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Locally Advanced Lung Large Cell Neuroendocrine Carcinoma

MedGen UID:
1791076
•Concept ID:
C5554635
•
Neoplastic Process

Definition

Lung large cell neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Lung Large Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

High-Grade Gastrointestinal Neuroendocrine Carcinoma Management and Outcomes: A National Cancer Database Study.
Alese OB, Jiang R, Shaib W, Wu C, Akce M, Behera M, El-Rayes BF
Oncologist 2019 Jul;24(7):911-920. Epub 2018 Nov 27 doi: 10.1634/theoncologist.2018-0382. PMID: 30482824Free PMC Article
Immune Checkpoint Inhibitors in the Treatment of Patients with Neuroendocrine Neoplasia.
Weber MM, Fottner C
Oncol Res Treat 2018;41(5):306-312. Epub 2018 Apr 26 doi: 10.1159/000488996. PMID: 29742518
Current concepts in the diagnosis and management of poorly differentiated gastrointestinal neuroendocrine carcinomas.
Koumarianou A, Chatzellis E, Boutzios G, Tsavaris N, Kaltsas G
Endokrynol Pol 2013;64(1):60-72. PMID: 23450449

Recent clinical studies

Etiology

Incidence, survival comparison, and novel prognostic evaluation approaches for stage iii-iv pulmonary large cell neuroendocrine carcinoma and small cell lung cancer.
Huang L, Feng Y, Xie T, Zhu H, Tang L, Shi Y
BMC Cancer 2023 Apr 5;23(1):312. doi: 10.1186/s12885-023-10797-3. PMID: 37020179Free PMC Article
Clinicopathological and genomic features in patients with head and neck neuroendocrine carcinoma.
Ohmoto A, Sato Y, Asaka R, Fukuda N, Wang X, Urasaki T, Hayashi N, Sato Y, Nakano K, Yunokawa M, Ono M, Tomomatsu J, Toshiyasu T, Mitani H, Takeuchi K, Mori S, Takahashi S
Mod Pathol 2021 Nov;34(11):1979-1989. Epub 2021 Jul 10 doi: 10.1038/s41379-021-00869-9. PMID: 34247193Free PMC Article
Results of Surgical Resection of Locally Advanced Pulmonary Neuroendocrine Tumors.
Girelli L, Casiraghi M, Sandri A, Petrella F, Galetta D, Gasparri R, Maisonneuve P, Fazio N, Spaggiari L
Ann Thorac Surg 2021 Aug;112(2):405-414. Epub 2020 Oct 29 doi: 10.1016/j.athoracsur.2020.09.021. PMID: 33130114
Outcomes for Surgery in Large Cell Lung Neuroendocrine Cancer.
Raman V, Jawitz OK, Yang CJ, Voigt SL, Tong BC, D'Amico TA, Harpole DH
J Thorac Oncol 2019 Dec;14(12):2143-2151. Epub 2019 Sep 23 doi: 10.1016/j.jtho.2019.09.005. PMID: 31557535Free PMC Article
Neuroendrocrine tumors of the uterine cervix: A therapeutic challenge for gynecologic oncologists.
Gadducci A, Carinelli S, Aletti G
Gynecol Oncol 2017 Mar;144(3):637-646. Epub 2017 Jan 3 doi: 10.1016/j.ygyno.2016.12.003. PMID: 28057354

Diagnosis

Incidence, survival comparison, and novel prognostic evaluation approaches for stage iii-iv pulmonary large cell neuroendocrine carcinoma and small cell lung cancer.
Huang L, Feng Y, Xie T, Zhu H, Tang L, Shi Y
BMC Cancer 2023 Apr 5;23(1):312. doi: 10.1186/s12885-023-10797-3. PMID: 37020179Free PMC Article
Complete remission of combined pulmonary large cell neuroendocrine carcinoma: a case report.
Xu J, Feng Q, Chen Y, Liu XL, Jiang O
J Int Med Res 2021 Nov;49(11):3000605211055387. doi: 10.1177/03000605211055387. PMID: 34738481Free PMC Article
Primary large cell neuroendocrine carcinoma of the ovary: A rare entity.
Safini F, Jouhadi H, El Attar H
Gulf J Oncolog 2021 Jan;1(35):82-85. PMID: 33716217
Results of Surgical Resection of Locally Advanced Pulmonary Neuroendocrine Tumors.
Girelli L, Casiraghi M, Sandri A, Petrella F, Galetta D, Gasparri R, Maisonneuve P, Fazio N, Spaggiari L
Ann Thorac Surg 2021 Aug;112(2):405-414. Epub 2020 Oct 29 doi: 10.1016/j.athoracsur.2020.09.021. PMID: 33130114
Neuroendrocrine tumors of the uterine cervix: A therapeutic challenge for gynecologic oncologists.
Gadducci A, Carinelli S, Aletti G
Gynecol Oncol 2017 Mar;144(3):637-646. Epub 2017 Jan 3 doi: 10.1016/j.ygyno.2016.12.003. PMID: 28057354

Therapy

Complete remission of combined pulmonary large cell neuroendocrine carcinoma: a case report.
Xu J, Feng Q, Chen Y, Liu XL, Jiang O
J Int Med Res 2021 Nov;49(11):3000605211055387. doi: 10.1177/03000605211055387. PMID: 34738481Free PMC Article
New Approaches to SCLC Therapy: From the Laboratory to the Clinic.
Poirier JT, George J, Owonikoko TK, Berns A, Brambilla E, Byers LA, Carbone D, Chen HJ, Christensen CL, Dive C, Farago AF, Govindan R, Hann C, Hellmann MD, Horn L, Johnson JE, Ju YS, Kang S, Krasnow M, Lee J, Lee SH, Lehman J, Lok B, Lovly C, MacPherson D, McFadden D, Minna J, Oser M, Park K, Park KS, Pommier Y, Quaranta V, Ready N, Sage J, Scagliotti G, Sos ML, Sutherland KD, Travis WD, Vakoc CR, Wait SJ, Wistuba I, Wong KK, Zhang H, Daigneault J, Wiens J, Rudin CM, Oliver TG
J Thorac Oncol 2020 Apr;15(4):520-540. Epub 2020 Feb 1 doi: 10.1016/j.jtho.2020.01.016. PMID: 32018053Free PMC Article
Complete tumor response of a locally advanced lung large-cell neuroendocrine carcinoma after palliative thoracic radiotherapy and immunotherapy with nivolumab.
Mauclet C, Duplaquet F, Pirard L, Rondelet B, Dupont M, Pop-Stanciu C, Vander Borght T, Remmelink M, D'Haene N, Lambin S, Wanet M, Remouchamps V, Ocak S
Lung Cancer 2019 Feb;128:53-56. Epub 2018 Dec 5 doi: 10.1016/j.lungcan.2018.12.006. PMID: 30642453
Immune Checkpoint Inhibitors in the Treatment of Patients with Neuroendocrine Neoplasia.
Weber MM, Fottner C
Oncol Res Treat 2018;41(5):306-312. Epub 2018 Apr 26 doi: 10.1159/000488996. PMID: 29742518
Challenges in the Diagnosis and Management of Well-Differentiated Neuroendocrine Tumors of the Lung (Typical and Atypical Carcinoid): Current Status and Future Considerations.
Wolin EM
Oncologist 2015 Oct;20(10):1123-31. Epub 2015 Aug 25 doi: 10.1634/theoncologist.2015-0198. PMID: 26306904Free PMC Article

Prognosis

Incidence, survival comparison, and novel prognostic evaluation approaches for stage iii-iv pulmonary large cell neuroendocrine carcinoma and small cell lung cancer.
Huang L, Feng Y, Xie T, Zhu H, Tang L, Shi Y
BMC Cancer 2023 Apr 5;23(1):312. doi: 10.1186/s12885-023-10797-3. PMID: 37020179Free PMC Article
Complete remission of combined pulmonary large cell neuroendocrine carcinoma: a case report.
Xu J, Feng Q, Chen Y, Liu XL, Jiang O
J Int Med Res 2021 Nov;49(11):3000605211055387. doi: 10.1177/03000605211055387. PMID: 34738481Free PMC Article
Results of Surgical Resection of Locally Advanced Pulmonary Neuroendocrine Tumors.
Girelli L, Casiraghi M, Sandri A, Petrella F, Galetta D, Gasparri R, Maisonneuve P, Fazio N, Spaggiari L
Ann Thorac Surg 2021 Aug;112(2):405-414. Epub 2020 Oct 29 doi: 10.1016/j.athoracsur.2020.09.021. PMID: 33130114
Factors associated with treatment receipt and overall survival for patients with locally advanced large cell neuroendocrine carcinoma of the lung: A National Cancer Database analysis.
Limonnik V, Abel S, Finley GG, Long GS, Wegner RE
Lung Cancer 2020 Dec;150:107-113. Epub 2020 Oct 6 doi: 10.1016/j.lungcan.2020.10.001. PMID: 33126090
Neuroendrocrine tumors of the uterine cervix: A therapeutic challenge for gynecologic oncologists.
Gadducci A, Carinelli S, Aletti G
Gynecol Oncol 2017 Mar;144(3):637-646. Epub 2017 Jan 3 doi: 10.1016/j.ygyno.2016.12.003. PMID: 28057354

Clinical prediction guides

Incidence, survival comparison, and novel prognostic evaluation approaches for stage iii-iv pulmonary large cell neuroendocrine carcinoma and small cell lung cancer.
Huang L, Feng Y, Xie T, Zhu H, Tang L, Shi Y
BMC Cancer 2023 Apr 5;23(1):312. doi: 10.1186/s12885-023-10797-3. PMID: 37020179Free PMC Article
Factors associated with treatment receipt and overall survival for patients with locally advanced large cell neuroendocrine carcinoma of the lung: A National Cancer Database analysis.
Limonnik V, Abel S, Finley GG, Long GS, Wegner RE
Lung Cancer 2020 Dec;150:107-113. Epub 2020 Oct 6 doi: 10.1016/j.lungcan.2020.10.001. PMID: 33126090
Outcomes for Surgery in Large Cell Lung Neuroendocrine Cancer.
Raman V, Jawitz OK, Yang CJ, Voigt SL, Tong BC, D'Amico TA, Harpole DH
J Thorac Oncol 2019 Dec;14(12):2143-2151. Epub 2019 Sep 23 doi: 10.1016/j.jtho.2019.09.005. PMID: 31557535Free PMC Article
A case of large cell neuroendocrine carcinoma exhibiting rhabdoid features in the esophagogastric junction.
Ichimata S, Aoyagi D, Takehana T, Uehara T, Shiozawa S
Pathol Int 2019 Aug;69(8):481-487. Epub 2019 Jun 24 doi: 10.1111/pin.12807. PMID: 31237049
Immune Checkpoint Inhibitors in the Treatment of Patients with Neuroendocrine Neoplasia.
Weber MM, Fottner C
Oncol Res Treat 2018;41(5):306-312. Epub 2018 Apr 26 doi: 10.1159/000488996. PMID: 29742518

Recent systematic reviews

Neuroendrocrine tumors of the uterine cervix: A therapeutic challenge for gynecologic oncologists.
Gadducci A, Carinelli S, Aletti G
Gynecol Oncol 2017 Mar;144(3):637-646. Epub 2017 Jan 3 doi: 10.1016/j.ygyno.2016.12.003. PMID: 28057354

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