U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Malignant Bone Neoplasm

MedGen UID:
79002
•Concept ID:
C0279530
•
Neoplastic Process
Synonyms: Bone Cancer; Cancer of Bone; Cancer of the Bone
SNOMED CT: Malignant neoplasm of bone (428281000)

Definition

A primary or metastatic malignant neoplasm affecting the bone or articular cartilage. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Bone Neoplasm

Professional guidelines

PubMed

Subsequent Malignant Neoplasm of Bone in Children and Adolescent-Possibility of Multimodal Treatment.
Raciborska A, Bilska K, Koziński T, Rodriguez-Galindo C
Curr Oncol 2022 Feb 11;29(2):1001-1007. doi: 10.3390/curroncol29020085. PMID: 35200584Free PMC Article

Recent clinical studies

Etiology

Towards the Search for Potential Biomarkers in Osteosarcoma: State-of-the-Art and Translational Expectations.
Pekarek L, De la Torre-Escuredo B, Fraile-Martinez O, García-Montero C, Saez MA, Cobo-Prieto D, Guijarro LG, Saz JV, De Castro-Martinez P, Torres-Carranza D, Pekarek T, Carrera AC, Alvarez-Mon M, Ortega MA
Int J Mol Sci 2022 Nov 29;23(23) doi: 10.3390/ijms232314939. PMID: 36499267Free PMC Article
Differences in stromal component of chordoma are associated with contrast enhancement in MRI and differential gene expression in RNA sequencing.
Park M, Park I, Hong CK, Kim SH, Cha YJ
Sci Rep 2022 Oct 3;12(1):16504. doi: 10.1038/s41598-022-20787-3. PMID: 36192442Free PMC Article
Primary malignant bone neoplasm: a case report of dedifferentiated chondrosarcoma in the rib and review of the literature.
Lin JR, Zhang WM, Wang ZC
Chin J Cancer 2010 Nov;29(11):964-8. doi: 10.5732/cjc.009.10390. PMID: 20979697
Incidence and natural history of Paget's disease of bone in England and Wales.
van Staa TP, Selby P, Leufkens HG, Lyles K, Sprafka JM, Cooper C
J Bone Miner Res 2002 Mar;17(3):465-71. doi: 10.1359/jbmr.2002.17.3.465. PMID: 11878305
Fractures in large-segment allografts.
Thompson RC Jr, Garg A, Clohisy DR, Cheng EY
Clin Orthop Relat Res 2000 Jan;(370):227-35. doi: 10.1097/00003086-200001000-00023. PMID: 10660718

Diagnosis

Towards the Search for Potential Biomarkers in Osteosarcoma: State-of-the-Art and Translational Expectations.
Pekarek L, De la Torre-Escuredo B, Fraile-Martinez O, García-Montero C, Saez MA, Cobo-Prieto D, Guijarro LG, Saz JV, De Castro-Martinez P, Torres-Carranza D, Pekarek T, Carrera AC, Alvarez-Mon M, Ortega MA
Int J Mol Sci 2022 Nov 29;23(23) doi: 10.3390/ijms232314939. PMID: 36499267Free PMC Article
Co-occurrence of malignant neoplasm and Hyperostosis Frontalis Interna in an Iron Age individual from Münsingen-Rain (Switzerland): A multi-diagnostic study.
Laffranchi Z, Milella M, Lombardo P, Langer R, Lösch S
Int J Paleopathol 2021 Mar;32:1-8. Epub 2020 Nov 8 doi: 10.1016/j.ijpp.2020.10.008. PMID: 33176226
Primary malignant bone neoplasm: a case report of dedifferentiated chondrosarcoma in the rib and review of the literature.
Lin JR, Zhang WM, Wang ZC
Chin J Cancer 2010 Nov;29(11):964-8. doi: 10.5732/cjc.009.10390. PMID: 20979697
Incidence and natural history of Paget's disease of bone in England and Wales.
van Staa TP, Selby P, Leufkens HG, Lyles K, Sprafka JM, Cooper C
J Bone Miner Res 2002 Mar;17(3):465-71. doi: 10.1359/jbmr.2002.17.3.465. PMID: 11878305
Osteosarcoma of the jaw bones.
Chindia ML
Oral Oncol 2001 Oct;37(7):545-7. doi: 10.1016/s1368-8375(00)00129-9. PMID: 11564573

Therapy

A meta-analysis comparing efficiency of limb-salvage surgery vs amputation on patients with osteosarcoma treated with neoadjuvant chemotherapy.
Abdelgawad MA, Parambi DGT, Ghoneim MM, Alotaibi NH, Alzarea AI, Hassan AH, Abdelrahim MEA
Int Wound J 2022 Nov;19(7):1616-1624. Epub 2022 Feb 5 doi: 10.1111/iwj.13758. PMID: 35122396Free PMC Article
Combination of CDK4/6 and mTOR Inhibitors Suppressed Doxorubicin-resistant Osteosarcoma in a Patient-derived Orthotopic Xenograft Mouse Model: A Translatable Strategy for Recalcitrant Disease.
Oshiro H, Tome Y, Miyake K, Higuchi T, Sugisawa N, Kanaya F, Nishida K, Hoffman RM
Anticancer Res 2021 Jul;41(7):3287-3292. doi: 10.21873/anticanres.15115. PMID: 34230123
Primary malignant bone neoplasm: a case report of dedifferentiated chondrosarcoma in the rib and review of the literature.
Lin JR, Zhang WM, Wang ZC
Chin J Cancer 2010 Nov;29(11):964-8. doi: 10.5732/cjc.009.10390. PMID: 20979697
Extraskeletal Ewing sarcoma of the diaphragm presenting with hemothorax.
Eroğlu A, Kürkçüoğlu IC, Karaoğlanoğlu N, Alper F, Gündoğdu C
Ann Thorac Surg 2004 Aug;78(2):715-7. doi: 10.1016/S0003-4975(03)01418-8. PMID: 15276562
Fractures in large-segment allografts.
Thompson RC Jr, Garg A, Clohisy DR, Cheng EY
Clin Orthop Relat Res 2000 Jan;(370):227-35. doi: 10.1097/00003086-200001000-00023. PMID: 10660718

Prognosis

Towards the Search for Potential Biomarkers in Osteosarcoma: State-of-the-Art and Translational Expectations.
Pekarek L, De la Torre-Escuredo B, Fraile-Martinez O, García-Montero C, Saez MA, Cobo-Prieto D, Guijarro LG, Saz JV, De Castro-Martinez P, Torres-Carranza D, Pekarek T, Carrera AC, Alvarez-Mon M, Ortega MA
Int J Mol Sci 2022 Nov 29;23(23) doi: 10.3390/ijms232314939. PMID: 36499267Free PMC Article
CDKL3 promotes osteosarcoma progression by activating Akt/PKB.
He A, Ma L, Huang Y, Zhang H, Duan W, Li Z, Fei T, Yuan J, Wu H, Liu L, Bai Y, Dai W, Wang Y, Li H, Sun Y, Wang Y, Wang C, Yuan T, Yang Q, Tian S, Dong M, Sheng R, Xiang D
Life Sci Alliance 2020 May;3(5) Epub 2020 Mar 31 doi: 10.26508/lsa.202000648. PMID: 32234750Free PMC Article
Primary malignant bone neoplasm: a case report of dedifferentiated chondrosarcoma in the rib and review of the literature.
Lin JR, Zhang WM, Wang ZC
Chin J Cancer 2010 Nov;29(11):964-8. doi: 10.5732/cjc.009.10390. PMID: 20979697
Osteosarcoma of the jaw bones.
Chindia ML
Oral Oncol 2001 Oct;37(7):545-7. doi: 10.1016/s1368-8375(00)00129-9. PMID: 11564573
Fractures in large-segment allografts.
Thompson RC Jr, Garg A, Clohisy DR, Cheng EY
Clin Orthop Relat Res 2000 Jan;(370):227-35. doi: 10.1097/00003086-200001000-00023. PMID: 10660718

Clinical prediction guides

Combination of CDK4/6 and mTOR Inhibitors Suppressed Doxorubicin-resistant Osteosarcoma in a Patient-derived Orthotopic Xenograft Mouse Model: A Translatable Strategy for Recalcitrant Disease.
Oshiro H, Tome Y, Miyake K, Higuchi T, Sugisawa N, Kanaya F, Nishida K, Hoffman RM
Anticancer Res 2021 Jul;41(7):3287-3292. doi: 10.21873/anticanres.15115. PMID: 34230123
MicroRNA-27a promotes proliferation, migration and invasion by targeting MAP2K4 in human osteosarcoma cells.
Pan W, Wang H, Jianwei R, Ye Z
Cell Physiol Biochem 2014;33(2):402-12. Epub 2014 Feb 11 doi: 10.1159/000356679. PMID: 24556602
Genome-wide array comparative genomic hybridization analysis reveals distinct amplifications in osteosarcoma.
Man TK, Lu XY, Jaeweon K, Perlaky L, Harris CP, Shah S, Ladanyi M, Gorlick R, Lau CC, Rao PH
BMC Cancer 2004 Aug 7;4:45. doi: 10.1186/1471-2407-4-45. PMID: 15298715Free PMC Article
Osteosarcoma of the jaw bones.
Chindia ML
Oral Oncol 2001 Oct;37(7):545-7. doi: 10.1016/s1368-8375(00)00129-9. PMID: 11564573

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...