277356
•Concept ID:
C1334685
•
Neoplastic Process

Definition

A medulloblastoma which has spread from its original site to the leptomeninges surrounding the brain and spinal cord. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMedulloblastoma with Leptomeningeal Spread

Professional guidelines

PubMed

Intrathecal delivery of nanoparticle PARP inhibitor to the cerebrospinal fluid for the treatment of metastatic medulloblastoma.
Khang M, Lee JH, Lee T, Suh HW, Lee S, Cavaliere A, Rushing A, Geraldo LH, Belitzky E, Rossano S, de Feyter HM, Shin K, Huttner A, Roussel MF, Thomas JL, Carson RE, Marquez-Nostra B, Bindra RS, Saltzman WM
Sci Transl Med 2023 Nov;15(720):eadi1617. Epub 2023 Nov 1 doi: 10.1126/scitranslmed.adi1617. PMID: 37910601Free PMC Article
Magnetic Resonance Imaging in the Contemporary Management of Medulloblastoma: Current and Emerging Applications.
Dasgupta A, Maitre M, Pungavkar S, Gupta T
Methods Mol Biol 2022;2423:187-214. doi: 10.1007/978-1-0716-1952-0_18. PMID: 34978700
Palliative endoscopic third ventriculostomy for pediatric primary brain tumors: a single-institution case series.
Rennert RC, Brandel MG, Srinivas S, Prajapati D, Al Jammal OM, Brown NJ, Diaz-Aguilar LD, Elster J, Gonda DD, Crawford JR, Levy ML
J Neurosurg Pediatr 2021 Oct 1;28(4):387-394. Epub 2021 Aug 6 doi: 10.3171/2021.3.PEDS20952. PMID: 34359046

Recent clinical studies

Etiology

5ALA in pediatric brain tumors is not routinely beneficial.
Roth J, Constantini S
Childs Nerv Syst 2017 May;33(5):787-792. Epub 2017 Mar 14 doi: 10.1007/s00381-017-3371-8. PMID: 28293736

Therapy

5ALA in pediatric brain tumors is not routinely beneficial.
Roth J, Constantini S
Childs Nerv Syst 2017 May;33(5):787-792. Epub 2017 Mar 14 doi: 10.1007/s00381-017-3371-8. PMID: 28293736

Prognosis

Cerebellar swelling after surgery for medulloblastoma with leptomeningeal dissemination in children. A case based-update.
Todeschi J, Stella I, Entz-Werle N, Coca HA, Joud A, Chastagner P, Proust F, Klein O
Neurochirurgie 2021 Apr;67(2):145-151. Epub 2020 Dec 16 doi: 10.1016/j.neuchi.2020.11.015. PMID: 33340509

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...