Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Diffusely thickened glomerular basement membrane

MedGen UID:: 1783796
•Concept ID:: C5539480
•: Finding

HPO:	HP:0033284

Definition

Prominent glomerular basement membrane (GBM) reflecting an diffuse and relatively uniform increase in thickness (subjective estimate) with no evidence of electron dense deposits by EM. Thickening is measured from endothelial to visceral epithelial plasma membrane and mainly attributable to an increase in thickness of the lamina densa, generally to an overall thickness more than 2 standard deviations greater than that of the normal mean GBM thickness for health age- and sex matched individuals. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVDiffusely thickened glomerular basement membrane

Abnormal renal glomerulus morphology
- Glomerular deposits
  - Glomerular subepithelial deposits
    - Abnormal glomerular basement membrane morphology
      - Thickened glomerular basement membrane
        Thickened glomerular basement membranes with no electron dense deposits
        Diffusely thickened glomerular basement membrane

Recent clinical studies

Etiology

Clinical and pathological analyses of transplant glomerulopathy cases.

Shimizu T, Ishida H, Toki D, Nozaki T, Omoto K, Tanabe K, Honda K, Koike J
Nephrology (Carlton) 2014 Jun;19 Suppl 3:21-6. doi: 10.1111/nep.12243. PMID: 24842817

Idiopathic nodular glomerulosclerosis: three Japanese cases and review of the literature.

Kusaba T, Hatta T, Sonomura K, Mori Y, Tokoro T, Nagata T, Umeda Y, Nagata K, Yasuda T, Sato T, Kimura K, Matsubara H
Clin Nephrol 2007 Jan;67(1):32-7. doi: 10.5414/cnp67032. PMID: 17269597

Isolate diffuse thickening of glomerular capillary basement membrane: a renal lesion in prediabetes?

Mac-Moune Lai F, Szeto CC, Choi PC, Ho KK, Tang NL, Chow KM, Li PK, To KF
Mod Pathol 2004 Dec;17(12):1506-12. doi: 10.1038/modpathol.3800219. PMID: 15254555

Prognostic indicators in idiopathic IgA mesangial nephropathy.

D'Amico G, Minetti L, Ponticelli C, Fellin G, Ferrario F, Barbiano di Belgioioso G, Imbasciati E, Ragni A, Bertoli S, Fogazzi G
Q J Med 1986 Apr;59(228):363-78. PMID: 3749442

Renal prognosis in women with hereditary nephritis.

Grünfeld JP, Noël LH, Hafez S, Droz D
Clin Nephrol 1985 Jun;23(6):267-71. PMID: 4028523

See all (17)

Diagnosis

Nephrotic syndrome as a clinical manifestation of systemic sclerosis.

Wielosz E, Majdan M, Suszek D, Smarz-Widelska I, Korolczuk A, Korobowicz E
Rheumatol Int 2007 Sep;27(11):1087-9. Epub 2007 Apr 11 doi: 10.1007/s00296-007-0340-7. PMID: 17429639

Nodular glomerulosclerosis in a non-diabetic patient: case report and review of literature.

Navaneethan SD, Singh S, Choudhry W
J Nephrol 2005 Sep-Oct;18(5):613-5. PMID: 16299690

Nonamyloidotic fibrillar glomerulopathy and recurrent gestational anasarca.

Bakir AA, Ainis H, Rhee HL
Am J Nephrol 1990;10(4):333-8. doi: 10.1159/000168129. PMID: 2240062

Renal prognosis in women with hereditary nephritis.

Grünfeld JP, Noël LH, Hafez S, Droz D
Clin Nephrol 1985 Jun;23(6):267-71. PMID: 4028523

Renal lipidosis associated with arteriohepatic dysplasia (Alagille's syndrome).

Chung-Park M, Petrelli M, Tavill AS, Hall PW 3rd, Henoch MS, Dahms BB
Clin Nephrol 1982 Dec;18(6):314-20. PMID: 7151349

See all (32)

Therapy

Hilar lymphadenopathy, development of tubulointerstitial nephritis, and dense deposit disease following Pfizer-BioNTech COVID-19 vaccination.

Nakamura H, Ueda M, Anayama M, Makino M, Makino Y
CEN Case Rep 2023 Aug;12(3):287-291. Epub 2022 Dec 13 doi: 10.1007/s13730-022-00762-7. PMID: 36513952 Free PMC Article

Lupus podocytopathy superimposed on diabetic glomerulosclerosis: A case report.

Liu L, Murray B, Tomaszewski JE
Medicine (Baltimore) 2021 Sep 17;100(37):e27077. doi: 10.1097/MD.0000000000027077. PMID: 34664831 Free PMC Article

Renal injury following long-term exposure to carbon disulfide: analysis of a case series.

Yan Y, Wang C, Zheng Z, Qu L, Zeng D, Li M
BMC Nephrol 2019 Oct 17;20(1):377. doi: 10.1186/s12882-019-1553-1. PMID: 31623563 Free PMC Article

Clinical and pathological analyses of transplant glomerulopathy cases.

Shimizu T, Ishida H, Toki D, Nozaki T, Omoto K, Tanabe K, Honda K, Koike J
Nephrology (Carlton) 2014 Jun;19 Suppl 3:21-6. doi: 10.1111/nep.12243. PMID: 24842817

Cryoglobulinemic glomerulonephritis: a membranoproliferative glomerulonephritis induced by hepatitis C virus.

D'Amico G, Fornasieri A
Am J Kidney Dis 1995 Mar;25(3):361-9. doi: 10.1016/0272-6386(95)90095-0. PMID: 7532915

See all (14)

Prognosis

Potential relationship between eGFR(cystatin C) /eGFR(creatinine) -ratio and glomerular basement membrane thickness in diabetic kidney disease.

Öberg CM, Lindström M, Grubb A, Christensson A
Physiol Rep 2021 Jul;9(13):e14939. doi: 10.14814/phy2.14939. PMID: 34254743 Free PMC Article

Clinical and pathological analyses of transplant glomerulopathy cases.

Shimizu T, Ishida H, Toki D, Nozaki T, Omoto K, Tanabe K, Honda K, Koike J
Nephrology (Carlton) 2014 Jun;19 Suppl 3:21-6. doi: 10.1111/nep.12243. PMID: 24842817

Spectrum of collagen type IV nephropathies: from thin basement membrane nephropathy to Alport syndrome.

Vizjak A, Ferluga D
Srp Arh Celok Lek 2008 Dec;136 Suppl 4:323-6. doi: 10.2298/sarh08s4323v. PMID: 20804103

Prognostic indicators in idiopathic IgA mesangial nephropathy.

D'Amico G, Minetti L, Ponticelli C, Fellin G, Ferrario F, Barbiano di Belgioioso G, Imbasciati E, Ragni A, Bertoli S, Fogazzi G
Q J Med 1986 Apr;59(228):363-78. PMID: 3749442

A re-evaluation of diabetic glomerulosclerosis 50 years after the discovery of insulin.

Bloodworth JM Jr
Hum Pathol 1978 Jul;9(4):439-53. doi: 10.1016/s0046-8177(78)80029-x. PMID: 711223

See all (16)

Clinical prediction guides

Potential relationship between eGFR(cystatin C) /eGFR(creatinine) -ratio and glomerular basement membrane thickness in diabetic kidney disease.

Öberg CM, Lindström M, Grubb A, Christensson A
Physiol Rep 2021 Jul;9(13):e14939. doi: 10.14814/phy2.14939. PMID: 34254743 Free PMC Article

Spectrum of collagen type IV nephropathies: from thin basement membrane nephropathy to Alport syndrome.

Vizjak A, Ferluga D
Srp Arh Celok Lek 2008 Dec;136 Suppl 4:323-6. doi: 10.2298/sarh08s4323v. PMID: 20804103

Intramembranous fine deposit disease associated with collagen disorders: a new morphological entity?

Sato H, Saito T, Yoshinaga K
Virchows Arch A Pathol Anat Histopathol 1992;420(5):447-51. doi: 10.1007/BF01600517. PMID: 1595195

Prognostic indicators in idiopathic IgA mesangial nephropathy.

D'Amico G, Minetti L, Ponticelli C, Fellin G, Ferrario F, Barbiano di Belgioioso G, Imbasciati E, Ragni A, Bertoli S, Fogazzi G
Q J Med 1986 Apr;59(228):363-78. PMID: 3749442

Renal prognosis in women with hereditary nephritis.

Grünfeld JP, Noël LH, Hafez S, Droz D
Clin Nephrol 1985 Jun;23(6):267-71. PMID: 4028523

See all (24)

MedGen

National Center for Biotechnology Information

Send to:

Diffusely thickened glomerular basement membrane

Definition

Term Hierarchy

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Clinical resources

Consumer resources

Reviews

Related information

Recent activity