U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Breast Classic Lobular Carcinoma In Situ

MedGen UID:
1788998
•Concept ID:
C5446877
•
Neoplastic Process
Synonym: Breast Classic LCIS

Definition

Breast lobular carcinoma in situ characterized by the presence of dyscohesive proliferations of type A and/or type B epithelial cells. Type A cells are small cells with uniform hyperchromatic nuclei, whereas type B cells have slightly larger vesicular nuclei, with mild variability in size and shape and with small nucleoli. The cell populations may be mixed in individual proliferations. (WHO 2019) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Classic Lobular Carcinoma In Situ

Professional guidelines

PubMed

Evolving Treatment Paradigms for Low-Risk Ductal Carcinoma In Situ: Imaging Needs.
Nguyen DL, Greenwood HI, Rahbar H, Grimm LJ
AJR Am J Roentgenol 2024 Mar;222(3):e2330503. Epub 2023 Dec 13 doi: 10.2214/AJR.23.30503. PMID: 38090808
The morphologic spectrum of lobular carcinoma in situ (LCIS) observations on clinical significance, management implications and diagnostic pitfalls of classic, florid and pleomorphic LCIS.
Brogi E
Virchows Arch 2022 Dec;481(6):823-837. Epub 2022 May 14 doi: 10.1007/s00428-022-03299-3. PMID: 35567633
Lobular carcinoma in situ: diagnostic criteria and molecular correlates.
Sokolova A, Lakhani SR
Mod Pathol 2021 Jan;34(Suppl 1):8-14. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00689-3. PMID: 33024303

Recent clinical studies

Etiology

Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Lobular Neoplasia.
Lunt L, Coogan A, Perez CB
Surg Clin North Am 2022 Dec;102(6):947-963. doi: 10.1016/j.suc.2022.07.001. PMID: 36335930
Ductal Carcinoma in Situ: State-of-the-Art Review.
Grimm LJ, Rahbar H, Abdelmalak M, Hall AH, Ryser MD
Radiology 2022 Feb;302(2):246-255. Epub 2021 Dec 21 doi: 10.1148/radiol.211839. PMID: 34931856Free PMC Article
Adenomyoepithelioma of the breast: a proposal for classification.
Rakha E, Tan PH, Ellis I, Quinn C
Histopathology 2021 Oct;79(4):465-479. Epub 2021 Jun 13 doi: 10.1111/his.14380. PMID: 33829532
Lobular Carcinoma In Situ.
Wen HY, Brogi E
Surg Pathol Clin 2018 Mar;11(1):123-145. Epub 2017 Dec 8 doi: 10.1016/j.path.2017.09.009. PMID: 29413653Free PMC Article

Diagnosis

Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Lobular Neoplasia.
Lunt L, Coogan A, Perez CB
Surg Clin North Am 2022 Dec;102(6):947-963. doi: 10.1016/j.suc.2022.07.001. PMID: 36335930
Ductal Carcinoma in Situ: State-of-the-Art Review.
Grimm LJ, Rahbar H, Abdelmalak M, Hall AH, Ryser MD
Radiology 2022 Feb;302(2):246-255. Epub 2021 Dec 21 doi: 10.1148/radiol.211839. PMID: 34931856Free PMC Article
Adenomyoepithelioma of the breast: a proposal for classification.
Rakha E, Tan PH, Ellis I, Quinn C
Histopathology 2021 Oct;79(4):465-479. Epub 2021 Jun 13 doi: 10.1111/his.14380. PMID: 33829532
Lobular Carcinoma In Situ.
Wen HY, Brogi E
Surg Pathol Clin 2018 Mar;11(1):123-145. Epub 2017 Dec 8 doi: 10.1016/j.path.2017.09.009. PMID: 29413653Free PMC Article

Therapy

Supplemental Breast Cancer Screening in Women with Dense Breasts and Negative Mammography: A Systematic Review and Meta-Analysis.
Hussein H, Abbas E, Keshavarzi S, Fazelzad R, Bukhanov K, Kulkarni S, Au F, Ghai S, Alabousi A, Freitas V
Radiology 2023 Mar;306(3):e221785. Epub 2023 Jan 31 doi: 10.1148/radiol.221785. PMID: 36719288
FISH and HER2/neu equivocal immunohistochemistry in breast carcinoma.
Patil Okaly GV, Panwar D, Lingappa KB, Kumari P, Anand A, Kumar P, Chikkalingaiah MH, Kumar RV
Indian J Cancer 2019 Apr-Jun;56(2):119-123. doi: 10.4103/ijc.IJC_333_18. PMID: 31062729
Breast-conserving surgery for pure non-classic lobular carcinoma in situ: A single institution's experience.
Hoffman DI, Zhang PJ, Tchou J
Surg Oncol 2019 Mar;28:190-194. Epub 2019 Jan 29 doi: 10.1016/j.suronc.2019.01.009. PMID: 30851899
Treatment Outcomes for Pleomorphic Lobular Carcinoma In Situ of the Breast.
Desai AA, Jimenez RE, Hoskin TL, Day CN, Boughey JC, Hieken TJ
Ann Surg Oncol 2018 Oct;25(10):3064-3068. Epub 2018 Jun 26 doi: 10.1245/s10434-018-6591-6. PMID: 29947004
UK national survey of management of breast lobular carcinoma in situ.
Chester R, Bokinni O, Ahmed I, Kasem A
Ann R Coll Surg Engl 2015 Nov;97(8):574-7. doi: 10.1308/rcsann.2015.0037. PMID: 26492902Free PMC Article

Prognosis

Absence of lobular carcinoma in situ is a poor prognostic marker in invasive lobular carcinoma.
Mouabbi JA, Raghavendra AS, Bassett RL Jr, Christgen M, Middleton L, Teshome M, Nasrazadani A, Hortobagyi G, Hassan A, Tripathy D, Layman RM
Eur J Cancer 2023 Sep;191:113250. Epub 2023 Jul 22 doi: 10.1016/j.ejca.2023.113250. PMID: 37573674Free PMC Article
Supplemental Breast Cancer Screening in Women with Dense Breasts and Negative Mammography: A Systematic Review and Meta-Analysis.
Hussein H, Abbas E, Keshavarzi S, Fazelzad R, Bukhanov K, Kulkarni S, Au F, Ghai S, Alabousi A, Freitas V
Radiology 2023 Mar;306(3):e221785. Epub 2023 Jan 31 doi: 10.1148/radiol.221785. PMID: 36719288
The morphologic spectrum of lobular carcinoma in situ (LCIS) observations on clinical significance, management implications and diagnostic pitfalls of classic, florid and pleomorphic LCIS.
Brogi E
Virchows Arch 2022 Dec;481(6):823-837. Epub 2022 May 14 doi: 10.1007/s00428-022-03299-3. PMID: 35567633
Ductal Carcinoma in Situ: State-of-the-Art Review.
Grimm LJ, Rahbar H, Abdelmalak M, Hall AH, Ryser MD
Radiology 2022 Feb;302(2):246-255. Epub 2021 Dec 21 doi: 10.1148/radiol.211839. PMID: 34931856Free PMC Article
Adenoid cystic carcinoma and basaloid carcinoma of the breast: A clinicopathological study.
Marco V, Garcia F, Rubio IT, Soler T, Ferrazza L, Roig I, Mendez I, Andreu X, Mínguez CG, Tresserra F
Rev Esp Patol 2021 Oct-Dec;54(4):242-249. Epub 2020 Dec 31 doi: 10.1016/j.patol.2020.09.005. PMID: 34544554

Clinical prediction guides

Absence of lobular carcinoma in situ is a poor prognostic marker in invasive lobular carcinoma.
Mouabbi JA, Raghavendra AS, Bassett RL Jr, Christgen M, Middleton L, Teshome M, Nasrazadani A, Hortobagyi G, Hassan A, Tripathy D, Layman RM
Eur J Cancer 2023 Sep;191:113250. Epub 2023 Jul 22 doi: 10.1016/j.ejca.2023.113250. PMID: 37573674Free PMC Article
Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Supplemental Breast Cancer Screening in Women with Dense Breasts and Negative Mammography: A Systematic Review and Meta-Analysis.
Hussein H, Abbas E, Keshavarzi S, Fazelzad R, Bukhanov K, Kulkarni S, Au F, Ghai S, Alabousi A, Freitas V
Radiology 2023 Mar;306(3):e221785. Epub 2023 Jan 31 doi: 10.1148/radiol.221785. PMID: 36719288
The morphologic spectrum of lobular carcinoma in situ (LCIS) observations on clinical significance, management implications and diagnostic pitfalls of classic, florid and pleomorphic LCIS.
Brogi E
Virchows Arch 2022 Dec;481(6):823-837. Epub 2022 May 14 doi: 10.1007/s00428-022-03299-3. PMID: 35567633
Ductal Carcinoma in Situ: State-of-the-Art Review.
Grimm LJ, Rahbar H, Abdelmalak M, Hall AH, Ryser MD
Radiology 2022 Feb;302(2):246-255. Epub 2021 Dec 21 doi: 10.1148/radiol.211839. PMID: 34931856Free PMC Article

Recent systematic reviews

Supplemental Breast Cancer Screening in Women with Dense Breasts and Negative Mammography: A Systematic Review and Meta-Analysis.
Hussein H, Abbas E, Keshavarzi S, Fazelzad R, Bukhanov K, Kulkarni S, Au F, Ghai S, Alabousi A, Freitas V
Radiology 2023 Mar;306(3):e221785. Epub 2023 Jan 31 doi: 10.1148/radiol.221785. PMID: 36719288
Risk for Upgrade to Malignancy After Breast Core Needle Biopsy Diagnosis of Lobular Neoplasia: A Systematic Review and Meta-Analysis.
Shehata MN, Rahbar H, Flanagan MR, Kilgore MR, Lee CI, Ryser MD, Lowry KP
J Am Coll Radiol 2020 Oct;17(10):1207-1219. Epub 2020 Aug 27 doi: 10.1016/j.jacr.2020.07.036. PMID: 32861602
Radioactive seed localization and wire guided localization in breast cancer: A systematic review and meta-analysis.
Wang GL, Tsikouras P, Zuo HQ, Huang MQ, Peng L, Bothou A, Zervoudis S, Tobias Teichmann A
J BUON 2019 Jan-Feb;24(1):48-60. PMID: 30941951

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...