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Reduced circulating acylcarnitine concentration

MedGen UID:
1785110
•Concept ID:
C5539598
•
Finding
HPO: HP:0033445

Definition

An abnormally reduced concentration in the blood circulation of acylcarnitine, which is produced by reversible esterification of the 3-hydroxyl group of carnitine. [from HPO]

Recent clinical studies

Etiology

Markers of branched-chain amino acid catabolism are not affected by exercise training in pregnant women with obesity.
Allman BR, Spray BJ, Mercer KE, Andres A, Børsheim E
J Appl Physiol (1985) 2021 Mar 1;130(3):651-659. Epub 2021 Jan 14 doi: 10.1152/japplphysiol.00673.2020. PMID: 33444120Free PMC Article
Metabolomic profiling of patients with high gradient aortic stenosis undergoing transcatheter aortic valve replacement.
Haase D, Bäz L, Bekfani T, Neugebauer S, Kiehntopf M, Möbius-Winkler S, Franz M, Schulze PC
Clin Res Cardiol 2021 Mar;110(3):399-410. Epub 2020 Oct 14 doi: 10.1007/s00392-020-01754-2. PMID: 33057764Free PMC Article
Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans.
Kien CL, Bunn JY, Stevens R, Bain J, Ikayeva O, Crain K, Koves TR, Muoio DM
Am J Clin Nutr 2014 Mar;99(3):436-45. Epub 2014 Jan 15 doi: 10.3945/ajcn.113.070557. PMID: 24429541Free PMC Article
Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans.
McGill MR, Li F, Sharpe MR, Williams CD, Curry SC, Ma X, Jaeschke H
Arch Toxicol 2014 Feb;88(2):391-401. Epub 2013 Aug 25 doi: 10.1007/s00204-013-1118-1. PMID: 23979652Free PMC Article
Daily non-soy legume consumption reverses vascular impairment due to peripheral artery disease.
Zahradka P, Wright B, Weighell W, Blewett H, Baldwin A, O K, Guzman RP, Taylor CG
Atherosclerosis 2013 Oct;230(2):310-4. Epub 2013 Aug 6 doi: 10.1016/j.atherosclerosis.2013.07.048. PMID: 24075762

Diagnosis

Metabolomic profiling of patients with high gradient aortic stenosis undergoing transcatheter aortic valve replacement.
Haase D, Bäz L, Bekfani T, Neugebauer S, Kiehntopf M, Möbius-Winkler S, Franz M, Schulze PC
Clin Res Cardiol 2021 Mar;110(3):399-410. Epub 2020 Oct 14 doi: 10.1007/s00392-020-01754-2. PMID: 33057764Free PMC Article
Genistein stimulates insulin sensitivity through gut microbiota reshaping and skeletal muscle AMPK activation in obese subjects.
Guevara-Cruz M, Godinez-Salas ET, Sanchez-Tapia M, Torres-Villalobos G, Pichardo-Ontiveros E, Guizar-Heredia R, Arteaga-Sanchez L, Gamba G, Mojica-Espinosa R, Schcolnik-Cabrera A, Granados O, López-Barradas A, Vargas-Castillo A, Torre-Villalvazo I, Noriega LG, Torres N, Tovar AR
BMJ Open Diabetes Res Care 2020 Mar;8(1) doi: 10.1136/bmjdrc-2019-000948. PMID: 32152146Free PMC Article
Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure.
Bedi KC Jr, Snyder NW, Brandimarto J, Aziz M, Mesaros C, Worth AJ, Wang LL, Javaheri A, Blair IA, Margulies KB, Rame JE
Circulation 2016 Feb 23;133(8):706-16. Epub 2016 Jan 27 doi: 10.1161/CIRCULATIONAHA.115.017545. PMID: 26819374Free PMC Article

Therapy

Markers of branched-chain amino acid catabolism are not affected by exercise training in pregnant women with obesity.
Allman BR, Spray BJ, Mercer KE, Andres A, Børsheim E
J Appl Physiol (1985) 2021 Mar 1;130(3):651-659. Epub 2021 Jan 14 doi: 10.1152/japplphysiol.00673.2020. PMID: 33444120Free PMC Article
Genistein stimulates insulin sensitivity through gut microbiota reshaping and skeletal muscle AMPK activation in obese subjects.
Guevara-Cruz M, Godinez-Salas ET, Sanchez-Tapia M, Torres-Villalobos G, Pichardo-Ontiveros E, Guizar-Heredia R, Arteaga-Sanchez L, Gamba G, Mojica-Espinosa R, Schcolnik-Cabrera A, Granados O, López-Barradas A, Vargas-Castillo A, Torre-Villalvazo I, Noriega LG, Torres N, Tovar AR
BMJ Open Diabetes Res Care 2020 Mar;8(1) doi: 10.1136/bmjdrc-2019-000948. PMID: 32152146Free PMC Article
Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans.
Kien CL, Bunn JY, Stevens R, Bain J, Ikayeva O, Crain K, Koves TR, Muoio DM
Am J Clin Nutr 2014 Mar;99(3):436-45. Epub 2014 Jan 15 doi: 10.3945/ajcn.113.070557. PMID: 24429541Free PMC Article
Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans.
McGill MR, Li F, Sharpe MR, Williams CD, Curry SC, Ma X, Jaeschke H
Arch Toxicol 2014 Feb;88(2):391-401. Epub 2013 Aug 25 doi: 10.1007/s00204-013-1118-1. PMID: 23979652Free PMC Article
Muscle carnitine deficiency in patients with severe peripheral vascular disease.
Brevetti G, Angelini C, Rosa M, Carrozzo R, Perna S, Corsi M, Matarazzo A, Marcialis A
Circulation 1991 Oct;84(4):1490-5. doi: 10.1161/01.cir.84.4.1490. PMID: 1914091

Prognosis

Metabolomic profiling of patients with high gradient aortic stenosis undergoing transcatheter aortic valve replacement.
Haase D, Bäz L, Bekfani T, Neugebauer S, Kiehntopf M, Möbius-Winkler S, Franz M, Schulze PC
Clin Res Cardiol 2021 Mar;110(3):399-410. Epub 2020 Oct 14 doi: 10.1007/s00392-020-01754-2. PMID: 33057764Free PMC Article

Clinical prediction guides

Longitudinal associations of plasma metabolites with persistent fatigue among colorectal cancer survivors up to 2 years after treatment.
van Roekel EH, Bours MJL, Breukink SO, Aquarius M, Keulen ETP, Gicquiau A, Rinaldi S, Vineis P, Arts ICW, Gunter MJ, Leitzmann MF, Scalbert A, Weijenberg MP
Int J Cancer 2023 Jan 15;152(2):214-226. Epub 2022 Sep 2 doi: 10.1002/ijc.34252. PMID: 36054767Free PMC Article
Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure.
Bedi KC Jr, Snyder NW, Brandimarto J, Aziz M, Mesaros C, Worth AJ, Wang LL, Javaheri A, Blair IA, Margulies KB, Rame JE
Circulation 2016 Feb 23;133(8):706-16. Epub 2016 Jan 27 doi: 10.1161/CIRCULATIONAHA.115.017545. PMID: 26819374Free PMC Article
Plasma and urine free L-carnitine in human diabetes mellitus.
De Palo E, Gatti R, Sicolo N, Padovan D, Vettor R, Federspil G
Acta Diabetol Lat 1981;18(1):91-5. doi: 10.1007/BF02056110. PMID: 7211090

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