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Refractory Ovarian Squamous Cell Carcinoma

MedGen UID:
1791971
•Concept ID:
C5555530
•
Neoplastic Process

Definition

Ovarian squamous cell carcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Ovarian Squamous Cell Carcinoma

Professional guidelines

PubMed

Technology evaluation: tgDCC-E1A, targeted genetics/MD Anderson.
Wagner JA
Curr Opin Mol Ther 1999 Apr;1(2):266-70. PMID: 11715950
Paclitaxel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer.
Spencer CM, Faulds D
Drugs 1994 Nov;48(5):794-847. doi: 10.2165/00003495-199448050-00009. PMID: 7530632
Recurrent stage I endometrial carcinoma: results of treatment and prognostic factors.
Mandell LR, Nori D, Hilaris B
Int J Radiat Oncol Biol Phys 1985 Jun;11(6):1103-9. doi: 10.1016/0360-3016(85)90056-2. PMID: 3997592

Recent clinical studies

Etiology

Clinical characteristics and laparoscopic surgical outcomes of ovarian dermoid cysts complicated by spontaneous rupture: nine cases and a literature review.
Takeda A, Koike W
J Int Med Res 2023 May;51(5):3000605231171023. doi: 10.1177/03000605231171023. PMID: 37138472Free PMC Article
Rethinking the significance of surgery for uterine cervical cancer.
Shimada M, Tsuji K, Shigeta S, Nagai T, Watanabe Z, Tokunaga H, Kigawa J, Yaegashi N
J Obstet Gynaecol Res 2022 Mar;48(3):576-586. Epub 2021 Dec 14 doi: 10.1111/jog.15112. PMID: 34908207
Folate Receptor Alpha Expression in Platinum Resistant/Refractory Ovarian Carcinomas and Primary Endocervical Adenocarcinomas.
Rubinsak LA, Cohen C, Khanna N, Horowitz IR, Hanley KZ
Appl Immunohistochem Mol Morphol 2018 Sep;26(8):567-572. doi: 10.1097/PAI.0000000000000476. PMID: 27941566
Lessons learned from independent central review.
Ford R, Schwartz L, Dancey J, Dodd LE, Eisenhauer EA, Gwyther S, Rubinstein L, Sargent D, Shankar L, Therasse P, Verweij J
Eur J Cancer 2009 Jan;45(2):268-74. doi: 10.1016/j.ejca.2008.10.031. PMID: 19101138
Phase I study to evaluate multiple regimens of intravenous 5-fluorouracil administered in combination with weekly gemcitabine in patients with advanced solid tumors: a potential broadly active regimen for advanced solid tumor malignancies.
Mani S, Vogelzang NJ, Bertucci D, Stadler WM, Schilsky RL, Ratain MJ
Cancer 2001 Sep 15;92(6):1567-76. doi: 10.1002/1097-0142(20010915)92:6<1567::aid-cncr1483>3.0.co;2-l. PMID: 11745236

Diagnosis

Malignant transformation from mature cystic teratoma of the ovary.
Shimada T, Higashijima A, Fukushima A, Komatsu N, Noguchi M, Ohashi K, Hasegawa Y, Miura K
J Obstet Gynaecol Res 2019 Sep;45(9):1957-1960. Epub 2019 Jun 19 doi: 10.1111/jog.14043. PMID: 31215124
Phase II trial of thio-TEPA in relapsed and refractory ovarian carcinoma.
Langer CJ, Nash S, Catalano R, Rosenblum NG, Hogan WM, Comis RL, O'Dwyer PJ
Gynecol Oncol 1991 Dec;43(3):242-6. doi: 10.1016/0090-8258(91)90028-4. PMID: 1752494

Therapy

Isatuximab plus atezolizumab in patients with advanced solid tumors: results from a phase I/II, open-label, multicenter study.
Simonelli M, Garralda E, Eskens F, Gil-Martin M, Yen CJ, Obermannova R, Chao Y, Lonardi S, Melichar B, Moreno V, Yu ML, Bongiovanni A, Calvo E, Rottey S, Machiels JP, Gonzalez-Martin A, Paz-Ares L, Chang CL, Mason W, Lin CC, Reardon DA, Vieito M, Santoro A, Meng R, Abbadessa G, Menas F, Lee H, Liu Q, Combeau C, Ternes N, Ziti-Ljajic S, Massard C
ESMO Open 2022 Oct;7(5):100562. Epub 2022 Aug 18 doi: 10.1016/j.esmoop.2022.100562. PMID: 35987165Free PMC Article
Safety, tolerability and efficacy of agonist anti-CD27 antibody (varlilumab) administered in combination with anti-PD-1 (nivolumab) in advanced solid tumors.
Sanborn RE, Pishvaian MJ, Callahan MK, Weise A, Sikic BI, Rahma O, Cho DC, Rizvi NA, Sznol M, Lutzky J, Bauman JE, Bitting RL, Starodub A, Jimeno A, Reardon DA, Kaley T, Iwamoto F, Baehring JM, Subramaniam DS, Aragon-Ching JB, Hawthorne TR, Rawls T, Yellin M, Keler T
J Immunother Cancer 2022 Aug;10(8) doi: 10.1136/jitc-2022-005147. PMID: 35940825Free PMC Article
Investigating the potential of bevacizumab in other indications: metastatic renal cell, non-small cell lung, pancreatic and breast cancer.
de Gramont A, Van Cutsem E
Oncology 2005;69 Suppl 3:46-56. Epub 2005 Nov 21 doi: 10.1159/000088483. PMID: 16301835
Review of phase I clinical studies with topotecan.
Rowinsky EK, Verweij J
Semin Oncol 1997 Dec;24(6 Suppl 20):S20-3-S20-10. PMID: 9425956
Paclitaxel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer.
Spencer CM, Faulds D
Drugs 1994 Nov;48(5):794-847. doi: 10.2165/00003495-199448050-00009. PMID: 7530632

Prognosis

Folate Receptor Alpha Expression in Platinum Resistant/Refractory Ovarian Carcinomas and Primary Endocervical Adenocarcinomas.
Rubinsak LA, Cohen C, Khanna N, Horowitz IR, Hanley KZ
Appl Immunohistochem Mol Morphol 2018 Sep;26(8):567-572. doi: 10.1097/PAI.0000000000000476. PMID: 27941566
Continuous low-dose GM-CSF as salvage therapy in refractory recurrent breast or female genital tract carcinoma.
Kurbacher CM, Kurbacher JA, Cramer EM, Rhiem K, Mallman PK, Reichelt R, Reinhold U, Stier U, Cree IA
Oncology (Williston Park) 2005 Apr;19(4 Suppl 2):23-6. PMID: 15934497
Recurrent stage I endometrial carcinoma: results of treatment and prognostic factors.
Mandell LR, Nori D, Hilaris B
Int J Radiat Oncol Biol Phys 1985 Jun;11(6):1103-9. doi: 10.1016/0360-3016(85)90056-2. PMID: 3997592
Adriamycin, 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU-NSC 409462), and cyclophosphamide in refractory adenocarcinoma of the breast and other tumors.
Presant CA, Kolhouse JF, Klahr C
Cancer 1976 Feb;37(2):620-8. doi: 10.1002/1097-0142(197602)37:2<620::aid-cncr2820370203>3.0.co;2-d. PMID: 1253101

Clinical prediction guides

Clinical characteristics and laparoscopic surgical outcomes of ovarian dermoid cysts complicated by spontaneous rupture: nine cases and a literature review.
Takeda A, Koike W
J Int Med Res 2023 May;51(5):3000605231171023. doi: 10.1177/03000605231171023. PMID: 37138472Free PMC Article
Isatuximab plus atezolizumab in patients with advanced solid tumors: results from a phase I/II, open-label, multicenter study.
Simonelli M, Garralda E, Eskens F, Gil-Martin M, Yen CJ, Obermannova R, Chao Y, Lonardi S, Melichar B, Moreno V, Yu ML, Bongiovanni A, Calvo E, Rottey S, Machiels JP, Gonzalez-Martin A, Paz-Ares L, Chang CL, Mason W, Lin CC, Reardon DA, Vieito M, Santoro A, Meng R, Abbadessa G, Menas F, Lee H, Liu Q, Combeau C, Ternes N, Ziti-Ljajic S, Massard C
ESMO Open 2022 Oct;7(5):100562. Epub 2022 Aug 18 doi: 10.1016/j.esmoop.2022.100562. PMID: 35987165Free PMC Article
Safety, tolerability and efficacy of agonist anti-CD27 antibody (varlilumab) administered in combination with anti-PD-1 (nivolumab) in advanced solid tumors.
Sanborn RE, Pishvaian MJ, Callahan MK, Weise A, Sikic BI, Rahma O, Cho DC, Rizvi NA, Sznol M, Lutzky J, Bauman JE, Bitting RL, Starodub A, Jimeno A, Reardon DA, Kaley T, Iwamoto F, Baehring JM, Subramaniam DS, Aragon-Ching JB, Hawthorne TR, Rawls T, Yellin M, Keler T
J Immunother Cancer 2022 Aug;10(8) doi: 10.1136/jitc-2022-005147. PMID: 35940825Free PMC Article
Investigating the potential of bevacizumab in other indications: metastatic renal cell, non-small cell lung, pancreatic and breast cancer.
de Gramont A, Van Cutsem E
Oncology 2005;69 Suppl 3:46-56. Epub 2005 Nov 21 doi: 10.1159/000088483. PMID: 16301835
Paclitaxel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer.
Spencer CM, Faulds D
Drugs 1994 Nov;48(5):794-847. doi: 10.2165/00003495-199448050-00009. PMID: 7530632

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