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Central Chondrosarcoma, Grade 1

MedGen UID:
1791510
•Concept ID:
C5555069
•
Neoplastic Process

Definition

A locally aggressive, low-grade chondrosarcoma arising in the medulla of bone in the axial skeleton. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral Chondrosarcoma, Grade 1

Professional guidelines

PubMed

A personalized medicine approach identifies enasidenib as an efficient treatment for IDH2 mutant chondrosarcoma.
Rey V, Tornín J, Alba-Linares JJ, Robledo C, Murillo D, Rodríguez A, Gallego B, Huergo C, Viera C, Braña A, Astudillo A, Heymann D, Szuhai K, Bovée JVMG, Fernández AF, Fraga MF, Alonso J, Rodríguez R
EBioMedicine 2024 Apr;102:105090. Epub 2024 Mar 27 doi: 10.1016/j.ebiom.2024.105090. PMID: 38547578Free PMC Article
Effect of Cryoablation Treatment on the Protein Expression Profile of Low-Grade Central Chondrosarcoma Identified by LC-ESI-MS/MS.
Madda R, Chen CM, Chen CF, Wang JY, Wu PK, Chen WM
J Am Soc Mass Spectrom 2021 Jun 2;32(6):1469-1489. Epub 2021 May 18 doi: 10.1021/jasms.1c00068. PMID: 34003650
Treatment strategies for central low-grade chondrosarcoma of long bones: a systematic review of the literature and meta-analysis.
Shemesh SS, Acevedo-Nieves JD, Pretell-Mazzini J
Musculoskelet Surg 2018 Aug;102(2):95-109. Epub 2017 Oct 6 doi: 10.1007/s12306-017-0507-7. PMID: 28986742

Recent clinical studies

Etiology

Bone and soft tissue tumors at the borderlands of malignancy.
Crim J, Layfield LJ
Skeletal Radiol 2023 Mar;52(3):379-392. Epub 2022 Jun 29 doi: 10.1007/s00256-022-04099-1. PMID: 35767018
The role of surgical margins in chondrosarcoma.
Stevenson JD, Laitinen MK, Parry MC, Sumathi V, Grimer RJ, Jeys LM
Eur J Surg Oncol 2018 Sep;44(9):1412-1418. Epub 2018 Jun 8 doi: 10.1016/j.ejso.2018.05.033. PMID: 29929901
Is intralesional resection suitable for central grade 1 chondrosarcoma: A systematic review and updated meta-analysis.
Chen X, Yu LJ, Peng HM, Jiang C, Ye CH, Zhu SB, Qian WW
Eur J Surg Oncol 2017 Sep;43(9):1718-1726. Epub 2017 Jun 14 doi: 10.1016/j.ejso.2017.05.022. PMID: 28666625
Intralesional curettage of central low-grade chondrosarcoma: A midterm follow-up study.
Chen YC, Wu PK, Chen CF, Chen WM
J Chin Med Assoc 2017 Mar;80(3):178-182. Epub 2016 Nov 23 doi: 10.1016/j.jcma.2016.10.002. PMID: 27889461
Dedifferentiated central chondrosarcoma.
Staals EL, Bacchini P, Bertoni F
Cancer 2006 Jun 15;106(12):2682-91. doi: 10.1002/cncr.21936. PMID: 16691621

Diagnosis

Bone and soft tissue tumors at the borderlands of malignancy.
Crim J, Layfield LJ
Skeletal Radiol 2023 Mar;52(3):379-392. Epub 2022 Jun 29 doi: 10.1007/s00256-022-04099-1. PMID: 35767018
The incidence and diagnostic relevance of pathological fracture in conventional central chondrosarcoma.
Alqubaisi A, Oliveira I, Singla N, Chavda A, Khoo M, Saifuddin A
Skeletal Radiol 2021 Jun;50(6):1131-1140. Epub 2020 Oct 30 doi: 10.1007/s00256-020-03651-1. PMID: 33123743
The role of surgical margins in chondrosarcoma.
Stevenson JD, Laitinen MK, Parry MC, Sumathi V, Grimer RJ, Jeys LM
Eur J Surg Oncol 2018 Sep;44(9):1412-1418. Epub 2018 Jun 8 doi: 10.1016/j.ejso.2018.05.033. PMID: 29929901
MRI differentiation of low-grade from high-grade appendicular chondrosarcoma.
Douis H, Singh L, Saifuddin A
Eur Radiol 2014 Jan;24(1):232-40. Epub 2013 Sep 10 doi: 10.1007/s00330-013-3003-y. PMID: 24337911
Dedifferentiated central chondrosarcoma.
Staals EL, Bacchini P, Bertoni F
Cancer 2006 Jun 15;106(12):2682-91. doi: 10.1002/cncr.21936. PMID: 16691621

Therapy

A Systematic Review of Adjuvant Chemotherapy in Localized Dedifferentiated Chondrosarcoma.
Tsukamoto S, Mavrogenis AF, Nitta Y, Righi A, Masunaga T, Honoki K, Fujii H, Kido A, Tanaka Y, Tanaka Y, Errani C
Curr Oncol 2024 Jan 19;31(1):566-578. doi: 10.3390/curroncol31010040. PMID: 38275833Free PMC Article
A machine learning-based model for clinical prediction of distal metastasis in chondrosarcoma: a multicenter, retrospective study.
Wei J, Lu S, Liu W, Liu H, Feng L, Tao Y, Pu Z, Liu Q, Hu Z, Wang H, Li W, Kang W, Yin C, Feng Z
PeerJ 2023;11:e16485. Epub 2023 Dec 18 doi: 10.7717/peerj.16485. PMID: 38130920Free PMC Article
Efficacy and safety of regorafenib in adult patients with metastatic osteosarcoma: a non-comparative, randomised, double-blind, placebo-controlled, phase 2 study.
Duffaud F, Mir O, Boudou-Rouquette P, Piperno-Neumann S, Penel N, Bompas E, Delcambre C, Kalbacher E, Italiano A, Collard O, Chevreau C, Saada E, Isambert N, Delaye J, Schiffler C, Bouvier C, Vidal V, Chabaud S, Blay JY; French Sarcoma Group
Lancet Oncol 2019 Jan;20(1):120-133. Epub 2018 Nov 23 doi: 10.1016/S1470-2045(18)30742-3. PMID: 30477937
Treatment strategies for central low-grade chondrosarcoma of long bones: a systematic review of the literature and meta-analysis.
Shemesh SS, Acevedo-Nieves JD, Pretell-Mazzini J
Musculoskelet Surg 2018 Aug;102(2):95-109. Epub 2017 Oct 6 doi: 10.1007/s12306-017-0507-7. PMID: 28986742
New chondrosarcoma cell lines and mouse models to study the link between chondrogenesis and chemoresistance.
Monderer D, Luseau A, Bellec A, David E, Ponsolle S, Saiagh S, Bercegeay S, Piloquet P, Denis MG, Lodé L, Rédini F, Biger M, Heymann D, Heymann MF, Le Bot R, Gouin F, Blanchard F
Lab Invest 2013 Oct;93(10):1100-14. Epub 2013 Aug 19 doi: 10.1038/labinvest.2013.101. PMID: 23958880

Prognosis

The incidence and diagnostic relevance of pathological fracture in conventional central chondrosarcoma.
Alqubaisi A, Oliveira I, Singla N, Chavda A, Khoo M, Saifuddin A
Skeletal Radiol 2021 Jun;50(6):1131-1140. Epub 2020 Oct 30 doi: 10.1007/s00256-020-03651-1. PMID: 33123743
The role of surgical margins in chondrosarcoma.
Stevenson JD, Laitinen MK, Parry MC, Sumathi V, Grimer RJ, Jeys LM
Eur J Surg Oncol 2018 Sep;44(9):1412-1418. Epub 2018 Jun 8 doi: 10.1016/j.ejso.2018.05.033. PMID: 29929901
Intralesional curettage of central low-grade chondrosarcoma: A midterm follow-up study.
Chen YC, Wu PK, Chen CF, Chen WM
J Chin Med Assoc 2017 Mar;80(3):178-182. Epub 2016 Nov 23 doi: 10.1016/j.jcma.2016.10.002. PMID: 27889461
MRI differentiation of low-grade from high-grade appendicular chondrosarcoma.
Douis H, Singh L, Saifuddin A
Eur Radiol 2014 Jan;24(1):232-40. Epub 2013 Sep 10 doi: 10.1007/s00330-013-3003-y. PMID: 24337911
Dedifferentiated central chondrosarcoma.
Staals EL, Bacchini P, Bertoni F
Cancer 2006 Jun 15;106(12):2682-91. doi: 10.1002/cncr.21936. PMID: 16691621

Clinical prediction guides

A machine learning-based model for clinical prediction of distal metastasis in chondrosarcoma: a multicenter, retrospective study.
Wei J, Lu S, Liu W, Liu H, Feng L, Tao Y, Pu Z, Liu Q, Hu Z, Wang H, Li W, Kang W, Yin C, Feng Z
PeerJ 2023;11:e16485. Epub 2023 Dec 18 doi: 10.7717/peerj.16485. PMID: 38130920Free PMC Article
The role of surgical margins in chondrosarcoma.
Stevenson JD, Laitinen MK, Parry MC, Sumathi V, Grimer RJ, Jeys LM
Eur J Surg Oncol 2018 Sep;44(9):1412-1418. Epub 2018 Jun 8 doi: 10.1016/j.ejso.2018.05.033. PMID: 29929901
Treatment strategies for central low-grade chondrosarcoma of long bones: a systematic review of the literature and meta-analysis.
Shemesh SS, Acevedo-Nieves JD, Pretell-Mazzini J
Musculoskelet Surg 2018 Aug;102(2):95-109. Epub 2017 Oct 6 doi: 10.1007/s12306-017-0507-7. PMID: 28986742
Is intralesional resection suitable for central grade 1 chondrosarcoma: A systematic review and updated meta-analysis.
Chen X, Yu LJ, Peng HM, Jiang C, Ye CH, Zhu SB, Qian WW
Eur J Surg Oncol 2017 Sep;43(9):1718-1726. Epub 2017 Jun 14 doi: 10.1016/j.ejso.2017.05.022. PMID: 28666625
Intralesional curettage of central low-grade chondrosarcoma: A midterm follow-up study.
Chen YC, Wu PK, Chen CF, Chen WM
J Chin Med Assoc 2017 Mar;80(3):178-182. Epub 2016 Nov 23 doi: 10.1016/j.jcma.2016.10.002. PMID: 27889461

Recent systematic reviews

A Systematic Review of Adjuvant Chemotherapy in Localized Dedifferentiated Chondrosarcoma.
Tsukamoto S, Mavrogenis AF, Nitta Y, Righi A, Masunaga T, Honoki K, Fujii H, Kido A, Tanaka Y, Tanaka Y, Errani C
Curr Oncol 2024 Jan 19;31(1):566-578. doi: 10.3390/curroncol31010040. PMID: 38275833Free PMC Article
Intralesional treatment versus wide resection for central low-grade chondrosarcoma of the long bones.
Dierselhuis EF, Goulding KA, Stevens M, Jutte PC
Cochrane Database Syst Rev 2019 Mar 7;3(3):CD010778. doi: 10.1002/14651858.CD010778.pub2. PMID: 30845364Free PMC Article
Treatment strategies for central low-grade chondrosarcoma of long bones: a systematic review of the literature and meta-analysis.
Shemesh SS, Acevedo-Nieves JD, Pretell-Mazzini J
Musculoskelet Surg 2018 Aug;102(2):95-109. Epub 2017 Oct 6 doi: 10.1007/s12306-017-0507-7. PMID: 28986742
Is intralesional resection suitable for central grade 1 chondrosarcoma: A systematic review and updated meta-analysis.
Chen X, Yu LJ, Peng HM, Jiang C, Ye CH, Zhu SB, Qian WW
Eur J Surg Oncol 2017 Sep;43(9):1718-1726. Epub 2017 Jun 14 doi: 10.1016/j.ejso.2017.05.022. PMID: 28666625

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