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Metastatic Low Grade Astrocytoma

MedGen UID:
1791573
•Concept ID:
C5555132
•
Neoplastic Process

Definition

Low grade astrocytoma that has spread from its primary site to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Low Grade Astrocytoma

Professional guidelines

PubMed

Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting.
Rautajoki KJ, Jaatinen S, Hartewig A, Tiihonen AM, Annala M, Salonen I, Valkonen M, Simola V, Vuorinen EM, Kivinen A, Rauhala MJ, Nurminen R, Maass KK, Lahtela SL, Jukkola A, Yli-Harja O, Helén P, Pajtler KW, Ruusuvuori P, Haapasalo J, Zhang W, Haapasalo H, Nykter M
Acta Neuropathol Commun 2023 Nov 6;11(1):176. doi: 10.1186/s40478-023-01669-9. PMID: 37932833Free PMC Article
Is chemotherapy alone an option as initial treatment for low-grade oligodendrogliomas?
Rudà R, Touat M, Soffietti R
Curr Opin Neurol 2020 Dec;33(6):707-715. doi: 10.1097/WCO.0000000000000866. PMID: 33027142
Molecular features assisting in diagnosis, surgery, and treatment decision making in low-grade gliomas.
Chen R, Ravindra VM, Cohen AL, Jensen RL, Salzman KL, Prescot AP, Colman H
Neurosurg Focus 2015 Mar;38(3):E2. doi: 10.3171/2015.1.FOCUS14745. PMID: 25727224

Recent clinical studies

Etiology

Managing Headache Disorders Associated with Tuberous Sclerosis and Neurofibromatosis.
Patniyot I, Qubty W
Curr Pain Headache Rep 2022 Apr;26(4):281-288. Epub 2022 Feb 18 doi: 10.1007/s11916-022-01032-y. PMID: 35179724
Glioblastoma: Is There Any Blood Biomarker with True Clinical Relevance?
Linhares P, Carvalho B, Vaz R, Costa BM
Int J Mol Sci 2020 Aug 13;21(16) doi: 10.3390/ijms21165809. PMID: 32823572Free PMC Article
Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study.
Baumert BG, Hegi ME, van den Bent MJ, von Deimling A, Gorlia T, Hoang-Xuan K, Brandes AA, Kantor G, Taphoorn MJB, Hassel MB, Hartmann C, Ryan G, Capper D, Kros JM, Kurscheid S, Wick W, Enting R, Reni M, Thiessen B, Dhermain F, Bromberg JE, Feuvret L, Reijneveld JC, Chinot O, Gijtenbeek JMM, Rossiter JP, Dif N, Balana C, Bravo-Marques J, Clement PM, Marosi C, Tzuk-Shina T, Nordal RA, Rees J, Lacombe D, Mason WP, Stupp R
Lancet Oncol 2016 Nov;17(11):1521-1532. Epub 2016 Sep 27 doi: 10.1016/S1470-2045(16)30313-8. PMID: 27686946Free PMC Article
Impending Impact of Molecular Pathology on Classifying Adult Diffuse Gliomas.
Macaulay RJ
Cancer Control 2015 Apr;22(2):200-5. doi: 10.1177/107327481502200211. PMID: 26068765
Current and future strategies in radiotherapy of childhood low-grade glioma of the brain. Part II: Treatment-related late toxicity.
Kortmann RD, Timmermann B, Taylor RE, Scarzello G, Plasswilm L, Paulsen F, Jeremic B, Gnekow AK, Dieckmann K, Kay S, Bamberg M
Strahlenther Onkol 2003 Sep;179(9):585-97. doi: 10.1007/s00066-003-8104-0. PMID: 14628124

Diagnosis

Glioblastoma: Is There Any Blood Biomarker with True Clinical Relevance?
Linhares P, Carvalho B, Vaz R, Costa BM
Int J Mol Sci 2020 Aug 13;21(16) doi: 10.3390/ijms21165809. PMID: 32823572Free PMC Article
The Multifaceted Metabolism of Glioblastoma.
Quinones A, Le A
Adv Exp Med Biol 2018;1063:59-72. doi: 10.1007/978-3-319-77736-8_4. PMID: 29946775
Incorporating Advances in Molecular Pathology Into Brain Tumor Diagnostics.
Velázquez Vega JE, Brat DJ
Adv Anat Pathol 2018 May;25(3):143-171. doi: 10.1097/PAP.0000000000000186. PMID: 29521646
Biomarker-driven diagnosis of diffuse gliomas.
Appin CL, Brat DJ
Mol Aspects Med 2015 Nov;45:87-96. Epub 2015 May 21 doi: 10.1016/j.mam.2015.05.002. PMID: 26004297
The definition of primary and secondary glioblastoma.
Ohgaki H, Kleihues P
Clin Cancer Res 2013 Feb 15;19(4):764-72. Epub 2012 Dec 3 doi: 10.1158/1078-0432.CCR-12-3002. PMID: 23209033

Therapy

Phase II Randomized Trial of Lenalidomide in Children With Pilocytic Astrocytomas and Optic Pathway Gliomas: A Report From the Children's Oncology Group.
Warren KE, Vezina G, Krailo M, Springer L, Buxton A, Peer CJ, Figg WD, William-Hughes C, Kessel S, Fouladi M, Gajjar A, Bowers D
J Clin Oncol 2023 Jun 20;41(18):3374-3383. Epub 2023 May 1 doi: 10.1200/JCO.22.01777. PMID: 37126770Free PMC Article
Laser Interstitial Thermal Therapy for the Treatment of Primary and Metastatic Brain Tumors: A Systematic Review and Meta-Analysis.
Alkazemi M, Lo YT, Hussein H, Mammi M, Saleh S, Araujo-Lama L, Mommsen S, Pisano A, Lamba N, Bunevicius A, Mekary RA
World Neurosurg 2023 Mar;171:e654-e671. Epub 2022 Dec 19 doi: 10.1016/j.wneu.2022.12.079. PMID: 36549438
Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor.
Hu H, Mu Q, Bao Z, Chen Y, Liu Y, Chen J, Wang K, Wang Z, Nam Y, Jiang B, Sa JK, Cho HJ, Her NG, Zhang C, Zhao Z, Zhang Y, Zeng F, Wu F, Kang X, Liu Y, Qian Z, Wang Z, Huang R, Wang Q, Zhang W, Qiu X, Li W, Nam DH, Fan X, Wang J, Jiang T
Cell 2018 Nov 29;175(6):1665-1678.e18. Epub 2018 Oct 18 doi: 10.1016/j.cell.2018.09.038. PMID: 30343896
Neuroradiological viewpoint on the diagnostics of space-occupying brain lesions.
Faehndrich J, Weidauer S, Pilatus U, Oszvald A, Zanella FE, Hattingen E
Clin Neuroradiol 2011 Sep;21(3):123-39. Epub 2011 May 3 doi: 10.1007/s00062-011-0073-6. PMID: 21538040
Current and future strategies in radiotherapy of childhood low-grade glioma of the brain. Part II: Treatment-related late toxicity.
Kortmann RD, Timmermann B, Taylor RE, Scarzello G, Plasswilm L, Paulsen F, Jeremic B, Gnekow AK, Dieckmann K, Kay S, Bamberg M
Strahlenther Onkol 2003 Sep;179(9):585-97. doi: 10.1007/s00066-003-8104-0. PMID: 14628124

Prognosis

Glioblastoma: Is There Any Blood Biomarker with True Clinical Relevance?
Linhares P, Carvalho B, Vaz R, Costa BM
Int J Mol Sci 2020 Aug 13;21(16) doi: 10.3390/ijms21165809. PMID: 32823572Free PMC Article
Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor.
Hu H, Mu Q, Bao Z, Chen Y, Liu Y, Chen J, Wang K, Wang Z, Nam Y, Jiang B, Sa JK, Cho HJ, Her NG, Zhang C, Zhao Z, Zhang Y, Zeng F, Wu F, Kang X, Liu Y, Qian Z, Wang Z, Huang R, Wang Q, Zhang W, Qiu X, Li W, Nam DH, Fan X, Wang J, Jiang T
Cell 2018 Nov 29;175(6):1665-1678.e18. Epub 2018 Oct 18 doi: 10.1016/j.cell.2018.09.038. PMID: 30343896
The genetic basis of intradural spinal tumors and its impact on clinical treatment.
Karsy M, Guan J, Sivakumar W, Neil JA, Schmidt MH, Mahan MA
Neurosurg Focus 2015 Aug;39(2):E3. doi: 10.3171/2015.5.FOCUS15143. PMID: 26235020
Biomarker-driven diagnosis of diffuse gliomas.
Appin CL, Brat DJ
Mol Aspects Med 2015 Nov;45:87-96. Epub 2015 May 21 doi: 10.1016/j.mam.2015.05.002. PMID: 26004297
The definition of primary and secondary glioblastoma.
Ohgaki H, Kleihues P
Clin Cancer Res 2013 Feb 15;19(4):764-72. Epub 2012 Dec 3 doi: 10.1158/1078-0432.CCR-12-3002. PMID: 23209033

Clinical prediction guides

Secondary dystonia following parenchymal brain tumors.
Baizabal-Carvallo JF, Jankovic J
J Neurol Sci 2023 Mar 15;446:120577. Epub 2023 Feb 1 doi: 10.1016/j.jns.2023.120577. PMID: 36738494
β-Catenin marks proliferating endothelial cells in glioblastoma.
Manoranjan B, Provias JP
J Clin Neurosci 2022 Apr;98:203-206. Epub 2022 Feb 18 doi: 10.1016/j.jocn.2022.02.018. PMID: 35189545
Glioblastoma: Is There Any Blood Biomarker with True Clinical Relevance?
Linhares P, Carvalho B, Vaz R, Costa BM
Int J Mol Sci 2020 Aug 13;21(16) doi: 10.3390/ijms21165809. PMID: 32823572Free PMC Article
A comparative analysis of clinicopathological features and survival among early adolescents/young adults and children with low-grade glioma: a report from the Children's Oncology Group.
Margol AS, Yeo KK, Xia C, Onar A, Robison NJ, Freyer DR, Dhall G
J Neurooncol 2018 Dec;140(3):575-582. Epub 2018 Sep 1 doi: 10.1007/s11060-018-2983-5. PMID: 30173409Free PMC Article
Metabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma.
Jalbert LE, Elkhaled A, Phillips JJ, Neill E, Williams A, Crane JC, Olson MP, Molinaro AM, Berger MS, Kurhanewicz J, Ronen SM, Chang SM, Nelson SJ
Sci Rep 2017 Mar 22;7:44792. doi: 10.1038/srep44792. PMID: 28327577Free PMC Article

Recent systematic reviews

Application of Machine Learning for Classification of Brain Tumors: A Systematic Review and Meta-Analysis.
Silva Santana L, Borges Camargo Diniz J, Mothé Glioche Gasparri L, Buccaran Canto A, Batista Dos Reis S, Santana Neville Ribeiro I, Gadelha Figueiredo E, Paulo Mota Telles J
World Neurosurg 2024 Jun;186:204-218.e2. Epub 2024 Apr 3 doi: 10.1016/j.wneu.2024.03.152. PMID: 38580093
Laser Interstitial Thermal Therapy for the Treatment of Primary and Metastatic Brain Tumors: A Systematic Review and Meta-Analysis.
Alkazemi M, Lo YT, Hussein H, Mammi M, Saleh S, Araujo-Lama L, Mommsen S, Pisano A, Lamba N, Bunevicius A, Mekary RA
World Neurosurg 2023 Mar;171:e654-e671. Epub 2022 Dec 19 doi: 10.1016/j.wneu.2022.12.079. PMID: 36549438
External beam radiation dose escalation for high grade glioma.
Khan L, Soliman H, Sahgal A, Perry J, Xu W, Tsao MN
Cochrane Database Syst Rev 2020 May 21;5(5):CD011475. doi: 10.1002/14651858.CD011475.pub3. PMID: 32437039Free PMC Article
A systematic review of outcome in intramedullary ependymoma and astrocytoma.
Hamilton KR, Lee SS, Urquhart JC, Jonker BP
J Clin Neurosci 2019 May;63:168-175. Epub 2019 Mar 2 doi: 10.1016/j.jocn.2019.02.001. PMID: 30833131
A systematic literature review of magnetic resonance spectroscopy for the characterization of brain tumors.
Hollingworth W, Medina LS, Lenkinski RE, Shibata DK, Bernal B, Zurakowski D, Comstock B, Jarvik JG
AJNR Am J Neuroradiol 2006 Aug;27(7):1404-11. PMID: 16908548Free PMC Article

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