U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Thickened glomerular basement membranes with no electron dense deposits

MedGen UID:
1778705
•Concept ID:
C5539481
•
Finding
HPO: HP:0033285

Definition

Prominent glomerular basement membrane (GBM) reflecting an increase in thickness (subjective estimate) with no evidence of electron dense deposits by electron microscopy. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThickened glomerular basement membranes with no electron dense deposits

Recent clinical studies

Etiology

Clinicopathological features of idiopathic membranous nephropathy combined with IgA nephropathy: a retrospective analysis of 9 cases.
Hu R, Xing G, Wu H, Zhang Z
Diagn Pathol 2016 Sep 13;11(1):86. doi: 10.1186/s13000-016-0538-7. PMID: 27624606Free PMC Article
Heterogeneous histologic and clinical evolution in 3 cases of dense deposit disease with long-term follow-up.
Figuères ML, Frémeaux-Bacchi V, Rabant M, Galmiche L, Marinozzi MC, Grünfeld JP, Noël LH, Servais A
Hum Pathol 2014 Nov;45(11):2326-33. Epub 2014 Aug 16 doi: 10.1016/j.humpath.2014.07.021. PMID: 25260719
Clinical and pathological features of dense deposit disease in Chinese patients.
Wang J, Tang Z, Luo C, Hu Y, Zeng C, Chen H, Liu Z
Clin Nephrol 2012 Sep;78(3):207-15. doi: 10.5414/cn107363. PMID: 22874109
Fibronectin non-amyloid glomerulopathy.
Yong JL, Killingsworth MC, Spicer ST, Wu XJ
Int J Clin Exp Pathol 2009 Nov 20;3(2):210-6. PMID: 20126589Free PMC Article
Immunological tubulo-interstitial deposits in IgA nephropathy.
Frascà GM, Vangelista A, Biagini G, Bonomini V
Kidney Int 1982 Aug;22(2):184-91. doi: 10.1038/ki.1982.151. PMID: 6752532

Diagnosis

German Shorthaired Pointer dogs with exfoliative cutaneous lupus erythematosus develop immune-complex membranous glomerulonephropathy.
Amerman HK, Cianciolo RE, Casal ML, Mauldin E
Vet Pathol 2023 Nov;60(6):843-848. Epub 2023 May 24 doi: 10.1177/03009858231173362. PMID: 37222157Free PMC Article
Direct observation of epoxy resin blocks for renal biopsy by low-vacuum scanning electron microscopy.
Tojo A, Abe M, Matsuyama KI
Med Mol Morphol 2023 Sep;56(3):206-216. Epub 2023 May 10 doi: 10.1007/s00795-023-00356-x. PMID: 37165248Free PMC Article
Hilar lymphadenopathy, development of tubulointerstitial nephritis, and dense deposit disease following Pfizer-BioNTech COVID-19 vaccination.
Nakamura H, Ueda M, Anayama M, Makino M, Makino Y
CEN Case Rep 2023 Aug;12(3):287-291. Epub 2022 Dec 13 doi: 10.1007/s13730-022-00762-7. PMID: 36513952Free PMC Article
Thrombotic microangiopathy mimicking membranoproliferative glomerulonephritis.
Brackman D, Sartz L, Leh S, Kristoffersson AC, Bjerre A, Tati R, Frémeaux-Bacchi V, Karpman D
Nephrol Dial Transplant 2011 Oct;26(10):3399-403. Epub 2011 Aug 1 doi: 10.1093/ndt/gfr422. PMID: 21810760
Hereditary nephritis mimicking immune complex-mediated glomerulonephritis.
Nasr SH, Markowitz GS, Goldstein CS, Fildes RD, D'Agati VD
Hum Pathol 2006 May;37(5):547-54. doi: 10.1016/j.humpath.2005.12.017. PMID: 16647952

Therapy

Hilar lymphadenopathy, development of tubulointerstitial nephritis, and dense deposit disease following Pfizer-BioNTech COVID-19 vaccination.
Nakamura H, Ueda M, Anayama M, Makino M, Makino Y
CEN Case Rep 2023 Aug;12(3):287-291. Epub 2022 Dec 13 doi: 10.1007/s13730-022-00762-7. PMID: 36513952Free PMC Article
Clinical and pathological features of dense deposit disease in Chinese patients.
Wang J, Tang Z, Luo C, Hu Y, Zeng C, Chen H, Liu Z
Clin Nephrol 2012 Sep;78(3):207-15. doi: 10.5414/cn107363. PMID: 22874109
A case of living-related renal transplant from the donor with membranous nephropathy.
Akioka K, Okamoto M, Ushigome H, Nobori S, Suzuki T, Sakai K, Sakamoto S, Urasaki K, Yanagisawa A, Fukatsu A, Yoshimura N
Clin Transplant 2009 Aug;23 Suppl 20:62-6. doi: 10.1111/j.1399-0012.2009.00999.x. PMID: 19594600
Resolution of membranoproliferative glomerulonephritis complicating angiofollicular lymph node hyperplasia (Castleman's disease).
Chan TM, Cheng IK, Wong KL, Chan KW
Nephron 1993;65(4):628-32. doi: 10.1159/000187576. PMID: 8302422
Development of a lesion resembling diabetic nephropathy in a renal homograft.
Doud R, Lee DB, Waisman J, Bergstein JM
Arch Intern Med 1977 Jul;137(7):945-7. PMID: 327961

Prognosis

Heterogeneous histologic and clinical evolution in 3 cases of dense deposit disease with long-term follow-up.
Figuères ML, Frémeaux-Bacchi V, Rabant M, Galmiche L, Marinozzi MC, Grünfeld JP, Noël LH, Servais A
Hum Pathol 2014 Nov;45(11):2326-33. Epub 2014 Aug 16 doi: 10.1016/j.humpath.2014.07.021. PMID: 25260719
Clinical and pathological features of dense deposit disease in Chinese patients.
Wang J, Tang Z, Luo C, Hu Y, Zeng C, Chen H, Liu Z
Clin Nephrol 2012 Sep;78(3):207-15. doi: 10.5414/cn107363. PMID: 22874109
Thrombotic microangiopathy mimicking membranoproliferative glomerulonephritis.
Brackman D, Sartz L, Leh S, Kristoffersson AC, Bjerre A, Tati R, Frémeaux-Bacchi V, Karpman D
Nephrol Dial Transplant 2011 Oct;26(10):3399-403. Epub 2011 Aug 1 doi: 10.1093/ndt/gfr422. PMID: 21810760
Fibronectin non-amyloid glomerulopathy.
Yong JL, Killingsworth MC, Spicer ST, Wu XJ
Int J Clin Exp Pathol 2009 Nov 20;3(2):210-6. PMID: 20126589Free PMC Article
Immunological tubulo-interstitial deposits in IgA nephropathy.
Frascà GM, Vangelista A, Biagini G, Bonomini V
Kidney Int 1982 Aug;22(2):184-91. doi: 10.1038/ki.1982.151. PMID: 6752532

Clinical prediction guides

Direct observation of epoxy resin blocks for renal biopsy by low-vacuum scanning electron microscopy.
Tojo A, Abe M, Matsuyama KI
Med Mol Morphol 2023 Sep;56(3):206-216. Epub 2023 May 10 doi: 10.1007/s00795-023-00356-x. PMID: 37165248Free PMC Article
C3 glomerulonephritis associated with ANCA positivity: a case report.
Li L, Liu LQ, Yang YY, Hu ZX
BMC Nephrol 2021 Apr 21;22(1):143. doi: 10.1186/s12882-021-02354-6. PMID: 33882866Free PMC Article
Heterogeneous histologic and clinical evolution in 3 cases of dense deposit disease with long-term follow-up.
Figuères ML, Frémeaux-Bacchi V, Rabant M, Galmiche L, Marinozzi MC, Grünfeld JP, Noël LH, Servais A
Hum Pathol 2014 Nov;45(11):2326-33. Epub 2014 Aug 16 doi: 10.1016/j.humpath.2014.07.021. PMID: 25260719
Peripheral glomerular capillary wall lesions in IgA nephropathy and their implications.
Ng WL, Chan KW, Yeung CK, Kwan S
Pathology 1984 Jul;16(3):324-30. doi: 10.3109/00313028409068545. PMID: 6393013
Immunological tubulo-interstitial deposits in IgA nephropathy.
Frascà GM, Vangelista A, Biagini G, Bonomini V
Kidney Int 1982 Aug;22(2):184-91. doi: 10.1038/ki.1982.151. PMID: 6752532

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...