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Metastatic Low Grade Astrocytoma

MedGen UID:
1791573
•Concept ID:
C5555132
•
Neoplastic Process

Definition

Low grade astrocytoma that has spread from its primary site to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Low Grade Astrocytoma

Professional guidelines

PubMed

Is chemotherapy alone an option as initial treatment for low-grade oligodendrogliomas?
Rudà R, Touat M, Soffietti R
Curr Opin Neurol 2020 Dec;33(6):707-715. doi: 10.1097/WCO.0000000000000866. PMID: 33027142
The genetic basis of intradural spinal tumors and its impact on clinical treatment.
Karsy M, Guan J, Sivakumar W, Neil JA, Schmidt MH, Mahan MA
Neurosurg Focus 2015 Aug;39(2):E3. doi: 10.3171/2015.5.FOCUS15143. PMID: 26235020
Molecular features assisting in diagnosis, surgery, and treatment decision making in low-grade gliomas.
Chen R, Ravindra VM, Cohen AL, Jensen RL, Salzman KL, Prescot AP, Colman H
Neurosurg Focus 2015 Mar;38(3):E2. doi: 10.3171/2015.1.FOCUS14745. PMID: 25727224

Recent clinical studies

Etiology

A Molecular Update and Review of Current Trials in Paediatric Low-Grade Gliomas.
Al-Jilaihawi S, Lowis S
Pediatr Neurosurg 2023;58(5):290-298. Epub 2023 Aug 21 doi: 10.1159/000533703. PMID: 37604126
Recurrence- and Malignant Progression-Associated Biomarkers in Low-Grade Gliomas and Their Roles in Immunotherapy.
Teng C, Zhu Y, Li Y, Dai L, Pan Z, Wanggou S, Li X
Front Immunol 2022;13:899710. Epub 2022 May 23 doi: 10.3389/fimmu.2022.899710. PMID: 35677036Free PMC Article
Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study.
Baumert BG, Hegi ME, van den Bent MJ, von Deimling A, Gorlia T, Hoang-Xuan K, Brandes AA, Kantor G, Taphoorn MJB, Hassel MB, Hartmann C, Ryan G, Capper D, Kros JM, Kurscheid S, Wick W, Enting R, Reni M, Thiessen B, Dhermain F, Bromberg JE, Feuvret L, Reijneveld JC, Chinot O, Gijtenbeek JMM, Rossiter JP, Dif N, Balana C, Bravo-Marques J, Clement PM, Marosi C, Tzuk-Shina T, Nordal RA, Rees J, Lacombe D, Mason WP, Stupp R
Lancet Oncol 2016 Nov;17(11):1521-1532. Epub 2016 Sep 27 doi: 10.1016/S1470-2045(16)30313-8. PMID: 27686946Free PMC Article
Molecular features assisting in diagnosis, surgery, and treatment decision making in low-grade gliomas.
Chen R, Ravindra VM, Cohen AL, Jensen RL, Salzman KL, Prescot AP, Colman H
Neurosurg Focus 2015 Mar;38(3):E2. doi: 10.3171/2015.1.FOCUS14745. PMID: 25727224
Molecular pathways in gliomagenesis and their relevance to neuropathologic diagnosis.
Appin CL, Brat DJ
Adv Anat Pathol 2015 Jan;22(1):50-8. doi: 10.1097/PAP.0000000000000048. PMID: 25461780

Diagnosis

The Multifaceted Metabolism of Glioblastoma.
Quinones A, Le A
Adv Exp Med Biol 2018;1063:59-72. doi: 10.1007/978-3-319-77736-8_4. PMID: 29946775
Incorporating Advances in Molecular Pathology Into Brain Tumor Diagnostics.
Velázquez Vega JE, Brat DJ
Adv Anat Pathol 2018 May;25(3):143-171. doi: 10.1097/PAP.0000000000000186. PMID: 29521646
Molecular features assisting in diagnosis, surgery, and treatment decision making in low-grade gliomas.
Chen R, Ravindra VM, Cohen AL, Jensen RL, Salzman KL, Prescot AP, Colman H
Neurosurg Focus 2015 Mar;38(3):E2. doi: 10.3171/2015.1.FOCUS14745. PMID: 25727224
Molecular pathways in gliomagenesis and their relevance to neuropathologic diagnosis.
Appin CL, Brat DJ
Adv Anat Pathol 2015 Jan;22(1):50-8. doi: 10.1097/PAP.0000000000000048. PMID: 25461780
The definition of primary and secondary glioblastoma.
Ohgaki H, Kleihues P
Clin Cancer Res 2013 Feb 15;19(4):764-72. Epub 2012 Dec 3 doi: 10.1158/1078-0432.CCR-12-3002. PMID: 23209033

Therapy

Is chemotherapy alone an option as initial treatment for low-grade oligodendrogliomas?
Rudà R, Touat M, Soffietti R
Curr Opin Neurol 2020 Dec;33(6):707-715. doi: 10.1097/WCO.0000000000000866. PMID: 33027142
Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor.
Hu H, Mu Q, Bao Z, Chen Y, Liu Y, Chen J, Wang K, Wang Z, Nam Y, Jiang B, Sa JK, Cho HJ, Her NG, Zhang C, Zhao Z, Zhang Y, Zeng F, Wu F, Kang X, Liu Y, Qian Z, Wang Z, Huang R, Wang Q, Zhang W, Qiu X, Li W, Nam DH, Fan X, Wang J, Jiang T
Cell 2018 Nov 29;175(6):1665-1678.e18. Epub 2018 Oct 18 doi: 10.1016/j.cell.2018.09.038. PMID: 30343896
Temozolomide low-dose chemotherapy in newly diagnosed low-grade gliomas: activity, safety, and long-term follow-up.
Villani V, Merola R, Vidiri A, Fabi A, Carosi M, Giannarelli D, Marucci L, Maschio M, Carapella CM, Pace A
Tumori 2017 May 12;103(3):255-260. Epub 2016 Sep 22 doi: 10.5301/tj.5000565. PMID: 27716874
Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study.
Baumert BG, Hegi ME, van den Bent MJ, von Deimling A, Gorlia T, Hoang-Xuan K, Brandes AA, Kantor G, Taphoorn MJB, Hassel MB, Hartmann C, Ryan G, Capper D, Kros JM, Kurscheid S, Wick W, Enting R, Reni M, Thiessen B, Dhermain F, Bromberg JE, Feuvret L, Reijneveld JC, Chinot O, Gijtenbeek JMM, Rossiter JP, Dif N, Balana C, Bravo-Marques J, Clement PM, Marosi C, Tzuk-Shina T, Nordal RA, Rees J, Lacombe D, Mason WP, Stupp R
Lancet Oncol 2016 Nov;17(11):1521-1532. Epub 2016 Sep 27 doi: 10.1016/S1470-2045(16)30313-8. PMID: 27686946Free PMC Article
Current and future strategies in radiotherapy of childhood low-grade glioma of the brain. Part II: Treatment-related late toxicity.
Kortmann RD, Timmermann B, Taylor RE, Scarzello G, Plasswilm L, Paulsen F, Jeremic B, Gnekow AK, Dieckmann K, Kay S, Bamberg M
Strahlenther Onkol 2003 Sep;179(9):585-97. doi: 10.1007/s00066-003-8104-0. PMID: 14628124

Prognosis

Recurrence- and Malignant Progression-Associated Biomarkers in Low-Grade Gliomas and Their Roles in Immunotherapy.
Teng C, Zhu Y, Li Y, Dai L, Pan Z, Wanggou S, Li X
Front Immunol 2022;13:899710. Epub 2022 May 23 doi: 10.3389/fimmu.2022.899710. PMID: 35677036Free PMC Article
Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor.
Hu H, Mu Q, Bao Z, Chen Y, Liu Y, Chen J, Wang K, Wang Z, Nam Y, Jiang B, Sa JK, Cho HJ, Her NG, Zhang C, Zhao Z, Zhang Y, Zeng F, Wu F, Kang X, Liu Y, Qian Z, Wang Z, Huang R, Wang Q, Zhang W, Qiu X, Li W, Nam DH, Fan X, Wang J, Jiang T
Cell 2018 Nov 29;175(6):1665-1678.e18. Epub 2018 Oct 18 doi: 10.1016/j.cell.2018.09.038. PMID: 30343896
The Multifaceted Metabolism of Glioblastoma.
Quinones A, Le A
Adv Exp Med Biol 2018;1063:59-72. doi: 10.1007/978-3-319-77736-8_4. PMID: 29946775
Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study.
Baumert BG, Hegi ME, van den Bent MJ, von Deimling A, Gorlia T, Hoang-Xuan K, Brandes AA, Kantor G, Taphoorn MJB, Hassel MB, Hartmann C, Ryan G, Capper D, Kros JM, Kurscheid S, Wick W, Enting R, Reni M, Thiessen B, Dhermain F, Bromberg JE, Feuvret L, Reijneveld JC, Chinot O, Gijtenbeek JMM, Rossiter JP, Dif N, Balana C, Bravo-Marques J, Clement PM, Marosi C, Tzuk-Shina T, Nordal RA, Rees J, Lacombe D, Mason WP, Stupp R
Lancet Oncol 2016 Nov;17(11):1521-1532. Epub 2016 Sep 27 doi: 10.1016/S1470-2045(16)30313-8. PMID: 27686946Free PMC Article
The definition of primary and secondary glioblastoma.
Ohgaki H, Kleihues P
Clin Cancer Res 2013 Feb 15;19(4):764-72. Epub 2012 Dec 3 doi: 10.1158/1078-0432.CCR-12-3002. PMID: 23209033

Clinical prediction guides

Recurrence- and Malignant Progression-Associated Biomarkers in Low-Grade Gliomas and Their Roles in Immunotherapy.
Teng C, Zhu Y, Li Y, Dai L, Pan Z, Wanggou S, Li X
Front Immunol 2022;13:899710. Epub 2022 May 23 doi: 10.3389/fimmu.2022.899710. PMID: 35677036Free PMC Article
Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study.
Baumert BG, Hegi ME, van den Bent MJ, von Deimling A, Gorlia T, Hoang-Xuan K, Brandes AA, Kantor G, Taphoorn MJB, Hassel MB, Hartmann C, Ryan G, Capper D, Kros JM, Kurscheid S, Wick W, Enting R, Reni M, Thiessen B, Dhermain F, Bromberg JE, Feuvret L, Reijneveld JC, Chinot O, Gijtenbeek JMM, Rossiter JP, Dif N, Balana C, Bravo-Marques J, Clement PM, Marosi C, Tzuk-Shina T, Nordal RA, Rees J, Lacombe D, Mason WP, Stupp R
Lancet Oncol 2016 Nov;17(11):1521-1532. Epub 2016 Sep 27 doi: 10.1016/S1470-2045(16)30313-8. PMID: 27686946Free PMC Article
Biomarker-driven diagnosis of diffuse gliomas.
Appin CL, Brat DJ
Mol Aspects Med 2015 Nov;45:87-96. Epub 2015 May 21 doi: 10.1016/j.mam.2015.05.002. PMID: 26004297
Molecular pathways in gliomagenesis and their relevance to neuropathologic diagnosis.
Appin CL, Brat DJ
Adv Anat Pathol 2015 Jan;22(1):50-8. doi: 10.1097/PAP.0000000000000048. PMID: 25461780
Isocitrate dehydrogenase status and molecular subclasses of glioma and glioblastoma.
Agnihotri S, Aldape KD, Zadeh G
Neurosurg Focus 2014 Dec;37(6):E13. doi: 10.3171/2014.9.FOCUS14505. PMID: 25434382

Recent systematic reviews

Laser Interstitial Thermal Therapy for the Treatment of Primary and Metastatic Brain Tumors: A Systematic Review and Meta-Analysis.
Alkazemi M, Lo YT, Hussein H, Mammi M, Saleh S, Araujo-Lama L, Mommsen S, Pisano A, Lamba N, Bunevicius A, Mekary RA
World Neurosurg 2023 Mar;171:e654-e671. Epub 2022 Dec 19 doi: 10.1016/j.wneu.2022.12.079. PMID: 36549438
External beam radiation dose escalation for high grade glioma.
Khan L, Soliman H, Sahgal A, Perry J, Xu W, Tsao MN
Cochrane Database Syst Rev 2020 May 21;5(5):CD011475. doi: 10.1002/14651858.CD011475.pub3. PMID: 32437039Free PMC Article
A systematic review of outcome in intramedullary ependymoma and astrocytoma.
Hamilton KR, Lee SS, Urquhart JC, Jonker BP
J Clin Neurosci 2019 May;63:168-175. Epub 2019 Mar 2 doi: 10.1016/j.jocn.2019.02.001. PMID: 30833131
A systematic literature review of magnetic resonance spectroscopy for the characterization of brain tumors.
Hollingworth W, Medina LS, Lenkinski RE, Shibata DK, Bernal B, Zurakowski D, Comstock B, Jarvik JG
AJNR Am J Neuroradiol 2006 Aug;27(7):1404-11. PMID: 16908548Free PMC Article

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