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Reactive lymphoid hyperplasia of lacrimal gland

MedGen UID:
1785022
•Concept ID:
C5446558
•
Pathologic Function
Synonym: Lacrimal Gland Reactive Lymphoid Hyperplasia
SNOMED CT: Reactive lymphoid hyperplasia of lacrimal gland (1197597007)

Definition

A polyclonal proliferation of lymphoid tissue in the lacrimal gland. It usually presents as painless palpable masses leading to globe displacement, decreased motility, diplopia, and ptosis. It has a tendency to involve bilateral lacrimal glands. There is a higher incidence in females and in the setting of autoimmune disease. (WHO 2018) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReactive lymphoid hyperplasia of lacrimal gland

Professional guidelines

PubMed

An analysis of IgG4-related disease (IgG4-RD) among idiopathic orbital inflammations and benign lymphoid hyperplasias using two consensus-based diagnostic criteria for IgG4-RD.
Andrew NH, Sladden N, Kearney DJ, Selva D
Br J Ophthalmol 2015 Mar;99(3):376-81. Epub 2014 Sep 2 doi: 10.1136/bjophthalmol-2014-305545. PMID: 25185258

Recent clinical studies

Etiology

Clinical characteristics, radiologic features, and histopathology of biopsied lacrimal gland tumors.
Aryasit O, Amornthatree P, Tsutsumi WD, Sittivarakul W, Geater AF, Tengtrisorn S, Prapakornkovit V
Sci Rep 2023 Oct 3;13(1):16615. doi: 10.1038/s41598-023-43817-0. PMID: 37789105Free PMC Article
IgG4-rich reactive lymphoid hyperplasia of the lacrimal gland.
Mancera N, Bajric J, Margo CE
Orbit 2020 Aug;39(4):285-288. Epub 2019 Nov 14 doi: 10.1080/01676830.2019.1687735. PMID: 31724473
Ocular adnexal reactive lymphoid hyperplasia in children.
Al-Mujaini A, Wali U, Ganesh A, Al-Hadabi I, Burney I
Middle East Afr J Ophthalmol 2012 Oct;19(4):406-9. doi: 10.4103/0974-9233.102760. PMID: 23248544Free PMC Article
Lymphadenopathy of IgG4-related disease: an underdiagnosed and overdiagnosed entity.
Cheuk W, Chan JK
Semin Diagn Pathol 2012 Nov;29(4):226-34. doi: 10.1053/j.semdp.2012.07.001. PMID: 23068302
Unifocal and multifocal reactive lymphoid hyperplasia vs follicular lymphoma of the ocular adnexa.
Stacy RC, Jakobiec FA, Schoenfield L, Singh AD
Am J Ophthalmol 2010 Sep;150(3):412-426.e1. doi: 10.1016/j.ajo.2010.04.007. PMID: 20599186

Diagnosis

Clinical characteristics, radiologic features, and histopathology of biopsied lacrimal gland tumors.
Aryasit O, Amornthatree P, Tsutsumi WD, Sittivarakul W, Geater AF, Tengtrisorn S, Prapakornkovit V
Sci Rep 2023 Oct 3;13(1):16615. doi: 10.1038/s41598-023-43817-0. PMID: 37789105Free PMC Article
Lymphoproliferative Tumors of the Ocular Adnexa.
Verdijk RM
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):132-142. doi: 10.22608/APO.2016209. PMID: 28399341
Clinical significance of routine lacrimal sac biopsy during dacryocystorhinostomy: A comprehensive review of literature.
Koturović Z, Knežević M, Rašić DM
Bosn J Basic Med Sci 2017 Feb 21;17(1):1-8. doi: 10.17305/bjbms.2016.1424. PMID: 27754826Free PMC Article
IgG4-Related Ophthalmic Disease. Part II: Clinical Aspects.
McNab AA, McKelvie P
Ophthalmic Plast Reconstr Surg 2015 May-Jun;31(3):167-78. doi: 10.1097/IOP.0000000000000364. PMID: 25564258
Lymphadenopathy of IgG4-related disease: an underdiagnosed and overdiagnosed entity.
Cheuk W, Chan JK
Semin Diagn Pathol 2012 Nov;29(4):226-34. doi: 10.1053/j.semdp.2012.07.001. PMID: 23068302

Therapy

IgG4-rich reactive lymphoid hyperplasia of the lacrimal gland.
Mancera N, Bajric J, Margo CE
Orbit 2020 Aug;39(4):285-288. Epub 2019 Nov 14 doi: 10.1080/01676830.2019.1687735. PMID: 31724473
Reactive lymphoid hyperplasia of lacrimal canaliculus caused by a silicone plug.
Han JH, Park JW, Kim SC
Ophthalmic Plast Reconstr Surg 2012 Nov-Dec;28(6):e138-40. doi: 10.1097/IOP.0b013e318249d406. PMID: 22743697
IgG4-related sclerosing disease: a critical appraisal of an evolving clinicopathologic entity.
Cheuk W, Chan JK
Adv Anat Pathol 2010 Sep;17(5):303-32. doi: 10.1097/PAP.0b013e3181ee63ce. PMID: 20733352
Lymphocytic hypophysitis with dacryoadenitis in a male patient: non-invasive diagnosis and high-dose methylprednisolone pulse therapy.
Lu Z, Li J, Ba J, Yang G, Dou J, Mu Y, Lu J
Neuro Endocrinol Lett 2009;30(6):700-4. PMID: 20038929

Prognosis

Lymphoproliferative Tumors of the Ocular Adnexa.
Verdijk RM
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):132-142. doi: 10.22608/APO.2016209. PMID: 28399341
IgG4-Related Ophthalmic Disease. Part II: Clinical Aspects.
McNab AA, McKelvie P
Ophthalmic Plast Reconstr Surg 2015 May-Jun;31(3):167-78. doi: 10.1097/IOP.0000000000000364. PMID: 25564258
Ocular adnexal reactive lymphoid hyperplasia in children.
Al-Mujaini A, Wali U, Ganesh A, Al-Hadabi I, Burney I
Middle East Afr J Ophthalmol 2012 Oct;19(4):406-9. doi: 10.4103/0974-9233.102760. PMID: 23248544Free PMC Article
Unifocal and multifocal reactive lymphoid hyperplasia vs follicular lymphoma of the ocular adnexa.
Stacy RC, Jakobiec FA, Schoenfield L, Singh AD
Am J Ophthalmol 2010 Sep;150(3):412-426.e1. doi: 10.1016/j.ajo.2010.04.007. PMID: 20599186
Lymphoproliferative lesions of the lacrimal gland: clinicopathological, immunohistochemical and molecular genetic analysis.
Farmer JP, Lamba M, Lamba WR, Jordan DR, Gilberg S, Sengar DP, Bence-Bruckler I, Burns BF
Can J Ophthalmol 2005 Apr;40(2):151-60. doi: 10.1016/S0008-4182(05)80026-2. PMID: 16049528

Clinical prediction guides

Clinico-pathological correlation of lacrimal caruncle tumors: a retrospective analysis over 22 years at the University Eye Hospital Bonn.
Clemens AC, Loeffler KU, Holz FG, Herwig-Carl MC
Graefes Arch Clin Exp Ophthalmol 2022 Apr;260(4):1415-1425. Epub 2021 Oct 28 doi: 10.1007/s00417-021-05464-x. PMID: 34709452Free PMC Article
An analysis of IgG4-related disease (IgG4-RD) among idiopathic orbital inflammations and benign lymphoid hyperplasias using two consensus-based diagnostic criteria for IgG4-RD.
Andrew NH, Sladden N, Kearney DJ, Selva D
Br J Ophthalmol 2015 Mar;99(3):376-81. Epub 2014 Sep 2 doi: 10.1136/bjophthalmol-2014-305545. PMID: 25185258
Orbital and lacrimal gland progressive transformation of germinal centres--an underdiagnosed entity?
Amin S, Ramsay A
Br J Ophthalmol 2012 Sep;96(9):1242-5. Epub 2012 Jul 11 doi: 10.1136/bjophthalmol-2012-301574. PMID: 22790435
Lymphoproliferative lesions of the ocular adnexa. Analysis of 112 cases.
Coupland SE, Krause L, Delecluse HJ, Anagnostopoulos I, Foss HD, Hummel M, Bornfeld N, Lee WR, Stein H
Ophthalmology 1998 Aug;105(8):1430-41. doi: 10.1016/S0161-6420(98)98024-1. PMID: 9709754
Immunohistochemical localization of epidermal growth factor receptor and epithelial antigen in tumors of the human conjunctiva, eyelid, lacrimal gland, and orbit.
Kodama T, Hayasaka S, Setogawa T
Graefes Arch Clin Exp Ophthalmol 1995 Nov;233(11):672-6. doi: 10.1007/BF00164668. PMID: 8566822

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