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Glomerular endocapillary leukocyte hypercellularity

MedGen UID:
1788168
•Concept ID:
C5539638
•
Finding
Synonym: Glomerular endocapillary hypercellularity consisting of leukocytes
 
HPO: HP:0033488

Definition

Increased number of leukocytes internal to the glomerular basement membrane (GBM), but not limited to within glomerular capillaries. [from HPO]

Recent clinical studies

Etiology

Genetic Variant CFH rs6677604 Might Play a Protective Role in lupus Nephritis.
Tao J, Tan M, Li LL, Chu H, Song D, Tan Y, Wang SX, Qu Z, Yu F
Am J Med Sci 2021 Mar;361(3):336-343. Epub 2020 Oct 9 doi: 10.1016/j.amjms.2020.10.008. PMID: 33309135
Studying cytokines of T helper cells in the kidney disease of IgA vasculitis (Henoch-Schönlein purpura).
Gülhan B, Orhan D, Kale G, Besbas N, Özen S
Pediatr Nephrol 2015 Aug;30(8):1269-77. Epub 2015 Feb 4 doi: 10.1007/s00467-015-3051-4. PMID: 25648880
The spectrum of renal thrombotic microangiopathy in lupus nephritis.
Song D, Wu LH, Wang FM, Yang XW, Zhu D, Chen M, Yu F, Liu G, Zhao MH
Arthritis Res Ther 2013 Jan 15;15(1):R12. doi: 10.1186/ar4142. PMID: 23320601Free PMC Article
Histological differences in new-onset IgA nephropathy between children and adults.
Ikezumi Y, Suzuki T, Imai N, Ueno M, Narita I, Kawachi H, Shimizu F, Nikolic-Paterson DJ, Uchiyama M
Nephrol Dial Transplant 2006 Dec;21(12):3466-74. Epub 2006 Aug 25 doi: 10.1093/ndt/gfl455. PMID: 16935895
Intraglomerular T cells and monocytes in nephritis: study with monoclonal antibodies.
Nolasco FE, Cameron JS, Hartley B, Coelho A, Hildreth G, Reuben R
Kidney Int 1987 May;31(5):1160-6. doi: 10.1038/ki.1987.123. PMID: 3496476

Diagnosis

Studying cytokines of T helper cells in the kidney disease of IgA vasculitis (Henoch-Schönlein purpura).
Gülhan B, Orhan D, Kale G, Besbas N, Özen S
Pediatr Nephrol 2015 Aug;30(8):1269-77. Epub 2015 Feb 4 doi: 10.1007/s00467-015-3051-4. PMID: 25648880
The spectrum of renal thrombotic microangiopathy in lupus nephritis.
Song D, Wu LH, Wang FM, Yang XW, Zhu D, Chen M, Yu F, Liu G, Zhao MH
Arthritis Res Ther 2013 Jan 15;15(1):R12. doi: 10.1186/ar4142. PMID: 23320601Free PMC Article
Late onset lupus nephritis in Chinese patients: classified by the 2003 International Society of Nephrology and Renal Pathology Society system.
Xu YX, Tan Y, Yu F, Zhao MH
Lupus 2011 Jul;20(8):801-8. Epub 2011 May 4 doi: 10.1177/0961203310397563. PMID: 21543512
Histological differences in new-onset IgA nephropathy between children and adults.
Ikezumi Y, Suzuki T, Imai N, Ueno M, Narita I, Kawachi H, Shimizu F, Nikolic-Paterson DJ, Uchiyama M
Nephrol Dial Transplant 2006 Dec;21(12):3466-74. Epub 2006 Aug 25 doi: 10.1093/ndt/gfl455. PMID: 16935895

Prognosis

Histological differences in new-onset IgA nephropathy between children and adults.
Ikezumi Y, Suzuki T, Imai N, Ueno M, Narita I, Kawachi H, Shimizu F, Nikolic-Paterson DJ, Uchiyama M
Nephrol Dial Transplant 2006 Dec;21(12):3466-74. Epub 2006 Aug 25 doi: 10.1093/ndt/gfl455. PMID: 16935895
Characteristics of acute glomerulonephritis associated with human parvovirus B19 infection.
Ieiri N, Hotta O, Taguma Y
Clin Nephrol 2005 Oct;64(4):249-57. doi: 10.5414/cnp64249. PMID: 16240895
Grading of acute and chronic renal lesions in Henoch-Schönlein purpura.
Szeto CC, Choi PC, To KF, Li PK, Hui J, Chow KM, Leung CB, Lui SF, Mac-Moune Lai F
Mod Pathol 2001 Jul;14(7):635-40. doi: 10.1038/modpathol.3880364. PMID: 11454994

Clinical prediction guides

Genetic Variant CFH rs6677604 Might Play a Protective Role in lupus Nephritis.
Tao J, Tan M, Li LL, Chu H, Song D, Tan Y, Wang SX, Qu Z, Yu F
Am J Med Sci 2021 Mar;361(3):336-343. Epub 2020 Oct 9 doi: 10.1016/j.amjms.2020.10.008. PMID: 33309135
Studying cytokines of T helper cells in the kidney disease of IgA vasculitis (Henoch-Schönlein purpura).
Gülhan B, Orhan D, Kale G, Besbas N, Özen S
Pediatr Nephrol 2015 Aug;30(8):1269-77. Epub 2015 Feb 4 doi: 10.1007/s00467-015-3051-4. PMID: 25648880
The spectrum of renal thrombotic microangiopathy in lupus nephritis.
Song D, Wu LH, Wang FM, Yang XW, Zhu D, Chen M, Yu F, Liu G, Zhao MH
Arthritis Res Ther 2013 Jan 15;15(1):R12. doi: 10.1186/ar4142. PMID: 23320601Free PMC Article
Grading of acute and chronic renal lesions in Henoch-Schönlein purpura.
Szeto CC, Choi PC, To KF, Li PK, Hui J, Chow KM, Leung CB, Lui SF, Mac-Moune Lai F
Mod Pathol 2001 Jul;14(7):635-40. doi: 10.1038/modpathol.3880364. PMID: 11454994
Intraglomerular monocytes in human glomerulonephritis.
Kobayashi M, Koyama A, Narita M, Shigematsu H
Nephron 1991;59(4):580-5. doi: 10.1159/000186647. PMID: 1766496

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