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Elevated circulating hydroxyphenlyllactic acid concentration

MedGen UID:
1789038
•Concept ID:
C5539519
•
Finding
HPO: HP:0033326

Definition

An increased concentration of 4-hydroxyphenlyllactic acid in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating hydroxyphenlyllactic acid concentration

Professional guidelines

PubMed

Australian Atherosclerosis Society Position Statement on Lipoprotein(a): Clinical and Implementation Recommendations.
Ward NC, Watts GF, Bishop W, Colquhoun D, Hamilton-Craig C, Hare DL, Kangaharan N, Kostner KM, Kritharides L, O'Brien R, Mori TA, Nestel PJ, Nicholls SJ, Psaltis PJ, Raffoul N, White HD, Sullivan DR
Heart Lung Circ 2023 Mar;32(3):287-296. Epub 2023 Jan 25 doi: 10.1016/j.hlc.2022.11.015. PMID: 36707360
Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms.
Quintás-Cardama A, Vaddi K, Liu P, Manshouri T, Li J, Scherle PA, Caulder E, Wen X, Li Y, Waeltz P, Rupar M, Burn T, Lo Y, Kelley J, Covington M, Shepard S, Rodgers JD, Haley P, Kantarjian H, Fridman JS, Verstovsek S
Blood 2010 Apr 15;115(15):3109-17. Epub 2010 Feb 3 doi: 10.1182/blood-2009-04-214957. PMID: 20130243Free PMC Article
Metabolic effects of three ketogenic diets in the treatment of severe epilepsy.
Schwartz RM, Boyes S, Aynsley-Green A
Dev Med Child Neurol 1989 Apr;31(2):152-60. doi: 10.1111/j.1469-8749.1989.tb03973.x. PMID: 2661288

Recent clinical studies

Etiology

How to Handle Elevated Triglycerides: Life after PROMINENT.
Pirillo A, Catapano AL
Curr Atheroscler Rep 2023 Dec;25(12):921-929. Epub 2023 Dec 20 doi: 10.1007/s11883-023-01175-2. PMID: 38114852
Role of Chronic Kidney Disease (CKD)-Mineral and Bone Disorder (MBD) in the Pathogenesis of Cardiovascular Disease in CKD.
Yamada S, Nakano T
J Atheroscler Thromb 2023 Aug 1;30(8):835-850. Epub 2023 May 30 doi: 10.5551/jat.RV22006. PMID: 37258233Free PMC Article
Perfluoroalkyl substances and sex hormones in postmenopausal women: NHANES 2013-2016.
Wang Y, Aimuzi R, Nian M, Zhang Y, Luo K, Zhang J
Environ Int 2021 Apr;149:106408. Epub 2021 Feb 3 doi: 10.1016/j.envint.2021.106408. PMID: 33548847
The importance of free fatty acids in the development of Type 2 diabetes.
Wilding JP
Diabet Med 2007 Sep;24(9):934-45. doi: 10.1111/j.1464-5491.2007.02186.x. PMID: 17725706
Clinically significant interactions of psychotropic agents with antipsychotic drugs.
Meyer MC, Baldessarini RJ, Goff DC, Centorrino F
Drug Saf 1996 Nov;15(5):333-46. doi: 10.2165/00002018-199615050-00004. PMID: 8941495

Diagnosis

Odevixibat treatment in progressive familial intrahepatic cholestasis: a randomised, placebo-controlled, phase 3 trial.
Thompson RJ, Arnell H, Artan R, Baumann U, Calvo PL, Czubkowski P, Dalgic B, D'Antiga L, Durmaz Ö, Fischler B, Gonzalès E, Grammatikopoulos T, Gupte G, Hardikar W, Houwen RHJ, Kamath BM, Karpen SJ, Kjems L, Lacaille F, Lachaux A, Lainka E, Mack CL, Mattsson JP, McKiernan P, Özen H, Rajwal SR, Roquelaure B, Shagrani M, Shteyer E, Soufi N, Sturm E, Tessier ME, Verkade HJ, Horn P
Lancet Gastroenterol Hepatol 2022 Sep;7(9):830-842. Epub 2022 Jul 1 doi: 10.1016/S2468-1253(22)00093-0. PMID: 35780807
Trimethyllysine, vascular risk factors and outcome in acute ischemic stroke (MARK-STROKE).
Schwedhelm E, von Lucadou M, Peine S, Lezius S, Thomalla G, Böger R, Gerloff C, Choe CU
Amino Acids 2021 Apr;53(4):555-561. Epub 2021 Mar 31 doi: 10.1007/s00726-021-02969-x. PMID: 33788002
Design of Tumor Acidity-Responsive Sheddable Nanoparticles for Fluorescence/Magnetic Resonance Imaging-Guided Photodynamic Therapy.
Fan F, Yu Y, Zhong F, Gao M, Sun T, Liu J, Zhang H, Qian H, Tao W, Yang X
Theranostics 2017;7(5):1290-1302. Epub 2017 Mar 7 doi: 10.7150/thno.18557. PMID: 28435466Free PMC Article
Homocysteine and Non-Cardiac Vascular Disease.
Katsiki N, Perez-Martinez P, Mikhailidis DP
Curr Pharm Des 2017;23(22):3224-3232. doi: 10.2174/1381612823666170317124913. PMID: 28317478
Tumor-targeting, pH-sensitive nanoparticles for docetaxel delivery to drug-resistant cancer cells.
Tran TH, Ramasamy T, Choi JY, Nguyen HT, Pham TT, Jeong JH, Ku SK, Choi HG, Yong CS, Kim JO
Int J Nanomedicine 2015;10:5249-62. Epub 2015 Aug 21 doi: 10.2147/IJN.S89584. PMID: 26346426Free PMC Article

Therapy

How to Handle Elevated Triglycerides: Life after PROMINENT.
Pirillo A, Catapano AL
Curr Atheroscler Rep 2023 Dec;25(12):921-929. Epub 2023 Dec 20 doi: 10.1007/s11883-023-01175-2. PMID: 38114852
Odevixibat treatment in progressive familial intrahepatic cholestasis: a randomised, placebo-controlled, phase 3 trial.
Thompson RJ, Arnell H, Artan R, Baumann U, Calvo PL, Czubkowski P, Dalgic B, D'Antiga L, Durmaz Ö, Fischler B, Gonzalès E, Grammatikopoulos T, Gupte G, Hardikar W, Houwen RHJ, Kamath BM, Karpen SJ, Kjems L, Lacaille F, Lachaux A, Lainka E, Mack CL, Mattsson JP, McKiernan P, Özen H, Rajwal SR, Roquelaure B, Shagrani M, Shteyer E, Soufi N, Sturm E, Tessier ME, Verkade HJ, Horn P
Lancet Gastroenterol Hepatol 2022 Sep;7(9):830-842. Epub 2022 Jul 1 doi: 10.1016/S2468-1253(22)00093-0. PMID: 35780807
HDL-Targeting Therapeutics: Past, Present and Future.
Zakiev E, Feng M, Sukhorukov V, Kontush A
Curr Pharm Des 2017;23(8):1207-1215. doi: 10.2174/1381612822666161027153140. PMID: 27799042
Amino acids: metabolism, functions, and nutrition.
Wu G
Amino Acids 2009 May;37(1):1-17. Epub 2009 Mar 20 doi: 10.1007/s00726-009-0269-0. PMID: 19301095
Hyperoxia and human performance: a brief review.
Welch HG
Med Sci Sports Exerc 1982;14(4):253-62. doi: 10.1249/00005768-198204000-00001. PMID: 6752626

Prognosis

Role of Chronic Kidney Disease (CKD)-Mineral and Bone Disorder (MBD) in the Pathogenesis of Cardiovascular Disease in CKD.
Yamada S, Nakano T
J Atheroscler Thromb 2023 Aug 1;30(8):835-850. Epub 2023 May 30 doi: 10.5551/jat.RV22006. PMID: 37258233Free PMC Article
Trimethyllysine, vascular risk factors and outcome in acute ischemic stroke (MARK-STROKE).
Schwedhelm E, von Lucadou M, Peine S, Lezius S, Thomalla G, Böger R, Gerloff C, Choe CU
Amino Acids 2021 Apr;53(4):555-561. Epub 2021 Mar 31 doi: 10.1007/s00726-021-02969-x. PMID: 33788002
Non-invasive detection of human cardiomyocyte death using methylation patterns of circulating DNA.
Zemmour H, Planer D, Magenheim J, Moss J, Neiman D, Gilon D, Korach A, Glaser B, Shemer R, Landesberg G, Dor Y
Nat Commun 2018 Apr 24;9(1):1443. doi: 10.1038/s41467-018-03961-y. PMID: 29691397Free PMC Article
Homocysteine and Non-Cardiac Vascular Disease.
Katsiki N, Perez-Martinez P, Mikhailidis DP
Curr Pharm Des 2017;23(22):3224-3232. doi: 10.2174/1381612823666170317124913. PMID: 28317478
Vitamin D and ischaemic heart disease.
Lund B, Badskjaer J, Lund B, Soerensen OH
Horm Metab Res 1978 Nov;10(6):553-6. doi: 10.1055/s-0028-1093390. PMID: 744575

Clinical prediction guides

Odevixibat treatment in progressive familial intrahepatic cholestasis: a randomised, placebo-controlled, phase 3 trial.
Thompson RJ, Arnell H, Artan R, Baumann U, Calvo PL, Czubkowski P, Dalgic B, D'Antiga L, Durmaz Ö, Fischler B, Gonzalès E, Grammatikopoulos T, Gupte G, Hardikar W, Houwen RHJ, Kamath BM, Karpen SJ, Kjems L, Lacaille F, Lachaux A, Lainka E, Mack CL, Mattsson JP, McKiernan P, Özen H, Rajwal SR, Roquelaure B, Shagrani M, Shteyer E, Soufi N, Sturm E, Tessier ME, Verkade HJ, Horn P
Lancet Gastroenterol Hepatol 2022 Sep;7(9):830-842. Epub 2022 Jul 1 doi: 10.1016/S2468-1253(22)00093-0. PMID: 35780807
Homocysteine and Non-Cardiac Vascular Disease.
Katsiki N, Perez-Martinez P, Mikhailidis DP
Curr Pharm Des 2017;23(22):3224-3232. doi: 10.2174/1381612823666170317124913. PMID: 28317478
Elevated cerebral lactate: Implications in the pathogenesis of hepatic encephalopathy.
Bosoi CR, Rose CF
Metab Brain Dis 2014 Dec;29(4):919-25. Epub 2014 Jun 11 doi: 10.1007/s11011-014-9573-9. PMID: 24916505
Fibroblast growth factor 23 and its receptors.
Yu X, White KE
Ther Apher Dial 2005 Aug;9(4):308-12. doi: 10.1111/j.1744-9987.2005.00287.x. PMID: 16076372
Vitamin D and ischaemic heart disease.
Lund B, Badskjaer J, Lund B, Soerensen OH
Horm Metab Res 1978 Nov;10(6):553-6. doi: 10.1055/s-0028-1093390. PMID: 744575

Recent systematic reviews

Endocannabinoids and Stress-Related Neurospsychiatric Disorders: A Systematic Review and Meta-Analysis of Basal Concentrations and Response to Acute Psychosocial Stress.
Gowatch LC, Evanski JM, Ely SL, Zundel CG, Bhogal A, Carpenter C, Shampine MM, O'Mara E, Mazurka R, Barcelona J, Mayo LM, Marusak HA
Cannabis Cannabinoid Res 2024 Oct;9(5):1217-1234. Epub 2024 Apr 29 doi: 10.1089/can.2023.0246. PMID: 38683635Free PMC Article
The Association between Circulating Branched Chain Amino Acids and the Temporal Risk of Developing Type 2 Diabetes Mellitus: A Systematic Review & Meta-Analysis.
Ramzan I, Ardavani A, Vanweert F, Mellett A, Atherton PJ, Idris I
Nutrients 2022 Oct 20;14(20) doi: 10.3390/nu14204411. PMID: 36297095Free PMC Article
Association of circulating branched-chain amino acids with risk of cardiovascular disease: A systematic review and meta-analysis.
Wang Y, Huang K, Liu F, Lu X, Huang J, Gu D
Atherosclerosis 2022 Jun;350:90-96. Epub 2022 Apr 25 doi: 10.1016/j.atherosclerosis.2022.04.026. PMID: 35576716
Gut Microbiota-Derived Trimethylamine N-Oxide and Kidney Function: A Systematic Review and Meta-Analysis.
Zeng Y, Guo M, Fang X, Teng F, Tan X, Li X, Wang M, Long Y, Xu Y
Adv Nutr 2021 Jul 30;12(4):1286-1304. doi: 10.1093/advances/nmab010. PMID: 33751019Free PMC Article
Head-to-head comparison of fibrates versus statins for elevation of circulating adiponectin concentrations: a systematic review and meta-analysis.
Sahebkar A
Metabolism 2013 Dec;62(12):1876-85. Epub 2013 Oct 2 doi: 10.1016/j.metabol.2013.08.017. PMID: 24095632

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