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Elevated circulating hydroxyphenlyllactic acid concentration

MedGen UID:
1789038
•Concept ID:
C5539519
•
Finding
HPO: HP:0033326

Definition

An increased concentration of 4-hydroxyphenlyllactic acid in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating hydroxyphenlyllactic acid concentration

Professional guidelines

PubMed

Australian Atherosclerosis Society Position Statement on Lipoprotein(a): Clinical and Implementation Recommendations.
Ward NC, Watts GF, Bishop W, Colquhoun D, Hamilton-Craig C, Hare DL, Kangaharan N, Kostner KM, Kritharides L, O'Brien R, Mori TA, Nestel PJ, Nicholls SJ, Psaltis PJ, Raffoul N, White HD, Sullivan DR
Heart Lung Circ 2023 Mar;32(3):287-296. Epub 2023 Jan 25 doi: 10.1016/j.hlc.2022.11.015. PMID: 36707360
Holotranscobalamin, a marker of vitamin B-12 status: analytical aspects and clinical utility.
Nexo E, Hoffmann-Lücke E
Am J Clin Nutr 2011 Jul;94(1):359S-365S. Epub 2011 May 18 doi: 10.3945/ajcn.111.013458. PMID: 21593496Free PMC Article
Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms.
Quintás-Cardama A, Vaddi K, Liu P, Manshouri T, Li J, Scherle PA, Caulder E, Wen X, Li Y, Waeltz P, Rupar M, Burn T, Lo Y, Kelley J, Covington M, Shepard S, Rodgers JD, Haley P, Kantarjian H, Fridman JS, Verstovsek S
Blood 2010 Apr 15;115(15):3109-17. Epub 2010 Feb 3 doi: 10.1182/blood-2009-04-214957. PMID: 20130243Free PMC Article

Recent clinical studies

Etiology

Plasma Cell-Free DNA Predicts Survival and Maps Specific Sources of Injury in Pulmonary Arterial Hypertension.
Brusca SB, Elinoff JM, Zou Y, Jang MK, Kong H, Demirkale CY, Sun J, Seifuddin F, Pirooznia M, Valantine HA, Tanba C, Chaturvedi A, Graninger GM, Harper B, Chen LY, Cole J, Kanwar M, Benza RL, Preston IR, Agbor-Enoh S, Solomon MA
Circulation 2022 Oct 4;146(14):1033-1045. Epub 2022 Aug 25 doi: 10.1161/CIRCULATIONAHA.121.056719. PMID: 36004627Free PMC Article
Elevated Levels of Circulating Biomarkers Related to Leaky Gut Syndrome and Bacterial Translocation Are Associated With Graves' Disease.
Zheng D, Liao H, Chen S, Liu X, Mao C, Zhang C, Meng M, Wang Z, Wang Y, Jiang Q, Xue Y, Zhou L, Chen Y
Front Endocrinol (Lausanne) 2021;12:796212. Epub 2021 Dec 16 doi: 10.3389/fendo.2021.796212. PMID: 34975767Free PMC Article
Perfluoroalkyl substances and sex hormones in postmenopausal women: NHANES 2013-2016.
Wang Y, Aimuzi R, Nian M, Zhang Y, Luo K, Zhang J
Environ Int 2021 Apr;149:106408. Epub 2021 Feb 3 doi: 10.1016/j.envint.2021.106408. PMID: 33548847
Uric acid and the cardio-renal effects of SGLT2 inhibitors.
Bailey CJ
Diabetes Obes Metab 2019 Jun;21(6):1291-1298. Epub 2019 Mar 15 doi: 10.1111/dom.13670. PMID: 30762288
Brown adipose tissue activity controls triglyceride clearance.
Bartelt A, Bruns OT, Reimer R, Hohenberg H, Ittrich H, Peldschus K, Kaul MG, Tromsdorf UI, Weller H, Waurisch C, Eychmüller A, Gordts PL, Rinninger F, Bruegelmann K, Freund B, Nielsen P, Merkel M, Heeren J
Nat Med 2011 Feb;17(2):200-5. Epub 2011 Jan 23 doi: 10.1038/nm.2297. PMID: 21258337

Diagnosis

The Association between Circulating Branched Chain Amino Acids and the Temporal Risk of Developing Type 2 Diabetes Mellitus: A Systematic Review & Meta-Analysis.
Ramzan I, Ardavani A, Vanweert F, Mellett A, Atherton PJ, Idris I
Nutrients 2022 Oct 20;14(20) doi: 10.3390/nu14204411. PMID: 36297095Free PMC Article
Plasma Cell-Free DNA Predicts Survival and Maps Specific Sources of Injury in Pulmonary Arterial Hypertension.
Brusca SB, Elinoff JM, Zou Y, Jang MK, Kong H, Demirkale CY, Sun J, Seifuddin F, Pirooznia M, Valantine HA, Tanba C, Chaturvedi A, Graninger GM, Harper B, Chen LY, Cole J, Kanwar M, Benza RL, Preston IR, Agbor-Enoh S, Solomon MA
Circulation 2022 Oct 4;146(14):1033-1045. Epub 2022 Aug 25 doi: 10.1161/CIRCULATIONAHA.121.056719. PMID: 36004627Free PMC Article
Odevixibat treatment in progressive familial intrahepatic cholestasis: a randomised, placebo-controlled, phase 3 trial.
Thompson RJ, Arnell H, Artan R, Baumann U, Calvo PL, Czubkowski P, Dalgic B, D'Antiga L, Durmaz Ö, Fischler B, Gonzalès E, Grammatikopoulos T, Gupte G, Hardikar W, Houwen RHJ, Kamath BM, Karpen SJ, Kjems L, Lacaille F, Lachaux A, Lainka E, Mack CL, Mattsson JP, McKiernan P, Özen H, Rajwal SR, Roquelaure B, Shagrani M, Shteyer E, Soufi N, Sturm E, Tessier ME, Verkade HJ, Horn P
Lancet Gastroenterol Hepatol 2022 Sep;7(9):830-842. Epub 2022 Jul 1 doi: 10.1016/S2468-1253(22)00093-0. PMID: 35780807
Universal lung epithelium DNA methylation markers for detection of lung damage in liquid biopsies.
Magenheim J, Rokach A, Peretz A, Loyfer N, Cann G, Amini H, Moradi P, Nagaraju S, Sameer W, Cohen A, Fogel O, Kuint R, Abutbul A, Abu Rmeileh A, Karameh M, Cohen Goichman P, Wald O, Korach A, Neiman D, Fox-Fisher I, Moss J, Cohen D, Piyanzin S, Ben Ami R, Quteineh A, Golomb E, Shemer R, Glaser B, Kaplan T, Fridlender ZG, Dor Y
Eur Respir J 2022 Nov;60(5) Epub 2022 Nov 3 doi: 10.1183/13993003.03056-2021. PMID: 35450968
PM20D1 is a circulating biomarker closely associated with obesity, insulin resistance and metabolic syndrome.
Yang R, Hu Y, Lee CH, Liu Y, Diaz-Canestro C, Fong CHY, Lin H, Cheng KKY, Pravelil AP, Song E, Lam KSL, Xu A
Eur J Endocrinol 2021 Dec 10;186(2):151-161. doi: 10.1530/EJE-21-0847. PMID: 34757919

Therapy

Odevixibat treatment in progressive familial intrahepatic cholestasis: a randomised, placebo-controlled, phase 3 trial.
Thompson RJ, Arnell H, Artan R, Baumann U, Calvo PL, Czubkowski P, Dalgic B, D'Antiga L, Durmaz Ö, Fischler B, Gonzalès E, Grammatikopoulos T, Gupte G, Hardikar W, Houwen RHJ, Kamath BM, Karpen SJ, Kjems L, Lacaille F, Lachaux A, Lainka E, Mack CL, Mattsson JP, McKiernan P, Özen H, Rajwal SR, Roquelaure B, Shagrani M, Shteyer E, Soufi N, Sturm E, Tessier ME, Verkade HJ, Horn P
Lancet Gastroenterol Hepatol 2022 Sep;7(9):830-842. Epub 2022 Jul 1 doi: 10.1016/S2468-1253(22)00093-0. PMID: 35780807
PM20D1 is a circulating biomarker closely associated with obesity, insulin resistance and metabolic syndrome.
Yang R, Hu Y, Lee CH, Liu Y, Diaz-Canestro C, Fong CHY, Lin H, Cheng KKY, Pravelil AP, Song E, Lam KSL, Xu A
Eur J Endocrinol 2021 Dec 10;186(2):151-161. doi: 10.1530/EJE-21-0847. PMID: 34757919
Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity.
Sharma R, Reinstadler B, Engelstad K, Skinner OS, Stackowitz E, Haller RG, Clish CB, Pierce K, Walker MA, Fryer R, Oglesbee D, Mao X, Shungu DC, Khatri A, Hirano M, De Vivo DC, Mootha VK
J Clin Invest 2021 Jan 19;131(2) doi: 10.1172/JCI136055. PMID: 33463549Free PMC Article
Uric acid and the cardio-renal effects of SGLT2 inhibitors.
Bailey CJ
Diabetes Obes Metab 2019 Jun;21(6):1291-1298. Epub 2019 Mar 15 doi: 10.1111/dom.13670. PMID: 30762288
Amino acids: metabolism, functions, and nutrition.
Wu G
Amino Acids 2009 May;37(1):1-17. Epub 2009 Mar 20 doi: 10.1007/s00726-009-0269-0. PMID: 19301095

Prognosis

Plasma Cell-Free DNA Predicts Survival and Maps Specific Sources of Injury in Pulmonary Arterial Hypertension.
Brusca SB, Elinoff JM, Zou Y, Jang MK, Kong H, Demirkale CY, Sun J, Seifuddin F, Pirooznia M, Valantine HA, Tanba C, Chaturvedi A, Graninger GM, Harper B, Chen LY, Cole J, Kanwar M, Benza RL, Preston IR, Agbor-Enoh S, Solomon MA
Circulation 2022 Oct 4;146(14):1033-1045. Epub 2022 Aug 25 doi: 10.1161/CIRCULATIONAHA.121.056719. PMID: 36004627Free PMC Article
Elevated Levels of Circulating Biomarkers Related to Leaky Gut Syndrome and Bacterial Translocation Are Associated With Graves' Disease.
Zheng D, Liao H, Chen S, Liu X, Mao C, Zhang C, Meng M, Wang Z, Wang Y, Jiang Q, Xue Y, Zhou L, Chen Y
Front Endocrinol (Lausanne) 2021;12:796212. Epub 2021 Dec 16 doi: 10.3389/fendo.2021.796212. PMID: 34975767Free PMC Article
Branched-chain Amino Acids and Relationship With Inflammation in Youth With Obesity: A Randomized Controlled Intervention Study.
Cosentino RG, Churilla JR, Josephson S, Molle-Rios Z, Hossain MJ, Prado WL, Balagopal PB
J Clin Endocrinol Metab 2021 Oct 21;106(11):3129-3139. doi: 10.1210/clinem/dgab538. PMID: 34286837
Genetically predicted circulating B vitamins in relation to digestive system cancers.
Yuan S, Carter P, Vithayathil M, Kar S, Mason AM, Burgess S, Larsson SC
Br J Cancer 2021 Jun;124(12):1997-2003. Epub 2021 Apr 9 doi: 10.1038/s41416-021-01383-0. PMID: 33837300Free PMC Article
Uric acid and the cardio-renal effects of SGLT2 inhibitors.
Bailey CJ
Diabetes Obes Metab 2019 Jun;21(6):1291-1298. Epub 2019 Mar 15 doi: 10.1111/dom.13670. PMID: 30762288

Clinical prediction guides

Plasma Cell-Free DNA Predicts Survival and Maps Specific Sources of Injury in Pulmonary Arterial Hypertension.
Brusca SB, Elinoff JM, Zou Y, Jang MK, Kong H, Demirkale CY, Sun J, Seifuddin F, Pirooznia M, Valantine HA, Tanba C, Chaturvedi A, Graninger GM, Harper B, Chen LY, Cole J, Kanwar M, Benza RL, Preston IR, Agbor-Enoh S, Solomon MA
Circulation 2022 Oct 4;146(14):1033-1045. Epub 2022 Aug 25 doi: 10.1161/CIRCULATIONAHA.121.056719. PMID: 36004627Free PMC Article
Odevixibat treatment in progressive familial intrahepatic cholestasis: a randomised, placebo-controlled, phase 3 trial.
Thompson RJ, Arnell H, Artan R, Baumann U, Calvo PL, Czubkowski P, Dalgic B, D'Antiga L, Durmaz Ö, Fischler B, Gonzalès E, Grammatikopoulos T, Gupte G, Hardikar W, Houwen RHJ, Kamath BM, Karpen SJ, Kjems L, Lacaille F, Lachaux A, Lainka E, Mack CL, Mattsson JP, McKiernan P, Özen H, Rajwal SR, Roquelaure B, Shagrani M, Shteyer E, Soufi N, Sturm E, Tessier ME, Verkade HJ, Horn P
Lancet Gastroenterol Hepatol 2022 Sep;7(9):830-842. Epub 2022 Jul 1 doi: 10.1016/S2468-1253(22)00093-0. PMID: 35780807
Universal lung epithelium DNA methylation markers for detection of lung damage in liquid biopsies.
Magenheim J, Rokach A, Peretz A, Loyfer N, Cann G, Amini H, Moradi P, Nagaraju S, Sameer W, Cohen A, Fogel O, Kuint R, Abutbul A, Abu Rmeileh A, Karameh M, Cohen Goichman P, Wald O, Korach A, Neiman D, Fox-Fisher I, Moss J, Cohen D, Piyanzin S, Ben Ami R, Quteineh A, Golomb E, Shemer R, Glaser B, Kaplan T, Fridlender ZG, Dor Y
Eur Respir J 2022 Nov;60(5) Epub 2022 Nov 3 doi: 10.1183/13993003.03056-2021. PMID: 35450968
Elevated Levels of Circulating Biomarkers Related to Leaky Gut Syndrome and Bacterial Translocation Are Associated With Graves' Disease.
Zheng D, Liao H, Chen S, Liu X, Mao C, Zhang C, Meng M, Wang Z, Wang Y, Jiang Q, Xue Y, Zhou L, Chen Y
Front Endocrinol (Lausanne) 2021;12:796212. Epub 2021 Dec 16 doi: 10.3389/fendo.2021.796212. PMID: 34975767Free PMC Article
Gut Microbiota-Derived Trimethylamine N-Oxide and Kidney Function: A Systematic Review and Meta-Analysis.
Zeng Y, Guo M, Fang X, Teng F, Tan X, Li X, Wang M, Long Y, Xu Y
Adv Nutr 2021 Jul 30;12(4):1286-1304. doi: 10.1093/advances/nmab010. PMID: 33751019Free PMC Article

Recent systematic reviews

The Association between Circulating Branched Chain Amino Acids and the Temporal Risk of Developing Type 2 Diabetes Mellitus: A Systematic Review & Meta-Analysis.
Ramzan I, Ardavani A, Vanweert F, Mellett A, Atherton PJ, Idris I
Nutrients 2022 Oct 20;14(20) doi: 10.3390/nu14204411. PMID: 36297095Free PMC Article
Association of circulating branched-chain amino acids with risk of cardiovascular disease: A systematic review and meta-analysis.
Wang Y, Huang K, Liu F, Lu X, Huang J, Gu D
Atherosclerosis 2022 Jun;350:90-96. Epub 2022 Apr 25 doi: 10.1016/j.atherosclerosis.2022.04.026. PMID: 35576716
Gut Microbiota-Derived Trimethylamine N-Oxide and Kidney Function: A Systematic Review and Meta-Analysis.
Zeng Y, Guo M, Fang X, Teng F, Tan X, Li X, Wang M, Long Y, Xu Y
Adv Nutr 2021 Jul 30;12(4):1286-1304. doi: 10.1093/advances/nmab010. PMID: 33751019Free PMC Article
Circulating levels of proprotein convertase subtilisin kexin type 9 are elevated by fibrate therapy: a systematic review and meta-analysis of clinical trials.
Sahebkar A
Cardiol Rev 2014 Nov-Dec;22(6):306-12. doi: 10.1097/CRD.0000000000000025. PMID: 24614537
Head-to-head comparison of fibrates versus statins for elevation of circulating adiponectin concentrations: a systematic review and meta-analysis.
Sahebkar A
Metabolism 2013 Dec;62(12):1876-85. Epub 2013 Oct 2 doi: 10.1016/j.metabol.2013.08.017. PMID: 24095632

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