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Ovarian Smooth Muscle Tumor of Uncertain Malignant Potential

MedGen UID:
1792085
•Concept ID:
C5555644
•
Neoplastic Process
Synonym: Ovarian Smooth Muscle Neoplasm of Uncertain Malignant Potential

Definition

A smooth muscle neoplasm that arises from the ovary and cannot be reliably diagnosed as benign or malignant, because of the presence of ambiguous morphologic findings. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian Smooth Muscle Tumor of Uncertain Malignant Potential

Professional guidelines

PubMed

Uterine Tumors Resembling Ovarian Sex Cord Tumors: A Clinicopathologic Study of 75 Cases Emphasizing Features Predicting Adverse Outcome and Differential Diagnosis.
Boyraz B, Watkins JC, Young RH, Oliva E
Am J Surg Pathol 2023 Feb 1;47(2):234-247. Epub 2022 Oct 27 doi: 10.1097/PAS.0000000000001981. PMID: 36306239
Epithelioid Leiomyosarcoma of the Uterus: Modern Outcome-based Appraisal of Diagnostic Criteria in a Large Institutional Series.
Chapel DB, Nucci MR, Quade BJ, Parra-Herran C
Am J Surg Pathol 2022 Apr 1;46(4):464-475. doi: 10.1097/PAS.0000000000001795. PMID: 34419987
CA-125 in Disease Progression and Treatment of Lymphangioleiomyomatosis.
Glasgow CG, Pacheco-Rodriguez G, Steagall WK, Haughey ME, Julien-Williams PA, Stylianou MP, Gochuico BR, Moss J
Chest 2018 Feb;153(2):339-348. Epub 2017 May 30 doi: 10.1016/j.chest.2017.05.018. PMID: 28576630Free PMC Article

Recent clinical studies

Etiology

Dedifferentiated leiomyosarcoma of the uterus: a clinicopathologic and immunohistochemical analysis of 23 cases.
Chapel DB, Maccio L, Bragantini E, Zannoni GF, Quade BJ, Parra-Herran C, Nucci MR
Histopathology 2023 May;82(6):812-825. Epub 2023 Feb 8 doi: 10.1111/his.14870. PMID: 36704944
Gynecological lesions in hereditary cancer predisposition syndromes.
Dundr P, Cibula D, Foretová L, Macek M Jr, Kopečková K, Petruželka L, Němejcová K, Bártů M, Hojný J, Hájková N, Jakša R, Janega P, Stružinská I
Cesk Patol 2021 Summer;57(2):96-104. PMID: 34275319
Protective Effects of Incretin Against Age-Related Diseases.
Zhang D, Ma M, Liu Y
Curr Drug Deliv 2019;16(9):793-806. doi: 10.2174/1567201816666191010145029. PMID: 31622202
Beyond Smooth Muscle-Other Mesenchymal Neoplasms of the Uterus.
Dickson BC
Surg Pathol Clin 2019 Mar;12(1):107-137. Epub 2018 Dec 24 doi: 10.1016/j.path.2018.10.005. PMID: 30709439
Cellular mesenchymal tumors of the uterus: a review emphasizing recent observations.
Oliva E
Int J Gynecol Pathol 2014 Jul;33(4):374-84. doi: 10.1097/PGP.0000000000000141. PMID: 24901397

Diagnosis

"Evolution" of intravascular leiomyomatosis.
Chen L, Yang Y, Zhao C
BMC Womens Health 2023 Sep 11;23(1):483. doi: 10.1186/s12905-023-02618-3. PMID: 37697329Free PMC Article
Periostin promotes ovarian cancer metastasis by enhancing M2 macrophages and cancer-associated fibroblasts via integrin-mediated NF-κB and TGF-β2 signaling.
Lin SC, Liao YC, Chen PM, Yang YY, Wang YH, Tung SL, Chuang CM, Sung YW, Jang TH, Chuang SE, Wang LH
J Biomed Sci 2022 Dec 22;29(1):109. doi: 10.1186/s12929-022-00888-x. PMID: 36550569Free PMC Article
The Uterine Plexiform Lesions Revisited.
Karpathiou G, Papoudou-Bai A, Clemenson A, Chauleur C, Peoc'h M
Am J Clin Pathol 2020 Jul 7;154(2):178-189. doi: 10.1093/ajcp/aqaa054. PMID: 32459343
Beyond Smooth Muscle-Other Mesenchymal Neoplasms of the Uterus.
Dickson BC
Surg Pathol Clin 2019 Mar;12(1):107-137. Epub 2018 Dec 24 doi: 10.1016/j.path.2018.10.005. PMID: 30709439
Uterine Mesenchymal Tumors: Hereditary Aspects.
Joehlin-Price AS, Garg K
Adv Anat Pathol 2018 Mar;25(2):96-105. doi: 10.1097/PAP.0000000000000175. PMID: 28945610

Therapy

Protective Effects of Incretin Against Age-Related Diseases.
Zhang D, Ma M, Liu Y
Curr Drug Deliv 2019;16(9):793-806. doi: 10.2174/1567201816666191010145029. PMID: 31622202
CA-125 in Disease Progression and Treatment of Lymphangioleiomyomatosis.
Glasgow CG, Pacheco-Rodriguez G, Steagall WK, Haughey ME, Julien-Williams PA, Stylianou MP, Gochuico BR, Moss J
Chest 2018 Feb;153(2):339-348. Epub 2017 May 30 doi: 10.1016/j.chest.2017.05.018. PMID: 28576630Free PMC Article
Ovarian steroids, stem cells and uterine leiomyoma: therapeutic implications.
Moravek MB, Yin P, Ono M, Coon JS 5th, Dyson MT, Navarro A, Marsh EE, Chakravarti D, Kim JJ, Wei JJ, Bulun SE
Hum Reprod Update 2015 Jan-Feb;21(1):1-12. Epub 2014 Sep 8 doi: 10.1093/humupd/dmu048. PMID: 25205766Free PMC Article
Pericyte-coverage of human tumor vasculature and nanoparticle permeability.
Zhang L, Nishihara H, Kano MR
Biol Pharm Bull 2012;35(5):761-6. doi: 10.1248/bpb.35.761. PMID: 22687413
Mixed epithelial and stromal tumor of the kidney.
Adsay NV, Eble JN, Srigley JR, Jones EC, Grignon DJ
Am J Surg Pathol 2000 Jul;24(7):958-70. doi: 10.1097/00000478-200007000-00007. PMID: 10895818

Prognosis

Dedifferentiated leiomyosarcoma of the uterus: a clinicopathologic and immunohistochemical analysis of 23 cases.
Chapel DB, Maccio L, Bragantini E, Zannoni GF, Quade BJ, Parra-Herran C, Nucci MR
Histopathology 2023 May;82(6):812-825. Epub 2023 Feb 8 doi: 10.1111/his.14870. PMID: 36704944
Periostin promotes ovarian cancer metastasis by enhancing M2 macrophages and cancer-associated fibroblasts via integrin-mediated NF-κB and TGF-β2 signaling.
Lin SC, Liao YC, Chen PM, Yang YY, Wang YH, Tung SL, Chuang CM, Sung YW, Jang TH, Chuang SE, Wang LH
J Biomed Sci 2022 Dec 22;29(1):109. doi: 10.1186/s12929-022-00888-x. PMID: 36550569Free PMC Article
The Role of CTHRC1 in Regulation of Multiple Signaling and Tumor Progression and Metastasis.
Mei D, Zhu Y, Zhang L, Wei W
Mediators Inflamm 2020;2020:9578701. Epub 2020 Aug 12 doi: 10.1155/2020/9578701. PMID: 32848510Free PMC Article
Beyond Smooth Muscle-Other Mesenchymal Neoplasms of the Uterus.
Dickson BC
Surg Pathol Clin 2019 Mar;12(1):107-137. Epub 2018 Dec 24 doi: 10.1016/j.path.2018.10.005. PMID: 30709439
Primary Leiomyosarcoma of the Ovarian Vein: Case Report and Literature Review.
López-Ruiz ME, Yébenes L, Berjón A, Hardisson D
Int J Surg Pathol 2017 Jun;25(4):339-343. Epub 2016 Nov 23 doi: 10.1177/1066896916679888. PMID: 27881610

Clinical prediction guides

"Evolution" of intravascular leiomyomatosis.
Chen L, Yang Y, Zhao C
BMC Womens Health 2023 Sep 11;23(1):483. doi: 10.1186/s12905-023-02618-3. PMID: 37697329Free PMC Article
Periostin promotes ovarian cancer metastasis by enhancing M2 macrophages and cancer-associated fibroblasts via integrin-mediated NF-κB and TGF-β2 signaling.
Lin SC, Liao YC, Chen PM, Yang YY, Wang YH, Tung SL, Chuang CM, Sung YW, Jang TH, Chuang SE, Wang LH
J Biomed Sci 2022 Dec 22;29(1):109. doi: 10.1186/s12929-022-00888-x. PMID: 36550569Free PMC Article
The Role of CTHRC1 in Regulation of Multiple Signaling and Tumor Progression and Metastasis.
Mei D, Zhu Y, Zhang L, Wei W
Mediators Inflamm 2020;2020:9578701. Epub 2020 Aug 12 doi: 10.1155/2020/9578701. PMID: 32848510Free PMC Article
Protective Effects of Incretin Against Age-Related Diseases.
Zhang D, Ma M, Liu Y
Curr Drug Deliv 2019;16(9):793-806. doi: 10.2174/1567201816666191010145029. PMID: 31622202
The usefulness of clinical measurements of cell proliferation in gynecological cancer.
Quinn CM, Wright NA
Int J Gynecol Pathol 1992;11(2):131-43. doi: 10.1097/00004347-199204000-00007. PMID: 1316322

Recent systematic reviews

The Uterine Plexiform Lesions Revisited.
Karpathiou G, Papoudou-Bai A, Clemenson A, Chauleur C, Peoc'h M
Am J Clin Pathol 2020 Jul 7;154(2):178-189. doi: 10.1093/ajcp/aqaa054. PMID: 32459343

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