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Segmentally thickened glomerular basement membrane

MedGen UID:
1785994
•Concept ID:
C5539479
•
Finding
HPO: HP:0033283

Definition

Prominent glomerular basement membrane (GBM) reflecting a segmental and increase in thickness (subjective estimate) with no evidence of electron dense deposits by EM. Thickening is measured from endothelial to visceral epithelial plasma membrane and mainly attributable to an increase in thickness of the lamina densa, generally to an overall thickness more than 2 standard deviations greater than that of the normal mean GBM thickness for health age- and sex matched individuals. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSegmentally thickened glomerular basement membrane

Professional guidelines

PubMed

Thickening of glomerular capillary walls: a guide to differential diagnosis by electron microscopy.
Seymour AE, Canny A, Spargo BH
Ultrastruct Pathol 1983 Mar-Apr;4(2-3):123-43. doi: 10.3109/01913128309140784. PMID: 6879730

Recent clinical studies

Etiology

Pathological influence of obesity on renal structural changes in chronic kidney disease.
Kato S, Nazneen A, Nakashima Y, Razzaque MS, Nishino T, Furusu A, Yorioka N, Taguchi T
Clin Exp Nephrol 2009 Aug;13(4):332-340. Epub 2009 Apr 29 doi: 10.1007/s10157-009-0169-3. PMID: 19533267
Ultrastructural examination of glomerular and tubular changes in renal allografts with cyclosporine toxicity.
Nacar A, Kiyici H, Oğüş E, Zağyapan R, Demirhan B, Ozdemir H, Haberal M
Ren Fail 2006;28(7):543-7. doi: 10.1080/08860220600923086. PMID: 17050236
Benign nephrosclerosis: incidence, morphology and prognosis.
Takebayashi S, Kiyoshi Y, Hisano S, Uesugi N, Sasatomi Y, Meng J, Sakata N
Clin Nephrol 2001 May;55(5):349-56. PMID: 11393379
Tubulointerstitial lesions in non-insulin dependent diabetes mellitus.
Ueno M, Kawashima S, Nishi S, Shimada H, Karasawa R, Suzuki Y, Maruyama Y, Arakawa M
Kidney Int Suppl 1997 Dec;63:S191-4. PMID: 9407456
Prognostic indicators in idiopathic IgA mesangial nephropathy.
D'Amico G, Minetti L, Ponticelli C, Fellin G, Ferrario F, Barbiano di Belgioioso G, Imbasciati E, Ragni A, Bertoli S, Fogazzi G
Q J Med 1986 Apr;59(228):363-78. PMID: 3749442

Diagnosis

Histological Manifestations of Diabetic Kidney Disease and its Relationship with Insulin Resistance.
Adeva-Andany MM, Adeva-Contreras L, Fernández-Fernández C, Carneiro-Freire N, Domínguez-Montero A
Curr Diabetes Rev 2023;19(1):e280322202705. doi: 10.2174/1573399818666220328145046. PMID: 35346008
Clinicopathological characteristics of high-altitude polycythemia-related kidney disease in Tibetan inhabitants.
Wang H, Tang C, Dang Z, Yong A, Liu L, Wang S, Zhao M
Kidney Int 2022 Jul;102(1):196-206. Epub 2022 May 2 doi: 10.1016/j.kint.2022.03.027. PMID: 35513124
Pathologic classification of diabetic nephropathy.
Tervaert TW, Mooyaart AL, Amann K, Cohen AH, Cook HT, Drachenberg CB, Ferrario F, Fogo AB, Haas M, de Heer E, Joh K, Noël LH, Radhakrishnan J, Seshan SV, Bajema IM, Bruijn JA; Renal Pathology Society
J Am Soc Nephrol 2010 Apr;21(4):556-63. Epub 2010 Feb 18 doi: 10.1681/ASN.2010010010. PMID: 20167701
Spectrum of collagen type IV nephropathies: from thin basement membrane nephropathy to Alport syndrome.
Vizjak A, Ferluga D
Srp Arh Celok Lek 2008 Dec;136 Suppl 4:323-6. doi: 10.2298/sarh08s4323v. PMID: 20804103
Kidney disease.
Mihatsch MJ, Zollinger HU
Pathol Res Pract 1980 May;167(1):88-117. doi: 10.1016/S0344-0338(80)80183-X. PMID: 7454603

Therapy

Lupus podocytopathy superimposed on diabetic glomerulosclerosis: A case report.
Liu L, Murray B, Tomaszewski JE
Medicine (Baltimore) 2021 Sep 17;100(37):e27077. doi: 10.1097/MD.0000000000027077. PMID: 34664831Free PMC Article
Renal injury following long-term exposure to carbon disulfide: analysis of a case series.
Yan Y, Wang C, Zheng Z, Qu L, Zeng D, Li M
BMC Nephrol 2019 Oct 17;20(1):377. doi: 10.1186/s12882-019-1553-1. PMID: 31623563Free PMC Article
MYO1E mutations and childhood familial focal segmental glomerulosclerosis.
Mele C, Iatropoulos P, Donadelli R, Calabria A, Maranta R, Cassis P, Buelli S, Tomasoni S, Piras R, Krendel M, Bettoni S, Morigi M, Delledonne M, Pecoraro C, Abbate I, Capobianchi MR, Hildebrandt F, Otto E, Schaefer F, Macciardi F, Ozaltin F, Emre S, Ibsirlioglu T, Benigni A, Remuzzi G, Noris M; PodoNet Consortium
N Engl J Med 2011 Jul 28;365(4):295-306. Epub 2011 Jul 14 doi: 10.1056/NEJMoa1101273. PMID: 21756023Free PMC Article
Ultrastructural examination of glomerular and tubular changes in renal allografts with cyclosporine toxicity.
Nacar A, Kiyici H, Oğüş E, Zağyapan R, Demirhan B, Ozdemir H, Haberal M
Ren Fail 2006;28(7):543-7. doi: 10.1080/08860220600923086. PMID: 17050236
Cryoglobulinemic glomerulonephritis: a membranoproliferative glomerulonephritis induced by hepatitis C virus.
D'Amico G, Fornasieri A
Am J Kidney Dis 1995 Mar;25(3):361-9. doi: 10.1016/0272-6386(95)90095-0. PMID: 7532915

Prognosis

An atypical anti-GBM disease complicated by idiopathic nodular glomerulosclerosis: Case report.
Qin J, Zhu T, Zhang H, Ou S
Clin Nephrol 2023 Feb;99(2):98-104. doi: 10.5414/CN110962. PMID: 36519941
Spectrum of collagen type IV nephropathies: from thin basement membrane nephropathy to Alport syndrome.
Vizjak A, Ferluga D
Srp Arh Celok Lek 2008 Dec;136 Suppl 4:323-6. doi: 10.2298/sarh08s4323v. PMID: 20804103
Benign nephrosclerosis: incidence, morphology and prognosis.
Takebayashi S, Kiyoshi Y, Hisano S, Uesugi N, Sasatomi Y, Meng J, Sakata N
Clin Nephrol 2001 May;55(5):349-56. PMID: 11393379
Nature of progressive glomerulosclerosis in human membranous nephropathy.
Lee HS, Koh HI
Clin Nephrol 1993 Jan;39(1):7-16. PMID: 8428410
Prognostic indicators in idiopathic IgA mesangial nephropathy.
D'Amico G, Minetti L, Ponticelli C, Fellin G, Ferrario F, Barbiano di Belgioioso G, Imbasciati E, Ragni A, Bertoli S, Fogazzi G
Q J Med 1986 Apr;59(228):363-78. PMID: 3749442

Clinical prediction guides

Clinicopathological characteristics of high-altitude polycythemia-related kidney disease in Tibetan inhabitants.
Wang H, Tang C, Dang Z, Yong A, Liu L, Wang S, Zhao M
Kidney Int 2022 Jul;102(1):196-206. Epub 2022 May 2 doi: 10.1016/j.kint.2022.03.027. PMID: 35513124
Renal glomerular alterations in patients with cancer: a clinical and immunohistochemical autopsy study.
Faria TV, Baptista MA, Burdmann EA, Cury PM
Ren Fail 2010;32(8):918-22. doi: 10.3109/0886022X.2010.502278. PMID: 20722557
Spectrum of collagen type IV nephropathies: from thin basement membrane nephropathy to Alport syndrome.
Vizjak A, Ferluga D
Srp Arh Celok Lek 2008 Dec;136 Suppl 4:323-6. doi: 10.2298/sarh08s4323v. PMID: 20804103
Proteinuria in a child with sialidosis: case report and histological studies.
Kashtan CE, Nevins TE, Posalaky Z, Vernier RL, Fish AJ
Pediatr Nephrol 1989 Apr;3(2):166-74. doi: 10.1007/BF00852901. PMID: 2701867
Prognostic indicators in idiopathic IgA mesangial nephropathy.
D'Amico G, Minetti L, Ponticelli C, Fellin G, Ferrario F, Barbiano di Belgioioso G, Imbasciati E, Ragni A, Bertoli S, Fogazzi G
Q J Med 1986 Apr;59(228):363-78. PMID: 3749442

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