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Elevated circulating hydroxyphenlyllactic acid concentration

MedGen UID:
1789038
•Concept ID:
C5539519
•
Finding
HPO: HP:0033326

Definition

An increased concentration of 4-hydroxyphenlyllactic acid in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating hydroxyphenlyllactic acid concentration

Professional guidelines

PubMed

Australian Atherosclerosis Society Position Statement on Lipoprotein(a): Clinical and Implementation Recommendations.
Ward NC, Watts GF, Bishop W, Colquhoun D, Hamilton-Craig C, Hare DL, Kangaharan N, Kostner KM, Kritharides L, O'Brien R, Mori TA, Nestel PJ, Nicholls SJ, Psaltis PJ, Raffoul N, White HD, Sullivan DR
Heart Lung Circ 2023 Mar;32(3):287-296. Epub 2023 Jan 25 doi: 10.1016/j.hlc.2022.11.015. PMID: 36707360
Holotranscobalamin, a marker of vitamin B-12 status: analytical aspects and clinical utility.
Nexo E, Hoffmann-Lücke E
Am J Clin Nutr 2011 Jul;94(1):359S-365S. Epub 2011 May 18 doi: 10.3945/ajcn.111.013458. PMID: 21593496Free PMC Article
Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms.
Quintás-Cardama A, Vaddi K, Liu P, Manshouri T, Li J, Scherle PA, Caulder E, Wen X, Li Y, Waeltz P, Rupar M, Burn T, Lo Y, Kelley J, Covington M, Shepard S, Rodgers JD, Haley P, Kantarjian H, Fridman JS, Verstovsek S
Blood 2010 Apr 15;115(15):3109-17. Epub 2010 Feb 3 doi: 10.1182/blood-2009-04-214957. PMID: 20130243Free PMC Article

Recent clinical studies

Etiology

How to Handle Elevated Triglycerides: Life after PROMINENT.
Pirillo A, Catapano AL
Curr Atheroscler Rep 2023 Dec;25(12):921-929. Epub 2023 Dec 20 doi: 10.1007/s11883-023-01175-2. PMID: 38114852
Role of Chronic Kidney Disease (CKD)-Mineral and Bone Disorder (MBD) in the Pathogenesis of Cardiovascular Disease in CKD.
Yamada S, Nakano T
J Atheroscler Thromb 2023 Aug 1;30(8):835-850. Epub 2023 May 30 doi: 10.5551/jat.RV22006. PMID: 37258233Free PMC Article
Circulating Bile Acid Profiles: A Need for Further Examination.
Qi L, Tian Y, Chen Y
J Clin Endocrinol Metab 2021 Oct 21;106(11):3093-3112. doi: 10.1210/clinem/dgab531. PMID: 34279029
Perfluoroalkyl substances and sex hormones in postmenopausal women: NHANES 2013-2016.
Wang Y, Aimuzi R, Nian M, Zhang Y, Luo K, Zhang J
Environ Int 2021 Apr;149:106408. Epub 2021 Feb 3 doi: 10.1016/j.envint.2021.106408. PMID: 33548847
Uric acid and the cardio-renal effects of SGLT2 inhibitors.
Bailey CJ
Diabetes Obes Metab 2019 Jun;21(6):1291-1298. Epub 2019 Mar 15 doi: 10.1111/dom.13670. PMID: 30762288

Diagnosis

Circulating H3K27 Methylated Nucleosome Plasma Concentration: Synergistic Information with Circulating Tumor DNA Molecular Profiling.
Grolleau E, Candiracci J, Lescuyer G, Barthelemy D, Benzerdjeb N, Haon C, Geiguer F, Raffin M, Hardat N, Balandier J, Rabeuf R, Chalabreysse L, Wozny AS, Rommelaere G, Rodriguez-Lafrasse C, Subtil F, Couraud S, Herzog M, Payen-Gay L
Biomolecules 2023 Aug 16;13(8) doi: 10.3390/biom13081255. PMID: 37627320Free PMC Article
Elevated circulating level of β-aminoisobutyric acid (BAIBA) in heart failure patients with type 2 diabetes receiving sodium-glucose cotransporter 2 inhibitors.
Katano S, Yano T, Kouzu H, Nagaoka R, Numazawa R, Yamano K, Fujisawa Y, Ohori K, Nagano N, Fujito T, Nishikawa R, Ohwada W, Katayose M, Sato T, Kuno A, Furuhashi M
Cardiovasc Diabetol 2022 Dec 20;21(1):285. doi: 10.1186/s12933-022-01727-x. PMID: 36539818Free PMC Article
Odevixibat treatment in progressive familial intrahepatic cholestasis: a randomised, placebo-controlled, phase 3 trial.
Thompson RJ, Arnell H, Artan R, Baumann U, Calvo PL, Czubkowski P, Dalgic B, D'Antiga L, Durmaz Ö, Fischler B, Gonzalès E, Grammatikopoulos T, Gupte G, Hardikar W, Houwen RHJ, Kamath BM, Karpen SJ, Kjems L, Lacaille F, Lachaux A, Lainka E, Mack CL, Mattsson JP, McKiernan P, Özen H, Rajwal SR, Roquelaure B, Shagrani M, Shteyer E, Soufi N, Sturm E, Tessier ME, Verkade HJ, Horn P
Lancet Gastroenterol Hepatol 2022 Sep;7(9):830-842. Epub 2022 Jul 1 doi: 10.1016/S2468-1253(22)00093-0. PMID: 35780807
Homocysteine and Non-Cardiac Vascular Disease.
Katsiki N, Perez-Martinez P, Mikhailidis DP
Curr Pharm Des 2017;23(22):3224-3232. doi: 10.2174/1381612823666170317124913. PMID: 28317478
Adult hypophosphatasia.
Sorensen E, Flodgaard H
Acta Med Scand 1975 May;197(5):357-60. doi: 10.1111/j.0954-6820.1975.tb04934.x. PMID: 167553

Therapy

Odevixibat treatment in progressive familial intrahepatic cholestasis: a randomised, placebo-controlled, phase 3 trial.
Thompson RJ, Arnell H, Artan R, Baumann U, Calvo PL, Czubkowski P, Dalgic B, D'Antiga L, Durmaz Ö, Fischler B, Gonzalès E, Grammatikopoulos T, Gupte G, Hardikar W, Houwen RHJ, Kamath BM, Karpen SJ, Kjems L, Lacaille F, Lachaux A, Lainka E, Mack CL, Mattsson JP, McKiernan P, Özen H, Rajwal SR, Roquelaure B, Shagrani M, Shteyer E, Soufi N, Sturm E, Tessier ME, Verkade HJ, Horn P
Lancet Gastroenterol Hepatol 2022 Sep;7(9):830-842. Epub 2022 Jul 1 doi: 10.1016/S2468-1253(22)00093-0. PMID: 35780807
Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity.
Sharma R, Reinstadler B, Engelstad K, Skinner OS, Stackowitz E, Haller RG, Clish CB, Pierce K, Walker MA, Fryer R, Oglesbee D, Mao X, Shungu DC, Khatri A, Hirano M, De Vivo DC, Mootha VK
J Clin Invest 2021 Jan 19;131(2) doi: 10.1172/JCI136055. PMID: 33463549Free PMC Article
Uric acid and the cardio-renal effects of SGLT2 inhibitors.
Bailey CJ
Diabetes Obes Metab 2019 Jun;21(6):1291-1298. Epub 2019 Mar 15 doi: 10.1111/dom.13670. PMID: 30762288
Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms.
Quintás-Cardama A, Vaddi K, Liu P, Manshouri T, Li J, Scherle PA, Caulder E, Wen X, Li Y, Waeltz P, Rupar M, Burn T, Lo Y, Kelley J, Covington M, Shepard S, Rodgers JD, Haley P, Kantarjian H, Fridman JS, Verstovsek S
Blood 2010 Apr 15;115(15):3109-17. Epub 2010 Feb 3 doi: 10.1182/blood-2009-04-214957. PMID: 20130243Free PMC Article
Amino acids: metabolism, functions, and nutrition.
Wu G
Amino Acids 2009 May;37(1):1-17. Epub 2009 Mar 20 doi: 10.1007/s00726-009-0269-0. PMID: 19301095

Prognosis

Role of Chronic Kidney Disease (CKD)-Mineral and Bone Disorder (MBD) in the Pathogenesis of Cardiovascular Disease in CKD.
Yamada S, Nakano T
J Atheroscler Thromb 2023 Aug 1;30(8):835-850. Epub 2023 May 30 doi: 10.5551/jat.RV22006. PMID: 37258233Free PMC Article
Prognostic value of circulating mitochondrial DNA in prostate cancer and underlying mechanism.
Borah S, Mishra R, Dey S, Suchanti S, Bhowmick NA, Giri B, Haldar S
Mitochondrion 2023 Jul;71:40-49. Epub 2023 May 19 doi: 10.1016/j.mito.2023.05.005. PMID: 37211294
Circulating Bile Acid Profiles: A Need for Further Examination.
Qi L, Tian Y, Chen Y
J Clin Endocrinol Metab 2021 Oct 21;106(11):3093-3112. doi: 10.1210/clinem/dgab531. PMID: 34279029
Uric acid and the cardio-renal effects of SGLT2 inhibitors.
Bailey CJ
Diabetes Obes Metab 2019 Jun;21(6):1291-1298. Epub 2019 Mar 15 doi: 10.1111/dom.13670. PMID: 30762288
Homocysteine and Non-Cardiac Vascular Disease.
Katsiki N, Perez-Martinez P, Mikhailidis DP
Curr Pharm Des 2017;23(22):3224-3232. doi: 10.2174/1381612823666170317124913. PMID: 28317478

Clinical prediction guides

Odevixibat treatment in progressive familial intrahepatic cholestasis: a randomised, placebo-controlled, phase 3 trial.
Thompson RJ, Arnell H, Artan R, Baumann U, Calvo PL, Czubkowski P, Dalgic B, D'Antiga L, Durmaz Ö, Fischler B, Gonzalès E, Grammatikopoulos T, Gupte G, Hardikar W, Houwen RHJ, Kamath BM, Karpen SJ, Kjems L, Lacaille F, Lachaux A, Lainka E, Mack CL, Mattsson JP, McKiernan P, Özen H, Rajwal SR, Roquelaure B, Shagrani M, Shteyer E, Soufi N, Sturm E, Tessier ME, Verkade HJ, Horn P
Lancet Gastroenterol Hepatol 2022 Sep;7(9):830-842. Epub 2022 Jul 1 doi: 10.1016/S2468-1253(22)00093-0. PMID: 35780807
Circulating Bile Acid Profiles: A Need for Further Examination.
Qi L, Tian Y, Chen Y
J Clin Endocrinol Metab 2021 Oct 21;106(11):3093-3112. doi: 10.1210/clinem/dgab531. PMID: 34279029
Homocysteine and Non-Cardiac Vascular Disease.
Katsiki N, Perez-Martinez P, Mikhailidis DP
Curr Pharm Des 2017;23(22):3224-3232. doi: 10.2174/1381612823666170317124913. PMID: 28317478
Homocysteine, methylenetetrahydrofolate reductase, folate status and atherothrombosis: A mechanistic and clinical perspective.
Santilli F, Davì G, Patrono C
Vascul Pharmacol 2016 Mar;78:1-9. Epub 2015 Jun 22 doi: 10.1016/j.vph.2015.06.009. PMID: 26111718
Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms.
Quintás-Cardama A, Vaddi K, Liu P, Manshouri T, Li J, Scherle PA, Caulder E, Wen X, Li Y, Waeltz P, Rupar M, Burn T, Lo Y, Kelley J, Covington M, Shepard S, Rodgers JD, Haley P, Kantarjian H, Fridman JS, Verstovsek S
Blood 2010 Apr 15;115(15):3109-17. Epub 2010 Feb 3 doi: 10.1182/blood-2009-04-214957. PMID: 20130243Free PMC Article

Recent systematic reviews

The Association between Circulating Branched Chain Amino Acids and the Temporal Risk of Developing Type 2 Diabetes Mellitus: A Systematic Review & Meta-Analysis.
Ramzan I, Ardavani A, Vanweert F, Mellett A, Atherton PJ, Idris I
Nutrients 2022 Oct 20;14(20) doi: 10.3390/nu14204411. PMID: 36297095Free PMC Article
Association of circulating branched-chain amino acids with risk of cardiovascular disease: A systematic review and meta-analysis.
Wang Y, Huang K, Liu F, Lu X, Huang J, Gu D
Atherosclerosis 2022 Jun;350:90-96. Epub 2022 Apr 25 doi: 10.1016/j.atherosclerosis.2022.04.026. PMID: 35576716
Gut Microbiota-Derived Trimethylamine N-Oxide and Kidney Function: A Systematic Review and Meta-Analysis.
Zeng Y, Guo M, Fang X, Teng F, Tan X, Li X, Wang M, Long Y, Xu Y
Adv Nutr 2021 Jul 30;12(4):1286-1304. doi: 10.1093/advances/nmab010. PMID: 33751019Free PMC Article
Circulating levels of proprotein convertase subtilisin kexin type 9 are elevated by fibrate therapy: a systematic review and meta-analysis of clinical trials.
Sahebkar A
Cardiol Rev 2014 Nov-Dec;22(6):306-12. doi: 10.1097/CRD.0000000000000025. PMID: 24614537
Head-to-head comparison of fibrates versus statins for elevation of circulating adiponectin concentrations: a systematic review and meta-analysis.
Sahebkar A
Metabolism 2013 Dec;62(12):1876-85. Epub 2013 Oct 2 doi: 10.1016/j.metabol.2013.08.017. PMID: 24095632

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