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Advanced Cervical Squamous Cell Carcinoma

MedGen UID:
1791020
•Concept ID:
C5554579
•
Neoplastic Process

Definition

Cervical squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Cervical Squamous Cell Carcinoma

Professional guidelines

PubMed

Comparison of treatment outcomes between squamous cell carcinoma and adenocarcinoma of cervix after definitive radiotherapy or concurrent chemoradiotherapy.
Hu K, Wang W, Liu X, Meng Q, Zhang F
Radiat Oncol 2018 Dec 17;13(1):249. doi: 10.1186/s13014-018-1197-5. PMID: 30558636Free PMC Article
Multimodal treatment including hysterectomy improves survival in patients with locally advanced cervical cancer: A population-based, propensity score-matched analysis.
Wu SG, Zhang WW, Sun JY, Li FY, He ZY, Zhou J
Int J Surg 2017 Dec;48:122-127. Epub 2017 Oct 12 doi: 10.1016/j.ijsu.2017.10.028. PMID: 29032160
Nonoperative assessment of nodal status for locally advanced cervical squamous cell carcinoma treated by radiotherapy with regard to patterns of treatment failure.
Ohara K, Tanaka YO, Tsunoda H, Sugahara S, Hashimoto T, Kagei K, Tokuuye K, Akine Y, Yoshikawa H, Itai Y
Int J Radiat Oncol Biol Phys 2003 Feb 1;55(2):354-61. doi: 10.1016/s0360-3016(02)03930-5. PMID: 12527048

Recent clinical studies

Etiology

Neoadjuvant chemotherapy does not improve the prognosis and lymph node metastasis rate of locally advanced cervical squamous cell carcinoma: A retrospective cohort study in China.
Yan W, Si L, Ding Y, Qiu S, Zhang Q, Liu L
Medicine (Baltimore) 2019 Sep;98(39):e17234. doi: 10.1097/MD.0000000000017234. PMID: 31574835Free PMC Article
Effectiveness of Image-guided Brachytherapy in Patients With Locally Advanced Cervical Squamous Cell Carcinoma Receiving Concurrent Chemoradiotherapy.
Chen SW, Liang JA, Hung YC, Yeh LS, Chang WC, Lin WC, Chang YY
Anticancer Res 2019 Jun;39(6):3015-3024. doi: 10.21873/anticanres.13434. PMID: 31177143
Comparison of treatment outcomes between squamous cell carcinoma and adenocarcinoma of cervix after definitive radiotherapy or concurrent chemoradiotherapy.
Hu K, Wang W, Liu X, Meng Q, Zhang F
Radiat Oncol 2018 Dec 17;13(1):249. doi: 10.1186/s13014-018-1197-5. PMID: 30558636Free PMC Article
Long-term Outcomes of Carbon-ion Radiotherapy for Locally Advanced Squamous Cell Carcinoma of the Uterine Cervix.
Okonogi N, Wakatsuki M, Kato S, Shiba S, Kobayashi D, Kiyohara H, Karasawa K, Ohno T, Nakano T, Kamada T, Shozu M; WORKING GROUP OF GYNECOLOGICAL TUMORS
Anticancer Res 2018 Jan;38(1):457-463. doi: 10.21873/anticanres.12244. PMID: 29277809
Expression of ERCC1 and TUBB3 in locally advanced cervical squamous cell cancer and its correlation with different therapeutic regimens.
Zwenger AO, Grosman G, Iturbe J, Leone J, Vallejo CT, Leone JP, Verdera PP, Pérez JE, Leone BA
Int J Biol Markers 2015 Jul 22;30(3):e301-14. doi: 10.5301/jbm.5000161. PMID: 26165688

Diagnosis

Vascular permeability determined using multi-slice spiral CT perfusion can predict response to chemoradiotherapy in patients with advanced cervical squamous cell carcinoma
.
Liu J, Fan H, Qiu GP
Int J Clin Pharmacol Ther 2017 Jul;55(7):619-626. doi: 10.5414/CP202847. PMID: 28291509
HK2 is a radiation resistant and independent negative prognostic factor for patients with locally advanced cervical squamous cell carcinoma.
Huang X, Liu M, Sun H, Wang F, Xie X, Chen X, Su J, He Y, Dai Y, Wu H, Shen L
Int J Clin Exp Pathol 2015;8(4):4054-63. Epub 2015 Apr 1 PMID: 26097593Free PMC Article
Co-expression of CD147 and GLUT-1 indicates radiation resistance and poor prognosis in cervical squamous cell carcinoma.
Huang XQ, Chen X, Xie XX, Zhou Q, Li K, Li S, Shen LF, Su J
Int J Clin Exp Pathol 2014;7(4):1651-66. Epub 2014 Mar 15 PMID: 24817962Free PMC Article
Umbilical surgical scar and vulval metastasis secondary to advanced cervical squamous cell carcinoma: a report of two cases.
Deka D, Gupta N, Bahadur A, Dadhwal V, Mittal S
Arch Gynecol Obstet 2010 Apr;281(4):761-4. Epub 2009 Sep 30 doi: 10.1007/s00404-009-1235-5. PMID: 19789888
Advanced cervical squamous cell carcinoma with skin metastasis.
Chen CH, Chao KC, Wang PH
Taiwan J Obstet Gynecol 2007 Sep;46(3):264-6. doi: 10.1016/S1028-4559(08)60031-5. PMID: 17962107

Therapy

Neoadjuvant chemotherapy does not improve the prognosis and lymph node metastasis rate of locally advanced cervical squamous cell carcinoma: A retrospective cohort study in China.
Yan W, Si L, Ding Y, Qiu S, Zhang Q, Liu L
Medicine (Baltimore) 2019 Sep;98(39):e17234. doi: 10.1097/MD.0000000000017234. PMID: 31574835Free PMC Article
Effectiveness of Image-guided Brachytherapy in Patients With Locally Advanced Cervical Squamous Cell Carcinoma Receiving Concurrent Chemoradiotherapy.
Chen SW, Liang JA, Hung YC, Yeh LS, Chang WC, Lin WC, Chang YY
Anticancer Res 2019 Jun;39(6):3015-3024. doi: 10.21873/anticanres.13434. PMID: 31177143
Long-term Outcomes of Carbon-ion Radiotherapy for Locally Advanced Squamous Cell Carcinoma of the Uterine Cervix.
Okonogi N, Wakatsuki M, Kato S, Shiba S, Kobayashi D, Kiyohara H, Karasawa K, Ohno T, Nakano T, Kamada T, Shozu M; WORKING GROUP OF GYNECOLOGICAL TUMORS
Anticancer Res 2018 Jan;38(1):457-463. doi: 10.21873/anticanres.12244. PMID: 29277809
Role of difucosylated Lewis Y antigen in outcome of locally advanced cervical squamous cell carcinoma treated with cisplatin regimen.
Leone J, Perez JE, Dominguez ME, Iturbe J, Leone JP, Mac Donnell MC, Grosman G, Vallejo CT, Leone BA, Zwenger AO
Int J Biol Markers 2016 Jul 30;31(3):e300-8. doi: 10.5301/jbm.5000206. PMID: 27197582
Expression of ERCC1 and TUBB3 in locally advanced cervical squamous cell cancer and its correlation with different therapeutic regimens.
Zwenger AO, Grosman G, Iturbe J, Leone J, Vallejo CT, Leone JP, Verdera PP, Pérez JE, Leone BA
Int J Biol Markers 2015 Jul 22;30(3):e301-14. doi: 10.5301/jbm.5000161. PMID: 26165688

Prognosis

Clinical value of serum biomarkers, squamous cell carcinoma antigen and apolipoprotein C-II in follow-up of patients with locally advanced cervical squamous cell carcinoma treated with radiation: A multicenter prospective cohort study.
Harima Y, Ariga T, Kaneyasu Y, Ikushima H, Tokumaru S, Shimamoto S, Takahashi T, Ii N, Tsujino K, Saito AI, Ushijima H, Toita T, Ohno T
PLoS One 2021;16(11):e0259235. Epub 2021 Nov 2 doi: 10.1371/journal.pone.0259235. PMID: 34727105Free PMC Article
Neoadjuvant chemotherapy does not improve the prognosis and lymph node metastasis rate of locally advanced cervical squamous cell carcinoma: A retrospective cohort study in China.
Yan W, Si L, Ding Y, Qiu S, Zhang Q, Liu L
Medicine (Baltimore) 2019 Sep;98(39):e17234. doi: 10.1097/MD.0000000000017234. PMID: 31574835Free PMC Article
Comparison of treatment outcomes between squamous cell carcinoma and adenocarcinoma of cervix after definitive radiotherapy or concurrent chemoradiotherapy.
Hu K, Wang W, Liu X, Meng Q, Zhang F
Radiat Oncol 2018 Dec 17;13(1):249. doi: 10.1186/s13014-018-1197-5. PMID: 30558636Free PMC Article
The Prognosis and Risk Stratification Based on Pelvic Lymph Node Characteristics in Patients With Locally Advanced Cervical Squamous Cell Carcinoma Treated With Concurrent Chemoradiotherapy.
Li X, Wei LC, Zhang Y, Zhao LN, Li WW, Ping LJ, Dang YZ, Hu J, Shi M
Int J Gynecol Cancer 2016 Oct;26(8):1472-9. doi: 10.1097/IGC.0000000000000778. PMID: 27400321
Expression of ERCC1 and TUBB3 in locally advanced cervical squamous cell cancer and its correlation with different therapeutic regimens.
Zwenger AO, Grosman G, Iturbe J, Leone J, Vallejo CT, Leone JP, Verdera PP, Pérez JE, Leone BA
Int J Biol Markers 2015 Jul 22;30(3):e301-14. doi: 10.5301/jbm.5000161. PMID: 26165688

Clinical prediction guides

Clinical value of serum biomarkers, squamous cell carcinoma antigen and apolipoprotein C-II in follow-up of patients with locally advanced cervical squamous cell carcinoma treated with radiation: A multicenter prospective cohort study.
Harima Y, Ariga T, Kaneyasu Y, Ikushima H, Tokumaru S, Shimamoto S, Takahashi T, Ii N, Tsujino K, Saito AI, Ushijima H, Toita T, Ohno T
PLoS One 2021;16(11):e0259235. Epub 2021 Nov 2 doi: 10.1371/journal.pone.0259235. PMID: 34727105Free PMC Article
Neoadjuvant chemotherapy does not improve the prognosis and lymph node metastasis rate of locally advanced cervical squamous cell carcinoma: A retrospective cohort study in China.
Yan W, Si L, Ding Y, Qiu S, Zhang Q, Liu L
Medicine (Baltimore) 2019 Sep;98(39):e17234. doi: 10.1097/MD.0000000000017234. PMID: 31574835Free PMC Article
Comparison of treatment outcomes between squamous cell carcinoma and adenocarcinoma of cervix after definitive radiotherapy or concurrent chemoradiotherapy.
Hu K, Wang W, Liu X, Meng Q, Zhang F
Radiat Oncol 2018 Dec 17;13(1):249. doi: 10.1186/s13014-018-1197-5. PMID: 30558636Free PMC Article
The Prognosis and Risk Stratification Based on Pelvic Lymph Node Characteristics in Patients With Locally Advanced Cervical Squamous Cell Carcinoma Treated With Concurrent Chemoradiotherapy.
Li X, Wei LC, Zhang Y, Zhao LN, Li WW, Ping LJ, Dang YZ, Hu J, Shi M
Int J Gynecol Cancer 2016 Oct;26(8):1472-9. doi: 10.1097/IGC.0000000000000778. PMID: 27400321
Expression of ERCC1 and TUBB3 in locally advanced cervical squamous cell cancer and its correlation with different therapeutic regimens.
Zwenger AO, Grosman G, Iturbe J, Leone J, Vallejo CT, Leone JP, Verdera PP, Pérez JE, Leone BA
Int J Biol Markers 2015 Jul 22;30(3):e301-14. doi: 10.5301/jbm.5000161. PMID: 26165688

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