U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Breast Classic Lobular Carcinoma In Situ

MedGen UID:
1788998
Concept ID:
C5446877
Neoplastic Process
Synonym: Breast Classic LCIS

Definition

Breast lobular carcinoma in situ characterized by the presence of dyscohesive proliferations of type A and/or type B epithelial cells. Type A cells are small cells with uniform hyperchromatic nuclei, whereas type B cells have slightly larger vesicular nuclei, with mild variability in size and shape and with small nucleoli. The cell populations may be mixed in individual proliferations. (WHO 2019) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Classic Lobular Carcinoma In Situ

Professional guidelines

PubMed

Sokolova A, Lakhani SR
Mod Pathol 2021 Jan;34(Suppl 1):8-14. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00689-3. PMID: 33024303
Calle C, Kuba MG, Brogi E
Breast J 2020 Jun;26(6):1148-1155. Epub 2020 Jun 4 doi: 10.1111/tbj.13857. PMID: 32500575
Desai AA, Jimenez RE, Hoskin TL, Day CN, Boughey JC, Hieken TJ
Ann Surg Oncol 2018 Oct;25(10):3064-3068. Epub 2018 Jun 26 doi: 10.1245/s10434-018-6591-6. PMID: 29947004

Recent clinical studies

Etiology

Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Lunt L, Coogan A, Perez CB
Surg Clin North Am 2022 Dec;102(6):947-963. doi: 10.1016/j.suc.2022.07.001. PMID: 36335930
Grimm LJ, Rahbar H, Abdelmalak M, Hall AH, Ryser MD
Radiology 2022 Feb;302(2):246-255. Epub 2021 Dec 21 doi: 10.1148/radiol.211839. PMID: 34931856Free PMC Article
Rakha E, Tan PH, Ellis I, Quinn C
Histopathology 2021 Oct;79(4):465-479. Epub 2021 Jun 13 doi: 10.1111/his.14380. PMID: 33829532
Wen HY, Brogi E
Surg Pathol Clin 2018 Mar;11(1):123-145. Epub 2017 Dec 8 doi: 10.1016/j.path.2017.09.009. PMID: 29413653Free PMC Article

Diagnosis

Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Lunt L, Coogan A, Perez CB
Surg Clin North Am 2022 Dec;102(6):947-963. doi: 10.1016/j.suc.2022.07.001. PMID: 36335930
Grimm LJ, Rahbar H, Abdelmalak M, Hall AH, Ryser MD
Radiology 2022 Feb;302(2):246-255. Epub 2021 Dec 21 doi: 10.1148/radiol.211839. PMID: 34931856Free PMC Article
Rakha E, Tan PH, Ellis I, Quinn C
Histopathology 2021 Oct;79(4):465-479. Epub 2021 Jun 13 doi: 10.1111/his.14380. PMID: 33829532
Wen HY, Brogi E
Surg Pathol Clin 2018 Mar;11(1):123-145. Epub 2017 Dec 8 doi: 10.1016/j.path.2017.09.009. PMID: 29413653Free PMC Article

Therapy

Hussein H, Abbas E, Keshavarzi S, Fazelzad R, Bukhanov K, Kulkarni S, Au F, Ghai S, Alabousi A, Freitas V
Radiology 2023 Mar;306(3):e221785. Epub 2023 Jan 31 doi: 10.1148/radiol.221785. PMID: 36719288
Huang X, Chen H, Ding Q, Robinson MK, Moseley TW, Bassett RL, Tang G, Lim B, Sahin AA
Hum Pathol 2021 Nov;117:51-59. Epub 2021 Aug 5 doi: 10.1016/j.humpath.2021.07.010. PMID: 34363799
Patil Okaly GV, Panwar D, Lingappa KB, Kumari P, Anand A, Kumar P, Chikkalingaiah MH, Kumar RV
Indian J Cancer 2019 Apr-Jun;56(2):119-123. doi: 10.4103/ijc.IJC_333_18. PMID: 31062729
Hoffman DI, Zhang PJ, Tchou J
Surg Oncol 2019 Mar;28:190-194. Epub 2019 Jan 29 doi: 10.1016/j.suronc.2019.01.009. PMID: 30851899
Desai AA, Jimenez RE, Hoskin TL, Day CN, Boughey JC, Hieken TJ
Ann Surg Oncol 2018 Oct;25(10):3064-3068. Epub 2018 Jun 26 doi: 10.1245/s10434-018-6591-6. PMID: 29947004

Prognosis

Hussein H, Abbas E, Keshavarzi S, Fazelzad R, Bukhanov K, Kulkarni S, Au F, Ghai S, Alabousi A, Freitas V
Radiology 2023 Mar;306(3):e221785. Epub 2023 Jan 31 doi: 10.1148/radiol.221785. PMID: 36719288
Grimm LJ, Rahbar H, Abdelmalak M, Hall AH, Ryser MD
Radiology 2022 Feb;302(2):246-255. Epub 2021 Dec 21 doi: 10.1148/radiol.211839. PMID: 34931856Free PMC Article
Marco V, Garcia F, Rubio IT, Soler T, Ferrazza L, Roig I, Mendez I, Andreu X, Mínguez CG, Tresserra F
Rev Esp Patol 2021 Oct-Dec;54(4):242-249. Epub 2020 Dec 31 doi: 10.1016/j.patol.2020.09.005. PMID: 34544554
Desai AA, Jimenez RE, Hoskin TL, Day CN, Boughey JC, Hieken TJ
Ann Surg Oncol 2018 Oct;25(10):3064-3068. Epub 2018 Jun 26 doi: 10.1245/s10434-018-6591-6. PMID: 29947004
Vargas AC, Lakhani SR, Simpson PT
Future Oncol 2009 Mar;5(2):233-43. doi: 10.2217/14796694.5.2.233. PMID: 19284381

Clinical prediction guides

Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Hussein H, Abbas E, Keshavarzi S, Fazelzad R, Bukhanov K, Kulkarni S, Au F, Ghai S, Alabousi A, Freitas V
Radiology 2023 Mar;306(3):e221785. Epub 2023 Jan 31 doi: 10.1148/radiol.221785. PMID: 36719288
Grimm LJ, Rahbar H, Abdelmalak M, Hall AH, Ryser MD
Radiology 2022 Feb;302(2):246-255. Epub 2021 Dec 21 doi: 10.1148/radiol.211839. PMID: 34931856Free PMC Article
Paulinelli RR, Ribeiro LFJ, Santos TD, Caires EMS, Pontes MGM, Faria BM, Luz MV, Faria SFC, Freitas-Junior R
Surg Oncol 2021 Dec;39:101660. Epub 2021 Sep 20 doi: 10.1016/j.suronc.2021.101660. PMID: 34555692
Desai AA, Jimenez RE, Hoskin TL, Day CN, Boughey JC, Hieken TJ
Ann Surg Oncol 2018 Oct;25(10):3064-3068. Epub 2018 Jun 26 doi: 10.1245/s10434-018-6591-6. PMID: 29947004

Recent systematic reviews

Hussein H, Abbas E, Keshavarzi S, Fazelzad R, Bukhanov K, Kulkarni S, Au F, Ghai S, Alabousi A, Freitas V
Radiology 2023 Mar;306(3):e221785. Epub 2023 Jan 31 doi: 10.1148/radiol.221785. PMID: 36719288
Shehata MN, Rahbar H, Flanagan MR, Kilgore MR, Lee CI, Ryser MD, Lowry KP
J Am Coll Radiol 2020 Oct;17(10):1207-1219. Epub 2020 Aug 27 doi: 10.1016/j.jacr.2020.07.036. PMID: 32861602
Wang GL, Tsikouras P, Zuo HQ, Huang MQ, Peng L, Bothou A, Zervoudis S, Tobias Teichmann A
J BUON 2019 Jan-Feb;24(1):48-60. PMID: 30941951

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...