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Glomerular lipoprotein thrombus

MedGen UID:
1785875
•Concept ID:
C5539489
•
Finding
HPO: HP:0033294

Definition

Intracapillary silver-positive material that is finely vacuolated and laminated, and stains with oil red O on frozen sections. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlomerular lipoprotein thrombus

Recent clinical studies

Etiology

Inflammation drives residual risk in chronic kidney disease: a CANTOS substudy.
Ridker PM, Tuttle KR, Perkovic V, Libby P, MacFadyen JG
Eur Heart J 2022 Dec 7;43(46):4832-4844. doi: 10.1093/eurheartj/ehac444. PMID: 35943897
Anti-PLA2R antibody measured by ELISA predicts the risk of vein thrombosis in patients with primary membranous nephropathy.
Zhu H, Xu L, Liu X, Liu B, Zhai C, Wang R, Yang X
Ren Fail 2022 Dec;44(1):594-600. doi: 10.1080/0886022X.2022.2057861. PMID: 35380081Free PMC Article
High frequency of aspirin resistance in patients with nephrotic syndrome.
Akoglu H, Agbaht K, Piskinpasa S, Falay MY, Dede F, Ozet G, Odabas AR
Nephrol Dial Transplant 2012 Apr;27(4):1460-6. Epub 2011 Aug 23 doi: 10.1093/ndt/gfr476. PMID: 21865214
HMG CoA reductase inhibitors and renoprotection: the weight of the evidence.
Romayne Kurukulasuriya L, Athappan G, Saab G, Whaley Connell A, Sowers JR
Ther Adv Cardiovasc Dis 2007 Oct;1(1):49-59. doi: 10.1177/1753944707082714. PMID: 19124395
Serum lipoprotein (a) concentration in patients with nephrotic syndrome and its clinical implication.
Yang X, Wang H, Zhu Z, Deng A
J Tongji Med Univ 1998;18(4):236-8. doi: 10.1007/BF02886481. PMID: 10806854

Diagnosis

Inflammation drives residual risk in chronic kidney disease: a CANTOS substudy.
Ridker PM, Tuttle KR, Perkovic V, Libby P, MacFadyen JG
Eur Heart J 2022 Dec 7;43(46):4832-4844. doi: 10.1093/eurheartj/ehac444. PMID: 35943897
Anti-PLA2R antibody measured by ELISA predicts the risk of vein thrombosis in patients with primary membranous nephropathy.
Zhu H, Xu L, Liu X, Liu B, Zhai C, Wang R, Yang X
Ren Fail 2022 Dec;44(1):594-600. doi: 10.1080/0886022X.2022.2057861. PMID: 35380081Free PMC Article
High frequency of aspirin resistance in patients with nephrotic syndrome.
Akoglu H, Agbaht K, Piskinpasa S, Falay MY, Dede F, Ozet G, Odabas AR
Nephrol Dial Transplant 2012 Apr;27(4):1460-6. Epub 2011 Aug 23 doi: 10.1093/ndt/gfr476. PMID: 21865214
A case of recurrent focal segmental glomerulosclerosis (FSGS) involving massive proteinuria (>50 g/day) immediately after renal transplantation.
Okamoto M, Koshino K, Sakai K, Nobori S, Matsuyama M, Ushigome H, Okajima H, Masuzawa N, Yoshimura N
Clin Transplant 2011 Jul;25 Suppl 23:53-8. doi: 10.1111/j.1399-0012.2011.01455.x. PMID: 21623916
Interaction of endothelial cells and triglyceride-rich lipoproteins with apolipoprotein E (Arg-->Cys) from a patient with lipoprotein glomerulopathy.
Murano T, Matsumura R, Misawa Y, Ozaki H, Miyashita Y, Yoshida S, Sueioshi M, Sugiyama T, Shirai K
Metabolism 2002 Feb;51(2):201-5. doi: 10.1053/meta.2002.29990. PMID: 11833049

Therapy

Inflammation drives residual risk in chronic kidney disease: a CANTOS substudy.
Ridker PM, Tuttle KR, Perkovic V, Libby P, MacFadyen JG
Eur Heart J 2022 Dec 7;43(46):4832-4844. doi: 10.1093/eurheartj/ehac444. PMID: 35943897
The Effects of 2'-O-Methoxyethyl Oligonucleotides on Renal Function in Humans.
Crooke ST, Baker BF, Pham NC, Hughes SG, Kwoh TJ, Cai D, Tsimikas S, Geary RS, Bhanot S
Nucleic Acid Ther 2018 Feb;28(1):10-22. Epub 2017 Nov 29 doi: 10.1089/nat.2017.0693. PMID: 29185862Free PMC Article
HMG CoA reductase inhibitors and renoprotection: the weight of the evidence.
Romayne Kurukulasuriya L, Athappan G, Saab G, Whaley Connell A, Sowers JR
Ther Adv Cardiovasc Dis 2007 Oct;1(1):49-59. doi: 10.1177/1753944707082714. PMID: 19124395
Omega-3 fatty acid supplementation and lipoprotein(a) concentrations in patients with chronic glomerular diseases.
Lenzi S, Caprioli R, Rindi P, Lazzerini G, Bernini W, Pardini E, Lucchetti A, Galli C, Carr L, De Caterina R
Nephron 1996;72(3):383-90. doi: 10.1159/000188900. PMID: 8852484
Clinical pharmacokinetics of heparin.
Estes JW
Clin Pharmacokinet 1980 May-Jun;5(3):204-20. doi: 10.2165/00003088-198005030-00002. PMID: 6993082

Prognosis

Clinicopathological characteristics and gene mutations in 11 patients with lipoprotein glomerulopathy.
Qin Y, Sun XJ, Hu YF, Jing M, Yu XJ, Zhao MH, Tan Y
Ren Fail 2024 Dec;46(1):2332491. Epub 2024 Mar 26 doi: 10.1080/0886022X.2024.2332491. PMID: 38584145Free PMC Article
Inflammation drives residual risk in chronic kidney disease: a CANTOS substudy.
Ridker PM, Tuttle KR, Perkovic V, Libby P, MacFadyen JG
Eur Heart J 2022 Dec 7;43(46):4832-4844. doi: 10.1093/eurheartj/ehac444. PMID: 35943897
Anti-PLA2R antibody measured by ELISA predicts the risk of vein thrombosis in patients with primary membranous nephropathy.
Zhu H, Xu L, Liu X, Liu B, Zhai C, Wang R, Yang X
Ren Fail 2022 Dec;44(1):594-600. doi: 10.1080/0886022X.2022.2057861. PMID: 35380081Free PMC Article
High frequency of aspirin resistance in patients with nephrotic syndrome.
Akoglu H, Agbaht K, Piskinpasa S, Falay MY, Dede F, Ozet G, Odabas AR
Nephrol Dial Transplant 2012 Apr;27(4):1460-6. Epub 2011 Aug 23 doi: 10.1093/ndt/gfr476. PMID: 21865214
A case of recurrent focal segmental glomerulosclerosis (FSGS) involving massive proteinuria (>50 g/day) immediately after renal transplantation.
Okamoto M, Koshino K, Sakai K, Nobori S, Matsuyama M, Ushigome H, Okajima H, Masuzawa N, Yoshimura N
Clin Transplant 2011 Jul;25 Suppl 23:53-8. doi: 10.1111/j.1399-0012.2011.01455.x. PMID: 21623916

Clinical prediction guides

Clinicopathological characteristics and gene mutations in 11 patients with lipoprotein glomerulopathy.
Qin Y, Sun XJ, Hu YF, Jing M, Yu XJ, Zhao MH, Tan Y
Ren Fail 2024 Dec;46(1):2332491. Epub 2024 Mar 26 doi: 10.1080/0886022X.2024.2332491. PMID: 38584145Free PMC Article
Inflammation drives residual risk in chronic kidney disease: a CANTOS substudy.
Ridker PM, Tuttle KR, Perkovic V, Libby P, MacFadyen JG
Eur Heart J 2022 Dec 7;43(46):4832-4844. doi: 10.1093/eurheartj/ehac444. PMID: 35943897
Anti-PLA2R antibody measured by ELISA predicts the risk of vein thrombosis in patients with primary membranous nephropathy.
Zhu H, Xu L, Liu X, Liu B, Zhai C, Wang R, Yang X
Ren Fail 2022 Dec;44(1):594-600. doi: 10.1080/0886022X.2022.2057861. PMID: 35380081Free PMC Article
The Effects of 2'-O-Methoxyethyl Oligonucleotides on Renal Function in Humans.
Crooke ST, Baker BF, Pham NC, Hughes SG, Kwoh TJ, Cai D, Tsimikas S, Geary RS, Bhanot S
Nucleic Acid Ther 2018 Feb;28(1):10-22. Epub 2017 Nov 29 doi: 10.1089/nat.2017.0693. PMID: 29185862Free PMC Article
Interaction of endothelial cells and triglyceride-rich lipoproteins with apolipoprotein E (Arg-->Cys) from a patient with lipoprotein glomerulopathy.
Murano T, Matsumura R, Misawa Y, Ozaki H, Miyashita Y, Yoshida S, Sueioshi M, Sugiyama T, Shirai K
Metabolism 2002 Feb;51(2):201-5. doi: 10.1053/meta.2002.29990. PMID: 11833049

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