U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Glomerular capillary microaneurysm

MedGen UID:
1789107
•Concept ID:
C5539470
•
Anatomical Abnormality
HPO: HP:0033271

Definition

Glomerular capillary dilatation due to loosening/detachment of the glomerular basement membrane (GBM) from its anchoring points, usually in the context of mesangiolysis or nodular glomerulosclerosis. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlomerular capillary microaneurysm

Recent clinical studies

Etiology

Associations between retinal microvascular abnormalities and declining renal function in the elderly population: the Cardiovascular Health Study.
Edwards MS, Wilson DB, Craven TE, Stafford J, Fried LF, Wong TY, Klein R, Burke GL, Hansen KJ
Am J Kidney Dis 2005 Aug;46(2):214-24. doi: 10.1053/j.ajkd.2005.05.005. PMID: 16112039
Extracellular actin impairs glomerular capillary repair in experimental mesangioproliferative glomerulonephritis.
Janssen U, Eitner F, Kunter U, Ostendorf T, Wolf G, Chaponnier C, Gabbiani G, Kerjaschki D, Floege J
Nephron Exp Nephrol 2003;93(4):e158-67. doi: 10.1159/000070240. PMID: 12759577
Glomerular membranopathy in children with IgA nephropathy and Henoch Schönlein purpura.
Vogler C, Eliason SC, Wood EG
Pediatr Dev Pathol 1999 May-Jun;2(3):227-35. doi: 10.1007/s100249900118. PMID: 10191346
Focal mesangiolysis and the pathogenesis of the Kimmelstiel-Wilson nodule.
Stout LC, Kumar S, Whorton EB
Hum Pathol 1993 Jan;24(1):77-89. doi: 10.1016/0046-8177(93)90066-p. PMID: 8418016

Diagnosis

A case of proliferative glomerulonephritis with monoclonal IgG3κ deposits accompanied by glomerular capillary microaneurysms.
Mii A, Terasaki M, Kunugi S, Seki M, Kashiwagi T, Sakai Y, Shimizu A
CEN Case Rep 2022 Aug;11(3):333-338. Epub 2022 Jan 13 doi: 10.1007/s13730-021-00676-w. PMID: 35025059Free PMC Article
Successful treatment with bortezomib and dexamethasone for proliferative glomerulonephritis with monoclonal IgG deposits in multiple myeloma: a case report.
Noto R, Kamiura N, Ono Y, Tabata S, Hara S, Yokoi H, Yoshimoto A, Yanagita M
BMC Nephrol 2017 Apr 6;18(1):127. doi: 10.1186/s12882-017-0524-7. PMID: 28385149Free PMC Article
A case of idiopathic nodular glomerulosclerosis with fibrin caps.
Kinoshita C, Inoue Y, Kanda Y, Kanda C
Clin Exp Nephrol 2011 Dec;15(6):937-41. Epub 2011 Aug 17 doi: 10.1007/s10157-011-0513-2. PMID: 21847522
Microcephaly and early-onset nephrotic syndrome--confusion in Galloway-Mowat syndrome.
Sano H, Miyanoshita A, Watanabe N, Koga Y, Miyazawa Y, Yamaguchi Y, Fukushima Y, Itami N
Pediatr Nephrol 1995 Dec;9(6):711-4. doi: 10.1007/BF00868718. PMID: 8747110
Pathogenesis and significance of nonprimary focal and segmental glomerulosclerosis.
Rennke HG, Klein PS
Am J Kidney Dis 1989 Jun;13(6):443-56. doi: 10.1016/s0272-6386(89)80001-0. PMID: 2658558

Therapy

Characteristic morphological changes in anti-VEGF therapy-induced glomerular microangiopathy.
Pfister F, Amann K, Daniel C, Klewer M, Büttner A, Büttner-Herold M
Histopathology 2018 Dec;73(6):990-1001. Epub 2018 Sep 25 doi: 10.1111/his.13716. PMID: 30014486
Immune Complex-Type Deposits in the Fischer-344 to Lewis Rat Model of Renal Transplantation and a Subset of Human Transplant Glomerulopathy.
Grau V, Zeuschner P, Immenschuh S, Bockmeyer CL, Zell S, Wittig J, Säuberlich K, Abbas M, Padberg W, Meyer-Schwesinger C, von Brandenstein M, Schlosser M, Dieplinger G, Galliford J, Clarke C, Roufosse C, Becker JU
Transplantation 2016 May;100(5):1004-14. doi: 10.1097/TP.0000000000001068. PMID: 26895216
PDGF-C mediates glomerular capillary repair.
Boor P, van Roeyen CR, Kunter U, Villa L, Bücher E, Hohenstein B, Hugo CP, Eriksson U, Satchell SC, Mathieson PW, Eitner F, Floege J, Ostendorf T
Am J Pathol 2010 Jul;177(1):58-69. Epub 2010 May 20 doi: 10.2353/ajpath.2010.091008. PMID: 20489153Free PMC Article
Extracellular actin impairs glomerular capillary repair in experimental mesangioproliferative glomerulonephritis.
Janssen U, Eitner F, Kunter U, Ostendorf T, Wolf G, Chaponnier C, Gabbiani G, Kerjaschki D, Floege J
Nephron Exp Nephrol 2003;93(4):e158-67. doi: 10.1159/000070240. PMID: 12759577
Glomerular basement membrane splitting and microaneurysm formation associated with nitrosourea therapy.
Tuttle SE, Sharma HM, Bay WH, Hebert LA
Am J Nephrol 1985;5(5):388-94. doi: 10.1159/000166969. PMID: 2998189

Prognosis

A case of idiopathic nodular glomerulosclerosis with fibrin caps.
Kinoshita C, Inoue Y, Kanda Y, Kanda C
Clin Exp Nephrol 2011 Dec;15(6):937-41. Epub 2011 Aug 17 doi: 10.1007/s10157-011-0513-2. PMID: 21847522
Peculiar glomerular lesions in Takayasu's arteritis.
Yoshimura M, Kida H, Saito Y, Yokoyama H, Tomosugi N, Abe T, Hattori N
Clin Nephrol 1985 Sep;24(3):120-7. PMID: 2864151
A re-evaluation of diabetic glomerulosclerosis 50 years after the discovery of insulin.
Bloodworth JM Jr
Hum Pathol 1978 Jul;9(4):439-53. doi: 10.1016/s0046-8177(78)80029-x. PMID: 711223

Clinical prediction guides

A case of idiopathic nodular glomerulosclerosis with fibrin caps.
Kinoshita C, Inoue Y, Kanda Y, Kanda C
Clin Exp Nephrol 2011 Dec;15(6):937-41. Epub 2011 Aug 17 doi: 10.1007/s10157-011-0513-2. PMID: 21847522
Endothelial dysfunction as a potential contributor in diabetic nephropathy.
Nakagawa T, Tanabe K, Croker BP, Johnson RJ, Grant MB, Kosugi T, Li Q
Nat Rev Nephrol 2011 Jan;7(1):36-44. Epub 2010 Nov 2 doi: 10.1038/nrneph.2010.152. PMID: 21045790Free PMC Article
Associations between retinal microvascular abnormalities and declining renal function in the elderly population: the Cardiovascular Health Study.
Edwards MS, Wilson DB, Craven TE, Stafford J, Fried LF, Wong TY, Klein R, Burke GL, Hansen KJ
Am J Kidney Dis 2005 Aug;46(2):214-24. doi: 10.1053/j.ajkd.2005.05.005. PMID: 16112039
Extracellular actin impairs glomerular capillary repair in experimental mesangioproliferative glomerulonephritis.
Janssen U, Eitner F, Kunter U, Ostendorf T, Wolf G, Chaponnier C, Gabbiani G, Kerjaschki D, Floege J
Nephron Exp Nephrol 2003;93(4):e158-67. doi: 10.1159/000070240. PMID: 12759577
Mesangiolytic glomerulopathy in severe congestive heart failure.
Yoshida H, Yashiro M, Liang P, Muso E, Takeuchi E, Shimada T, Sekita K, Ono T, Kanatsu K, Sugiyama T, Kawai C, Sasayama S
Kidney Int 1998 Apr;53(4):880-91. doi: 10.1111/j.1523-1755.1998.00830.x. PMID: 9551394

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...