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Metastatic Lung Large Cell Neuroendocrine Carcinoma

MedGen UID:
1791075
•Concept ID:
C5554634
•
Neoplastic Process

Definition

Lung large cell neuroendocrine carcinoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Lung Large Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Management of pulmonary neuroendocrine tumors.
Ramirez RA, Chauhan A, Gimenez J, Thomas KEH, Kokodis I, Voros BA
Rev Endocr Metab Disord 2017 Dec;18(4):433-442. doi: 10.1007/s11154-017-9429-9. PMID: 28868578
Neuroendocrine Tumors of the Lung: Current Challenges and Advances in the Diagnosis and Management of Well-Differentiated Disease.
Hendifar AE, Marchevsky AM, Tuli R
J Thorac Oncol 2017 Mar;12(3):425-436. Epub 2016 Nov 24 doi: 10.1016/j.jtho.2016.11.2222. PMID: 27890494
Diagnosis and treatment of neuroendocrine lung tumors.
Sánchez de Cos Escuín J
Arch Bronconeumol 2014 Sep;50(9):392-6. Epub 2014 Mar 28 doi: 10.1016/j.arbres.2014.02.004. PMID: 24685201

Recent clinical studies

Etiology

Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Capecitabine and Temozolomide in Advanced Lung Neuroendocrine Neoplasms.
Al-Toubah T, Morse B, Strosberg J
Oncologist 2020 Jan;25(1):e48-e52. Epub 2019 Aug 27 doi: 10.1634/theoncologist.2019-0361. PMID: 31455747Free PMC Article
Neuroendocrine Tumors of the Lung: Current Challenges and Advances in the Diagnosis and Management of Well-Differentiated Disease.
Hendifar AE, Marchevsky AM, Tuli R
J Thorac Oncol 2017 Mar;12(3):425-436. Epub 2016 Nov 24 doi: 10.1016/j.jtho.2016.11.2222. PMID: 27890494
Large Cell Neuroendocrine Carcinoma of the Lung: Clinico-Pathologic Features, Treatment, and Outcomes.
Naidoo J, Santos-Zabala ML, Iyriboz T, Woo KM, Sima CS, Fiore JJ, Kris MG, Riely GJ, Lito P, Iqbal A, Veach S, Smith-Marrone S, Sarkaria IS, Krug LM, Rudin CM, Travis WD, Rekhtman N, Pietanza MC
Clin Lung Cancer 2016 Sep;17(5):e121-e129. Epub 2016 Jan 21 doi: 10.1016/j.cllc.2016.01.003. PMID: 26898325Free PMC Article
Pulmonary large-cell neuroendocrine carcinoma (LCNEC).
Hage R, Seldenrijk K, de Bruin P, van Swieten H, van den Bosch J
Eur J Cardiothorac Surg 2003 Apr;23(4):457-60. doi: 10.1016/s1010-7940(02)00837-0. PMID: 12694759

Diagnosis

Therapeutic options in lung neuroendocrine tumors: between established concepts and new hopes.
Brighi N, Lamberti G, Manuzzi L, Maggio I, Campana D
Anticancer Drugs 2019 Aug;30(7):e0784. doi: 10.1097/CAD.0000000000000784. PMID: 30896503
Management of pulmonary neuroendocrine tumors.
Ramirez RA, Chauhan A, Gimenez J, Thomas KEH, Kokodis I, Voros BA
Rev Endocr Metab Disord 2017 Dec;18(4):433-442. doi: 10.1007/s11154-017-9429-9. PMID: 28868578
Diagnosis and treatment of neuroendocrine lung tumors.
Sánchez de Cos Escuín J
Arch Bronconeumol 2014 Sep;50(9):392-6. Epub 2014 Mar 28 doi: 10.1016/j.arbres.2014.02.004. PMID: 24685201
Bronchopulmonary neuroendocrine tumors.
Gustafsson BI, Kidd M, Chan A, Malfertheiner MV, Modlin IM
Cancer 2008 Jul 1;113(1):5-21. doi: 10.1002/cncr.23542. PMID: 18473355
Pulmonary large-cell neuroendocrine carcinoma (LCNEC).
Hage R, Seldenrijk K, de Bruin P, van Swieten H, van den Bosch J
Eur J Cardiothorac Surg 2003 Apr;23(4):457-60. doi: 10.1016/s1010-7940(02)00837-0. PMID: 12694759

Therapy

Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Therapeutic options in lung neuroendocrine tumors: between established concepts and new hopes.
Brighi N, Lamberti G, Manuzzi L, Maggio I, Campana D
Anticancer Drugs 2019 Aug;30(7):e0784. doi: 10.1097/CAD.0000000000000784. PMID: 30896503
Neuroendocrine Tumors of the Lung: Current Challenges and Advances in the Diagnosis and Management of Well-Differentiated Disease.
Hendifar AE, Marchevsky AM, Tuli R
J Thorac Oncol 2017 Mar;12(3):425-436. Epub 2016 Nov 24 doi: 10.1016/j.jtho.2016.11.2222. PMID: 27890494
Large Cell Neuroendocrine Carcinoma of the Lung: Clinico-Pathologic Features, Treatment, and Outcomes.
Naidoo J, Santos-Zabala ML, Iyriboz T, Woo KM, Sima CS, Fiore JJ, Kris MG, Riely GJ, Lito P, Iqbal A, Veach S, Smith-Marrone S, Sarkaria IS, Krug LM, Rudin CM, Travis WD, Rekhtman N, Pietanza MC
Clin Lung Cancer 2016 Sep;17(5):e121-e129. Epub 2016 Jan 21 doi: 10.1016/j.cllc.2016.01.003. PMID: 26898325Free PMC Article
Dramatic response with capecitabine after cranial radiation to the brain parenchymal and leptomeningeal metastases from lung cancer.
Paydas S, Bicakci K, Yavuz S
Eur J Intern Med 2009 Jan;20(1):96-9. Epub 2008 Jun 25 doi: 10.1016/j.ejim.2008.04.015. PMID: 19237101

Prognosis

Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Therapeutic options in lung neuroendocrine tumors: between established concepts and new hopes.
Brighi N, Lamberti G, Manuzzi L, Maggio I, Campana D
Anticancer Drugs 2019 Aug;30(7):e0784. doi: 10.1097/CAD.0000000000000784. PMID: 30896503
Dramatic response with capecitabine after cranial radiation to the brain parenchymal and leptomeningeal metastases from lung cancer.
Paydas S, Bicakci K, Yavuz S
Eur J Intern Med 2009 Jan;20(1):96-9. Epub 2008 Jun 25 doi: 10.1016/j.ejim.2008.04.015. PMID: 19237101
Bronchopulmonary neuroendocrine tumors.
Gustafsson BI, Kidd M, Chan A, Malfertheiner MV, Modlin IM
Cancer 2008 Jul 1;113(1):5-21. doi: 10.1002/cncr.23542. PMID: 18473355
Pulmonary large-cell neuroendocrine carcinoma (LCNEC).
Hage R, Seldenrijk K, de Bruin P, van Swieten H, van den Bosch J
Eur J Cardiothorac Surg 2003 Apr;23(4):457-60. doi: 10.1016/s1010-7940(02)00837-0. PMID: 12694759

Clinical prediction guides

Incidence, survival comparison, and novel prognostic evaluation approaches for stage iii-iv pulmonary large cell neuroendocrine carcinoma and small cell lung cancer.
Huang L, Feng Y, Xie T, Zhu H, Tang L, Shi Y
BMC Cancer 2023 Apr 5;23(1):312. doi: 10.1186/s12885-023-10797-3. PMID: 37020179Free PMC Article
Clinical-Pathologic Challenges in the Classification of Pulmonary Neuroendocrine Neoplasms and Targets on the Horizon for Future Clinical Practice.
Derks JL, Rijnsburger N, Hermans BCM, Moonen L, Hillen LM, von der Thüsen JH, den Bakker MA, van Suylen RJ, Speel EM, Dingemans AC
J Thorac Oncol 2021 Oct;16(10):1632-1646. Epub 2021 Jun 15 doi: 10.1016/j.jtho.2021.05.020. PMID: 34139363
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Diagnostic difficulties with the diagnosis of small cell carcinoma of the lung.
Marchevsky AM, Wick MR
Semin Diagn Pathol 2015 Nov;32(6):480-8. Epub 2015 Nov 10 doi: 10.1053/j.semdp.2015.11.001. PMID: 26597580
Pulmonary large-cell neuroendocrine carcinoma (LCNEC).
Hage R, Seldenrijk K, de Bruin P, van Swieten H, van den Bosch J
Eur J Cardiothorac Surg 2003 Apr;23(4):457-60. doi: 10.1016/s1010-7940(02)00837-0. PMID: 12694759

Recent systematic reviews

Large Cell Neuroendocrine Carcinoma of the Prostate: A Systematic Review and Pooled Analysis.
Tu X, Chang T, Nie L, Qiu S, Xu H, Huang Y, Bao Y, Liu Z, Yang L, Wei Q
Urol Int 2019;103(4):383-390. Epub 2019 Apr 9 doi: 10.1159/000499883. PMID: 30965328
Neuroendrocrine tumors of the uterine cervix: A therapeutic challenge for gynecologic oncologists.
Gadducci A, Carinelli S, Aletti G
Gynecol Oncol 2017 Mar;144(3):637-646. Epub 2017 Jan 3 doi: 10.1016/j.ygyno.2016.12.003. PMID: 28057354

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