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Ovarian squamous cell carcinoma

MedGen UID:
384474
•Concept ID:
C2019443
•
Neoplastic Process
Synonyms: ovarian squamous cell cancer; Ovarian Squamous Cell Carcinoma; ovarian squamous cell carcinoma; ovary squamous cell carcinoma
 
Monarch Initiative: MONDO:0003494

Definition

A usually high grade squamous cell carcinoma that arises from the ovary and is not associated with a germ cell tumor. The prognosis is poor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian squamous cell carcinoma

Professional guidelines

PubMed

APOBEC3C is a novel target for the immune treatment of lower-grade gliomas.
Zhao S, Li Y, Xu J, Shen L
Neurol Res 2024 Mar;46(3):227-242. Epub 2024 Jan 22 doi: 10.1080/01616412.2023.2287340. PMID: 38007705
Menopause hormone treatment after cancer.
Gompel A
Climacteric 2023 Jun;26(3):240-247. Epub 2023 Apr 3 doi: 10.1080/13697137.2023.2176216. PMID: 37011657
Assessment of causal effects of visceral adipose tissue on risk of cancers: a Mendelian randomization study.
Lu Y, Tang H, Huang P, Wang J, Deng P, Li Y, Zheng J, Weng L
Int J Epidemiol 2022 Aug 10;51(4):1204-1218. doi: 10.1093/ije/dyac025. PMID: 35218345Free PMC Article

Recent clinical studies

Etiology

High-risk HPV-associated ovarian squamous cell carcinoma: A case report and literature review.
Li J
Medicine (Baltimore) 2023 Nov 3;102(44):e35907. doi: 10.1097/MD.0000000000035907. PMID: 37932970Free PMC Article
Squamous cell carcinoma in mature cystic teratoma of the ovary induced by human papillomavirus 16 infection: A case report and literature review.
Shi Z, Yang L, Bian C
Medicine (Baltimore) 2022 Sep 23;101(38):e30667. doi: 10.1097/MD.0000000000030667. PMID: 36197169Free PMC Article
Poorer prognosis of ovarian squamous cell carcinoma than serous carcinoma: a propensity score matching analysis based on the SEER database.
Zhang C, Ma T
J Ovarian Res 2020 Jul 1;13(1):75. doi: 10.1186/s13048-020-00675-y. PMID: 32611433Free PMC Article
Recurrence of ovarian squamous cell carcinoma with MET gene copy number variation: a case report and review of literature.
Dong X, Yuan L, Yao L
J Ovarian Res 2020 May 31;13(1):62. doi: 10.1186/s13048-020-00659-y. PMID: 32475345Free PMC Article
Overexpression of CASC11 in ovarian squamous cell carcinoma mediates the development of cancer cell resistance to chemotherapy.
Shen F, Feng L, Zhou J, Zhang H, Xu Y, Jiang R, Zhang H, Chen Y
Gene 2019 Aug 20;710:363-366. Epub 2019 Jun 7 doi: 10.1016/j.gene.2019.06.011. PMID: 31181314

Diagnosis

High-risk HPV-associated ovarian squamous cell carcinoma: A case report and literature review.
Li J
Medicine (Baltimore) 2023 Nov 3;102(44):e35907. doi: 10.1097/MD.0000000000035907. PMID: 37932970Free PMC Article
Squamous cell carcinoma in mature cystic teratoma of the ovary induced by human papillomavirus 16 infection: A case report and literature review.
Shi Z, Yang L, Bian C
Medicine (Baltimore) 2022 Sep 23;101(38):e30667. doi: 10.1097/MD.0000000000030667. PMID: 36197169Free PMC Article
Ovarian squamous cell carcinoma.
Tobar PR, Assad RA, Nazal ON, Suárez ER
J Cancer Res Ther 2022 Apr-Jun;18(3):777-779. doi: 10.4103/jcrt.JCRT_562_20. PMID: 35900555
Poorer prognosis of ovarian squamous cell carcinoma than serous carcinoma: a propensity score matching analysis based on the SEER database.
Zhang C, Ma T
J Ovarian Res 2020 Jul 1;13(1):75. doi: 10.1186/s13048-020-00675-y. PMID: 32611433Free PMC Article
A case of squamous cell carcinoma arising from endometriosis of the ovary.
Hasegawa E, Nishi H, Terauchi F, Isaka K
Eur J Gynaecol Oncol 2011;32(5):554-6. PMID: 22053674

Therapy

Case of pure ovarian squamous cell carcinoma resistant to combination chemotherapy with paclitaxel and carboplatin but responsive to monotherapy with weekly irinotecan.
Nakamura Y, Kamei T, Shinagawa M, Sakamoto Y, Miwa I
J Obstet Gynaecol Res 2015 May;41(5):809-12. Epub 2014 Dec 16 doi: 10.1111/jog.12631. PMID: 25511544
Ovarian squamous cell carcinoma which metastasized 8 years after cervical conization for early microinvasive cervical cancer: a case report.
Hidaka T, Nakashima A, Hasegawa T, Nomoto K, Ishizawa S, Tsuneyama K, Takano Y, Saito S
Jpn J Clin Oncol 2011 Jun;41(6):807-10. Epub 2011 Apr 5 doi: 10.1093/jjco/hyr041. PMID: 21467082
De novo primary squamous cell carcinoma of the ovary: a case of a rare malignancy with an aggressive clinical course.
Amjad AI, Pal I
J Pak Med Assoc 2008 May;58(5):272-4. PMID: 18655408
A case of pure-type ovarian squamous cell carcinoma for which combination chemotherapy consisting of paclitaxel and carboplatin was not effective.
Todo Y, Minobe S, Sasaki M, Yamamoto R, Sakuragi N
Gynecol Oncol 2005 Apr;97(1):223-7. doi: 10.1016/j.ygyno.2004.11.055. PMID: 15790463
A case of rapidly growing ovarian squamous cell carcinoma successfully controlled by weekly paclitaxel-carboplatin administration.
Ohtani K, Sakamoto H, Masaoka N, Shimada K, Kanaeda T, Kurihara M, Nagai N, Satoh K
Gynecol Oncol 2000 Dec;79(3):515-8. doi: 10.1006/gyno.2000.5985. PMID: 11104632

Prognosis

Squamous cell carcinoma in mature cystic teratoma of the ovary induced by human papillomavirus 16 infection: A case report and literature review.
Shi Z, Yang L, Bian C
Medicine (Baltimore) 2022 Sep 23;101(38):e30667. doi: 10.1097/MD.0000000000030667. PMID: 36197169Free PMC Article
Poorer prognosis of ovarian squamous cell carcinoma than serous carcinoma: a propensity score matching analysis based on the SEER database.
Zhang C, Ma T
J Ovarian Res 2020 Jul 1;13(1):75. doi: 10.1186/s13048-020-00675-y. PMID: 32611433Free PMC Article
Recurrence of ovarian squamous cell carcinoma with MET gene copy number variation: a case report and review of literature.
Dong X, Yuan L, Yao L
J Ovarian Res 2020 May 31;13(1):62. doi: 10.1186/s13048-020-00659-y. PMID: 32475345Free PMC Article
Overexpression of CASC11 in ovarian squamous cell carcinoma mediates the development of cancer cell resistance to chemotherapy.
Shen F, Feng L, Zhou J, Zhang H, Xu Y, Jiang R, Zhang H, Chen Y
Gene 2019 Aug 20;710:363-366. Epub 2019 Jun 7 doi: 10.1016/j.gene.2019.06.011. PMID: 31181314
HPV induced ovarian squamous cell carcinoma: case report and review of the literature.
Verguts J, Amant F, Moerman P, Vergote I
Arch Gynecol Obstet 2007 Sep;276(3):285-9. Epub 2007 Feb 28 doi: 10.1007/s00404-007-0333-5. PMID: 17333225

Clinical prediction guides

Ovarian squamous cell carcinoma associated with teratoma: a report of six cases with genomic analysis.
Liang Y, Ruan H, Yu M, Lü B
Pathology 2023 Dec;55(7):966-973. Epub 2023 Sep 6 doi: 10.1016/j.pathol.2023.08.001. PMID: 37739924
Poorer prognosis of ovarian squamous cell carcinoma than serous carcinoma: a propensity score matching analysis based on the SEER database.
Zhang C, Ma T
J Ovarian Res 2020 Jul 1;13(1):75. doi: 10.1186/s13048-020-00675-y. PMID: 32611433Free PMC Article
Pure primary ovarian squamous cell carcinoma.
Ben-Baruch G, Menashe Y, Herczeg E, Menczer J
Gynecol Oncol 1988 Feb;29(2):257-62. doi: 10.1016/0090-8258(88)90223-5. PMID: 3276582

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